检索结果-南通市图书馆

Solution Stirring Enables to Generate Nucleation and Improve Quality of Adenosine Deaminase Crystal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solution Stirring Enables to Generate Nucleation and Improve...

家禽瘦素(Leptin)信息传导及其生理功能(续完)

10～(th) International Conference on the Crystallization of Biological Macromlecules

作者： adachi h. Takano K. Niino A. Matsumura h. Kinoshita T. Warizaya M. Inoue T. Mori Y. Sasaki T. Department of Electrical Engineering Osaka UniversitySOSHO Project（Crystal Design Project）Osaka UniversityNEDO SOShO Project（Crystal Design Project） Osaka UniversityNEDODepartment of Material and Life ScienceOsaka University SOShO Project（Crystal Design Project） Osaka University SOShO Project（Crystal Design Project） Osaka UniversityNEDODepartment of Materials ChemistryOsaka UniversityYamadaoka 2-1SuitaOsaka565-0871Japan Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd. TokodaiTsukuba 300-2698Japan Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd. TokodaiTsukuba 300-2698Japan SOShO Project（Crystal Design Project） Osaka UniversityNEDODepartment of Materials ChemistryOsaka University Yamadaoka 2-1SuitaOsaka565-0871Japan Department of Electrical Engineering Osaka UniversitySOSHO Project（Crystal Design Project）Osaka UniversityNEDO Department of Electrical Engineering Osaka UniversitySOSHO Project（Crystal Design Project）Osaka UniversityNEDO

＜正＞ We have developed a new crystallization technique, solution stirring technique. This is entirely different approach compared with the conventional methods （adachi et al., 2002）. In this work, we show the generation of nucleation and improvement of crystal quality of adenosine deaminase （ADA） using solution stirring *** is one of the enzymes involved in the purine pathway and is found in most mammalian tissues. It has been reported that elevated ADA levels are associated with a number of diseases. ADA inhibitors have been used as antimetabolic and

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

国外畜牧学（猪与禽） 2009年第6期29卷 61-63页

作者：何忠武 T.Ohkubo h.adachi

续2009年第4期：上一期总体介绍了瘦素的一般情况，并详细介绍了瘦素受体的结构和基因表达。

关键词：瘦素受体生理功能信息传导家禽基因表达

SBMA患者的变异雄激素受体在细胞核和胞质内广泛堆积

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 16-17页

作者： adachi h. Katsuno M. Minamiyama M. G.Sobue 郭俊 Department of Neurology Nagoya Univ. Grad. Sch. Of Medicine 65 Tsurumai-cho Showa-kuNagoya 466- 8550Japan Dr.

Spinal and bulbar muscular atrophy (SBMA) is an inherited adult onset motor ne uron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR), affecting only males. The characteristic pathological f inding is nuclear inclusions (NIs) consisting of mutant AR with an expanded poly Q in residual motor neurons, and in certain visceral organs. We immunohistochemi cally examined 11 SBMA patients at autopsy with 1C2, an antibody that specifical ly recognizes expanded *** study demonstrated that diffuse nuclear accumul ation of mutant AR was far more frequent and extensive than NIs being distribute d in a wide array of CNS nuclei, and in more visceral organs than thus far belie ved. Mutant AR accumulation was also present in the cytoplasm, particularly in t he Golgi apparatus; nuclear or cytoplasmic predominance of accumulation was tiss ue specific. Furthermore,the extent of diffuse nuclear accumulation of mutant AR in motor and sensory neurons of the spinal cord was closely related to CAG repe at length. Thus, diffuse nuclear accumulation of mutant AR apparently is a cardi nal pathogenetic process underlying neurological manifestations, as in SBMA tran sgenic mice, while cytoplasmic accumulation may also contribute to SBMA pathophy siology.

关键词：雄激素受体 SBMA 运动神经元细胞质内核包涵体链扩增特异性识别转基因小鼠免疫组织化学组织特异性

日本社区人群血浆肾素活性与静息心率的相关性

在线全文

学校读者我要写书评

暂无评论

中华高血压杂志 2015年第11期23卷 1098-1098页

作者：练桂丽叶鹏 adachi h Enomoto M Fukami A Kumagai E Nakamura S Yoshimura A Obuchi A hori K Nohara Y Nakao E Fukumoto Y

心率是死亡、肥胖和糖尿病发展的强有力预测因素。肾素血管紧张素醛固酮系统在血压调节和血容量稳态中起重要作用，但缺乏心率与血浆肾素活性的流行病学证据。该研究探讨心率与肾素活性是否相关。方法：入选2009年在日本久留米市进行的... 详细信息

心率是死亡、肥胖和糖尿病发展的强有力预测因素。肾素血管紧张素醛固酮系统在血压调节和血容量稳态中起重要作用，但缺乏心率与血浆肾素活性的流行病学证据。该研究探讨心率与肾素活性是否相关。方法：入选2009年在日本久留米市进行的一次健康检查的受试者1943人，采用放射免疫分析检测血浆肾素和醛固酮水平。

关键词：血浆肾素活性静息心率社区人群肾素血管紧张素醛固酮系统日本相关性放射免疫分析 2009年

在线全文

学校读者我要写书评

暂无评论

心率过快会增加肥胖和糖尿病的风险

药品评价 2009年第4期6卷 155-155页

作者： Shigetoh Y adachi h Yamagishi S

日本一项前瞻性研究证实，心率过快的人更易肥胖和罹患糖尿病。该研究1979年对614名20岁以上的健康体检者进行血生化和心电图检查，1999年对这些人再次行上述检查，发现静息心率与血压、游离脂肪酸、血糖、胰岛素抵抗指数等心血管风险... 详细信息

日本一项前瞻性研究证实，心率过快的人更易肥胖和罹患糖尿病。该研究1979年对614名20岁以上的健康体检者进行血生化和心电图检查，1999年对这些人再次行上述检查，发现静息心率与血压、游离脂肪酸、血糖、胰岛素抵抗指数等心血管风险因子呈交叉的线性相关关系。

关键词：静息心率风险因子糖尿病肥胖胰岛素抵抗指数心电图检查健康体检者游离脂肪酸

Probing CO on a rutile TiO_(2)(110)surface using atomic force microscopy and Kelvin probe force microscopy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第3期15卷 1909-1915页

作者： Yuuki adachi Yasuhiro Sugawara Yan Jun Li Department of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan

Probing CO at a specific site on a metal oxide surface is essential for characterizing various applications such as CO oxidation,hydrogenation,and water–gas shift ***,we use atomic force microscopy and Kelvin probe force microscopy to probe the CO on a rutile TiO_(2)(110)*** results indicate that CO can be manipulated along the Ti row by the repulsive lateral force of“pushing”***,the joint combination of precise manipulation and the distance dependence of local contact potential difference allow us to resolve the interatomic dipole moment and charge state of CO at atomic ***,we found that the negatively charged CO with the dipole moment of negative pole down on the rutile TiO_(2)(110)*** results suppose that both the charge state as well as the on-surface dipole interaction are very effective for CO reaction on rutile TiO_(2)(110)surface.

关键词： CO rutile TiO_(2) dipole moment charge state atomic force microscopy Kelvin probe force microscopy

FORSETI: A visual analysis environment enabling provenance awareness for the accountability of e-autopsy reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Visual Informatics 2022年第3期6卷 69-80页

作者： Baoqing Wang Noboru adachi Issei Fujishiro Keio University Graduate School of Science and Technology3-14-1 HiyoshiKohoku-kuYokohama223-8522 KanagawaJapan University of Yamanashi Graduate School of Medical Science1110 ShimokatoChuo409-3898 YamanashiJapan

Autopsy reports play a pivotal role in forensic *** examiners(MEs)and diagnostic radiologists(DRs)cross-reference autopsy results in the form of autopsy reports,while judicial personnel derive legal documents from final autopsy *** our prior study,we presented a visual analysis system called the forensic autopsy system for e-court instruments(FORSETI)with an extended legal medicine markup language(x-LMML)that enables MEs and DRs to author and review e-autopsy *** this paper,we present our extended work to incorporate provenance infrastructure with authority management into FORSETI for forensic data accountability,which contains two *** first is a novel provenance management mechanism that combines the forensic autopsy workflow management system(FAWfMS)and a version control system called lmmlgit for x-LMML *** management mechanism allows much provenance data on e-autopsy reports and their documented autopsy processes to be individually *** second is provenance-supported immersive analytics,which is intended to ensure that the DRs’and MEs’autopsy provenances can be viewed,listed,and analyzed so that a principal ME can author their own report through accountable autopsy referencing in an augmented reality setting.A fictitious case with a synthetic wounded body is used to demonstrate the effectiveness of the provenance-aware FORSETI system in terms of data accountability through the experience of experts in legal medicine.

关键词： Computational forensics Legal medicine Accountability Provenance Immersive analytics Authority

Soft ground tunnel lithology classification using clustering-guided light gradient boosting machine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2857-2867页

作者： Kursat Kilic hajime Ikeda Tsuyoshi adachi Youhei Kawamura Department of Geosciences Geotechnology and Materials Engineering for ResourcesGraduate School of International Resource SciencesAkita UniversityAkita010-8502Japan Division of Sustainable Resources Engineering Faculty of EngineeringHokkaido UniversityKita 13Nishi 8Kita-kuSapporo060-8628Japan

During tunnel boring machine(TBM)excavation,lithology identification is an important issue to understand tunnelling performance and avoid time-consuming ***,site investigation generally lacks ground samples and the information is subjective,heterogeneous,and imbalanced due to mixed ground *** this study,an unsupervised(K-means)and synthetic minority oversampling technique(SMOTE)-guided light-gradient boosting machine(LightGBM)classifier is proposed to identify the soft ground tunnel classification and determine the imbalanced issue of tunnelling *** the tunnel excavation,an earth pressure balance(EPB)TBM recorded 18 different operational parameters along with the three main tunnel *** proposed model is applied using Python low-code PyCaret ***,four decision tree-based classifiers were obtained in a short time period with automatic hyperparameter tuning to determine the best model for clustering-guided SMOTE *** addition,the Shapley additive explanation(ShAP)was implemented to avoid the model black box *** proposed model was evaluated using different metrics such as accuracy,F1 score,precision,recall,and receiver operating characteristics(ROC)curve to obtain a reasonable outcome for the minority *** shows that the proposed model can provide significant tunnel lithology identification based on the operational parameters of *** proposed method can be applied to heterogeneous tunnel formations with several TBM operational parameters to describe the tunnel lithologies for efficient tunnelling.

关键词： Earth pressure balance(EPB) Tunnel boring machine(TBM) Soft ground tunnelling Tunnel lithology Operational parameters Synthetic minority oversampling technique (SMOTE) K-means clustering

MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第9期14卷 1378-1382页

作者： Toshie Okada Tokihiko Sawada Tatsushi Osawa Masakazu adachi Keiichi Kubota Second Department of Surgery Dokkyo University School of Medicine Kitakobayashi 880MibuShimotsugaTochigi 321-0293Japan Second Department of Surgery Dokkyo University School of Medicine Kitakobayashi 880MibuShimotsuga Tochigi 321-0293Japan Japan Apricot Co.Ltd.1-11-7 MidorichoTakasakiGunma 370-0073 Japan Japan Apricot Co. Ltd.1-11-7 MidorichoTakasakiGunma 370-0073 Japan Second Department of Surgery Dokkyo University School of MedicineKitakobayashi 880Mibu ShimotsugaTochigi 321-0293Japan

AIM:To investigate the anti-neoplastic effect of MK615, an anti-neoplastic compound isolated from Japanese apricot, against human pancreatic cancer cells in vitro. METhODS: Three human pancreatic cancer cell lines PANC-1, PK-1, and PK45h were cultured with MK615 at concentrations of 600, 300, 150, and 0 μg/mL. Growth inhibition was evaluated by cell proliferation assay, and killing activity was determined by lactate dehydrogenase (LDh) assay. Expression of Aurora A and B kinases was detected by real-time polymerase chain reaction (PCR) and Western blotting. Cell cycle stages were evaluated by flow cytometry. RESULTS: The growth inhibitory rates of MK615 at 150, 300, and 600 μg/mL were 2.3% ± 0.9%, 8.9% ± 3.2% and 67.1% ± 8.1% on PANC1 cells, 1.3% ± 0.3%, 8.7% ± 4.1% and 45.7 ± 7.6% on PK1 cells, and 1.2 ± 0.8%, 9.1% ± 2.1% and 52.1% ± 5.5% on PK45h cells, respectively (P he percentage cytotoxicities of MK615 at 0, 150, 300, and 600 μg/mL were 19.6% ± 1.3%, 26.7% ± 1.8%, 25.5% ± 0.9% and 26.4% ± 0.9% in PANC1 cells, 19.7% ± 1.3%, 24.7% ± 0.8%, 25.9% ± 0.9% and 29.9% ± 1.1% in PK1 cells, and 28.0% ± 0.9%, 31.2% ± 0.9%, 30.4% ± 1.1% and 35.3 ± 1.0% in PK45h cells, respectively (P howed that MK615 dually inhibited the expression of Aurora A and B kinases. Cell cycle analysis revealed that MK615 increased the population of cells in G2/M phase. CONCLUSION: MK615 exerts an anti-neoplastic effect on human pancreatic cancer cells in vitro by dual inhibition of Aurora A and B kinases.

关键词： Japanese apricot Aurora kinases Pancreatic cancer Cell cycle