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Radiologic-histological correlation of hepatocellular carcinoma treated via pre-liver transplant locoregional therapies

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 34-41页

作者： Galal El-Gazzaz achuthan sourianarayanane KV Narayanan Menon Juan Sanabria Koji Hashimoto Cristiano Quintini Dympna Kelly Bijan Eghtesad Charles Miller John Fung Federico Aucejo Hepatobiliary & Liver Transplant Surgery Cleveland Clinic Foundation

BACKGROUND:Locoregional therapies(LRTs) are treatments to achieve local control of hepatocellular carcinoma(HCC).Correlation between radiologic response to LRT and degree of induced tumor necrosis is not well *** aim of this study was to evaluate different levels of radiologic response after pre-liver transplant(LT) LRT and its correlation with percentage of tumor necrosis on explanted ***:Institutional Review Board approved LT database was queried for treated HCC in patients undergoing *** response was evaluated to predict tumor necrosis in the explanted *** response was evaluated 1 to 3 months after LRT with computed tomography or MRI via Response Evaluation Criteria in Solid Tumors(RECIST),and European Association for the Study of the Liver(EASL) *** was repeated as needed until time of *** tumor necrosis was graded as complete(100%),partial(50%-99%),or poor(<50%).RESULTS:Between 2002 and 2011,128 patients(97 men and 31 women) received pre-LT LRT including transarterial therapy(93),radiofrequency ablation(20),or combination of both(15).The mean age of the patients was 58±9 *** mean follow-up was 35±27 *** median waitlist time was 55 *** hundred(78%) patients had HCC within the Milan criteria at the initial radiologic ***(15%) of the patients had complete tumor necrosis on histopathology ***(39%) of the patients exhibited partial necrosis,52(41%) showed poor or no necrosis and 7(5%) showed progressive *** overall pre-LT radiologic staging was correlated with explant pathology in 73(57%) of the *** tumor stage was noted in 49(38%) patients,and overestimated tumor stage in 6(5%) *** post-LT 3-year overall survival and disease free survival were 82% and 80%,and the rates for complete and partial tumor necrosis were 100% vs 78%(P=0.02) and 100% vs 75%(P=0.03),***:In the current era,interpretat

关键词： locoregional therapy radiologic response hepatocellular carcinoma

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