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Role of renin-angiotensin system/angiotensin converting enzyme-2 mechanism and enhanced COVID-19 susceptibility in type 2 diabetes mellitus

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World Journal of Diabetes 2024年第4期15卷 606-622页

作者： Ashwin kumar Shukla Komal Awasthi Kauser Usman Monisha banerjee Molecular and Human Genetics Laboratory Department of ZoologyUniversity of LucknowLucknow 226007Uttar PradeshIndia Department of Medicine King Georges’Medical UniversityLucknow 226003Uttar PradeshIndia Institute of Advanced Molecular Genetics and Infectious Diseases(IAMGID)University of LucknowLucknow 226007Uttar PradeshIndia

Coronavirus disease 2019(COVID-19)is a disease that caused a global pandemic and is caused by infection of severe acute respiratory syndrome coronavirus 2 *** has affected over 768 million people worldwide,resulting in approx-imately 6900000 ***-risk groups,identified by the Centers for Disease Control and Prevention,include individuals with conditions like type 2 diabetes mellitus(t2DM),obesity,chronic lung disease,serious heart conditions,and chronic kidney *** indicates that those with t2DM face a hei-ghtened susceptibility to COVID-19 and increased mortality compared to non-diabetic *** the renin-angiotensin system(RAS),a vital regulator of blood pressure and pulmonary stability,reveals the significance of the angiotensin-converting enzyme(ACE)and ACE2 *** converts angiotensin-I to the vasoconstrictor angiotensin-II,while ACE2 counters this by converting angiotensin-II to angiotensin 1-7,a *** ACE2 exp-ression,common in diabetes,intensifies RAS activity,contributing to conditions like inflammation and *** ACE inhibitors and angiotensin receptor blockers can be therapeutically beneficial by increasing ACE2 levels,concerns arise regarding the potential elevation of ACE2 receptors on cell membranes,potentially facilitating COVID-19 *** review explored the role of the RAS/ACE2 mechanism in amplifying severe acute respiratory syndrome cor-onavirus 2 infection and associated complications in *** treatment strategies,including recombinant human ACE2 therapy,broad-spectrum antiviral drugs,and epigenetic signature detection,are discussed as promising avenues in the battle against this pandemic.

关键词： Angiotensin-converting enzyme 2 Angiotensin-converting enzyme inhibitors Angiotensin-II receptor blockers Complex diseases COVID-19 type 2 diabetes

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Mathematical modelling of ball and plate system with experimental and correlation function-based model validation

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Control theory and technology 2024年第2期22卷 326-341页

作者： t.R.Dil kumar S.J.Mija Department of Electrical Engineering National Institute of Technology CalicutKozhikode673601KeralaIndia

the ball and plate system is an inherently nonlinear under actuated benchmark system used for validating the performance of various control schemes. A mathematical model depicting the dynamics close to that of the system is very much required for such a test bed. In this correspondence, the complete nonlinear model, a simplified nonlinear model, and a linearized model of the ball and plate system are developed. the system comprises a ball and plate mechanism and a rotary servo unit. the ball and plate mechanism is modelled using the Euler–Lagrange method, whereas the rotary servo subsystem is modelled from the first principles. the nonlinear model of the combined system is developed by including the dynamics of the servo motor with gear and rolling resistance between the ball and the plate. the simplified nonlinear model of the system is obtained with suitable assumptions. the model is linearized around the operating point using the Jacobian. the validity of the developed models is investigated through correlation function analysis. the open-loop response of the three models, viz., nonlinear, simplified nonlinear, and linearized models, is analyzed in the MAtLAB/Simulink platform. Since the open-loop system is unstable, the experimental validation of the model is performed with a double-loop PSO (particle swarm optimization) PID control scheme.

关键词： Ball and plate system Correlation function Model validation Particle swarm optimization(PSO) PSO PID controller

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Aerodynamics of a tandem-Bladed Axial Compressor Rotor under Circumferential Distortion at Different Rotational Speeds

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Journal of thermal Science 2024年第4期33卷 1340-1356页

作者： Amit kumar Jerry t.JOHN A.M.PRADEEP R.A.DAKKERMANS Dragan KOZULOVIC Department of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India Department of Automotive and Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propulsion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,inflow distortion is *** distortion is known to degrade the aerodynamic performance and stable operating limits of a *** rotor configuration is an arrangement that effectively controls the growth of the boundary layer over the suction surface of the ***,a higher total pressure rise can be achieved through this unconventional design approach involving the splitting of the blade into forward and aft *** is expected that the effect of inlet flow distortion would be more severe for a tandem-rotor design due to the greater flow turning inherent in such ***,this aspect needs to be thoroughly *** present study discusses the effect of circumferential distortion on the tandem-rotor at different rotational ***-annulus RANS simulations using ANSYS CFX are used in the present *** performance of the rotor at a particular flow coefficient and different rotational speeds is *** total pressure and efficiency are observed to drop at lower mass flow rates under the influence of circumferential *** loss region in each blade passage is mainly associated with the blade wake,tip leakage vortex,secondary flow,and boundary ***,their contribution varies from passage to passage,particularly in the distorted *** the lower span,the wake width is found to be higher than that at a higher *** to the redistribution of the mass flow,the circumferential extent reduces at a higher *** the undistorted sector,the strength of the tip leakage vortex is significantly higher at the design rotational speed than at lower *** distortion near the tip region promotes an early vortex breakdown even at the design operating *** adversely affects the total pressure,efficiency,and stall *** clean flow conditions,this phenomenon is only observed near the stall *** the design operating condition,the breakdown of the forward rotor tip l

关键词： tandem rotor circumferential distortion loss tip leakage vortex vortex breakdown diffusion factor aerodynamics of compressor blade

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Multi-scale habitat influences sprainting and group size of a freshwater-obligate smooth-coated otter(Lutrogale perspicillata) in tungabhadra Otter Conservation Reserve, India

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Ecological Processes 2024年第1期13卷 159-175页

作者： Ankit Moun P.Ramesh kumar M.Malathi Priya t.Ramesh Riddhika Kalle Sálim Ali Centre for Ornithology and Natural History Deputy Conservator of Forests Bellary Territorial Forest Division Deputy Conservator of Forests Working Plan and Survey and Research WingBellary Territorial Forest Division Centre for Functional Biodiversity University of Kwa Zulu-Natal

Background the impact of changing land-use patterns and associated anthropogenic threats on scale-dependent habitat use of semi-aquatic mustelids in scent-marking and social behaviour can provide important insights into the habitat ecology of smooth-coated otters(Lutrogale perspicillata).Methods We sampled 180 stream segments(100–400 m) as spatial replicates of 60 1-km2 sites to record indirect evidence(i.e. spraints and mass latrine sites) and group sizes of smooth-coated otters along the tungabhadra Otter Conservation Reserve(tOCR) during the dry season. to quantify habitat, we recorded stream characteristics, riparian vegetation, and anthropogenic disturbances at the local scale, and hydro-environmental characteristics and land uses at the landscape scale. Using Markovian-chain detection and occupancy models, we assessed the multi-scale habitat use of otters in their selection of suitable areas for scent-marking based on repeated presence-absence data on spraint/latrine locations along the tOCR. We further used linear regression techniques to explore relationships between the number of individuals in smooth-coated otter group and hydro-environmental characteristics, spraint/latrine encounter rate, anthropogenic pressure, land cover, topography, and *** At the local scale, the probability of spraint deposition and group size decreased with anthropogenic disturbance while the probability of spraint detections decreased with grass cover. At the landscape scale, the probability of otter site use for spraint deposition and group sizes increased in southeast flowing streams. Spraint deposition increased with the proportion of sugarcane fields, whereas in contrast, group size decreased with proportion of sugarcane *** Our findings highlight the first empirical evidence on multi-scale habitat use of a southern Indian population of smooth-coated otters in an inland freshwater ecosystem surrounded by the scrub jungle–agriculture matrix. We sug

关键词： Presence-absence modelling Inland river Freshwater ecosystem Semi-aquatic mammal Smooth-coated otter

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Morphological and molecular description of a new species of sandfly,Sergentomyia(Neophlebotomus)ashwanii ***.(Diptera:Psychodidae)from Western Ghats,India

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Asian Pacific Journal of tropical Medicine 2024年第5期17卷 226-234页

作者： Prasanta Saini Harish kumar Shah Mathew Jessu Sonia t tom Anns KP Amju ICMR-Vector Control Research Centre(Field Station) KottayamKeralaIndia

Objective:to report a new species of sandfly,Sergentomyia(Neophlebotomus)ashwanii ***.(Diptera:Psychodidae)from Western Ghats,***:A systematic sandfly survey was conducted in the thrissur and Kollam districts of Kerala,India using mechanical aspirators,light and sticky traps,both indoor and outdoor habitats,for a period of one *** acid barcoding of samples was performed targeting mitochondrial cytochrome oxidase I(COI)gene and sequence generated was subjected to phylogenetic ***:Sergentomyia(Neophlebotomus)ashwanii,a new sandfly species is recorded and described in this communication.A single row of 10-12 pointed teeth in the cibarium with 4-6 small denticles or fore-teeth are the key characteristics that is distinctive from other members of the subgenus *** COI barcode followed by phylogenetic analysis of the nucleotide sequence confirms that specimens of the species belong to the same taxonomic group while the genetic distance(14.2%)with the congeners established it to be a different ***:the Western Ghats'being an important biodiversity hotspot and has dearth of systematic entomological surveys on *** current study tried to fill the void and also report a new sandfly species.

关键词： Sergentomyia(Neophlebotomus)ashwanii COI barcode Western Ghats Phlebotomine sandflies

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thermodynamic properties and phase diagram of quark matter within non-extensive Polyakov chiral SU(3)quark mean field model

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Chinese Physics C 2024年第5期48卷 60-71页

作者： Dhananjay Singh Arvind kumar Department of Physics Dr.B R Ambedkar National Institute of Technology JalandharJalandhar–144008PunjabIndia

In the present study,we applied tsallis non-extensive statistics to investigate the thermodynamic properties and phase diagram of quark matter in the Polyakov chiral SU(3)quark mean field *** this model,the properties of the quark matter were modified through the scalar fieldsσ,ζ,δ,χ,vector fieldsω,ρ,ϕ,and Polyakov fieldsΦandΦ¯at finite temperature and chemical ***-extensive effects were introduced through a dimensionless parameter q,and the results were compared to those of the extensive case(q→1).In the non-extensive case,the exponential in the Fermi-Dirac(FD)function was modified to a q-exponential *** influence of the q parameter on the thermodynamic properties,pressure,energy,and entropy density,as well as trace anomaly,was *** speed of sound and specific heat with non-extensive effects were also ***,the effect of non-extensivity on the deconfinement phase transition as well as the chiral phase transition of u,d,and s quarks was *** found that the critical end point(CEP),which defines the point in the(t−μ)phase diagram where the order of the phase transition changes,shifts to a lower value of temperature,tCEP,and a higher value of chemical potential,μCEP,as the non-extensivity is increased,that is,q>1.

关键词： quark matter quark mean field model QCD phase diagram non-extensive statistics

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钒技术在难减排行业和能源转型中的作用评估

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钢铁钒钛 2024年第4期45卷 84-94页

作者： David ASantos Manish KDixit Pranav Pradeep kumar Sarbajit banerjee 德克萨斯农工大学化学系德克萨斯农工大学材料科学和工程系德克萨斯农工大学建筑科学系德克萨斯农工大学土木与环境工程学院

重工业的减碳和可再生能源技术的出现皆与获得矿物资源有着密不可分的联系。因此，迫切需要对关键元素在减少温室气体排放方面的作用进行基准评估。考察了钒作为微合金元素在建筑碳减排以及作为电网储能用液流电池的主要成分在能源转型... 详细信息

重工业的减碳和可再生能源技术的出现皆与获得矿物资源有着密不可分的联系。因此，迫切需要对关键元素在减少温室气体排放方面的作用进行基准评估。考察了钒作为微合金元素在建筑碳减排以及作为电网储能用液流电池的主要成分在能源转型中的作用。研究结果表明，钒可使每年减少总计1.85亿t碳排放。其中，中国和欧盟的减排幅度分别为各自排放量的1.15%和0.18%。研究结果强调了关键金属在发展低碳基础设施中的作用，同时指出了进行全面评估并施加政策干预减轻供应链风险的必要性。

关键词：钒微合金化液流电池碳减排

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Heavy metal pollution of river water and eco-friendly remediation using potent microalgal species

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Water Science and Engineering 2024年第1期17卷 41-50页

作者： Amudham Radha Amal Raj Prabhakaran Mylsamy V.Sivasankar B.Sathish kumar Kiyoshi Omine t.G.Sunitha Phycological Research Laboratory Research Department of BotanyPachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Research Department of Chemistry Pachaiyappa's College(Affiliated to University of Madras)Chennai 600030India Department of Botany Sri Vidya Mandir Arts&Science College(Autonomous)KatteriUthangarai 636902India Department of Civil Engineering School of Engineering.Nagasaki UniversityNagasaki-Daigaku1-14 Bunkyo-machiNagasaki 8528521Japan

Pollution of rivers is mainly caused by anthropogenic activities such as discharge of effluent from industrial facilities,maintenance of sewage/effluent treatment plants,and dumping of solid waste on river *** study dealt with the pollution issues of the Cooum River in the well-known city of Chennai in South *** samples from 27 locations were collected and analyzed for 12 elements,including Ba,B,and Al,as well as heavy metals such as Pb,Cr,Mn,Fe,Co,Ni,Cu,Zn,and *** samples showed levels of these elements that exceeded World Health Organization *** correlation analysis revealed the inter-dependency among elements,and the contribution of each element based on factor loadings showed its percentage contribution compared to *** samples from six significant locations were chosen for remediation with three algae:Chlorella vulgaris,Scenedesmus dimorphus,and Phormedium *** uptake of pollutants led to the continuous growth of algae during the incubation period of 15 d,effectively removing heavy metals from the river *** increasing levels of algal counts and the chlorophyll a content confirmed the algal growth during the incubation period,followed by a declining stage after the incubation *** scanning electron microscopic images of algae before and after the remediation showed no remarkable modification of morphological *** study showed that the uptake of heavy metals using algae is an effective water pollution remediation measure,making the process practicable in the field on a large scale in the near future.

关键词： Heavy metal Cooum river Phycoremediation Microalgae Factor analysis

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Radiative heat transfer analysis of a concave porous fin under the local thermal non-equilibrium condition:application of the clique polynomial method and physics-informed neural networks

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1613-1632页

作者： K.CHANDAN K.KARtHIK K.V.NAGARAJA B.C.PRASANNAkumarA R.S.VARUN kumar t.MUHAMMAD Amrita School of Artificial Intelligence Amrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Studies in Mathematics Davangere UniversityDavangere 577002KarnatakaIndia Computational Science Lab Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Pure and Applied Mathematics School of Mathematical SciencesSunway UniversityPetaling Jaya 47500Malaysia Department of Mathematics College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

the heat transfer through a concave permeable fin is analyzed by the local thermal non-equilibrium(LtNE)*** governing dimensional temperature equations for the solid and fluid phases of the porous extended surface are modeled,and then are nondimensionalized by suitable dimensionless ***,the obtained nondimensional equations are solved by the clique polynomial method(CPM).the effects of several dimensionless parameters on the fin's thermal profiles are shown by graphical ***,the current study implements deep neural structures to solve physics-governed coupled equations,and the best-suited hyperparameters are attained by comparison with various network *** results of the CPM and physicsinformed neural network(PINN)exhibit good agreement,signifying that both methods effectively solve the thermal modeling problem.

关键词： heat transfer fin porous fin local thermal non-equilibrium(LtNE)model physics-informed neural network(PINN)

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A nano-plasmonic HMIM waveguide based concurrent dual-band BPF using circular ring resonator

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Optoelectronics Letters 2024年第3期20卷 152-156页

作者： Miriyala Sridhar Surendra kumar Bitra tS N Murthy Koppireddi Padmaraju Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationGunturIndia Astra Microwave Products Ltd. HyderabadIndia Department of Electronics and Communication Engineering JNTU-GV College of EngineeringVizianagaramIndia Department of Electronics and Communication Engineering Jawaharlal Nehru Technological University KakinadaKakinadaIndia

this article analyzes the transmission line characteristics of plasmonic hybrid metal insulator metal(HMIM) wave-guide, circular ring resonator(CRR) based dual-band band-pass filters with two transmission poles in both pass-bands in the optical regime using coupled line feed. the transmission line characteristics of an HMIM waveguide, such as characteristic impedance(Z_(PV)), effective refractive index(n_(eff)) and propagation length(L_(spp)), have been obtained by using full wave simulation.

关键词： waveguide resonator circular

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