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Targets and molecular mechanisms of a citrus flavonoid, hesperidin, against luminal breast cancer cells: an integrative bioinformatics analysis

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Asian Pacific Journal of Tropical Biomedicine 2019年第12期9卷 531-538页

作者： adam Hermawan Herwandhani Putri Department of Pharmaceutical Chemistry Faculty of PharmacyUniversitas Gadjah MadaSekip Utara Ⅱ55281 YogyakartaIndonesia Cancer Chemoprevention Research Center Faculty of PharmacyUniversitas Gadjah MadaSekip Utara Ⅱ55281 YogyakartaIndonesia

Objective:To identify the potential target and mechanisms of hesperidin in MCF-7 estrogen receptor-positive breast cancer cells using bioinformatics ***:Gene expression profiles were accessed from public database *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis was carried out with Database for Annotation,Visualization and Integrated *** protein-protein interaction network was analyzed by STRING-DB and visualized by *** factor regulatory networks were constructed from TRED,TRRUST,Reg Network and visualized by *** association analysis was conducted by Web ***:GO and KEGG pathway enrichment analysis revealed biological processes,cellular components and molecular functions that were related to cancer and estrogen signaling *** pathway enrichment analysis of the genes in transcription factor-differential expression genes regulatory network showed regulation of cancer,estrogen signaling pathways,epidermal growth factor receptor tyrosine kinase inhibitor resistance,and endocrine ***,drug association analysis revealed that hesperidin affected the expression of the same gene as ***:Hesperidin targets estrogen receptor signaling in estrogen receptor-positive breast cancer *** of this study could trace the molecular mechanism of hesperidin in estrogen receptor-positive breast cancer cells and integrative bioinformatics analysis could accelerate drug discovery and development.

关键词： Hesperidin breast cancer Bioinformatics Estrogen receptor Signaling pathway

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Fuel and vegetation changes in southwestern, unburned portions of Great Smoky Mountains National Park, USA, 2003-2019

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Journal of Forestry Research 2022年第5期33卷 1459-1470页

作者： T.adam Coates W.Mark Ford Department of Forest Resources and Environmental Conservation Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA U.S.Geological Survey Virginia Cooperative Fish and Wildlife Research UnitDepartment of Fisheries and Wildlife ConservationVirginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA

Overstory basal area,ericaceous shrub cover(Kalmia latifolia *** Rhododendron maximum L.),and fuels(i.e.,woody fuel loads and depths and O Horizon thickness) were assessed within Great Smoky Mountains National Park,USA,in *** to recent wildfire activity within the southern Appalachian Mountain region(including Great Smoky Mountains National Park),the potential spread and expansion of ericaceous shrubs,and the impacts of the hemlock woolly adelgid(Adelges tsugae Annand) on eastern hemlock(Tsuga canadensis(L.) Carrière),these same ecosystem components were again assessed in *** and moisture regime(xeric,intermediate,and mesic) were included in this assessment as potential influential *** evaluation of repeated measurements from 40 plots suggested that O Horizon thickness did not change significantly over the 16-year period,but increased as elevation increased,and moisture regime(xeric O Horizon thickness> mesic O Horizon thickness) was a significant,related *** sum of 1-,10-,and 100-h fuel loads(fuels less 7.6 cm diameter),total woody fuel loads,ericaceous shrub cover,total basal area,or live *** basal area were *** *** basal area decreased with increasing ***,standing *** basal area increased from 2003-2019,and that increase was most pronounced as elevation increased on xeric and intermediate ***,we found that:*** increases in total woody fuel loads and ericaceous shrub cover were not present;and *** and moisture regime were most related to observed changes in vegetation and fuel condition.

关键词： Eastern hemlock Hemlock woolly adelgid Mountain laurel Rhododendron

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Transgenic plum Prunus domestica L., clone C5(cv. Honey Sweet) for protection against sharka disease

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Journal of Integrative Agriculture 2017年第3期16卷 516-522页

作者： Jaroslav Polák Jiban K Kundu Boris Krska Eva Beoni Petr Komínek Jitka Pívalová Jana Jarosová Division of Crop Protecting and Plant Health Crop Research Institute Prague 16106 Czech Republic Horticultural Faculty Lednice Mendel University Brno Lednice 69144 Czech Republic

Sharka caused by Plum pox virus（PPV）is the most harmful disease of stone fruits in Europe and elsewhere in the *** is no highly PPV resistant cultivar of *** approach has led to the development of resistance through genetic *** this study,we evaluated a transgenic plum Prunus domestica L.,clone C5（*** Sweet）,where the PPV resistance is based on RNA interference（RNAi）.Resistance in C5 plums has been evaluated for PPV,Prune dwarf virus（PDV）,and Apple chlorotic leaf spot virus（ACLSV）in a regulated field trial in the Czech Republic for 12 years（2002–2013）.Even under high and permanent infection pressure introduced through graft inoculation of the viruses,PPV has been detected in C5 trees only in several leaves situated close to the point of inoculum grafting in the first nine *** symptoms of PPV disappeared year by *** PPV symptoms were observed in the last three years and results of ELISA detection were *** results were obtained,when RT-PCR was used for PPV *** natural infection of PPV by aphids was recorded in C5 plums,even if PPV infected plants were growing in the same experimental field in close ***-infections of PPV with PDV and/or ACLSV had practically no influence on stability of resistance in C5 *** years of field testing in the Czech Republic clearly demonstrated the high level of resistance of C5 either to PPV infection by graft inoculation or natural infection through aphid vectors.

关键词： PPV C5 resistance transgenic plum HoneySweet

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Superparamagnetic iron oxide nanoparticles: promote neuronal regenerative capacity?

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Neural Regeneration Research 2015年第10期10卷 1568-1569页

作者： Jenni Neubert Anja U.bräuer Institute of Cell Biology and Neurobiology Center for AnatomyCharité–Universitätsmedizin Berlin Institute for Anatomy Universitätsmedizin Rostock

Currently,we know that neuronal outgrowth during development and regeneration requires a complex interaction of intra-and extracellular molecules such as growth factors,neurotransmitters and extracellular matrix proteins（O’Donnell et al.,2009）.Furthermore,the discovery of a broad spectrum of growth-promoting cues has led to novel concepts for thera-peutic strategies.

关键词： SPIO Superparamagnetic iron oxide nanoparticles promote neuronal regenerative capacity RGCs

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The analysis of the operational process of a complex fire alarm system used in transport facilities

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Building Simulation 2022年第4期15卷 615-629页

作者： Jacek Pas Tomasz Klimczak adam Rosinski Marek Stawowy Military University of Technology Faculty of Electronic Institute of Electronic SystemsDivision of Electronic Systems Exploitationsul.gen.S.Kaliskiego 200-908 WarsawPoland The Main School of Fire Service ul.Juliusza Stowackiego 52/5401-629 WarsawPoland Warsaw University of Technology Faculty of TransportDepartment of Telecommunications in Transportul.Koszykowa 7500-662 WarsawPoland

A fire alarm system(FAS)is a system comprising signalling-alarm devices,which automatically detect and transmit information about fire,but also receivers of fire alarms and receivers for damage *** alarm systems function in different environmental *** operation they should be in state of *** is determined by the reliability of the assembled units and rational management of the operation *** a reliability and operational analysis of fire alarm systems as a whole is *** article presents an authorial model and an operational and reliability analysis of FAS,which is exploited in a transport *** also demonstrates relationships occurring in the analysed system,where to an addressable fire alarm central unit with detection loops and control-monitoring loops alarm device lines(with monitored relay outputs for actuation of alarm-signalling devices)were *** and analysis of results for representative FAS,which were exploited in similar environmental conditions,were conducted in order to determine operational and reliability parameters of the investigated *** computer simulation was run during the time t=1 year of safety system *** led to the calculation of the probability value of the analysed FAS staying in the examined operational states.

关键词： modelling reliability operation fire alarm systems(FAS) simulation

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Bad neighborhoods:apoptotic and necroptotic microenvironments determine liver cancer subtypes

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 404-406页

作者： Dieter adam Institut fur Immunologie Christian-Albrechts-Universitat zu KielKielGermany

Cancer and cell death are inextricably intertwined. Impaired cell death is a prerequisite for cancer development, and artificial induction of cell death is a key strategy in cancer therapy. At present, clinical approaches to kill tumor cells mostly rely on the induction of apoptosis. For many years, apoptosis has been regarded as the only physiologic form of cell suicide. However, over the last two decades, it has become clear that alternative forms of regulated cell death exist which operate via distinct molecular mechanisms. Therefore, these novel forms of non-apoptotic cell death represent putative therapeutic options to overcome apoptosis resistance of cancer cells, potentially paving the way to more effective tumor therapies (1-3). Representing the currently best studied form of non-apoptotic cell death, necroptosis is elicited by triggers such as death receptors, toll like receptors (TLR) or sensors for intracellular nucleic acids (1,4,5). Their signals converge on the phosphorylation/activation of receptor-interacting serine/threonine protein kinase 3 (RIPK3). Phosphorylation of mixed-lineage kinase domain-like (MLKL) by RIPK3 results in oligomerization and membrane translocation of MLKL and subsequent rupture of the plasma membrane. The release of damage-associated molecular patterns (DAMPs) from the bursting necroptotic cells then promotes inflammation and activation of the innate and adaptive immune response (4-6).

关键词： cancer inflammation neighborhood

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Probabilistic analysis of ultimate seismic bearing capacity of strip foundations

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第4期10卷 717-724页

作者： adam Hamrouni Badreddine Sbartai Daniel Dias Laboratory InfraRes Mohammed Cherif Messaadia UniversitySouk-AhrasAlgeria Department of Civil Engineering Badji Mokhtar-Annaba UniversityAnnabaAlgeria Laboratory LMGHU Skikda UniversitySkikdaAlgeria School of Automotive and Transportation Engineering Hefei University of TechnologyHefei230009China Grenoble Alpes University Laboratory 3SRGrenobleFrance

This paper presents a reliability analysis of the pseudo-static seismic bearing capacity of a strip foundation using the limit equilibrium theory. The first-order reliability method(FORM) is employed to calculate the reliability index. The response surface methodology(RSM) is used to assess the Hasofer e Lind reliability index and then it is optimized using a genetic algorithm(GA). The random variables used are the soil shear strength parameters and the seismic coefficients(khand kv). Two assumptions(normal and non-normal distribution) are used for the random variables. The assumption of uncorrelated variables was found to be conservative in comparison to that of negatively correlated soil shear strength parameters. The assumption of non-normal distribution for the random variables can induce a negative effect on the reliability index of the practical range of the seismic bearing capacity.

关键词： Strip foundations Seismic bearing capacity First-order reliability method (FORM) Response surface methodology (RSM) Reliability Genetic algorithm (GA)

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Comparative studies on storage cells in tardigrades during starvation and anhydrobiosis

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Current Zoology 2010年第2期56卷 259-263页

作者： Andy REUNER Steffen HENGHERR Franz brümmer Ralph O.SCHILL Universitt Stuttgart Biological Institute Zoology UniversittStuttgart Biological Institute Zoology

The impact of starvation and anhydrobiosis on the number and size of the storage cells in the tardigrade species Milnesium tardigradum, Paramacrobiotus tonollii and Macrobiotus sapiens was investigated to gain more insight on the energetic side of anhydrobiosis. Storage cells are free floating cells within the body cavity of tardigrades and are presumed to store and release energy in form of glycogen, protein and fat to maintain a constant nutrient regime for the other tissues. The body size of the animals was not correlated with the size of the storage cells, however, M. tardigradum the largest species analysed also had the largest storage cells. A reduction in the size of the storage cells is apparent in all three species after seven days of starvation. A seven-day period of anhydrobiosis leads to a decrease in cell size in M. tardigradum but not in P. tonollii and M. sapiens. Although M. sapiens was raised on green algae, and M. tardigradum and P. tonollii were fed with rotifers and nematodes this difference in nourishment was not reflected in the response of the storage cells to anhydrobiosis

关键词： Tardigrada cryptobiosis Milnesium tardigradum Paramacrobiotus tonollii Macrobiotus sapiens

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Perspectives on the role of mTORC2 in B lymphocyte development,immunity and tumorigenesis

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Protein & Cell 2011年第7期2卷 523-530页

作者： adam S.Lazorchak Bing Su Department of Immunobiology and the Vascular Biology and Therapeutic Program Yale School of MedicineNew HavenCT 06519USA

Mammalian target of rapamycin complex 2(mTORC2)is a key downstream mediator of phosphoinositol-3-kinase(PI3K)dependent growth factor *** lymphocytes,mTORC2 has emerged as an important regulator of cell development,homeostasis and immune ***,our current understanding of mTORC2 functions and the molecular mechanisms regulating mTORC2 signaling in B and T cells are still largely *** studies have begun to shed light on this important *** have previously reported that mTORC2 mediates growth factor dependent phosphorylation of Akt and facilitates Akt dependent phosphorylation and inactivation of transcription factors FoxO1 and *** have recently explored the functions of mTORC2 in B cells and show that mTORC2 plays a key role in regulating survival and immunoglobulin(Ig)gene recombination of bone marrow B cells through an Akt2-FoxO1 dependent *** recombination is suppressed in proliferating B cells to ensure that DNA double strand breaks are not generated in actively dividing *** results raise the possibility that genetic or pharmacologic inhibition of mTORC2 may promote B cell tumor development as a result of inefficient suppression of Ig recombination in dividing B *** also propose a novel strategy to treat cancers based on our recent discovery that mTORC2 regulates Akt protein stability.

关键词： mTOR lymphocyte B cell cancer mTORC2 FoxO Akt Sin1

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The development of the Rook's(Corvus frugilegus)colony in the face of shifting spring phenology

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Avian Research 2022年第2期13卷 170-174页

作者： adam Zbyryt Karol Zub Cezary Mitrus Doctoral School of Exact and Natural Sciences University of Bialystok Mammal Research Institute Polish Academy of Sciences Department of Vertebrate Ecology and Paleontology Institute of BiologyWroclaw University of Environmental and Life Sciences

Many birds species breed in *** of the species in the Corvidae family nesting in groups is the Rook(Corvus frugilegus).The construction of the nest is costly for birds and needs high energy ***,birds should optimize the time of nest building in relation to environmental,especially weather,***,birds should adapt their breeding phenology,including the date of starting the construction of nests for climate *** observed the dynamics of increasing numbers of nests in a colony of Rooks in relation to air temperature,wind,rainfall,snowfall and day-length(indirect indicator of photoperiodism).Observations were carried out during three breeding seasons(2015-2017)in a large rookery in a big city in north-eastern *** increase in the number of nests was correlated only with day length and no effect of climatic factors on the number of nests in the colony was *** of nests varied significantly between successive years of *** the case of the Rook(predictable breeders),the photoperiod seems to be the most important factor influencing breeding behavior,especially nest *** the last three decades,increasing temperature and time of spring phases have advanced and have influenced changes in the phenology of the availability of food ***,a rapid decline in the numbers of breeding pairs of the Rook in Poland has been observed,especially in the last three *** attachment to the length of the day,which is the main factor responsible for the development of the breeding colony,makes the Rook appear to be a species with low plasticity in the face of rapid climate ***,we suggest that may indirectly influence the decrease in the breeding population of the Rook.

关键词： breeding colony Climate change Corvus frugilegus Nest building Photoperiodism Predictable breeding

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