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SARS-coV-2 spike variants differ in their allosteric responses to linoleic acid

Journal of Molecular cell Biology 2023年第3期15卷 55-66页

作者： A.Sofia F.Oliveira Deborah K.Shoemark Andrew D.Davidson Imre berger christiane Schaffitzel Adrian J.Mulholland School of chemistry Centre for Computational ChemistryUniversity of BristolBristol BS81TSUK School of chemistry University of BristolBristol BS81TSUK School of Biochemistry University of BristolBristol BS81TDUK School of cellular and Molecular Medicine University of BristolUniversity WalkBristol BS81TDUK School of chemistry Max Planck Bristol Centre for Minimal BiologyBristol BS81TSUK

The SARS-coV-2 spike protein contains a functionally important fatty acid(FA)binding site,which is also found in some other coronaviruses,***-coV and *** occupancy of the FA site by linoleic acid(LA)reduces infectivity by‘locking’the spike in a less infectious ***,we use dynamical-nonequilibrium molecular dynamics(D-NEMD)simulations to compare the allosteric responses of spike variants to LA removal.D-NEMD simulations show that the FA site is coupled to other functional regions of the protein,*** receptor-binding motif(RBM),N-terminal domain(NTD),furin cleavage site,and regions surrounding the fusion peptide.D-NEMD simulations also identify the allosteric networks connecting the FA site to these functional *** comparison between the wild-type spike and four variants(Alpha,Delta,Delta plus,and Omicron BA.1)shows that the variants differ significantly in their responses to LA *** allosteric connections to the FA site on Alpha are generally similar to those on the wild-type protein,with the exception of the RBM and the S71–R78 region,which show a weaker link to the FA *** contrast,Omicron is the most different variant,exhibiting significant differences in the RBM,NTD,V622–L629,and furin cleavage *** differences in the allosteric modulation may be of functional relevance,potentially affecting transmissibility and *** comparison of the effects of LA on SARS-coV-2 variants,including emerging variants,is warranted.

关键词： SARS-coV-2 spike allosteric modulation D-NEMD simulations fatty acid binding site SARS-coV-2 variants

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Genomic heterogeneity meets cellular energetics: crosstalk between the mitochondria and the cell cycle

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Journal of cancer Metastasis and Treatment 2018年第1期4卷 483-494页

作者： Erica L.Herrera Seham Z.Azzam Madison c.berger Laura A.Diaz-Martinez Department of Biological Sciences The University of Texas at El PasoEl PasoTX 79968USA

changes in cellular energetics and genomic instability are two characteristics of cancers that have been studied *** of cross-talk between mitochondria function and nuclear function has started to emerge,suggesting that these pathways can influence one *** we review recent evidence that links the mitochondria and the cell *** evidence indicates bidirectional cross-talk where mitochondria function can regulate the cell cycle and induce genomic instability,and conversely,the cell cycle machinery regulates mitochondria *** for this cross-talk in the development of cancer are discussed.

关键词： Mitochondria dynamics cell cycle mitochondria heterogeneity genomic heterogeneity

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Plasma optics in the context of high intensity lasers

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Matter and Radiation at Extremes 2019年第6期4卷 1-7页

作者： H.Peng J.-R.Marques L.Lancia F.Amiranoff R.L.berger S.Weber c.Riconda LULI Sorbonne UniversiteCNRSEcole PolytechniqueCEAF-75252 ParisFrance Department of Optical Science and Engineering Fudan UniversityShanghai 200433China Laser Fusion Research center China Academy of Engineering PhysicsMianyang 621900China LULI CNRSEcole PolytechniqueCEAUniversite Paris-SaclaySorbonne UniversiteF-91128 PalaiseauFrance LULI Sorbonne UniversiteCNRSEcole PolytechniqueCEAUniversite Paris-SaclayF-75252 ParisFrance Lawrence Livermore National Laboratory LivermoreCalifornia 94550USA Institute of Physics of the AScR ELI-Beamlines Project18221 PragueCzech Republic School of Science Xi’an Jiaotong UniversityXi’an 710049China

The use of plasmas provides a way to overcome the low damage threshold of classical solid-state based optical materials,which is the main limitation encountered in producing and manipulating intense and energetic laser *** can directly amplify or alter the characteristics of ultra-short laser pulses via the three-wave coupling equations for parametric *** strong-coupling regime of Brillouin scattering(sc-SBS)is of particular interest:recent progress in this domain is presented *** includes the role of the global phase in the spatio-temporal evolution of the three-wave coupled equations for backscattering that allows a description of the coupling dynamics and the various stages of amplification from the initial growth to the so-called self-similar *** understanding of the phase evolution allows control of the directionality of the energy transfer via the phase relation between the pulses.A scheme that exploits this coupling in order to use the plasma as a wave plate is also suggested.

关键词： scattering coupling regime

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加州南部安扎地震台网剪切波偏振的定量测量:剪切波分裂与地震预测之间的关系

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世界地震译丛 1994年第4期25卷 38-46页

作者： R.c.Aster P.M.Shearer J.berger 周民都国家地震局兰州地震研究所

1.引言对地震剪切波质点运动的大量研究显示出异常现象,这可能是由于地壳各向异性产生剪切波分裂造成的(例如 Gupta,1973b;Booth 等,1985;buchbinder,1985;crampin 等,1985;crampin

关键词：地震预报剪切波偏振定量测量

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用单克隆抗体研究患T淋巴细胞瘤病人的外周血

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国外医学.皮肤病学分册 1985年第2期11卷 89-92页

作者： berger c L 黄钧莉

皮肤T淋巴细胞瘤是一种显著亲表皮组织的T辅助细胞恶性肿瘤。这种病可起源于皮肤经表皮自然迁移的正常T辅助细胞的恶性转变而来。恶变的T细胞分裂形成恶性T辅助细胞的克隆,起初保留了正常T细胞前体的特性,包括表现型,功能和转归型。当... 详细信息

皮肤T淋巴细胞瘤是一种显著亲表皮组织的T辅助细胞恶性肿瘤。这种病可起源于皮肤经表皮自然迁移的正常T辅助细胞的恶性转变而来。恶变的T细胞分裂形成恶性T辅助细胞的克隆,起初保留了正常T细胞前体的特性,包括表现型,功能和转归型。当疾病发展时可出现更恶性的细胞,表面抗原发生改变,并失去亲表皮性。这些瘤细胞可出现在真皮下层,带有活化抗原或其他与增生相关的抗原,并能扩散到内脏器官。已从单克隆抗体的研究获得了支持皮肤T淋巴细胞瘤个体发生解释的证据。

关键词： T淋巴细胞瘤单克隆抗体细胞分化皮下层表皮组织瘤细胞胸腺细胞混合白细胞培养个体发生朗格罕细胞

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Meridional Distributions of Historical Zonal Averages and Their Use to Quantify the Global and Spheroidal Mean Near-Surface Temperature of the Terrestrial Atmosphere

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Natural Science 2020年第3期12卷 80-124页

作者： Gerhard Kramm Martina berger Ralph Dlugi Nicole Molders Engineering Meteorology consulting FairbanksAKUSA Arbeitsgruppe Atmospharische Prozesse(AGAP) MunichGermany Department of Atmospheric Sciences and Geophysical Institute University of Alaska FairbanksFairbanksAKUSA

The zonal averages of temperature (the so-called normal temperatures) for numerous parallels of latitude published between 1852 and 1913 by Dove, Forbes, Ferrel, Spitaler, Batchelder, Arrhenius, von Bezold, Hopfner, von Hann, and Börnstein were used to quantify the global (spherical) and spheroidal mean near-surface temperature of the terrestrial atmosphere. Only the datasets of Dove and Forbes published in the 1850s provided global averages below 〈T〉=14°c, mainly due to the poor coverage of the Southern Hemisphere by observations during that time. The global averages derived from the distributions of normal temperatures published between 1877 and 1913 ranged from 〈T〉=14.0°c (Batchelder) to 〈T〉=15.1°c (Ferrel). The differences between the global and the spheroidal mean near-surface air temperature are marginal. To examine the uncertainty due to interannual variability and different years considered in the historic zonal mean temperature distributions, the historical normal temperatures were perturbed within ±2σ to obtain ensembles of 50 realizations for each dataset. Numerical integrations of the perturbed distributions indicate uncertainties in the global averages in the range of ±0.3°c to ±0.6°c and depended on the number of available normal temperatures. compared to our results, the global mean temperature of 〈T〉=15.0°c published by von Hann in 1897 and von Bezold in 1901 and 1906 is notably too high, while 〈T〉=14.4°c published by von Hann in 1908 seems to be more adequate within the range of uncertainty. The HadcRUT4 record provided 〈T〉≌?13.7°c for 1851-1880 and 〈T〉=13.6°c for 1881-1910. The Berkeley record provided 〈T〉=13.6°c and 〈T〉≌?13.5°c for these periods, respectively. The NASA GISS record yielded 〈T〉=13.6°c for 1881-1910 as well. These results are notably lower than those based on the historic zonal means. For 1991-2018, the HadcRUT4, Berkeley, and NASA GISS records provided 〈T〉=14.4°c, 〈T〉=14.5°c, and 〈T〉=14.5°c, respectively. The comparison of the

关键词： Global Mean Temperature Spheroidal Mean Temperature climatological Mean Values for the Parallels of Latitude Zonal Averages Normal Temperature Temperature Anomaly Isothermal charts Solar climate

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单组份聚氨酯泡沫气雾剂阀门防粘结性能的改进

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气雾剂通讯 2007年第3期 12-14页

作者： Ric berger Joseph c．Lott 美国克雷顿公司

在2005年末,美国克雷顿公司上市了用于单组份聚氨酯泡沫气雾剂的专利产品——900系列阀门,该阀门被设计用来防止聚合物前体粘结阀门而导致的阀门闭塞。聚氨酯的聚合物前体在储存或运输过程中不正常地与阀门保持接触就会发生粘结．聚合... 详细信息

在2005年末,美国克雷顿公司上市了用于单组份聚氨酯泡沫气雾剂的专利产品——900系列阀门,该阀门被设计用来防止聚合物前体粘结阀门而导致的阀门闭塞。聚氨酯的聚合物前体在储存或运输过程中不正常地与阀门保持接触就会发生粘结．聚合物前体与阀门的粘结取于它们接触的时间、温度以及气雾剂的配方。

关键词：单组份聚氨酯泡沫气雾剂粘结性能阀门聚合物专利产品运输过程前体

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On the Solar climate of the Moon and the Resulting Surface Temperature Distribution

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Natural Science 2022年第9期14卷 386-420页

作者： Gerhard Kramm Nicole Mölders Martina berger Ralph Dlugi Engineering Meteorology consulting Fairbanks USA Department of Atmospheric Sciences and Geophysical Institute University of Alaska Fairbanks Fairbanks USA Arbeitsgruppe Atmosphä rische Prozesse (AGAP) Munich Germany

The solar climate of our Moon is analyzed using the results of numerical simulations and the recently released data of the Diviner Lunar Radiometer Experiment (DLRE) to assess (a) the resulting distribution of the surface temperature, (b) the related global mean surface temperature Ts>, and (c) the effective radiation temperature Te often considered as a proxy for Ts> of rocky planets and/or their natural satellites, where Te is based on the global radiation budget of the well-known “thought model” of the Earth in the absence of its atmosphere. Because the Moon consists of similar rocky material like the Earth, it comes close to this thought model. However, the Moon’s astronomical features (e.g., obliquity, angular velocity of rotation, position relative to the disc of the solar system) differ from that of the Earth. Being tidally locked to the Earth, the Moon’s orbit around the Sun shows additional variation as compared to the Earth’s orbit. Since the astronomical parameters affect the solar climate, we predicted the Moon’s orbit coordinates both relative to the Sun and the Earth for a period of 20 lunations starting May 24, 2009, 00:00 UT1 with the planetary and lunar ephemeris DE430 of the Jet Propulsion Laboratory of the california Institute of Technology. The results revealed a mean heliocentric distance for the Moon and Earth of 1.00124279 AU and 1.00166376 AU, respectively. The mean geocentric distance of the Moon was 384792 km. The synodic and draconic months deviated from their respective means in a range of -5.7 h to 6.9 h and ±3.4 h, respectively. The deviations of the anomalistic months from their mean range between -2.83 d and 0.97 d with the largest negative deviations occurring around the points of inflection in the curve that represents the departure of the synodic month from its mean. Based on the two successive passages of the Sun through the ascending node of the lunar equator plane

关键词： Solar climate Temperature Inequality Hölder’s Inequility Global Radiation Budget Local Radiation Budget Global Energy Budget Local Energy Budget Global Albedo Global Averaging Effective Radiation Temperature Surface Temperature Slab Temperature Multilayer-Force-Restore Method

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单克隆抗体

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国外医学.皮肤病学分册 1984年第2期10卷 88-90页

作者： berger c L 郑茂荣

新近单克隆抗体的问世已为临床医师及研究者提供了一强有力的研究工具.已经生产的单克隆抗体可对人类的单个核细胞群进行分析.商业上可得到的单克隆抗体选择性地与辅助性T细胞、抑制性T细胞、成熟的外周血T细胞、不同分化水平的胸腺细... 详细信息

新近单克隆抗体的问世已为临床医师及研究者提供了一强有力的研究工具.已经生产的单克隆抗体可对人类的单个核细胞群进行分析.商业上可得到的单克隆抗体选择性地与辅助性T细胞、抑制性T细胞、成熟的外周血T细胞、不同分化水平的胸腺细胞、郎格罕细胞及单核细胞起反应.另一些与激活的抗原、多种细胞受体(如转铁

关键词：单克隆抗体细胞亚群郎格罕细胞表皮抗原反应细胞毒性皮肤抗原调变 cTcL

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Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells

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World Journal of Gastroenterology 2008年第24期14卷 3829-3840页

作者： Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik christoph c Schimanski Martin R berger Arno Schad Achim Weber Steffen Heeger Peter R Galle Markus Moehler First Department of Medicine Johannes-Gutenberg-University Mainz German cancer Research center Institute of Pathology University of Mainz Department of Pathology Institute of Surgical PathologyUniversity Hospital Merck Pharma GmbH

AIM： TO explore the role of Bcl-XL and Myeloid cell leukaemia （Mcl）-I for the apoptosis resistance of colorectal carcinoma （cRc） cells towards current treatment modalities. METHODS： Bcl-XL and Mcl-1 mRNA and protein expression were analyzed in cRc cell lines as well as human cRc tissue by Western blot, quantitative PcRand immunohistochemistry. Bcl-XL and Mcl-1 protein expression was knocked down or increased in cRc cell lines by applying specific siRNAs or expression plasmids, respectively. After modulation of protein expression, cRc cells were treated with chemotherapeutic agents, an antagonistic epidermal growth factor receptor （EGFR1） antibody, an EGFR1 tyrosine kinase inhibitor, or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS： Here we show that in human cRc tissue and various cRc cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in cRc tissue than in surrounding non-malignant tissue, both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in malignant tissues. However, protein expression was slightly higher. Viability rates of cRc cells were significantly decreased after knock down of Bcl-xL expression, and, to a lower extent, after knock down of Mcl-1 expression. Furthermore, cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatinand irinotecan-induced apoptosis, and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand, upregulation of Bcl-xL by transfection of an expression plasmid decreased chemotherapeutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in cRc cells. Apoptosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly, cD95- and TRAIL-induced apoptosis was increased by Bcl-xL knock down. cONcLUSION： Our data suggest that Bcl-xL and, to a lower extent, Mcl-1, are important anti-apoptotic

关键词： colorectal carcinoma Bcl-XL Myeloid cellleukaemia-1 Epidermal growth factor receptor 1 Apoptosis 5-fluorouracil Irinotecan Oxaliplatin

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