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Is transesophageal echocardiography needed for evaluating tissue-based transient ischemic attack？

Neural Regeneration Research 2018年第7期13卷 1212-1215页

作者： Mohamed Al-Khaled Bjorn Scheef Toralf brüning Department of Neurology University of Lubeck Lubeck Germany Department of Ophthalmology University of Rostock Rostock Germany

Transient ischemic attack（TIA） is a warning signal for stroke.A comprehensive evaluation of TIA may reduce the risk for subsequent *** on the findings of cardiac evaluation with transesophageal echocardiography（TEE） in patients with TIA are *** aims were to determine the frequency of TEE performance and to investigate the findings of TEE in patients with TIA based on the new definition of TIA（i.e.,transient neurological symptoms without evidence of infarction）.During a 4-year period（2011–2014）,1071 patients（mean age,70 ± 13 years;female,49.7%） with TIA were included in a prospective study and *** 1071 consecutive patients suffering from TIA,288 patients（27%） underwent *** median time between admission and TEE was 6 *** with TIA who were evaluated by TEE were younger（67 vs.71 years,P 〈 0.001） than those who were not evaluated by *** had a higher rate of sensibility disturbance as a TIA symptom（39% vs.31%,P = 0.012） but a lower rate of previous stroke（15% vs.25%,P = 0.001） and atrial fibrillation（2% vs.21%,P 〈 0.001） than those who did *** ovale was detected in 71 patients（25.7%）,atrial septal aneurysm in 13 patients（4.6%）,and severe atherosclerotic plaques（grade 4 and 5） in the aortic arch in 25 patients（8.7%）.One patient（0.3%） had a fibroma detected by *** 17 of the 288 patients（6%） who underwent TEE,the indication for anticoagulation therapy was based on the TEE results,and 1 patient with fibroma underwent heart *** hospitalization,7 patients experienced a subsequent stroke,and 27 patients had a recurrent *** 3 months following discharge,the rates of readmission,stroke,recurrent TIA,and death were 19%,2.7%,4.2%,and 1.6%,*** rates of mortality（0.9% vs.1.8%,P = 0.7）,stroke risk（1.9% vs.3.0%,P = 0.8）,and recurrent TIA（5.0% vs.3.9%,P = 0.8） were similar in patients who underwent TEE and in those who did *** TEE in patients with tissue-based TIA is helpful in detecting cardiac so

关键词： transesophageal echocardiography transient ischemic stroke anticoagulation management therapy change

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Current and emerging trends in prostate cancer immunotherapy

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Asian Journal of Andrology 2019年第1期21卷 6-11页

作者： adam Schatz Badar M Mian Division of Urology Albany Medical CollegeAlbany NY 12054USA.

There have been a number of recent developments in the treatment of castration-resistant prostate cancer which seek to exploit the hormonal ***,the castration-resistant prostate cancer remains a major challenge since this is the lethal and incurable phenotype which results in tens of thousands of deaths every *** has been emerging interest in utilizing anticancer immunotherapy in prostate cancer,especially since the development of *** other prostate cancer therapeutic vaccines including autologous and allogeneic vaccines,as well as viral vector-based vaccines,have demonstrated promising results in early trials.

关键词： prostate cancer immunotherapy hormonal axis

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Genetic pathways controlling inflorescence architecture and development in wheat and barley

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Journal of Integrative Plant Biology 2019年第3期61卷 296-309页

作者： adam Gauley Scott A.Boden Department of Crop Genetics John Innes Centre Norwich Research Park

Modifications of inflorescence architecture have been crucial for the successful domestication of wheat and barley, which are central members of the Triticeae tribe that provide essential grains for the human diet. Investigation of the genes and alleles that underpin domestication-related traits has provided valuable insights into the molecular regulation of inflorescence development of the Triticeae, and further investigation of modified forms of architecture are proving to be equally *** identified genes are involved in diverse biological processes, including transcriptional regulation, hormone biosynthesis and metabolism, post-transcriptional and post-translational regulation, which alter inflorescence architecture by modifying the development and fertility of lateral organs, called spikelets and florets. Recent advances in sequencing capabilities and the generation of mutant populations are accelerating the identification of genes that influence inflorescence development, which is important given that genetic variation for this trait promises to be a valuable resource for optimizing grain production. This review assesses recent advances in our understanding of the genes controlling inflorescence development in wheat and barley, with the aim of highlighting the importance of improvements in developmental biology for optimizing the agronomic performance of staple crop plants.

关键词： Genetic pathways Modifications architecture

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The Efficacy of the Application of Highly Specialised Surface Engineering Methods in the Economy. Case Study.

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材料热处理学报 2004年第05B期25卷 1321-1324页

作者： adam Mazurkiewicz Jerzy Smolik Jan Walkowicz Institute for Terotechnology Pulaskiego 6/10 Radom 26-600 PolandInstitute for Terotechnology Pulaskiego 6/10 Radom 26-600 PolandInstitute for Terotechnology Pulaskiego 6/10 Radom 26-600 Poland

The development of materials technologies, including surface engineering is one of the main trends in the knowledge-based economy. The direct advantages of the application of these technologies are the energy and raw materials saving and the lack of negative influence on the natural environment. The disadvantages are the high equipment and operating costs, the requirement of the highest service qualifications and the necessity to develop specialized technological solutions for different kinds of applications, tools and processes. The potential economic and practical effects are so significant that except for new scientific and technological solutions new innovative organizational solutions are being searched. They should enable an extensive application of innovations in all economy sectors, including SMEs, so the investment possibilities and specialized skills would not constitute decisive limitations. A concept, assumptions, principles of operation and practical implementation of such a model organisational structure - Plasma Technologies Centre of the Institute for Terotechnology (ITeE Radom, Poland) are presented in the article. Development trends directly correlated with the needs of the national market and economy as well as network connections within Framework Programmes of the European Union are depicted. Examples of several highly specialised technological solutions (out of a few dozen solutions implemented in the PTC) and their technological efficacy are described.

关键词：表面工程经营活动经济效益技术功效

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Impaired cellulose decomposition in a headwater stream receiving subsurface agricultural drainage

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Ecological Processes 2022年第1期11卷 845-861页

作者： Rebecca Poisson adam G.Yates Department of Geography Western UniversityLondonONCanada Department of Biology University of WaterlooWaterloo University200 University Avenue WestWaterlooON N2L 3G1Canada

Background:Agricultural development of former wetlands has resulted in many headwater streams being sourced by subsurface agricultural drainage *** drainage inputs can significantly influence stream environmental conditions,such as temperature,hydrology,and water chemistry,that drive ecological ***,ecological assessments of subsurface drainage impacts are *** assessed the impact of an agricultural drainage system on cellulose decomposition and benthic respiration using a paired stream study in a headwater branch of Nissouri Creek,in Ontario,*** first order segments sourced by a spring-fed marsh and a cropped field with subsurface drainage,as well as the adjoining trunk segment,were sampled over a year using the cotton strip assay to measure cellulose decomposition and benthic ***:Assessments of cellulose decomposition revealed a one-third reduction in the drainage-sourced segment compared to marsh-sourced *** segment differences in cellulose decomposition were associated with reduced summer temperatures in the drainage-sourced *** of stream cooling from the drainage-sourced segment were transmitted downstream as cellulose decomposition was slower than expected throughout the drainage-sourced segment and for several hundred meters down the adjoining trunk *** respiration only differed between the drainage-and marsh-sourced segments in spring,when stream temperatures were ***:Our findings suggest there may be a widespread reduction in cellulose decomposition in streams across similar agricultural regions where subsurface drainage is ***,cooling of streams receiving significant amounts of water inputs from subsurface drainage systems may impart increased resiliency to future climate warming.

关键词： Stream Agriculture Cotton strip assay Seasonality Organic matter breakdown Benthic respiration

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An ultraviolet to visible scheme to estimate chromophoric dissolved organic matter absorption in a Case-2 water from remote sensing reflectance

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Frontiers of Earth Science 2020年第2期14卷 384-400页

作者： Xia LEI Jiayi PAN adam DEVLIN Institute of Space and Earth Information Science The Chinese University of Hong KongHong KongChina School of Geography and Environment Jiangxi Normal UniversityNanchang 330022China

In a typical Case-2 coastal water environment(here,the Pearl River Estuary(PRE),China),chromophoric dissolved organic matter(CDOM)and suspended particulates dominate the water optical properties,and CDOM fluorescence contributes considerably to surface water *** this paper,an ultraviolet(UV)to visible scheme to retrieve CDOM absorption(ag)is developed based on a set of in situ ***,the CDOM UV absorption and spectral slope(Sg)are derived directly from the visible remote sensing reflectance;then the Sg is extrapolated to obtain the spectrum from UV to visible spectral *** algorithm performs well,with an overall mean absolute percent difference(MAPD)of^30%,~5%and^6%for the estimation of ag in 250–450 nm,Sg over 250–400 nm,and 250–700 nm,*** effectiveness and stability of the algorithm is further demonstrated in capturing the distribution pattern of CDOM absorption in the PRE from satellite ocean color imagery with multiple spatial and spectral resolution,namely:the Visible Infrared Imaging Radiometer Suite(VIIRS)(750 m/Multispectral),the Ocean and Land Color Instrument(OLCI)(300 m/Multispectral),the Hyperspectral Imager for the Coastal Ocean(HICO)(100 m/Hyperspectral),and the Landsat 8 Operational Land Imager(OLI)(30 m/Multispectral).The UV to visible scheme can benefit the CDOM absorption estimation in two aspects:1)it is free from the disturbance of suspended matter;2)it avoids uncertainties caused by the low signalto-noise ratio(SNR)of ag measurements in the visible *** algorithm is effective in revealing multiple scales of variation of CDOM absorption from ocean color observations.

关键词： Chromophoric dissolved organic matter ocean color remote sensing Pearl River Estuary ultraviolet

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Use of Microwave Radiances from Metop-C and Fengyun-3 C/D Satellites for a Northern European Limited-area Data Assimilation System

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Advances in Atmospheric Sciences 2021年第8期38卷 1415-1428页

作者： Magnus LINDSKOG adam DYBbrOE Roger RANDRIAMAMPIANINA Swedish Meteorological and Hydrological Institute Folkborgsvägen 1760361 NorrköpingSweden Norwegian Meteorological Institute Henrik Mohns Plass 10371 OsloNorway

MetCoOp is a Nordic collaboration on operational Numerical Weather Prediction based on a common limited-area km-scale ensemble system. The initial states are produced using a 3-dimensional variational data assimilation scheme utilizing a large amount of observations from conventional in-situ measurements, weather radars, global navigation satellite system, advanced scatterometer data and satellite radiances from various satellite platforms. A version of the forecasting system which is aimed for future operations has been prepared for an enhanced assimilation of microwave radiances. This enhanced data assimilation system will use radiances from the Microwave Humidity Sounder, the Advanced Microwave Sounding Unit-A and the Micro-Wave Humidity Sounder-2 instruments on-board the Metop-C and Fengyun-3 C/D polar orbiting satellites. The implementation process includes channel selection, set-up of an adaptive bias correction procedure, and careful monitoring of data usage and quality control of observations. The benefit of the additional microwave observations in terms of data coverage and impact on analyses, as derived using the degree of freedom of signal approach, is demonstrated. A positive impact on forecast quality is shown, and the effect on the precipitation for a case study is examined. Finally, the role of enhanced data assimilation techniques and adaptions towards nowcasting are discussed.

关键词： data assimilation regional numerical weather prediction microwave radiances

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Biomedical applications of magneto-responsive scaffolds

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Nano Research 2018年第10期11卷 5049-5064页

作者： Adedokun A. Adedoyin adam K. Ekenseair Department of Chemical Engineering Northeastern University Boston MA 02115-5000 USA

Stimuli-responsive biomaterials, capable of responding on-demand to changes in their local environment, have become a subject of interest in the field of regenerative medicine. Magneto-responsive biomaterials, which can be manipulated spatiotemporally via an external magnetic field, have emerged as promising candidates as active scaffolds for advanced drug delivery and tissue regeneration applications. These specialized biomaterials can be synthesized by physically and/or chemically incorporating magnetic nanoparticles into the biomaterial structure. However, despite their promising impact on the future of regenerative medicine, magneto-responsive biomaterials still have several limitations that need to be overcome before they can be implemented clinically in a reliable manner, as predicting their behavior and biocompatibility remains an ongoing challenge. This review article will focus on discussing the current fabrication methods used to synthesize magneto-responsive materials, efforts to predict and characterize magneto-responsive biomaterial behavior, and the application of magneto-responsive biomaterials as controlled drug delivery systems, tissue engineering scaffolds, and artificial muscles.

关键词： biomaterials magnetic nanoparticles magneto-responsive scaffolds regenerative medicine stimuli-responsive materials tissue engineering biomaterials magnetic nanoparticles magneto-responsivescaffolds regenerative medicine stimuli-responsivematerials tissue engineering

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Gasification of lignite from Polish coal mine to hydrogen-rich gas

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International Journal of Coal Science & Technology 2022年第6期9卷 151-160页

作者： adam Smolinski Slawomir Wochna Natalia Howaniec Central Mining Institute Plac Gwarkow 140-166 KatowicePoland PGE Górnictwo i Energetyka Konwencjonalna S.A. Oddz.Kopalnia Wegla Brunatnego TurówGórników Turowa 159-916 BogatyniaPoland Department of Energy Saving and Air Protection Central Mining InstitutePlac Gwarkow 140-166 KatowicePoland

The efforts of the world research activities involved in clean coal technologies development focus to a considerable extent on integrated hydrogen and power generation technologies based on coal *** an alternative to combustion pro-cesses,gasification offers increased efficiency,lower negative environmental impact as well as wider application range of the main product—synthesis gas—in power generation and chemical *** order to select the most optimal lignite for the purpose of gasification,it is necessary to determine coal reactivity,the key parameter characterizing how fast the fuel reacts with the gasifying medium and controlling its process ability in thermochemical conversion to energy and/or energy *** paper presents the experimental results of oxygen/steam gasification of lignite coal char in a fixed bed reactor under atmospheric pressure and at the temperature of 700,800 and 900℃;the samples come from an open pit lignite mine in the southwest of *** effectiveness of the gasification process was tested in terms of the total gas and hydrogen yields,gas composition,carbon conversion rate and chars reactivity.

关键词： Coal gasification Hydrogen Syngas Clean coal technologies

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Effects of symmetric and asymmetric salt conditions on a selective solid-state nanopore assay

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Nano Research 2022年第11期15卷 9936-9942页

作者： Ian D.Wadsworth adam R.Hall Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences Wake Forest School of MedicineWinston-SalemNC 27101USA Comprehensive Cancer Center Wake Forest School of MedicineWinston-SalemNC 27157USA

Conventional solid-state nanopore measurements sense all translocating entities,necessitating meticulous analysis to differentiate target *** address this,we have established a selective assay with the platform that has shown utility in quantifying several nucleic acid ***,limited detection efficiency and intrinsic noise have so far limited assay resolution to 10 *** in this value require manipulation of translocation ***,we report the effects of NaCl conditions on assay *** first investigate symmetric conditions,finding sensitivity increases with salt concentration but selectivity is maximized at 1.0 M *** then probe asymmetric conditions,showing a remarkable impact on assay sensitivity and selectivity when measurement buffer NaCl concentration in the reservoir with the translocating molecules is low and the opposite reservoir is *** optimum conditions,we demonstrate detection of target biomolecules down to a concentration of 100 pM which is an improvement of 2 orders of magnitude over past results.

关键词： solid-state nanopores biomarkers amplification-free detection salt gradient nucleic acids

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