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Influence of an Uncontrolled Strength and Aerobic Exercise on Clinical and Echocardiographic Parameters in a Patient Following Anterior Myocardial Infarction

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Case Reports in Clinical Medicine 2017年第8期6卷 217-220页

作者： adam staron Najdat Bazarbashi Bartlomiej Wojtasik Department of Cardiac Rehabilitation Murcki Hospital Katowice Poland Department of Cardiology Prince Sultan Cardiac Center Prince Sultan Military Medical City Riyadh Saudi Arabia

Cardiac rehabilitation has been strongly recommended as a major therapeutic measure for coronary artery disease. Exercises, including resistance training, Ti-chi and yoga surprisingly show various and promising outcomes. We present an unusual case which certain aerobic techniques over a period of 5 weeks have improved a patient’s myocardial contractility and overall function after sustaining an anterior myocardial infarction.

关键词： Anterior MI Strength Exercise Resistance Training Aerobic Training Cardiac Rehabilitation

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The Unusual Improvement of Intermittent Claudication Distance in Patient with Peripheral Arterial Disease Utilizing “2/3 Claudication Distance” Protocol of Exercise Training

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Case Reports in Clinical Medicine 2020年第1期9卷 29-34页

作者： adam staron Mohammed Al-Subaie Jana Al-Qahtani Cardiac Rehabilitation Unit Adult Cardiology Department Prince Sultan Cardiac Center Riyadh KSA

Peripheral arterial disease (PAD) affects 12% - 20% of the population over 65 years. PAD is a component of systemic atherosclerosis and is associated with increased rate of all-cause mortality and cardiovascular events, compared with those without PAD. The strongest risk factors for PAD are older age and cigarette smoking. PAD accelerates functional decline leading to physical disability. Many randomized clinical trials demonstrated that treadmill walking training increases pain-free and maximal walking distances in patients with PAD. Exercise intervention is strongly recommended for patients with PAD and symptoms of intermittent claudication (IC). The need to provide an exercise training program to patients with peripheral arterial disease is essential, as almost half of these patients will eventually develop coronary artery disease. There are many existing treadmill walking protocols for patients with PAD. Most of these are based on claudication severity. We present a case of significant improvement of pain-free distance and maximum treadmill walking distance in a patient with PAD after 12 weeks of walking training program utilizing the “2/3 claudication distance” formula.

关键词： Peripheral Arterial Disease Intermittent Claudication Aerobic Training Car-diac Rehabilitation

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Tremendous Improvement of the Functional Capacity in Patient with Chronic Heart Failure after 12-Weeks of Exercise Training Program

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Case Reports in Clinical Medicine 2020年第8期9卷 236-241页

作者： adam staron Jadwiga Wolszakiewicz Mohammed Al Otaiby Justyna Irla-Czyzycka Ibrahim Al Malki Deemah Al-Khodairay Cardiac Rehabilitation Unit Prince Sultan Cardiac Center Riyadh KSA Department of Cardiology Cardiology Institute Krakow Poland

Cardiac rehabilitation is recommended for patients with chronic heart failure (CHF) with preserved, or reduced left ventricular ejection fraction (LVEF). A cardiac rehabilitation program generally includes physical exercise, diet counseling, educational classes on lifestyle changes, and disease management as well as psychosocial support for patients and their families. Exercise training is a core component of the comprehensive cardiac rehabilitation program and is strongly recommended in combination with pharmacological treatment to patients with CHF, due to cardiorespiratory, metabolic, and autonomic cardiac response. Exercise-based cardiac rehabilitation affects positively functional capacity, exercise tolerance, and quality of life in CHF patients. The physical inactivity rate in Arabian Peninsula countries is extremely high, and exercise training of habitually physically inactive individuals should result in marked improvements of physical capacity. We present a case that demonstrates such a significant improvement in the physical capacity of a patient with CHF and a review of literature.

关键词： Cardiac Rehabilitation Chronic Heart Failure Low-Intensity Interval Training Functional Capacity

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开口射流风洞主动湍流产生过程中动态射流特性

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同济大学学报（自然科学版） 2019年第S1期47卷 14-19页

作者： staron Domenic STOLL Daniel RIEGEL Matthias BLUMRICH Reinhard WIEDEMANN Jochen WAGNER Andreas Research Institute of Automotive Engineering and Vehicle Engines Stuttgart 德国斯图加特70569

出于可重复性考虑,车辆空气动力学和气动声学的研发工作主要在风洞中稳态流动条件下进行,然而在真实路况下车辆经受着非稳态湍流,这是由比如侧风阵风、路边障碍物与稳定侧风的组合影响或前方行驶的车辆所引起的.为了能够以可重复再现的... 详细信息

出于可重复性考虑,车辆空气动力学和气动声学的研发工作主要在风洞中稳态流动条件下进行,然而在真实路况下车辆经受着非稳态湍流,这是由比如侧风阵风、路边障碍物与稳定侧风的组合影响或前方行驶的车辆所引起的.为了能够以可重复再现的方式来模拟该路面场景,开发了一套主动湍流发生器系统FKFS swing?,并运用于斯图加特大学的全尺寸气动声学风洞中,风洞由FKFS运营.该系统由垂直跨越风洞喷口的8个翼型组成,能够以高达10 Hz的频率动态改变流动角度.先前的研究表明,开口射流对主动偏转的动态响应改变了由位置和频率变化所产生的流动角度.一种用于量化该特性的方法被提出并运用于斯特劳哈尔数高达0.45的情况.本研究中,该方法被用于分析更高斯特劳哈尔数至1.2情况下的动态响应,这与非稳态气动声学相关.结果表明,在更高的斯特劳哈尔数下射流特性对流动角度的影响减小.

关键词：车辆工程汽车空气动力学汽车气动声学风洞主动湍流生成

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Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

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Protein & Cell 2018年第1期9卷 121-129页

作者： Philip D. Bardwelll Matthew M. staron Junjian Liu Qingfeng Tao Susanne scesney Gail Bukofzer Luis E. Rodriguez Chee-Ho Choi Jennifer Wang Qing Chang Feng Dong Cherrie Donawho Jieyi Wang Christine M. Grinnell Edit Tarcsa Charles Hutchins Tariq Ghayur Jijie Gu Foundational Immunology AbbVie Bioresearch Center Worcester MA 01605 USA Global Preclinical Safety AbbVie Bioresearch Center Worcester MA 01605 USA Oncology Discovery AbbVie Inc. North Chicago IL 60064 USA DMPK-BA AbbVie Bioresearch Center Worcester MA 01605 USA Research and Development AbbVie Inc. North Chicago IL 60064 USA Torque Therapeutics Inc. Cambridge MA 02142 USA Innovent Bioloqics Inc. Suzhou China Lyvgen Biopharma Shanghai 201203 China

Novel biologics that redirect cytotoxic T lymphocytes （CTLs） to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens （TAA） expressed on tumor cells remains a challenge of both technology and biol- ogy. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each speci- ficity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.

关键词： DVD-Ig Half DVD-Ig Halt'body epidermal growth factor receptor redirected T-cell cytotoxicity rCTL

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