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Rela.ionship Between Individua.s’Epidemic Risk Perception Within Living Spa.e a.d Subjective Well-Being:Empirica. Evidence from China.a.ter the First Wa.e of CoVID-19

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Chinese Geogra.hica. Science 2024年第2期34卷 369-382页

作者： SoNG Jia.gyu ZHoU Suhong KWa. Mei-po ZHENG Zhong School of Geogra.hy a.d Pla.ning Sun Yat-sen UniversityGuangzhou 510006China Gua.gdong Provincia. Engineering Resea.ch Center for Public Security a.d Disa.ter Guangzhou 510275China Institute of Spa.e a.d Ea.th Informa.ion Science the Chinese University of Hong KongHong Kong 999077China Depa.tment of Geogra.hy a.d Resource Ma.a.ement the Chinese University of Hong KongHong Kong 999077China Institute of Future Cities the Chinese University of Hong KongHong Kong 999077China Center for Territoria. Spa.ia. Pla.ning a.d Rea. Esta.e Studies Beijing Normal UniversityZhuhai 519000China

It is common to observe the epidemic risk perception(ERP)a.d a.decline in subjective well-being(SWB)in the context of public hea.th events,such a. Corona.Virus Disea.e 2019(CoVID-19).However,there ha.e been few studies exploring the impa.t of individua.s’ERP within living spa.e on their SWB,especia.ly from a.geogra.hica. a.d da.ly a.tivity perspective a.ter the resumption of work a.d other a.tivities following a.wa.e of the *** this pa.er,we conducted a.study with 789 pa.ticipa.ts in urba. China.mea.uring their ERP within living spa.e a.d exa.ining its influence on their SWB using pa.h *** results indica.ed tha. individua.s’ERP within their living spa.e had a.significa.t nega.ive effect on their *** density of certa.n types of fa.ilities within their living spa.e,such a. bus stops,subwa. sta.ions,resta.ra.ts,fa.t food shops,convenience shops,hospita.s,a.d public toilets,had a.significa.tly nega.ive impa.t on their SWB,media.ed by their ERP within living ***,pa.ticipa.ion in out-of-home work a.d other a.tivities not only increa.ed individua.s’ERP within living spa.e,but a.so strengthened its nega.ive effect on their SWB.

关键词： subjective well-being epidemic risk perception living spa.e the density of fa.ilities out-of-home a.tivities

Gra.hFlow+:Exploiting Conversa.ion Flow in Conversa.iona. Ma.hine Comprehension with Gra.h Neura. Networks

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Ma.hine Intelligence Resea.ch 2024年第2期21卷 272-282页

作者： Jing Hu Lingfei Wu Yu Chen po Hu Moha.med J.Za.i School of Computer Science Central China Normal UniversityWuhan 430079China Pinterest San Francisco 94016USA Meta Mountain View 94039USA Renssela.r polytechnic Institute Troy 12180USA

The conversa.ion ma.hine comprehension(MC)ta.k a.ms to a.swer questions in the multi-turn conversa.ion for a.single ***,recent a.proa.hes don’t exploit informa.ion from historica. conversa.ions effectively,which results in some references a.d ellipsis in the current question ca.not be *** addition,these methods do not consider the rich sema.tic rela.ionships between words when rea.oning a.out the pa.sa.e *** this pa.er,we propose a.novel model Gra.hFlow+,which constructs a.context gra.h for ea.h conversa.ion turn a.d uses a.unique recurrent gra.h neura. network(GNN)to model the tempora. dependencies between the context gra.hs of ea.h ***,we exploit three different wa.s to construct text gra.hs,including the dyna.ic gra.h,sta.ic gra.h,a.d hybrid gra.h tha. combines the *** experiments on CoQa.Qua. a.d DoQa.show tha. the Gra.hFlow+model ca. outperform the sta.e-of-the-a.t a.proa.hes.

关键词： Conversa.iona. ma.hine comprehension(MC) reading comprehension question a.swering gra.h neura. networks(GNNs) na.ura. la.gua.e processing(NLP)

Fermented Lentinus edodes extra.t conta.ningα-gluca. a.eliora.es conca.a.a.in a.induced a.toimmune hepa.itis in mice

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Food Science a.d Huma. Wellness 2024年第4期13卷 2102-2115页

作者： Xin Hu Da. Cheng Yingxia.Zha.g po Li Xia.ping Wu Junsheng Fu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China Mycologica. Resea.ch Center Fujian Agriculture and Forestry UniversityFuzhou 350002China Sha.gha. Lithy one-Hea.th Group Technology Co. Ltd.Shanghai 200235China

a.toimmune hepa.itis(a.H)is a.chronic infla.ma.ory liver disea.e tha. threa.ens huma. hea.th *** a.m of this study wa. to detect the protective effect of a.fermented Lentinus edodes extra.t conta.ningα-gluca.(FLa.,in a.conca.a.a.in a.Con a.-induced a.H mouse model a.d to determine the underlying liver-protective *** results showed tha. compa.ed with the model group,the level of proinfla.ma.ory cytokines in serum of FLa.pretrea.ed mice wa. significa.tly decrea.ed,a.d the degree of infla.ma.ory cell infiltra.ion in liver,thymus a.d spleen wa. significa.tly *** polymera.e cha.n rea.tion,immunohistochemistry,a.d Western blotting showed tha. FLa.pre-trea.ment inhibited the Con a.induced a.optosis of hepa.ocytes by down-regula.ing the expression of Ba. a.d up-regula.ing the expression of *** resea.ch found tha. FLa.ma. improve liver injury in mice by a.tiva.ing NRF2 signa.ing pa.hwa. a.d inhibiting TRa.6/NF-κB signa.ing ***,FLa.ma. improve liver injury in mice by shifting gut microbia. composition to reduce the relea.e of infla.ma.ory cytokines in the serum a.d prevent the necrosis of ***-regula.ion of NRF2 signa.ing pa.hwa.,down-regula.ion of TRa.6/NF-κB signa.ing pa.hwa.,a.d a. increa.e in the rela.ive a.unda.ce of La.toba.illus_johnsonii a.d Ligila.toba.illus_murinus pla. a.protective role in liver.

关键词： a.toimmune hepa.itis Conca.a.a.in A Lentinus edodes TRa.6/NF-κB NRF2

a.tion of circula.ing a.d infiltra.ing B cells in the immune microenvironment of colorecta. ca.cer by single-cell sequencing a.a.ysis

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World Journa. of Ga.trointestina. oncology 2024年第6期16卷 2683-2696页

作者： Jing-po Zha.g Bing-Zheng Ya. Jie Liu Wei Wa.g Depa.tment of Hepa.obilia.y a.d Pa.crea.ic Surgery First Hospital of Hebei Medical UniversityShijiazhuang 050032Hebei ProvinceChina Depa.tment of Hepa.obilia.y Surgery Hunan Provincial People’s HospitalChangsha 410002Hunan ProvinceChina

Ba.KGRoUND The complexity of the immune microenvironment ha. a. impa.t on the trea.ment of colorecta. ca.cer(CRC),one of the most preva.ent ma.igna.cies *** this study,multi-omics a.d single-cell sequencing techniques were used to investiga.e the mecha.ism of a.tion of circula.ing a.d infiltra.ing B cells in *** revea.ing the heterogeneity a.d functiona. differences of B cells in ca.cer immunity,we a.m to deepen our understa.ding of immune regula.ion a.d provide a.scientific ba.is for the development of more effective ca.cer trea.ment *** To explore the role of circula.ing a.d infiltra.ing B cell subsets in the immune microenvironment of CRC,explore the potentia. driving mecha.ism of B cell development,a.a.yze the intera.tion between B cells a.d other immune cells in the immune microenvironment a.d the functions of communica.ion molecules,a.d sea.ch for possible regula.ory pa.hwa.s to promote the a.ti-tumor effects of B *** a.tota. of 69 pa.a.a.cer(norma.),tumor a.d periphera. blood sa.ples were collected from 23 pa.ients with CRC from The Ca.cer Genome a.la. da.a.a.e(https://***/).a.ter the immune cells were sorted by multicolor flow cytometry,the single cell tra.scriptome a.d B cell receptor group libra.y were sequenced using the 10X Genomics pla.form,a.d the da.a.were a.a.yzed using bioinforma.ics tools such a. *** differences in the number a.d function of B cell infiltra.ion between tumor a.d norma. tissue,the intera.tion between B cell subsets a.d T cells a.d myeloid cell subsets,a.d the tra.scription fa.tor regula.ory network of B cell subsets were explored a.d *** Compa.ed with norma. tissue,the infiltra.ing number of CD20+B cell subsets in tumor tissue increa.ed *** them,germina. center B cells(GCB)pla.ed the most prominent role,with positive clone expa.sion a.d hea.y cha.n muta.ion level increa.ing,a.d the trend of differentia.ion into memory B cells ***,the

关键词： Colorecta. ca.cer Multi-omics a.a.ysis Single-cell sequencing a.a.ysis Immune microenvironment Infiltra.ing B cells

Mecha.ica.ly driven a.sembly of biomimetic 2D-ma.eria. microtextures with bioinspired multifunctiona.ity

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Na.o Resea.ch 2024年第2期17卷 663-678页

作者： Ya.g Li Lin Jing Joshua.M.Little Ha.chen Ya.g Tsa.-Chun Chung po-Yen Chen Depa.tment of Chemica. a.d Biomolecula. Engineering University of MarylandCollege ParkMD 20740USA Ma.yla.d Robotics Center University of MarylandCollege ParkMD 20742USA School of Ma.eria.s Science a.d Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Na.ure provides a.wea.th of bio-inspira.ion for adva.ced ma.eria. *** va.ious na.oma.eria.s into biomimetic microtextures with bioinspired functiona.ities ha. spurred increa.ing resea.ch interests a.d fa.ilita.ed technologica. adva.ces in va.ious *** recent yea.s,two-dimensiona. ma.eria.s(2DMs)ha.e emerged a. importa.t building block units in the biomimicry field due to their distinct chemica.,physica.,electrica.,electrochemica.,a.d ca.a.ytic *** this review a.ticle,va.ious mecha.ica.ly driven a.sembly a.proa.hes a.e summa.ized to fa.rica.e va.ious genea.ogies of biomimetic 2DM microtextures with bio-inspired ***,sequentia. deforma.ion stra.egies a.e discussed to progra.ma.ly construct higher dimensiona. 2DM microtextures,ra.ging from wrinkles/crumples(one-time deforma.ion)to multisca.e hiera.chies(multiple deforma.ions).Next,the current progress using higher dimensiona. 2DM microtextures to imita.e different biologica. structures a.d/or induce bio-inspired multifunctiona.ity is systema.ica.ly *** showca.es of bio-inspira.ion a.d biomimicry using different 2DM na.osheets a.e highlighted:(1)wrinkle pa.terns of a. ea.thworm tha. spur the design of stra.n sensors with progra.ma.le working ra.ges a.d sensitivities,(2)wrinkle a.pea.a.ce of a.Sha.-Pei dog tha. motiva.es the fa.rica.ion of stretcha.le energy stora.e devices,(3)hiera.chica. sca.e textures of a.desert liza.d tha. inspire ca.ion-induced gela.ion pla.forms for 2DM a.rogels,a.d(4)wrinkle skin of a. elepha.t tha. influences the development of 2DM protective skin for soft ***,cha.lenges a.d future opportunities of adopting 2DM na.osheets to a.semble biomimetic microstructures with synergistic functiona.ities a.e discussed.

关键词： two-dimensiona.(2D)ma.eria.s mecha.ica.ly driven a.sembly biomimetic microtextures functiona. na.ocomposite bio-inspired multifunctiona.ity

a.do-keto reducta.e fa.ily member C3(a.R1C3)promotes hepa.ocellula. ca.cinoma.cell growth by producing prosta.la.din F2α

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oncology Resea.ch 2024年第1期32卷 163-174页

作者： KUo-SHYa.G JENG po-YU CHENG YUEH-HSIEN LIN po-CHUN LIU PING-HUI TSENG YU-CHa. Wa.G CHIUNG-Fa.G CHa.G CHUEN-MIIN LEU Division of Genera. Surgery Far Eastern Memorial HospitalNew Taipei City22060Taiwan Institute of Microbiology a.d Immunology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biochemistry a.d Molecula. Biology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biomedica. Informa.ics National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Depa.tment of Medica. Resea.ch Far Eastern Memorial HospitalNew Taipei City22060Taiwan

Hepa.ocellula. ca.cinoma.HCC)is a.leading ca.se of dea.h *** thera.ies a.e effective for HCC pa.ients with ea.ly disea.e,but ma.y pa.ients suffer recurrence a.ter surgery a.d ha.e a.poor response to ***,new thera.eutic ta.gets a.e *** a.a.yzed gene expression profiles between HCC tissues a.d norma. adja.ent tissues from public da.a.a.es a.d found tha. the expression of genes involved in lipid meta.olism wa. significa.tly *** a.a.ysis showed tha. a.R1C3 wa. upregula.ed in tumors,a.d high a.R1C3 expression wa. a.socia.ed with a.poorer prognosis in HCC *** vitro,a.sa.s demonstra.ed tha. the knockdown of a.R1C3 or the addition of the a.R1C3 inhibitor indometha.in suppressed the growth a.d colony forma.ion of HCC cell *** of a.R1C3 in Huh7 cells reduced tumor growth in *** explore the mecha.ism,we performed pa.hwa. enrichment a.a.ysis,a.d the results linked the expression of a.R1C3 with prosta.la.din F2 a.pha.PGF2a.downstrea. ta.get *** of a.R1C3 a.tivity reduced the production of PGF2a.a.d supplementa.ion with PGF2a.restored the growth of indometha.in-trea.ed Huh7 *** of the PGF receptor(PTGFR)a.d trea.ment with a.PTGFR inhibitor significa.tly reduced HCC *** showed tha. indometha.in potentia.ed the sensitivity of Huh7 cells to *** summa.y,our results indica.e tha. a.R1C3 upregula.ion ma. promote HCC growth by promoting the production of PGF2α,a.d suppression of PTGFR limited HCC ***,ta.geting the a.R1C3-PGF2a.PTGFR a.is ma. be a.new stra.egy for the trea.ment of HCC.

关键词： Hepa.ocellula. ca.cinoma a.do-keto reducta.e fa.ily member C3 Prosta.la.din F2 a.pha Prosta.la.din F receptor

Templa.ed synthesis of tra.sition meta. phosphide electroca.a.ysts for oxygen a.d hydrogen evolution rea.tions

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Journa. of Energy Chemistry 2024年第2期89卷 646-669,I0014页

作者： Rose a.ne a.edera.a.icia.Theresse Dumla. DJ Donn Ma.ienzo Ma.icor Divina.ra.ia.Julie a.ne del Rosa.io Pa.a.gua.po-Ya.a.el Chua.g Joey ocon La.ora.ory of Electrochemica. Engineering(LEE) Department of Chemical EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines Mecha.ica. Engineering University of CaliforniaMercedCA 95343USA Energy Engineering Progra. College of EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Tra.sition meta. phosphides(TMPs)ha.e been rega.ded a. a.terna.ive hydrogen evolution rea.tion(HER)a.d oxygen evolution rea.tion(oER)ca.a.ysts owing to their compa.a.le a.tivity to those of noble meta.-ba.ed *** ha.e been produced in va.ious morphologies,including hollow a.d porous na.ostructures,which a.e fea.ures deemed desira.le for electroca.a.ytic *** synthesis routes a.e often responsible for such *** pa.er reviews the la.est adva.ces a.d existing cha.lenges in the synthesis of TMP-ba.ed oER a.d HER ca.a.ysts through templa.ed methods.a.comprehensive review of the structure-property-performa.ce of TMP-ba.ed HER a.d oER ca.a.ysts prepa.ed using different templa.es is *** discussion proceeds a.cording to a.plica.ion,first by HER a.d further divided a.ong the types of templa.es used-from ha.d templa.es,sa.rificia. templa.es,a.d soft templa.es to the emerging dyna.ic hydrogen bubble *** ca.a.ysts a.e then reviewed a.d grouped a.cording to their ***,prospective resea.ch directions for the synthesis of hollow a.d porous TMP-ba.ed ca.a.ysts,such a. improvements on both a.tivity a.d sta.ility of TMPs,design of environmenta.ly benign templa.es a.d processes,a.d a.a.ysis of the rea.tion mecha.ism through adva.ced ma.eria. cha.a.teriza.ion techniques a.d theoretica. ca.cula.ions,a.e suggested.

关键词： oER HER Tra.sition meta. phosphide Templa.ed synthesis Electroca.a.ysts

Effect of Pre-stra.n on Microstructure a.d Sta.ping Performa.ce of High-strength Low-a.loy Steel

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Journa. of Wuha. University of Technology(Ma.eria.s Science) 2024年第3期39卷 774-780页

作者：刘坡 WEN Zhicheng LIU Zheng 许峰 School of Mecha.ica. Engineering Guilin University of Aerospace TechnologyGuilin 541004China School of a.tomotive Engineer-ing Changshu Institute of TechnologyChangshu 215500China

In this study,pre-stra.n ra.ging from 0 to 0.12 wa. a.plied through unia.ia. tension on high-strength low-a.loy(HSLa.specimens with four kinds of gra.n *** of pre-stra.n a.d gra.n size on me-cha.ica. property wa. investiga.ed through tensile *** of the pre-stra.ned a.d tensile tested sa.ples were a.a.yzed,*** 30.8°v-bending a.d following fla.tening,a. well a. Erichson cupping tests,were performed on the pre-stra.ned *** show the elonga.ion ra.io of gra.n a.d disloca.ion density increa.es with *** pla.form is removed when pre-stra.n is la.ger tha. 0.06 while yielding pla.ea. period decrea.es with pre-stra.n less tha. 0.06 due to reduction of pinning *** 30.8°v-bending a.d the following fla.tening tests a.e successfully a.complished on a.l the pre-stra.ned sa.ples with different gra.n *** in gra.n size,a.ong with increa.e in pre-stra.n,ca.ses increa.e in strength a.d decrea.e in elonga.ion ra.e a. well a. cupping ***-stra.n ca.ses very slight effect on bending a.ility,much less tha. tha. on mecha.ica. property a.d cupping test *** impa.t of the pre-stra.n a.d gra.n size on HSLa.steel deforma.ility is inconspicuous.

关键词： stra.n ha.dening disloca.ion texture bending erichson cupping test

Molecula. cha.a.teriza.ion a.d structure ba.is of a.ma.onyltra.sfera.e with both substra.e promiscuity a.d ca.a.ytic regiospecificity from Cista.che tubulosa

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a.ta.Pha.ma.eutica.Sinica.B 2024年第5期14卷 2333-2348页

作者： Xia. Liu Yuyu Liu Xiping Xu Wenqia. Hua.g Ya.u Ya. Yingxia.Wa.g Weisheng Tia. Ting Mo Xia.xue Cui Jun Li She-po Shi Pengfei Tu Modern Resea.ch Center for Traditiona. Chinese Medicine Beijing Research Institute of Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China Modern Resea.ch Center for Traditiona. Chinese Medicine School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China

Enzyma.ic ma.onyla.ion of na.ura. glycosides provides a.promising a.terna.ive method for drug-like ma.onyla.ed glycosides ***,the ca.a.ytic potentia. a.d structura. ba.is of pla.t ma.onyltra.sfera.e a.e fa. from being fully *** work identified a.new ma.onyltra.sfera.e CtMa.1 from Cista.che *** displa.ed unprecedented mono-a.d/or di-ma.onyla.ion a.tivity towa.d diverse glucosides with different a.lycons.a.one-pot”system by CtMa.1 a.d a.ma.onyl-Coa.syntheta.e wa. esta.lished to biosynthesize nine new ma.onyla.ed *** investiga.ions revea.ed tha. CtMa.1 possesses a. adequa.ely spa.ious a.yl-a.ceptor pocket ca.a.le of a.commoda.ing diverse ***,it recognizes ma.onyl-Coa.through strong electrota.tic a.d hydrogen ***/MM ca.cula.ion revea.ed the H167-media.ed SN2 rea.tion mecha.ism of CtMa.1,while dyna.ic simula.ions detected the forma.ion of sta.le hydrogen bonds between the glucose-6-oH group a.d H167,resulting in its high ma.onyla.ion *** energy profiles of two isomeric glycosides highlighted lower rea.tion energy ba.riers towa.ds glucoside substra.es,empha.izing CtMa.1's preference for ***,a.muta.t CtMa.1H36a.with nota.ly increa.ed di-ma.onyla.ion a.tivity wa. *** underlying molecula. mecha.ism wa. illumina.ed through MM/GBSa.binding free energy *** study significa.tly adva.ces the understa.ding of pla.t a.yltra.sfera.es from both functiona. a.d protein structura. perspectives,while a.so providing a.versa.ile tool for enzyma.ic ma.onyla.ion a.plica.ions in pha.ma.ology.

关键词： Pla.t a.yltra.sfera.e Ma.onyltra.sfera.e Ma.onyla.ed glycosides Enzyma.ic ca.a.ysis Enzyme promiscuity