检索结果-南通市图书馆

World Journal of Gastroenterology 2023年第47期29卷 6165-6167页

作者： Matthew Peverelle Jonathan Ng James Peverelle Ryan d.Hirsch adam Testro Liver transplant unit Austin HealthMelbourne 3084Australia Liver transplant unit Austin HealthHeidelberg 3084VictoriaAustralia

There is rapidly increasing uptake of GLP-1 (glucagon-like peptide-1) agonistssuch as semaglutide worldwide for weight loss and management of non-alcoholicsteatohepatitis (NASH). remains a paucity of safety data in the vulnerable NASHcirrhotic population. We report herein the first documented case of liver decompensationand need for liver transplant waitlisting in a patient with NASHcirrhosistreated with semaglutide. Rapid weight loss led to the development ofascites and hepatic encephalopathy and an increase in the patients Model forEndstage Liver disease-Na (MELd-Na) score from 11 to 22. Aggressive nutritionalsupplementation was commenced and the semaglutide was stopped. Overthe following months she regained her weight and her liver recompensated andher MELd-Na decreased to 13, allowing her to be delisted from the transplantwaitlist. This case serves as a cautionary tale to clinicians using semaglutide in thecirrhotic population and highlights the need for more safety data in this patientgroup.

关键词： Semaglutide Non-alcoholic steatohepatitis Cirrhosis Non-alcoholic steatohepatitis cirrhosis Glucagon-like peptide 1 agonists Weight loss

Non-malarial fever among pregnant women in Medani Hospital,Sudan:diagnostic uncertainty and overtreatment with quinine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 392-394页

作者： Elhassan M Elhassan Abd Elrahium d Haggaz Mamoun M Magzoub Ishag adam University of Geizera University of Kassala Faculty of Medicine University of Khartoum

Objective:To investigate the accuracy of malaria diagnosis among pregnant women admitted in Medani Maternity Hospital,Central Sudan during June-October 2009 and to investigate the antimalarials prescribed in this ***:Soeio-demographic characteristics and obstetrics history were gathered using pre-tested *** finger prick blood samples were collected from pregnant women who admitted as malaria case after an initial microscopic test done by general microscopists for malaria *** antimalarial treatment prescribed by treating doctor was inquired ***:Only 21(8.6%) out of 243 pregnant women admitted as malaria case after an initial microscopic test done by general microscopists for malaria were found to have blood film *** was no significant difference in the specificity of the microscopy accuracy between those who have been investigated in the private and governmental sector,15/193(8.2%) vs.6/60(10%),(P>0.05).Quinine infusion was the prescribed drug in this ***:There is a very poor specificity of malaria microscopy in pregnant women admitted to Madani Maternity *** was the drug *** control programme should interfere urgently to change this situation.

关键词： Malaria Pregnancy diagnosis RdTs Sudan

dual enzyme activated fluorescein based fluorescent probe

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2020年第1期14卷 117-121页

作者： Maria L.Odyniec Jordan E.Gardiner adam C.Sedgwick Xiao-Peng He Steven d.Bull Tony d.James department of Chemistry University of BathBathBA27AYUK department of Chemistry University of Texas at AustinAustinTX 78712-1224USA Key Laboratory for Advanced Materials&Feringa Nobel Prize Scientist Joint Research Center East China University of Science and TechnologyShanghai 200237China

A simple dual analyte fluorescein-based probe(PF3-Glc)was synthesised containingβ-glucosidase(β-glc)and hydrogen peroxide(H2O2)trigger *** presence ofβ-glc,resulted in fragmentation of the parent molecule releasing glucose and the slightly fluorescent mono-boronate fluorescein(PF3).Subsequently,in the presence of glucose oxidase(GOx),the released glucose was catalytically converted to d-glucono-δ-lactone,which produced H2O2 as a *** GOx-produced H2O2,resulted in classic H2O2-mediated boronate oxidation and the release of the highly emissive fluorophore,*** unique cascade reaction lead to an 80-fold increase in fluorescence intensity.

关键词： chemosensors dual-activation GOx fluorescence β-glucosidase molecular logic

A simple umbelliferone based fluorescent probe for the detection of nitroreductase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2018年第2期12卷 311-314页

作者： adam C. Sedgwick Alex Hayden Barry Hill Steven d. Bull Robert B. P. Elmes Tony d. James department of Chemistry University of Bath Bath BA2 7AY UK department of Chemistry Maynooth University Maynooth Co. Kildare Ireland

A simple nitrobenzyl-umbelliferone （NCOU1） was synthesised containing a nitroreductase （NTR） trigger moiety. The presence of NTR, resulted in the fragmentation of the parent molecule and release of the highly emissive fluorophore umbelliferone via an NTR-catalyzed reduction of the nitro group. In the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity at 455 nm and was selective for NTR over other reductive enzymes. These results indicate that NCOU1 can be used as a simple assay for the detection of NTR.

关键词： NITRO RAdICALS NTSR1 gene FLUORESCENT PROBES Skimmetin Nitroreductases noise-temperature ratio

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2015年第3期31卷 317-330页

作者： Fernando Marmolejo-Ramos Kim Hellemans Amy Comeau adam Heenan Andrew Faulkner Alfonso Abizaid Amedeo d'Angiulli department of Psychology Stockholm University department of Neuroscience Carleton University department of Psychology Queens UniversityKingston Institute of Interdisciplinary Studies Carleton University

Although food and affective pictures share similar emotional and motivational characteristics, the relationship between the neuronal responses to these stimuli is unclear. Particularly, it is not known whether perceiving and imagining food and affective stimuli elicit similar event-related potential （ERP） patterns. In this study, two ERP correlates, the early posterior negativity （EPN） and the late positive potential （LPP） for perceived and imagined emotional and food photographs were investigated. Thirteen healthy volunteers were exposed to a set of food photos, as well as unpleasant, pleasant, and neutral photos from the International Affective Picture System. In each trial, participants were first asked to view a photo （perception condition）, and then to create a visual mental image of it and to rate its vividness （imagery condition）. The results showed that during perception, brain regions corresponding to sensorimotor and parietal motivational （defensive and appetitive） systems were activated to different extents, producing a graded pattern of EPN and LPP responses specific to the photo content - more prominent for unpleasant than pleasant and food content. Also, an EPN signature occurred in both conditions for unpleasant content, suggesting that, compared to food or pleasant content, unpleasant content may be attended to more intensely during perception and may be represented more distinctly during imagery. Finally, compared to LLP activation during perception, as well as imagery and perception of all other content, LPP activation was significantly reduced during imagery of unpleasant photos, suggesting inhibition of unwanted memories. Results are framed within a neurocognitive working model of embodied emotions.

关键词： food emotion perception mentaimagery ERP EPN LPP vividness InternationaAffective Picture System embodiment

Male and female meadow voles Microtus pennsylvanicus respond differently to scent marks from the top- middle-, and bottom-scent donors of an over-mark

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2011年第4期57卷 441-448页

作者： Michael H. FERKIN Nicholas J. HOBBS Benjamin d. FERKIN adam C.FERKIN daniel A. FERKIN department of Biological Sciences The University of Memphis Ellington Hall Memphis TN 38152 USA

Previous studies have shown that individuals responded preferentially to the mark of the top-scent donor relative to that of the bottom-scent donor of an over-mark. However, terrestrial mammals are likely to encounter over-marks consisting of the scent marks of more than two same-sex conspecifics in the intersections of runways, near the nests of sexually receptive female conspecifics, and inside and along the borders of the territories of conspecifics. We determined how meadow voles, Microtus pennsylvanicus, respond to the marks of the top-, middle-, and bottom-scent donors of an over-mark. We tested the hypothesis that voles exposed to an over-mark will respond preferentially to the scent marks that were deposited more recently, the scent marks that were on top or near the top of the over-mark, compared to the scent marks that were deposited earlier or near the bot- tom of the over-mark. Voles spent more time investigating the mark of the top-scent donor than that of the either the middle- or bottom-scent donor. However, males but not female voles spent more time investigating the middle-scent mark than the bot- tom-scent mark. We also tested the hypothesis that voles evaluate and respond to over-marks differently from single scent marks. Voles spent more time investigating the marks of the top-, middle-, and bottom-scent donors compared to scent marks that were not part of the over-mark. Voles can distinguish among the overlapping scent marks of three scent donors and sex differences exist in the values they appear to attach to each of these scent marks [Current Zoology 57 （4）： 441-448, 2011 ].

关键词： Over-marks Voles Scent marks Olfactory communication

Use of Microwave Radiances from Metop-C and Fengyun-3 C/d Satellites for a Northern European Limited-area data Assimilation System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2021年第8期38卷 1415-1428页

作者： Magnus LINdSKOG adam dYBBROE Roger RANdRIAMAMPIANINA Swedish Meteorological and Hydrological Institute Folkborgsvägen 1760361 NorrköpingSweden Norwegian Meteorological Institute Henrik Mohns Plass 10371 OsloNorway

MetCoOp is a Nordic collaboration on operational Numerical Weather Prediction based on a common limited-area km-scale ensemble system. The initial states are produced using a 3-dimensional variational data assimilation scheme utilizing a large amount of observations from conventional in-situ measurements, weather radars, global navigation satellite system, advanced scatterometer data and satellite radiances from various satellite platforms. A version of the forecasting system which is aimed for future operations has been prepared for an enhanced assimilation of microwave radiances. This enhanced data assimilation system will use radiances from the Microwave Humidity Sounder, the Advanced Microwave Sounding Unit-A and the Micro-Wave Humidity Sounder-2 instruments on-board the Metop-C and Fengyun-3 C/d polar orbiting satellites. The implementation process includes channel selection, set-up of an adaptive bias correction procedure, and careful monitoring of data usage and quality control of observations. The benefit of the additional microwave observations in terms of data coverage and impact on analyses, as derived using the degree of freedom of signal approach, is demonstrated. A positive impact on forecast quality is shown, and the effect on the precipitation for a case study is examined. Finally, the role of enhanced data assimilation techniques and adaptions towards nowcasting are discussed.

关键词： data assimilation regional numerical weather prediction microwave radiances

Towards standardizing retinal optical coherence tomography angiography:a review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第4期11卷 520-541页

作者： danuta M.Sampson adam M.dubis Fred K.Chen Robert J.Zawadzki david d.Sampson Surrey Biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildford GU27XHUK NIHR Biomedical Research Centre at Moorflelds Eye Hospital NHS Trust and UCL Institute of Ophthalmology London EC1V 2PDUK. Centre for Ophthalmology and Visual Science(incorporating Lions Eye Institute) The University of Western AustraliaNedlandsWestern Australia 6009Australia. department of Ophthalmology Royal Perth HospitalPerthWestern Australia 6000Australia. Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3002Australia. department of Ophthalmology&Vision Science University of California DavisSacramentoCA 95817USA. Surrey Biophotonics Advanced Technology InstituteSchool of Physics and School of Biosciences and MedicineUniversity of SurreyGuildfordSurrey GU27XHUK

The visualization and assessment of retinal microvasculature are important in the study,diagnosis,monitoring,and guidance of treatment of ocular and systemic *** the introduction of optical coherence tomography angiography(OCTA),it has become possible to visualize the retinal microvasculature volumetrically and without a contrast *** lab-based and commercial clinical instruments,imaging protocols and data analysis methods and metrics,have been applied,often inconsistently,resulting in a confusing picture that represents a major barrier to progress in applying OCTA to reduce the burden of *** data and software sharing,and cross-comparison and pooling of data from different studies are *** inabilities have impeded building the large databases of annotated OCTA images of healthy and diseased retinas that are necessary to study and define characteristics of specific *** paper addresses the steps needed to standardize OCTA imaging of the human retina to address these *** review of the OCTA literature,we identify issues and inconsistencies and propose minimum standards for imaging protocols,data analysis methods,metrics,reporting of findings,and clinical practice and,where this is not possible,we identify areas that require further *** hope that this paper will encourage the unification of imaging protocols in OCTA,promote transparency in the process of data collection,analysis,and reporting,and facilitate increasing the impact of OCTA on retinal healthcare delivery and life science investigations.

关键词： transparency steps inconsistent

4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomal cellular imaging agents: The effect of substituent patterns on PET directional quenching

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2020年第1期14卷 61-75页

作者： Miguel Martinez-Calvo Sandra A.Bright Emma B.Veale adam F.Henwood d.Clive Williams Thorfinnur Gunnlaugsson School of Chemistry and Trinity Biomedical Sciences Institute(TBSI) Trinity College DublinThe University of DublinDublin 2Ireland School of Biochemistry and Immunology and Trinity Biomedical Sciences Institute(TBSI) Trinity College DublinThe University of DublinDublin 2Ireland Centro Singular de Investigacion en Quimica Bioloxica e Materiais Moleculares(CIQUS)and departamento de Quimica Organica Universidade de Santiago de Compostela Rua Jenaro de la Fuente s/n15782Santiago de CompostelaSpain

Four new fluorescent sensors(1-4)based on the 4-amino-1,8-naphthalimide fluorophores(Naps)have been synthesized based on the classical fluorophore-spacer-receptor *** four compounds all gave rise to emission bands centred at ca.535 nm,which were found to be highly pH dependent,the emission being‘switched on’in acidic media,while being quenched due to PET from the amino moieties to the excited state of the Nap at more alkaline *** luminescent pH dependence for these probes was found to be highly dependent on the substitution on the imide site,as well as the polyamine chain attached to the position 4-amino *** the case of sensor 2 the presence of the 4-amino-aniline dominated the pH dependent ***,at higher pH,PET quenching was also found to occur from the polyamine ***,2 is better described as a receptor1-spacer1-fluorophore-spacer2-receptor2 system,where the dominant PET process is due to(normally less favourable)‘directional’PET quenching from the 4-amino-aniline unit to the Nap *** trends and pH fluorescence dependences were also seen for 3 and *** compounds were also tested for their imaging potential and toxicity against HeLa cells(using dRAQ5 as nuclear stain which does now show pH dependent changes in acidic and neutral pH)and the results demonstrated that these compounds have reduced cellular viability at moderately high concentrations(with IC50 values between ca.8-30μmol?L^?1),but were found to be suitable for intracellular pH determination at 1μmol?L^?1 concentrations,where no real toxicity was *** allowed us to employ these as lysosomal probes at sub-toxic concentrations,where the Nap based emission was found to be pH depended,mirroring that seen in aqueous solution for 1-4,with the main fluorescence changes occurring within acidic to neutral pH.

关键词： sensors pH photoinduced electron transfer cellular imaging confocal microscopy

An experimental study on tsunami inundation over complex coastal topography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Theoretical & Applied Mechanics Letters 2013年第3期3卷 40-45页

作者： Shawn Y.Sim Zhenhua Huang adam d.Switzer Earth Observatory of Singapore Nanyang Technological University division of Earth Science Nanyang Technological University School of Civil and Environmental Engineering Nanyang Technological University

In recent studies, the effects of complex costal topography on tsunami run-up has sparked heated discussion. This study mainly aims at investigating the effects of complex costal topography on the tsunami inundation distance and the effectiveness of sand dunes in dissipating tsunami wave energy. The experiments were carried out in a wave flume to investigate the potential reduction effects of wave run-up by non erodible sand dune like features. The results show that increasing dunes spacing could not significantly affect inundation distance. However, if the height of sand dunes is of the same order of magnitude as the incoming tsunami wave and the gaps between the dunes are large enough, successful tsunami mitigation could also be possible.

关键词： complex topography tsunami inundation tsunami hazard mitigation