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Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice

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Acta Pharmaceutica Sinica B 2022年第2期12卷 801-820页

作者： Mallory Little Moumita Dutta Hao Li adam matson Xiaojian Shi Gabby Mascarinas Bruk Molla Kris Weigel Haiwei Gu Sridhar Mani Julia Yue Cui Department of Environmental and Occupational Health Sciences University of WashingtonSeattleWA 98105USA Department of Medicine Molecular Pharmacology and GeneticsAlbert Einstein College of MedicineBronxNY 10461USA University of Connecticut HartfordCT 06106USA Arizona Metabolomics Laboratory College of Health SolutionsArizona State UniversityPhoenixAZ 85004USA

Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study, we discovered bivalent hormetic functions of PXR/CAR modulating the richness of the gut microbiome using genetically engineered mice. The absence of PXR or CAR increased microbial richness, and absence of both receptors synergistically increased microbial richness. PXR and CAR deficiency increased the pro-inflammatory bacteria Helicobacteraceae and Helicobacter. Deficiency in both PXR and CAR increased the relative abundance of Lactobacillus, which has bile salt hydrolase activity, corresponding to decreased primary taurine-conjugated bile acids(BAs) in feces, which may lead to higher internal burden of taurine and unconjugated BAs, both of which are linked to inflammation, oxidative stress, and cytotoxicity. The basal effect of PXR/CAR on the gut microbiome was distinct from pharmacological and toxicological activation of these receptors. Common PXR/CAR-targeted bacteria were identified, the majority of which were suppressed by these receptors. h PXR-TG mice had a distinct microbial profile as compared to wild-type mice. This study is the first to unveil the basal functions of PXR and CAR on the gut microbiome.

关键词： PXR CAR Gut microbiome Bile acids Inflammation Mice Nuclear receptor Feces

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Nurses’experiences of caring for preterm infants in pain:A metaethnography

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International Journal of Nursing Sciences 2022年第4期9卷 533-541页

作者： Tingting Zhao Angela R.Starkweather adam matson Shabnam Lainwala Wanli Xu Xiaomei Cong School of Nursing University of ConnecticutStorrsCTUSA College of Nursing University of FloridaGainesvilleFLUSA Division of Neonatology Connecticut Children’s Medical CenterHartfordCTUSA Department of Pediatrics University of Connecticut School of MedicineFarmingtonCTUSA School of Nursing Yale UniversityOrangeCTUSA

Objective:Preterm infants are subjected to numerous painful procedures during their neonatal intensive care unit(NICU)*** advancements in pain alleviation,nurses remain challenged to provide timely and effective pain management for preterm *** understanding of the lived experience of nurses caring for preterm infants in pain could provide novel insights to improve pain management for this vulnerable *** aim of this meta-ethnography was to synthesize and interpret qualitative findings of nurses’experiences of taking care of preterm infants in ***:An extensive literature search in PubMed,CINAHL,PsycINFO,Scopus,BIOSIS and ProQuest Dissertation and Theses Database was conducted,including studies within the past 10 *** nursing researchers conducted data extraction and analysis *** criteria were applied to search for qualitative studies of nurse participants who worked in the NICU taking care of preterm *** published in a language other than English,articles that did not include qualitative data and qualitative data that could not be extracted from the findings or did not discuss nurses’experiences were *** Appraisal Skills Programme was used for literature quality ***:Eight studies remained after further screening according to inclusion and exclusion *** eight studies were conducted from 2013 to 2018 and totally enrolled 205 nurses from Iran,Canada,the United States,Finland,Sweden,Switzerland,and *** themes emerged on the nurses’perspectives of taking care of preterm infants in pain:1)They sense the neonatal pain;2)Adverse consequences of unrelieved pain;3)Barriers of managing pain;4)Concerns of available approaches for pain relief;5)Failure to work with ***:This meta-ethnography identified nurses’understanding of pain in preterm infants that can be assessed,and they acknowledged that unrelieved pain could cause deve

关键词： Neonatal intensive care units Premature infant Pain measurement Parents Pain Nursing care Nurses

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Adrenomedullin and endocrine control of immune cells during pregnancy

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Cellular & Molecular Immunology 2014年第5期11卷 456-459页

作者： Brooke C matson Kathleen M Caron Departments of Cell Biology & Physiology University of North Carolina at Chapel Hill Chapel Hill NC USA Genetics University of North Carolina at Chapel Hill Chapel Hill NC USA

The immunology of pregnancy is complex and incompletely understood. Aberrant immune activity in the decidua and in the placenta is believed to play a role in diseases of pregnancy, such as infertility, miscarriage, fetal growth restriction and preeclampsia. Here, we briefly review the endocrine control of uterine natural killer cell populations and their functions by the peptide hormone adrenomedullin. Studies in genetic animal models have revealed the critical importance of adrenomedullin dosage at the maternal-fetal interface, with cells from both the maternal and fetal compartments contributing to essential aspects underlying appropriate uterine receptivity, implantation and vascular remodeling of spiral arteries. These basic insights into the crosstalk between the endocrine and immune systems within the maternal- fetal interface may ultimately translate to a better understanding of the functions and consequences of dysregulated adrenomedullin levels in clinically complicated pregnancies.

关键词： adrenomedullin preeclampsia pregnancy spiral artery remodeling uNK cells

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Comprehensive DDoS Attack Classification Using Machine LearningAlgorithms

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Computers, Materials & Continua 2022年第10期73卷 577-594页

作者： Olga Ussatova Aidana Zhumabekova Yenlik Begimbayeva Eric T.matson Nikita Ussatov Al-Farabi Kazakh National University Almaty050040Kazakhstan Institute of Information and Computational Technologies Almaty050010Kazakhstan Satbayev University Almaty050013Kazakhstan Purdue University West Lafayette47907INUSA Turan University Almaty050013Kazakhstan

The fast development of Internet technologies ignited the growthof techniques for information security that protect data, networks, systems,and applications from various threats. There are many types of threats. Thededicated denial of service attack (DDoS) is one of the most serious andwidespread attacks on Internet resources. This attack is intended to paralyzethe victim’s system and cause the service to fail. This work is devoted tothe classification of DDoS attacks in the special network environment calledSoftware-Defined Networking (SDN) using machine learning algorithms. Theanalyzed dataset included instances of two classes: benign and *** the dataset contained twenty-two features, the feature selection techniques were required for dimensionality reduction. In these experiments, theInformation gain, the Chi-square, and the F-test were applied to decreasethe number of features to ten. The classes were also not completely balanced, so undersampling, oversampling, and synthetic minority oversampling(SMOTE) techniques were used to balance classes equally. The previousresearch works observed the classification of DDoS attacks applying variousfeature selection techniques and one or more machine learning ***, they did not pay much attention to classifying the combinations offeature selection and balancing methods with different machine learningalgorithms. This work is devoted to the classification of datasets with eightmachine learning algorithms: naïve Bayes, logistic regression, support vectormachine, k-nearest neighbors, decision tree, random forest, XGBoost, andCatBoost. In the experimental results, the Information gain and F-test featureselection methods achieved better performance with all eight ML algorithmsthan with the Chi-square technique. Furthermore, the accuracy values of theoversampled and SMOTE datasets were higher than that of the undersampledand imbalanced datasets. Among machine learning algorithms, the accuracyof support vector

关键词： Internet security networks systems DDoS software-defined networking feature selection class balancing machine learning XGBoost CatBoost

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Enriched Diets and the Growth,Development and Survival of Litoria moorei(Anura)Tadpoles Reared in Captivity at Low Density

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Asian Herpetological Research 2010年第2期1卷 103-110页

作者： Phillip matson Glen Gaikhorst Wendy Kappelle Sandy Webb Suzanne Brown Perth Zoo 20 Labouchere RoadSouth PerthWestern Australia 6151 School of Veterinary and Biomedical Sciences Murdoch University Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital

Increasing numbers of amphibian species require conservation breeding programs for their survival.A major challenge is the efficient rearing of tadpoles,many of which require complex habitats and specialised *** tadpoles of the West Australian frog Litoria moorei were kept at low density(1 tadpole per 1.95 litres water) in aquaria at 25℃.Fed on a staple diet of boiled lettuce and leaf litter,group of diets were supplemented with either control,Wardley Premium Spirulina Discs,SeraTMGVG-mix tropical fish food,or a combination of Wardley Premium Spirulina discs and SeraTMGVG-mix fish *** was a relatively high loss(i.e.,found dead,euthanized due to scoliosis,or not found) of tadpoles fed with the lettuce/leaf litter alone,but this was increased significantly when supplemented with Wardley Premium Spirulina discs,either alone or with SeraTMGVG-mix fish food,and SeraTMGVG fish food ***,the survived tadpoles fed on the three supplements were all heavier after three weeks and at metamorphosis than those fed with lettuce/leaf litter alone,and reached metamorphosis *** is concluded that any benefit of the food supplements in terms of increasing the rate of growth and development of the tadpoles is outweighed by greater *** is now a need for the efficient rearing of tadpoles,many from novel species that need complex *** studies of diet are required due to the current conservation crisis of amphibians.

关键词： Litoria moorei commercial food protein tadpole

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Proposed age-stratified reference intervals of FSH derived from normozoospermic men

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Asian pacific Journal of Reproduction 2021年第4期10卷 162-167页

作者： Emily-Jane Waller Jason Conceicao Phillip matson John L Yovich School of Medical and Health Sciences Edith Cowan UniversityJoondalupPerthAustralia PIVET Medical Centre LeedervillePerthAustralia School of Pharmacy and Biomedical Sciences Faculty of Health SciencesCurtin UniversityBentleyPerthAustralia

Objective:To demonstrate that serum follicle-stimulating hormone(FSH)in men rises with age,and to explore FSH reference intervals of age-related ***:Men aged 20-50 years(n=1190)underwent semen analysis according to World Health Organization(2010)*** was frozen prior to measurement of FSH by using the Siemens ADVIA Centaur®XP immunoassay *** central 95%intervals after logarithmic transformation based on age were derived from 1037 normozoospermic *** were then applied to oligozoospermic and azoospermic *** producing azoospermic semen samples were further classified as having non-obstructive azoospermia by clinical diagnostic criteria,including genetic analysis and surgical ***:Serum FSH in normozoospermic men increased with age(P<0.05),and reference intervals were determined with 10-year brackets:21-30 years[(1.0-8.2)IU/L],31-40 years[(1.4-9.5)IU/L],41-50 years[(1.9-12.0)IU/L].The proportion of oligozoospermic men with normal FSH concentrations was less than the normozoospermic men,which in turn was lower among azoospermic men(both P<0.01).The azoospermic men were further broken down according to the nature of the azoospermia as either obstructive or non-obstructive azoospermia,and 86.4%(38/44)men with non-obstructive azoospermia had elevated serum FSH concentrations whereas only 6.7%(1/15)men with obstructive azoospermia had high FSH levels,and this was significantly different(P<0.01).Conclusions:FSH concentrations increase in men between 20-50 years,and clinical interpretation of serum FSH results in men must be made by using age-based reference intervals.

关键词： Male infertility FSH Reference intervals Age Obstructive azoospermia Non-obstructive azoospermia

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Cooking for Canines Chef Colin Murray creates treats to howl over.

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英语沙龙（高中） 2015年第4期 46-47,62-63页

作者： Sara matson

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Speed-Math Champ of 4B

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英语沙龙（高中） 2015年第4期 32-33,48-49页

作者： Sara matson

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Time-lapse videography reveals different morphokinetic profiles of human embryos displaying direct or reverse cleavage at different stages of development: A retrospective sibling embryo study

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Asian pacific Journal of Reproduction 2020年第6期9卷 261-266页

作者： Chloé Brits Katie Feenan Vince Chapple Phillip L.matson Yan-he Liu School of Medical and Health Science Edith Cowan UniversityJoondalupWestern AustraliaAustralia Fertility Specialists of Western Australia ClaremontWestern AustraliaAustralia Fertility North Joondalup Private HospitalJoondalupWestern AustraliaAustralia School of Human Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia Monash IVF Group SouthportQueenslandAustralia

Objective:To investigate morphokinetic characteristics of embryos displaying either reverse cleavage or direct cleavage during the first,second or third cleavage ***:A total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(35.0±4.6)years]were included for reverse cleavage analysis,and a total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(33.8±4.3)years]were included for direct cleavage analysis in this *** a sibling-embryo design,morphokinetic profiles(both before and after the onset of abnormal event)of embryos displaying reverse cleavage(n=241)or direct cleavage(n=244)were compared with their unaffected siblings(the controls)in the first,second and third cell cycles(n=32,n=142,n=562;n=195,n=412,n=205,respectively),at different developmental stages up to day ***:Direct cleavage embryos demonstrated significantly delayed cleavage rates prior to the event regardless of developmental stage of the occurrence,while reverse cleavage embryos showed similar cleavage rates to their unaffected *** event,direct cleavage embryos sped up cleavage rates while reverse cleavage embryos slowed ***:Altered morphokinetic profiles are displayed by direct cleavage embryos both before and after their occurrence and reverse cleavage embryos after the occurrence,which could potentially confound morphokinetic comparisons if not separated from their unaffected sibling *** study is warranted in order to fully understand the biological mechanisms of such events.

关键词： Time-lapse Direct cleavage Reverse cleavage Morphokinetics Cleavage abnormality

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工业冷却水中HEDP的氯分解作用及其稳定化

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工业水处理 1991年第2期11卷 18-23页

作者：黄龙峰 J.V.matson 安徽省化工研究所美国德州休斯敦大学

本文在实验室装置上研究了循环冷却水的有效氯浓度、水温和多种化合物对HEDP氯分解作用的影响,提出了加入稳定剂抑制这种分解的办法。通过筛选,认为CA、DMH和SA等数种有机化合物是具有显著效率的稳定剂,在克服HEDP的氯分解方面取得了令... 详细信息

本文在实验室装置上研究了循环冷却水的有效氯浓度、水温和多种化合物对HEDP氯分解作用的影响,提出了加入稳定剂抑制这种分解的办法。通过筛选,认为CA、DMH和SA等数种有机化合物是具有显著效率的稳定剂,在克服HEDP的氯分解方面取得了令人满意的结果。

关键词：氯冷却水水处理分解稳定 HEDP

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