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Transcomplementation, but not Physical Association of the CC-NB-ARC and LRR Domains of Tomato R Protein mi-1.2 is Altered by Mutations in the ARC2 Subdomain

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Molecular Plant 2008年第3期1卷 401-410页

作者： Gerben van Ooijen Gabriele Mayr Mario Albrecht ben J. C. Cornelissen Frank L.W. Takken Plant Pathology Swammerdam Institute for Life Sciences University of Amsterdam PO Box 94062 1090 GB Amsterdam the Netherlands Max Planck Institute for Informatics Stuhlsatzenhausweg 85 66123 Saarbrücken Germany

Race-specific disease resistance in plants is mediated by Resistance （R） proteins that recognize pathogen at- tack and initiate defence responses. Most R proteins contain a central NB-ARC domain and a C-terminal leucine-rich repeat （LRR） domain. We analyzed the intramolecular interaction of the LRR domain of tomato R protein mi-1.2 with its N- terminus. We expressed the CC-NB-ARC and LRR parts in trans and analyzed functional transcomplementation and physical interactions. We show that these domains functionally transcomplement when expressed in trans. Known autoactivating LRR domain swaps were found to induce a hypersensitive response （HR） upon co-expression. Likewise, autoactivating mutants in the NB subdomain transcomplemented to induce HR. Point mutations in the ARC2 subdomain that induce strong autoactivation in the full-length mi-1.2 protein, however, fail to induce HR in the transcomplementation assay, These data indicate distinct functions for the NB-ARC subdomains in induction of HR signalling. Furthermore, dissociation of the LRR is not required to release its negative regulation, as in all combinations of CC-NB-ARC and LRR domains tested, a physical interaction was observed.

关键词： RESISTANCE PROTEIN DISEASE RESISTANCE NUCLEOTIDE-BINDING CELL-DEATH HYPERSENSITIVE RESPONSE

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优化照片色调

影像视觉 2010年第1期11卷 70-73页

作者：华风 ben Brain Ali Jennings ed Godden 《影像视觉》

这里有你需要的、关于摄影的一切建议。本期重点：1.修正色调2.增加中间色调的视觉冲击力3.有选择地调整色阶一张不错的照片和一张出色的照片有什么分别？什么元素能组成绝佳的构图？如果你需要一些建议为日常的拍摄注入情趣,我们的专... 详细信息

这里有你需要的、关于摄影的一切建议。本期重点：1.修正色调2.增加中间色调的视觉冲击力3.有选择地调整色阶一张不错的照片和一张出色的照片有什么分别？什么元素能组成绝佳的构图？如果你需要一些建议为日常的拍摄注入情趣,我们的专家会给你提供满意的答案。

关键词：照片色调优化方法摄影师

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用正交偶极阵列声波测井研究地层地应力场

中国石油大学学报（自然科学版） 2008年第4期32卷 42-46页

作者：王晓杰彭仕宓吕本勋马建英中国石油大学资源与信息学院北京102249 LandMark国际绘图北京100004 大港油田测井公司天津300280

提出了一种利用正交偶极子声波测井资料计算地层主应力的新方法。该方法利用了当地层地应力不均衡时,横波发生双折射形成快横波和慢横波的物理特征,在应力不均衡井段建立快、慢横波应力-速度方程。通过岩心实验确定了快、慢横波应力-速... 详细信息

提出了一种利用正交偶极子声波测井资料计算地层主应力的新方法。该方法利用了当地层地应力不均衡时,横波发生双折射形成快横波和慢横波的物理特征,在应力不均衡井段建立快、慢横波应力-速度方程。通过岩心实验确定了快、慢横波应力-速度方程的耦合系数,从而计算地层最大、最小水平主应力数值,并从理论上证明了快横波传播方向与最大水平主应力方向一致。应用该方法,对大港油田碳酸盐岩地层进行了地应力评价,并用成像测井对评价结果进行验证,结果证明该方法有效。

关键词：正交偶极声波测井地应力场横波双折射快横波慢横波

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教育公平制度设计的三种取向及其启示

教育科学 2007年第4期23卷 1-4页

作者：陈云奔李如密哈尔滨师范大学教育系黑龙江哈尔滨150025 南京师范大学课程所江苏南京210097

近年来,教育公平是处于变革中的中国所出现的比较强烈的社会诉求之一,也是教育理论研究的热点问题。本文分别介绍了功利主义、平等的自由主义、自由至上主义等三种西方主流公平理论的要点,分析了这三种不同取向公平理论观照下的教育公... 详细信息

近年来,教育公平是处于变革中的中国所出现的比较强烈的社会诉求之一,也是教育理论研究的热点问题。本文分别介绍了功利主义、平等的自由主义、自由至上主义等三种西方主流公平理论的要点,分析了这三种不同取向公平理论观照下的教育公平制度设计的特征,以期对我国社会和教育发展现实下进行教育公平制度设计有所启示。

关键词：教育公平制度设计功利主义平等的自由主义自由至上主义

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来稿点评

影像视觉 2009年第5期10卷 94-97页

作者： ben Brain Ali Jennings Rachael D’Cruze ed Godden 《影像视觉》英文版数码技术

这里有你需要的、关于摄影的一切建议。本期重点提示：1、使用黑白效果增强图片的视觉冲击力。2、通过调整色阶和饱和度，保证图片的真实感。

关键词：视觉冲击力黑白效果饱和度真实感图片

Epidemiology and risk factors for mortality in critically ill patients with pancreatic infection

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Journal of Intensive Medicine 2024年第1期4卷 81-93页

作者： Marie Dejonckheere Massimo Antonelli Kostoula Arvaniti Koen Blot ben CreaghBrown Dylan Wde Lange Jan De Waele mieke Deschepper Yalim Dikmen George Dimopoulos Christian Eckmann Guy Francois Massimo Girardis Despoina Koulenti Sonia Labeau Jeffrey Lipman Fernando Lipovestky Emilio Maseda Philippe Montravers Adam mikstacki JoseArtur Paiva Cecilia Pereyra Jordi Rello JeanFrancois Timsit Dirk Vogelaers Stijn Blot the Abdominal Sepsis Study(AbSeS)group on behalf of the Trials Group of the European Society of Intensive Care Medicine Department of Internal Medicine and Pediatrics Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium Department of Anesthesiology Intensive Care and Emergency MedicineFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly UniversitàCattolica del Sacro Cuore RomeItaly Intensive Care Unit Papageorgiou University Affiliated HospitalThessaloníkiGreece Department of Epidemiology and Public Health SciensanoIxellesBelgium Surrey Perioperative Anaesthetic Critical Care Collaborative Research Group(SPACeR) Royal Surrey County HospitalGuildfordUK Department of Clinical and Experimental Medicine University of SurreyGuildfordUK Department of Intensive Care Medicine University Medical Center UtrechtUniversity UtrechtUtrechtthe Netherlands Department of Intensive Care Medicine Ghent University HospitalGhentBelgium Data Science Institute Ghent University HospitalGhentBelgium Department of Anesthesiology and Reanimation Cerrahpasa School of MedicineIstanbul University-CerrahpasaIstanbulTurkey rd Department of Critical Care “EVGENIDIO”HospitalNational and Kapodistrian University of AthensAthensGreece Department of General Visceral and Thoracic SurgeryKlinikum Hannoversch-MuendenGoettingen UniversityGöttingenGermany Division of Scientific Affairs-Research European Society of Intensive Care MedicineBrusselsBelgium Anesthesia and Intensive Care Department University Hospital of ModenaModenaItaly UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneQLDAustralia nd Critical Care Department Attikon University HospitalAthensGreece Department of Nursing Faculty of EducationHealth and Social WorkUniversity College GhentGhentBelgium Jamieson Trauma Institute The University of QueenslandBrisbaneQLDAustralia Nimes University Hospital University of MontpellierNimesFrance Critical Care Department Hospital of the Interamerican Open University(UAI)Buenos AiresArgentina Surgical Critical Care Department of AnesthesiaHospital Universitario

Background:The AbSeS-classification defines specific phenotypes of patients with intra-abdominal infection based on the(1)setting of infection onset(community-acquired,early onset,or late-onset hospital-acquired),(2)presence or absence of either localized or diffuse peritonitis,and(3)severity of disease expression(infection,sepsis,or septic shock).This classification system demonstrated reliable risk stratification in intensive care unit(ICU)patients with intra-abdominal *** study aimed to describe the epidemiology of ICU patients with pancreatic infection and assess the relationship between the components of the AbSeS-classification and ***:This was a secondary analysis of an international observational study(“AbSeS”)investigating ICU patients with intra-abdominal *** patients with pancreatic infection were included in this analysis(n=165).Mortality was defined as ICU mortality within 28 days of observation for patients discharged earlier from the *** with mortality were assessed using logistic regression analysis and reported as odds ratio(OR)and 95%confidence interval(CI).Results:The overall mortality was 35.2%(n=58).The independent risk factors for mortality included older age(OR=1.03,95%CI:1.0 to 1.1 P=0.023),localized peritonitis(OR=4.4,95%CI:1.4 to 13.9 P=0.011),and persistent signs of inflammation at day 7(OR=9.5,95%CI:3.8 to 23.9,Ped(n=58,49.2%)without clinically relevant differences in microbial etiology between survivors and ***:In pancreatic infection,a challenging source/damage control and ongoing pancreatic inflammation appear to be the strongest contributors to an unfavorable short-term *** this limi.ed series,essentials of the AbSeS-classification,such as the setting of infection onset,diffuse

关键词： Pancreatic infection Intensive care unit Mortality Intra-abdominal infection Sepsis

Medical management of erectile dysfunction in aging males： is it too late to treat？

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Asian Journal of Andrology 2014年第1期16卷 153-156页

作者： Kai Zhang ben Xu De-Feng Liu Xiao-Feng Wang Ji-Chuan Zhu Jie Jin Hui Jiang Department of Urology Peking University First Hospital Beijing China Department of Urology Peking University Third Hospital Beiiing China Department of Urology Peking University People's Hospital Beijing China

Erectile dysfunction （ed） is a common disorder among aging males. However, most aging males refuse to seek medical help and believe that ed is an irreversible event in the aging process. The purpose of this study was to describe the current medical management of ed in aging males and to examine whether it is too late to treat this disorder in these elderly men. From 2007 to 2008, 4507 patients diagnosed with ed were gathered from 46 centers in China; 4241 completed the study, 3837 of whom were treated with sildenafil. The 3837 patients were divided into five groups based on age （group A： 20-30 years; group B： 31-40 years; group C： 41-50 years; group D： 51-60 years; and group E：〉60 years）. After comparing pre- and posttreatment International Index of Erectile Function-Erectile Function domain （IIEF-EF） questionnaires, Erection Hardness Scale （EHS）, and IIEF Q13 （＂How satisfied have you been with your overall sex life？＂）, we discovered that the aging males had worse erectile function, erection hardness, and sexual satisfaction than the younger males （P〈 0.001）. After treatment, the improvement rates in the IIEF-EF, EHS, and IIEF Q13 scores were 107.0%, 83.1%, and 116.5%, respectively. The magnitude of these changes demonstrated significant differences among groups （P 〈 0.001）. Accordingly, aging males are likely to benefit more from medical treatment. We propose that aging males should be informed that age is not a limiting factor for medical ed management, and it is never too late to treat.

关键词： aging males erectile dysfunction international index of erectile dysfunction (IIEF) sildenafil sex

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Skriba■o!El Kie?

世界 1994年第Z3期 12-13页

作者： ben Zamir

Nekredeble,mi sukcesis,li *** laboro estis pli malfaeila ol enerale,kaj en lia nuna situacio…Pot sukcese starigikaj funkciigi la rnainaron,kiel li jus faris,necesas povi pensi,zorge rigardi ion vidindan,

关键词： longe regula Skriba o!El Kie 子结构构造法她说

Human microbiome is a diagnostic biomarker in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 109-115页

作者： ben-Chen Rao Jia-min Lou Wei-Jie Wang Ang Li Guang-Ying Cui Zu-Jiang Yu Zhi-Gang Ren Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Gene Hospital of Henan Province Precision Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Hepatocellular carcinoma(HCC)is the third leading cause of cancer mortality *** evidence indicates a close relationship between HCC and the human ***,we reviewed the important potential of the human microbiota as a diagnostic biomarker of *** sources:Several innovative studies have investigated the characteristics of the gut and oral micro-biomes in patients with HCC and proposed that the human microbiome has the potential to be a diag-nostic biomarker of *** from February 1999 to February 2019 was searched in the PubMed database using the keywords"microbiota"or"microbiome"or"microbe"and"liver cancer"or"hepato-cellular carcinoma",and the results of clinical and experimental studies were ***:Specific changes occur in the human microbiome of patients with ***,the gut mi-crobiome and oral microbiome can be used as non-invasive diagnostic biomarkers for ***,they also have certain diagnostic potential for precancerous diseases of *** diagnostic potential of the blood microbiota and ascites microbiota in HCC will be gradually discovered in the ***:The human microbiome is valuable to the diagnosis of HCC and provides a novel strategy for targeted therapy of *** human microbiome may be widely used in the diagnosis,treatment and prognosis for multiple system diseases or cancers in the future.

关键词： Human microbiome Gut microbiome Oral microbiome Hepatocellular carcinoma Diagnostic biomarker