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Targets and molecular mechanisms of a citrus flavonoid, hesperidin, against luminal breast cancer cells: an integrative bioinformatics analysis

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Asian Pacific Journal of Tropical Biomedicine 2019年第12期9卷 531-538页

作者： adam hermawan Herwandhani Putri Department of Pharmaceutical Chemistry Faculty of PharmacyUniversitas Gadjah MadaSekip Utara Ⅱ55281 YogyakartaIndonesia Cancer Chemoprevention Research Center Faculty of PharmacyUniversitas Gadjah MadaSekip Utara Ⅱ55281 YogyakartaIndonesia

Objective:To identify the potential target and mechanisms of hesperidin in MCF-7 estrogen receptor-positive breast cancer cells using bioinformatics ***:Gene expression profiles were accessed from public database *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis was carried out with Database for Annotation,Visualization and Integrated *** protein-protein interaction network was analyzed by STRING-DB and visualized by *** factor regulatory networks were constructed from TRED,TRRUST,Reg Network and visualized by *** association analysis was conducted by Web ***:GO and KEGG pathway enrichment analysis revealed biological processes,cellular components and molecular functions that were related to cancer and estrogen signaling *** pathway enrichment analysis of the genes in transcription factor-differential expression genes regulatory network showed regulation of cancer,estrogen signaling pathways,epidermal growth factor receptor tyrosine kinase inhibitor resistance,and endocrine ***,drug association analysis revealed that hesperidin affected the expression of the same gene as ***:Hesperidin targets estrogen receptor signaling in estrogen receptor-positive breast cancer *** of this study could trace the molecular mechanism of hesperidin in estrogen receptor-positive breast cancer cells and integrative bioinformatics analysis could accelerate drug discovery and development.

关键词： Hesperidin Breast cancer Bioinformatics Estrogen receptor Signaling pathway

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Effect of the water extract of Macrosolen cochinchinensis(Lour.) *** on 7,12-dimethylbenz[a]antracene induced female mice liver carcinogensis

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Journal of Chinese Pharmaceutical Sciences 2011年第6期20卷 627-632页

作者： adam hermawan Retno Murwanti Nina Artanti Edy Meiyanto Cancer Chemoprevention Research Center Faculty of Pharmacy Universitas Gadjah MadaSekip Utara IIYogyakarta 55281 Indonesia Research Center for Chemistry Indonesian Institute of SciencesKawasan PUSPIPTEK Serpong 15314Indonesia

Liver cancer is the third most common cause of death from cancer ***,natural products were used widely as an alternative therapy for liver *** study reported Macrosolen cochnichinensis(Lour.) *** grows in the host star fruit inhibited breast cancer cells growth in *** study aims to observe the effect of water extract of *** leaves(MCE) on Balb/c mice hepatocyte after initiation of 7,12-dimethylbenz[a]anthracene(DMBA) as a liver cancer model *** experiment consisted of four mice groups,corn oil solvent control group,the DMBA dose 20 mg/kgBW *** times twice a week,DMBA+MCE dose 250 mg/kgBW,and DMBA+MCE 750 mg/*** which was dissolved into 0.5%CMC-Na was administered daily by the oral route 1 week before,during and terminated 1 week after the DMBA *** the end of the study,rat livers were collected and stained with Haematoxyllene and Eosin(H&E) method. Administration of MCE could not inhibit hepatic carcinogenesis in DMBA-induced female *** was no difference in liver tissue histopathology profile between the extract treatment group and DMBA control group.

关键词： Macrosolen cochincinensis Carcinogenesis Liver cancer DMBA

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Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model

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Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 371-375页

作者： Herwandhani Putri Standie Nagadi Yonika Arum Larasati Nindi Wulandari adam hermawan Cancer Chemoprevention Research Center Faculty of PharmacyUniversitas Gadjah MadaSekip Utara Ⅱ

Objective:To observe the combination effect of doxorubicin and Citrus hystrix(kaffir lime's)peel ethanolic extract(ChEE)on blood serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)activity and cardio-hepato-histopathology of female Sprague Dawley ***:Doxorubicin and ChEE(5 rats per group)were administered in five groups of 3 rats each for 11 *** I:doxorubicin(dox)4.67 mg/kg body weight;Group II:dox+ChEE 500 mg/kg body weight;Group HI:dox+ChEE 1000 mg/kg body weight;Group IV:ChEE 1000 mg/kg body weight;Group V:untreated(control).Results:ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats,but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and ***:ChEE has potency to be developed as cardioprotector agent in chemotherapy.

关键词： Citrus hystrix D.C. Cardiohepatoprotector Histopathology Chemoterapy

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Combinational effects of hexane insoluble fraction of Ficus septica *** doxorubicin chemotherapy on T47D breast cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2013年第4期3卷 297-302页

作者： Agung Endro Nugroho adam hermawan Dyaningtyas Dewi Pamungkas Putri Anindya Novika Edy Meiyanto Cancer Chemoprevention Research Center Faculty of PharmacyGadjah Mada UniversityJogjakarta 55281Indonesia Department of Pharmacology and Clinical Pharmacy Faculty of PharmacyGadjah Mada UniversityJogjakarta 55281Indonesia Department of Pharmaceutical Chemistry Faculty of PharmacyGadjah Mada UniversityJogjakarta 55281Indonesia

Objective:To evaluate the effects of n-hexane insoluble fraction(HIF)of Ficus septica leaves in combination with doxorubicin on cytotoxicity,cell cycle and apoptosis induction of breast cancer T47D cell ***:The in vitro drugs-stimulated cytotoxic effects were determined using MTT *** of cell cycle distribution was performed using flowcytometer and the data was analyzed using ModFit LT 3.0 *** assay was earned out by double staining method using ethydium bromide-acridin *** expression of cleaved-poly(ADP-ribose)polymerase(PARP)on T47D cell lines was identified using ***:The combination exhibited higher inhibitory effect on cell growth than the single treatment of doxorubicin in T47D *** addition,combination of doxorubicin and HIF increased the incidence of cells undergoing *** could improve doxorubicin cytotoxic effect by changing the accumulation of cell cycle phase from G_2/M to G_1 *** combination also exhibited upregulation of cleaved-PARP in T47D ***:Based on this results,HIF is potential to be developed as co-chemotherapeutic agent for breast cancer by inducing apoptosis and cell cycle ***,the molecular mechanism need to be explored further.

关键词： Ficus septica Burm.F.,Cancer T47D cells Cytotoxic

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Experiment and simulation to determine the optimum orientation of building-integrated photovoltaic on tropical building façades considering annual daylight performance and energy yield

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Energy and Built Environment 2024年第3期5卷 414-425页

作者： Rizki A.Mangkuto Dhian Nur Aziz T.Tresna Ikhwan M.hermawan Justin Pradipta Nurul Jamala Beta Paramita Atthaillah Building Physics Research Group Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Engineering Physics Program Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Engineering Physics Research Group Faculty of Industrial TechnologyInstitut Teknologi BandungLabtek VIJl.Ganesha 10Bandung 40132Indonesia Department of Architecture Faculty of EngineeringHasanuddin UniversityJl.Poros Malino Km.6Gowa 92171Indonesia Architecture Study Program Faculty of Technology and Vocational EducationUniversitas Pendidikan IndonesiaJl.Dr.Setiabudhi 229Bandung 40152Indonesia Architecture Program Faculty of EngineeringUniversitas MalikussalehJl.Cot Teungku NieAceh Utara 24355Indonesia

Building-Integrated Photovoltaic(BIPV)on vertical façades is a potential PV application in today’s *** performance of BIPV on façades is significantly influenced by the façade *** tropical cities,the optimum façade orientation,in terms of maximum energy yield and daylight performance,cannot be simply determined,due to relatively symmetrical sun path throughout the *** study therefore aims to determine the optimum orientation for BIPV on tropical building faç*** achieve the objective,experiment,modelling,and computational simulation are conducted to evaluate the BIPV energy yield and to predict the indoor daylight performance in a scale-model building with a 105Wp monocrystalline silicon PV,facing each cardinal orienta-tion in Bandung,*** South orientation yields practically zero ASE_(1000,250),providing the best annual daylight performance,and yielding the most desirable value in four out of five daylight *** greatest annual energy yield is at the North orientation,providing 179-186 kWh(95%prediction interval)per year,but with larger uncertainty compared to that at the South,due to direct sunlight *** on three different objective functions,the South orientation is considered optimum for placing the BIPV panel on the prototype façade in the location.

关键词： Building-integrated photovoltaic Orientation Daylight metric Energy yield Tropical building façade

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棱果榕乙酸乙酯萃取物和阿霉素化疗对人类乳腺癌细胞T47D的协同效应（英文）

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中西医结合学报 2012年第10期10卷 1162-1170页

作者： Agung E.Nugroho adam hermawan Dyaningtyas D.P.Putri Edy Meiyanto Lukman Hakim Cancer Chemoprevention Research Center Faculty of PharmacyUniversitas Gadjah MadaJogjakarta 55281Indonesia Department of Pharmacology and Clinical Pharmacy Faculty of PharmacyUniversitas Gadjah MadaJogjakarta 55281Indonesia Department of Pharmaceutical Chemistry Faculty of PharmacyUniversitas Gadjah MadaJogjakarta 55281Indonesia

目的:以往研究已证实,棱果榕树叶的乙醇提取物及其乙酸乙酯萃取物(ethyl acetate soluble fraction,EASF)对人类乳腺癌细胞T47D有很强的细胞毒效应。本研究将进一步明确棱果榕树叶乙醇提取物的EASF联合阿霉素对人类乳腺癌T47D细胞系在... 详细信息

目的:以往研究已证实,棱果榕树叶的乙醇提取物及其乙酸乙酯萃取物(ethyl acetate soluble fraction,EASF)对人类乳腺癌细胞T47D有很强的细胞毒效应。本研究将进一步明确棱果榕树叶乙醇提取物的EASF联合阿霉素对人类乳腺癌T47D细胞系在细胞毒性、细胞周期阻滞以及诱导细胞凋亡方面的协同效应。方法:使用溴化噻唑蓝四氮唑比色法分析T47D细胞毒性效应,流式细胞仪进行细胞周期分析,ModFitLT3.0程序进行数据处理;采用溴化乙锭/吖啶橙双染色法检测细胞凋亡;免疫组织化学法识别T47D细胞系的聚ADP-核苷酸聚合酶(poly ADP-ribose polymerase,PARP)的表达。结果:EASF(0.875～7μg/mL)与阿霉素(2～8nmol/L)联合使用比单纯使用阿霉素能更有效地抑制T47D细胞生长。此外,二者联合使用能够增加细胞凋亡的发生率。研究发现,EASF能通过改变细胞从G2/M期至G1期而增强阿霉素的细胞毒效应。并且,二者的结合比单独使用能刺激T47D细胞中裂解性PARP的表达。结论:EASF可以通过诱导细胞凋亡和细胞周期停滞加强T47D细胞中的阿霉素活性。

关键词：榕属植物提取物乳腺肿瘤细胞系,肿瘤药物疗法,联合细胞凋亡

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MXene-Based Photocatalysts and Electrocatalysts for CO_(2) Conversion to Chemicals

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Transactions of Tianjin University 2022年第4期28卷 307-322页

作者： Tahta Amrillah Abdul Rohman Supandi Vinda Puspasari Angga hermawan Zhi Wei Seh Department of Nanotechnology Faculty of Advanced Technology and MultidisciplineUniversitas AirlanggaSurabaya 60115Indonesia Faculty of Textile Science and Technology Shinshu UniversityNagano 386-8567Japan Research Center for Metallurgy National Research and Innovation Agency(BRIN)South Tangerang CityBanten 15314Indonesia Research Center for Advanced Materials National Research and Innovation Agency(BRIN)South Tangerang CityBanten 15314Indonesia Institute of Materials Research and Engineering Agency for ScienceTechnology and Research(A*STAR)Innovis 138634Singapore

The interest in CO_(2)conversion to value-added chemicals and fuels has increased in recent years as part of strategic eff orts to mitigate and use the excessive CO_(2)concentration in the *** attention has been given to developing two-dimensional catalytic materials with high-effi ciency CO_(2)adsorption capability and conversion *** several candidates are being investigated,MXenes stand out as one of the most promising catalysts and co-catalysts for CO_(2)reduction,given their excellent surface functionalities,unique layered structures,high surface areas,rich active sites,and high chemical *** review aims to highlight research progress and recent developments in the application of MXene-based catalysts for CO_(2)conversion to value-added chemicals,paying special attention to photoreduction and ***,the underlying photocatalytic and electrocatalytic CO_(2)conversion mechanisms are ***,we provide an outlook for future research in this fi eld,including photoelectrocatalysis and photothermal CO_(2)reduction.

关键词： MXenes CO_(2)conversion Photocatalyst Electrocatalyst Nanocomposite

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Engine Performance Using Blended Fuels of Biodiesel and Eco Diesel

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Energy Engineering 2023年第1期120卷 107-123页

作者： Muhammad Idris IHusin Indra hermawan Uun Novalia RDBatubara Nugroho Agung Pambudi Alfan Sarifudin Study Program of Mechanical Engineering Universitas Medan AreaMedan20156Indonesia Study Program of Mechanical Engineering Politeknik Negeri MedanMedan20156Indonesia Study Program of Industrial Engineering Universitas Harapan MedanMedan20156Indonesia Department of Mechanical Engineering Education Universitas Sebelas MaretSurakarta57126Indonesia

Diesel engines is an internal combustion engine with high thermal efficiency,which also uses biodiesel fuel,an environmentally friendly,non-toxic,and low sulfur *** has been around for a long time due to its similar characteristics to diesel fuels which has limited ***,several disadvantages are associated with biodiesel,such as poor volatility and high viscosity,which reduces engine ***,this study was carried out to improve the diesel engine performance by mixing biodiesel with ecodiesel(ED),an additive produced from natural ingredients that is dissolvable in *** biodiesel fuel properties used are density 860 kg/m3,dynamic viscosity 4.50E-06 m2/s,cetane number 45,and flashpoint 52°*** results showed that biodiesel-ED mixture could improve engine performance and the optimum performance was at a speed of 3000 rpm on 43.30(kW),124.93(N.m)of the engine torque,and 2.45E–5(kg/kW.s)of the specific fuel *** to paired sample t-test,the difference in the engine performance is only experienced in the torque,which has a significant increase in the composition of the biodiesel+ED by 0.07 gr mixture.

关键词： Car vehicle experiment combustion ED renewable energy

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CONFLICT ANALYSIS OF CITARUM RIVER BASIN POLLUTION IN INDONESIA:A DRAMA-THEORETIC MODEL

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Journal of Systems Science and Systems Engineering 2009年第1期18卷 16-37页

作者： Pri hermawan Kyoichi KIJIMA Department of Value and Decision Science Tokyo Institute of Technology2-12-1-W9-39 O-okayama.Meguro-kuTokyo 152-8552Japan

The need to manage water resource within a holistic approach is crucial in Indonesia. Conflict situation which involves a variety of stakeholder needs an appropriate methodology to handle it. The purpose of this paper is to provide an integrated framework of a river basin pollution case in Indonesia. This research try to obtain an understanding of the complexity of inter-relationship between stakeholders of the Citarum River Basin and to give feasible recommendations based on a new developed integrated framework. We first describe the problem in a comprehensive way, then develop a framework to analyze the conflict. Next, we propose a general procedure to apply it, which we call Drama-theoretic Dilemma Analysis （DtDA）. After analyzing the conflicts that arise there between stakeholders using DtDA, we will show how to resolve the dilemmas by using holistic as well as intensive approaches. By applying DtDA in stakeholder analysis and resolving the dilemmas that arise in the interactions between them, we can identify barriers for collaboration.

关键词： Negotiation drama theory holistic view dilemma conflict pollution

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Morphology control of aluminum nitride(AlN)for a novel high-temperature hydrogen sensor

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International Journal of Minerals,Metallurgy and Materials 2020年第11期27卷 1560-1567页

作者： Angga hermawan Yusuke Asakura Shu Yin Institute of Multidisciplinary Research for Advanced Material(IMRAM) Tohoku UniversitySendai 980-8577Japan

Hydrogen is a promising renewable energy source for fossil-free transportation and electrical energy ***,leaking hydrogen in high-temperature production processes can cause an explosion,which endangers production workers and surrounding *** detect leaks early,we used a sensor material based on a wide bandgap aluminum nitride(AlN)that can withstand a high-temperature *** unique AlN morphologies(rod-like,nest-like,and hexagonal plate-like)were synthesized by a direct nitridation method at 1400℃usingγ-AlOOH as a *** gas-sensing performance shows that a hexagonal plate-like morphology exhibited p-type sensing behavior and showed good repeatability as well as the highest response(S=58.7)toward a 750 ppm leak of H2 gas at high temperature(500°C)compared with the rod-like and nest-like ***,the hexagonal plate-like morphology showed fast response and recovery times of 40 and 82 s,*** surface facet of the hexagonal morphology of AlN might be energetically favorable for gas adsorption–desorption for enhanced hydrogen detection.

关键词： aluminum nitride controllable morphology direct nitridation γ-AlOOH hydrogen sensor

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