检索结果-南通市图书馆

Effectiveness of post-COVID-19 primary care attendance in improving survival in very old patients with multimorbidity:a territory-wide target trial emulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2024年第3期12卷 25-35页

作者： Cuiling Wei Vincent Ka Chun Yan Camille Maringe Wenxin Tian Rachel Yui Ki Chu Wenlong Liu Boyan Liu Yuqi Hu Lingyue Zhou Celine Sze Ling Chui Xue Li Eric Yuk Fai Wan Ching Lung Cheung Esther Wai Yin Chan William Chi Wai Wong ian Chi Kei Wong Francisco Tsz Tsun Lai Centre for Safe Medication Practice and Research Department of Pharmacology and PharmacyLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Health Services Research and Policy Faculty of Public Health and PolicyLondon School of Hygiene and Tropical MedicineLondonUK School of Nursing Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong School of Public Health Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Laboratory of Data Discovery for Health(D24H) Hong KongHong Kong advanced Data Analytics for Medical Science(adAMS)Limited Hong KongHong Kong Department of Medicine School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Family Medicine and Primary Care School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongHong Kong Department of Pharmacy The University of Hong Kong-Shenzhen HospitalShenzhenPeople's Republic of China Aston Pharmacy School Aston UniversityBirminghamUK School of Pharmacy Macao University of Science and TechnologyTaipaMacao

Objectives Older individuals with multimorbidity are at an elevated risk of infection and complications from *** of post-COVID-19 interventions or care models in reducing subsequent adverse outcomes in these individuals have rarely been *** study aims to examine the effectiveness of attending general outpatient within 30 days after discharge from COVID-19 on 1-year survival among older adults aged 85 years or above with *** Retrospective cohort study emulating a randomised target trial using electronic health *** We used data from the Hospital Authority and the Department of Health in Hong Kong,which provided comprehensive electronic health records,COVID-19 confirmed case data,population-based vaccination records and other individual characteristics for the *** adults aged 85 years or above with multimorbidity who were discharged after hospitalisation for COVID-19 between January 2020 and August *** Attending a general outpatient within 30 days of last COVID-19 discharge defined the exposure,compared to no outpatient *** outcome measures Primary outcome was all-cause mortality within one *** outcomes included mortality from respiratory,cardiovascular and cancer *** A total of 6183 eligible COVID-19 survivors were included in the *** all-cause mortality rate following COVID-19 hospitalisation was lower in the general outpatient visit group(17.1 deaths per 100 person-year)compared with non-visit group(42.8 deaths per 100 person-year).After adjustment,primary care consultations within 30 days after discharge were associated with a significantly greater 1-year survival(difference in 1-year survival:11.2%,95%CI 8.1%to 14.4%).We also observed significantly better survival from respiratory diseases in the general outpatient visit group(difference in 1-year survival:6.3%,95%CI 3.5%to 8.9%).In a sensitivity analysis for different grace period lengths

关键词： morbidity visit records

Indications for 5-aminosalicylate in inflammatory bowel disease:Is the body of evidence complete?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第38期12卷 6115-6123页

作者： ad A van Bodegraven Chris JJ Mulder Section of Inflammatory Bowel Diseases VU University medical centre Amsterdam The Netherlands Department of Gastroenterology VU University medical centre Amsterdam The Netherlands

Mesalazine is a safe drug, although adverse events may be seen in a minority of patients. This applies also to pregnant women and children. The role of mesalazine in combination therapy to improve efficacy and con- comitant drug pharmacokinetics, or in chemoprevention against inflammatory bowel disease (IBD)-related co- lonic carcinoma has not yet been completely elucidated. Therapeutic success of mesalazine may be optimized by a combination of high dose and low frequency of dos- age to improve compliance. Therefore, due to its supe- rior safety profile and pharmacokinetic characteristics, mesalazine is preferable to sulphasalazine. This paper reviews the literature concerning mechanisms of action, indications and off-label use, pharmacokinetic properties and formulations, therapeutic efficacy, compliance, pae- diatric indications, chemoprevention, and safety issues and adverse event profile of mesalazine treatment versus sulphasalazine. It also highlights these controversies in order to clarify the potential benefits of mesalazines in IBD therapy and evidence for its use.

关键词： Mesalazine Sulphasalazine Review Ulcerative colitis Crohn's disease Treatment Chemoprevention Pregnancy adverse events

Historical reflections on autoimmune hepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第21期14卷 3292-3300页

作者： ian R Mackay Department of Biochemistry & Molecular Biology Monash UniversityClayton Victoria 3800Australia

Autoimmune hepatitis(AIH),initially known as chronic active or active chronic hepatitis(and by various other names),first came under clinical notice in the late ***,quite likely,chronic active hepatitis(CAH) had been observed prior to this and was attributed to a persistently destructive virus infection of the *** earlier(and controversial) designation in 1956 as lupoid hepatitis was derived from associated *** test positivity and emphasized accompanying multisystem features and immunological *** women featured prominently in early descriptions of *** was first applied in 1965 as a descriptive ***-characteristic autoantibodies were defined from the early 1960s,notably antinuclear antibody(ANA),smooth muscle antibody(SMA) and liver-kidney microsomal(LKM) *** are still widely used diagnostically but their relationship to pathogenesis is still not evident.A liver and disease specific autoantigen has long been searched for but *** immunosuppressive therapy with predisolone and azathioprine in the 1960s proved beneficial and remains standard therapy *** like many other autoimmune diseases is associated with particular HLA alleles especially with the "ancestral" B8,DR3 haplotype,and also with *** forwards,AIH is one of the several enigmatic autoimmune diseases that,despite being(relatively) organ specific,are marked by autoimmune reactivities with non-organ-specific *** paradigms are needed to explain the occurrence,expressions and pathogenesis of such diseases.

关键词： Medical history Autoimmune hepatitis Lupoid hepatitis Liver disease autoantibodies Immunosuppressive therapy HLA-disease associations

Fluctuating resources,disturbance and plant strategies:diverse mechanisms underlying plant invasions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Arid Land 2013年第3期5卷 284-297页

作者： ian J RadFORD CSIRO Sustainable Ecosystems Davies LaboratoryPrivate Mailbag POAitkenvale 4814Australia Botany Department University of OtagoPO Box 56Dunedin 9054New Zealand

This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. （2000）. I measured relative functional responses of both invasive and native plants to changed resource availability due to nutrient enrichment and rainfall, and to increased disturbance. Data are presented from studies in two contrasting ecosystems. First is a series of glasshouse and field experiments on the invader Hieracium lepidulum and associated invasive and native species in subalpine temperate New Zealand. Second is a field study of invasive and native plant responses to altered disturbance regimes and rainfall from tropical savannas of north eastern Australia. Invaders responded differently from native species to changes in resource availability in both subalpine and tropical studies. However, invaders differed among themselves showing that different species exploit different functional niches to invade their respective habitats. These findings contribute to the contention that the fluctuating resource hypothesis does not provide a universal explanation for plant invasions. The diverse functional responses to increased resource availability among invaders in this and previous studies suggest that the cause of invasion depends on unique combinations of habitat and functional attributes of invaders and native assemblages. Such findings imply that universal predictions of what will happen under climate change scenarios across the globe will be difficult to make.

关键词： plant invasion plant strategies C-S-R triangle fluctuating resources disturbance

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

50 years change in urban land use and ecological planning globally in the era of design with nature

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ecosystem Health and Sustainability 2019年第1期5卷 185-198,I0001页

作者： ian Douglas School of Environment Education and DevelopmentUniversity of ManchesterManchesterUK

ian McHarg’s 1969 book,Design with Nature,was grounded in earlier good practice,especially the European vision of fitting cities into the regional landscape and carrying thorough surveys before planning *** book emerged in the wake of publications that worried about the ability of the earth to support expanding populations and their growing impact on the *** argued that ecological design should follow planning based on detailed site *** McHarg advised many urban authorities in the USA and other countries,especially in Africa,Asia and Europe,and his ideas had influenced some British new towns,they had little attention in the planning of Milton Keynes,England’s largest new urban settlement,where the initial geological surveys were inadequate,but a successful large tree-planting programhas created a“city in the forest.”McHarg was however closely involved in planning the Nigerian Capital city,Abuja,but his sound master plan was ill-equipped to provide for a nation undergoing post-conflict rebuilding and a local population more concerned with access to land than ecological ***,McHarg helped us to promote,protect,and preserve urban green *** teams from different disciplines now work well together,the integrated thinking advocated by McHarg remains sometimes in short supply in local practice.

关键词： Planning design urban nature garden city site investigation

Scale,Information-Processing,and Complementarities in Old-World Axial Age Societies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Social Computing 2022年第2期3卷 119-127页

作者： ian Morris the Department of Classics Stanford UniversityStanfordCA 94305-2145USA

Recent cross-disciplinary work on quantifying historical dynamics has made major contributions to ***,efforts to specify relationships between scale and information-processing always run a risk of shoehorning messy realities into overly rigid *** the case of the first-millennium BCE“Axial Age”in the Old World,networks of collective computing were structured more by cultural systems than by polities,and to understand the relationships between political scale and collective computational abilities,scholars need categories flexible enough to clarify the complementarities between political and cultural systems.

关键词： scale information-processing Axial Age ancient Greece

Safety of anti-tumor necrosis factor therapy in inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第17期15卷 2067-2073页

作者： Frank Hoentjen ad A van Bodegraven Department of Gastroenterology VU University Medical Center PO Box 7057 1007 MB Amsterdam The Netherlands

Inflammatory bowel disease (IBD), in particular Crohn's disease refractory to conventional therapy, fistulizing Crohn's disease and chronic active ulcerative colitis, generally respond well to anti-tumor necrosis factor (TNF) therapy. However, serious side effects do occur, necessitating careful monitoring of therapy. Potential side effects of anti-TNF therapy include opportunistic infections, which show a higher incidence when concomitant immunosuppression is used. Furthermore, antibody formation against anti-TNF is associated with decreased efficacy and an increased frequency of infusion reactions. The hypothesis of a slightly increased risk of lymphomas in IBD patients treated with anti TNF-therapy is debatable, since most studies lack the specific design to properly address this issue. Alarmingly, the occurrence of hepatosplenic T-cell lymphomas coincides with combined immunosuppressive therapy. Despite the potential serious side effects, anti-TNF therapy is an effective and relatively safe treatment option for refractory IBD. Future research is needed to answer important questions, such as the long-term risk of malignancies, safety during pregnancy, when to discontinue and when to switch anti-TNF therapy, as well as to determine the balance between therapeutic and toxic effects.

关键词： Anti-tumor necrosis factor Biologics Inflammatory bowel diseases Crohn's disease Infliximab

Analyzing excited-state processes and optical signatures of a ratiomeric fluorine anion sensor: a quantum look

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2014年第10期57卷 1363-1368页

作者： LAURENT adèle D. JACQUEMIN Denis CEISAM UMR CNRS 6230 BP 92208 Universitè de Nantes 2 Rue de la Houssinière44322 Nantes Cedex 3 France Institut Universitaire de France 103 bd St Michel75005 Paris Cedex 5 France

Recently, the spectroscopic signatures of a benzoselenadiazole derivative have been investigated in the framework of designing a new ratiometric fluoride sensor （Saravanan et al., Org Lett, 2014, 16： 354-357）. It was suggested that this sensor is un- dergoing excited-state intramolecular proton transfer. In this work, we provide a new look at these experimental data, using a state-of-the-art time-dependent density fimctiona/theory approach to mimic the spectroscopic signatures. New insights about the nature of the excited-state processes are obtained.

关键词： excited-state intramolecular proton transfer (ESIPT) time-dependent density functional theory (TD-DFT) benzoselenadiazole