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Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh Kumar Jha Shreesh Ojha dinesh Kumar Niraj Kumar Jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

Rapid Green Synthesis of Silver Nanoparticles by Reishi and Their Antibacterial Activity and Mechanisms

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Journal of Biomaterials and Nanobiotechnology 2024年第3期15卷 51-63页

作者： Akamu J. Ewunkem T’nasia Priester Desia Williams Bailey Ariyon Ilunga Tshimanga Brittany Justice dinesh K. singh Department of Biological Sciences Winston-Salem State University Winston-Salem North Carolina USA

Nanotechnology is a rapidly growing field in biomedical engineering with references to efficiency, safety, and cost-effective approaches. Herein, the objective of this study was to examine an innovative approach to rapidly synthesis silver nanoparticles from an aqueous extract of medicinal mushroom Ganoderma lucidum (also known as reishi). The structural and dimensional dispersion of the biosynthesized silver nanoparticles from reishi was confirmed by UV-Vis spectrophotometer (UV-Vis) and Scanning Electron Microscopy (SEM) analysis. Additionally, the biosynthesized silver nanoparticles from resihi were used to explore their potential antimicrobial activity against Staphylococcus aureus and Micrococcus luteus and Escherichia coli and Klebsiella pneumoniae. The results from this study revealed that the silver nanoparticles mediated by reishi adopted a spherical shape morphology with sizes, less than 100 nm and revealed strong absorption plasmon band at 440 nm. Furthermore, the biosynthesized silver nanoparticles from reishi exhibited antibacterial activity against the tested S. aureus and M. luteus and E. coli and K. pneumoniae by altering their morphology which signifies their biomedical potential.

关键词： Nanotechnology Reishi Nanoparticles Antimicrobial Green Synthesis

Brain Tumor Segmentation through Level Based Learning Model

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Computer Systems Science & Engineering 2023年第1期44卷 709-720页

作者： K.dinesh Babu C.Senthil singh Department of Electronics and Communication Engineering Adhi College of Engineering and Technology631605India Department of Electronics and Communication Engineering Infant Jesus College of EngineeringVallanaduThoothukudi628851India

Brain tumors are potentially fatal presence of cancer cells over a human brain,and they need to be segmented for accurate and reliable planning of *** process must be carried out in different regions based on which the stages of cancer can be accurately *** patients exhibit a different level of challenge in terms of cancer or tumors detection as the Magnetic Resonance Imaging(MRI)images possess varying sizes,shapes,positions,and *** scanner used for sensing the location of tumors cells will be sub-jected to additional protocols and measures for accuracy,in turn,increasing the time and affecting the performance of the entire *** this view,Convolutional Neural Networks deliver suitable models for efficient segmentation and thus delivered promising *** previous strategies and models failed to adhere to diversity of sizes and shapes,proving to be a well-established solution for detecting tumors of bigger *** tend to be smaller in size and shape during their premature stages and they can easily evade the algorithms of Convolutional Neural Network(CNN).This proposal intends to furnish a detailed model for sensing early stages of cancer and hence perform segmentation irrespective of the current size and shape of *** size of networks and layers will lead to a significant weightage when multiple kernel sizes are involved,especially in multi-resolution *** the other hand,the proposed model is designed with a novel approach including a dilated convolution and level-based learning *** the convolution process is dilated,the process of feature extraction deals with multiscale objective and level-based learning eliminates the shortcoming of previous models,thereby enhancing the quality of smaller tumors cells and *** level-based learning approach also encapsulates the feature recon-struction processes which highlights the sensing of small-scale tumors ***,segmenting t

关键词： Glioma detection segmentation smaller tumour growth machine learning feature analysis

Detection of Behavioral Patterns Employing a Hybrid Approach of Computational Techniques

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Computers, Materials & Continua 2022年第7期72卷 2015-2031页

作者： Rohit Raja Chetan Swarup Abhishek Kumar Kamred Udham singh Teekam singh dinesh Gupta Neeraj Varshney Swati Jain Department of Information Technology Guru Ghasidas VishwavidyalayaBilaspur495009India Department of Basic Science College of Science&Theoretical StudiesSaudi Electronic University13316Saudi Arabia Department of Computer Science&IT JAIN(Deemed to be University)Bangalore560069India Computer Science and Information Science Cheng Kung University621301Taiwan School of Computer Science University of Petroleum and Energy StudiesDehradun248007India Department of CSE I K Gujral Punjab Technical UniversityJalandhar144603India Department of Computer Engineering and Applications GLA UniversityMathura281406India Department of Computer Science Government J Yoganandam Chhattisgarh CollegeRaipur492001India

As far as the present state is concerned in detecting the behavioral pattern of humans(subject)using morphological image processing,a considerable portion of the study has been conducted utilizing frontal vision data of human *** present research work had used a side vision of human-face data to develop a theoretical framework via a hybrid analytical model *** this example,hybridization includes an artificial neural network(ANN)with a genetic algorithm(GA).We researched the geometrical properties extracted from side-vision human-face *** additional study was conducted to determine the ideal number of geometrical characteristics to pick while *** close vicinity ofminimum distance measurements is done for these clusters,mapped for proper classification and decision process of behavioral *** identify the data acquired,support vector machines and artificial neural networks are utilized.A method known as an adaptiveunidirectional associative memory(AUTAM)was used to map one side of a human face to the other side of the same *** behavioral pattern has been detected based on two-class problem classification,and the decision process has been done using a genetic algorithm with best-fit *** developed algorithm in the present work has been tested by considering a dataset of 100 subjects and tested using standard databases like FERET,Multi-PIE,Yale Face database,RTR,CASIA,*** complexity measures have also been calculated under worst-case and best-case situations.

关键词： Adaptive-unidirectional-associative-memory technique artificial neural network genetic algorithm hybrid approach

Assessment of tumor markers CA 19-9,CEA,CA 125,and CA 242 for the early diagnosis and prognosis prediction of gallbladder cancer

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World Journal of Gastrointestinal Surgery 2022年第11期14卷 1272-1284页

作者： Seema Rani Sinha Prem Prakash Rakesh Kumar singh dinesh Kumar Sinha Biochemistry Indira Gandhi Institute of Medical SciencesPatna 800014India General Surgery Indira Gandhi Institute of Medical SciencesPatna 800014India Surgical Gastroenterology Indira Gandhi Institute of Medical SciencesPatna 800014India Radiation Oncology State Cancer InstituteIndira Gandhi Institute of Medical SciencesPatna 800014BiharIndia

BACKGROUND Gallbladder cancer(GBC)is one of the leading and aggressive cancers in this region of *** is very difficult to diagnose in the early stage,as it lacks typical early signs and symptoms;thus,the diagnosis is often in the advanced stage,which ultimately leads to a poor 5-year survival *** markers including carbohydrate antigen 19-9(CA 19-9),carcinoembryonic antigen(CEA),CA 125,CA 242,and alpha fetoprotein are used as indicators in the diagnosis and prognosis of *** To compare tumor marker levels between GBC and benign GB diseases(GBDs)and to assess the combined use of tumor markers to increase the diagnostic accuracy for *** Patients of either sex aged≥18 years,with suspected GBC(GB polyp,irregular thick GB wall,GB mass,porcelain GB)on the basis of radiological imaging were included in this *** wall thickness using ultrasonography and tumor markers CEA,CA 125,CA 19-9,and CA 242 in all patients were *** cases after surgical intervention were divided into two groups,GBC and benign GBD,according to histopathological examination *** cases were followed up and clinical findings,radiological findings,and levels of tumor markers were *** A total of 200 patients were included in this study,of whom 80 patients had GBC and 120 patients had benign *** median(interquartile range)age was 52.0(41.0-60.0)years and the majority of patients(132,66.0%)were *** markers including CA 19-9,CA 125,CEA,and CA 242 were significantly elevated in patients with GBC(P<0.001).There was a significant reduction in tumor markers at 3 and 6 mo from baseline(P<0.001).The mean survival of patients with normal and elevated levels of tumor markers CA 125,CA 19-9,and CEA was comparable;however lymph node metastasis and CA 242 expression level were independent prognostic *** Serum levels of tumor markers including CA 19-9,CA 125,CEA,and CA 242 were significantly associated with ***,no significant asso

关键词： Benign gallbladder Tumor markers Survival Benign lesions Sensitivity Specificity

Fault Pattern Diagnosis and Classification in Sensor Nodes Using Fall Curve

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Computers, Materials & Continua 2022年第7期72卷 1799-1814页

作者： Mudita Uppal Deepali Gupta Divya Anand Fahd S.Alharithi Jasem Almotiri Arturo Mansilla dinesh singh Nitin Goyal Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Computer Science&Engineering Department Lovely Professional UniversityJalandharPunjabIndia Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Higher Polytechnic School/Industrial Organization Engineering Universidad Europea del AtlánticoIsabel Torres 2139011SantanderSpain Department of Project Management Universidad Internacional IberoamericanaCampeche24560Mexico Computer Science and Engineering Department Deenbandhu Chhotu Ram University of Science and TechnologyMurthalSonipatHaryanaIndia

The rapid expansion of Internet of Things(IoT)devices deploys various sensors in different applications like homes,cities and *** applications depend upon the accuracy of sensor ***,it is necessary to predict faults in the sensor and isolate their cause.A novel primitive technique named fall curve is presented in this paper which characterizes sensor *** technique identifies the faulty sensor and determines the correct working of the *** sources of sensor faults are explained in detail whereas various faults that occurred in sensor nodes available in IoT devices are also presented in tabular *** prediction in digital and analog sensors along with methods of sensor fault prediction are *** are several advantages and disadvantages of sensor fault prediction methods and the fall curve ***,some solutions are provided to overcome the limitations of the fall curve *** this paper,a bibliometric analysis is carried out to visually analyze 63 papers fetched from the Scopus database for the past five *** novelty is to predict a fault before its occurrence by looking at the fall *** sensing of current flow in devices is important to prevent a major ***,the fall curves of ACS712 current sensors configured on different devices are drawn for predicting faulty or non-faulty *** analysis result proved that if any of the current sensors gets faulty,then the fall curve will differ and the value will immediately drop to *** evaluation metrics for fault prediction are also described in this *** last,this paper also addresses some possible open research issues which are important to deal with false IoT sensor data.

关键词： Fault identification fault classification IoT sensor nodes analog sensors digital sensors fall curve

Anisotropic turbulence of kinetic Alfvén waves and heating in solar corona

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Research in Astronomy and Astrophysics 2019年第12期19卷 327-342页

作者： Hemam dinesh singh Bheem singh Jatav Department of Physics Sikkim University

Understanding solar coronal heating has been one of the unresolved problems in solar physics in spite of the many theories that have been developed to explain it. Past observational studies suggested that kinetic Alfven waves(KAWs) may be responsible for solar coronal heating by accelerating the charged particles in solar plasma. In this paper, we investigated the transient dynamics of KAWs with modified background density due to ponderomotive force and Joule heating. A numerical simulation based on pseudospectral method was applied to study the evolution of KAW magnetic coherent structures and generation of magnetic turbulence. Using different initial conditions in simulations, the dependence of KAW dynamics on the nature of inhomogeneous solar plasma was thoroughly investigated. The saturated magnetic power spectra follow Kolmogorov scaling of k^-5/3 in the inertial range, then followed by steep anisotropic scaling in the dissipation range. The KAW has anisotropy of k||∝ k^0.53⊥, k|| ∝ k^0.50⊥, k||∝ k^0.83⊥ and k||∝ k^0.30⊥ depending on the kind of initial conditions of inhomogeneity. The power spectra of magnetic field fluctuations showing the spectral anisotropy in wavenumber space indicate that the nonlinear interactions may be redistributing the energy anisotropically among higher modes of the wavenumber. Therefore, anisotropic turbulence can be considered as one of the candidates responsible for the particle energization and heating of the solar plasmas.

关键词： plasmas turbulence waves Sun:corona

Residue recycling options and their implications for sustainable nitrogen management in rice–wheat agroecosystems

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Ecological Processes 2023年第4期12卷 91-109页

作者： Ajay Kumar Bhardwaj Kapil Malik Manu Rani Uttam Kumar Mandal Nirmalendu Basak Awtar singh Rajender Kumar Yadav Suresh Kumar Chaudhari dinesh Kumar Sharma Central Soil Salinity Research Institute Central Soil Salinity Research Institute Regional Research Station Indian Council of Agricultural Research

Background In the Indo-Gangetic Plain, rice–wheat is the most extensively practiced crop rotation. The escalating issue of crop residue burning, particularly rice straw, and the necessity to lower the exorbitant expenses associated with fertilizer inputs stand out as significant challenges for farmers in the region. A well-suited integrated nutrient management（INM） strategy that focuses on recycling crop residues can serve as a solution to address these issues. Such a strategy not only mitigates air pollution resulting from residue burning but also helps combat water pollution due to nitrate losses from agroecosystems. Field experiments were used to evaluate the suitability of eight INM-modules that included various combinations of inorganic fertilizer rates（50%, 100%, 150% of recommended dose）, crop residues（wheat and rice stubble retention at 30 cm standing stubble equivalent to 1/3 the straw yield）, rice straw compost（RSC）, farmyard manure（FYM）, and green manuring（GM）, compared to 100% recommended dose of fertilizers（F） and no fertilizer *** There was a considerable improvement in nitrogen mineralization, grain yields, and nitrogen use efficiency under GM + RSC-F50 and GM + FYM-F50. These INM modules would permit a 50% reduction in the use of chemical fertilizers. There was a little yield penalty with in situ rice residue incorporation at 100% F; however, this could be overcome with 150% F fertilizer application. In situ retention of wheat straw with a full application of fertilizer resulted in steadily rising crop yields over time. Changes in the redox potential, soil p H, and soil organic carbon best accounted for the observed trajectories in nitrogen use *** The most promising INM modules for adoption by farmers in the Indo-Gangetic Plain to judiciously use crop residues and curtail chemical fertilizer inputs are green manuring with Sesbania aculeata + rice straw compost at 5 t ha-1+ only 50% of recommended dose of fertilizers

关键词： Rice–wheat Nitrogen use efficiency Sustainable nitrogen management index Crop residue Rice straw compost

Effect of COVID-19 pandemic on blood transfusion service:an experience from a regional blood transfusion center

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Blood Science 2023年第3期5卷 209-217页

作者： Sanjay K.Thakur Anil K.Sinha dinesh K.Negi Sompal singh PhD Research Scholar P.G.Department of ZoologyVeer Kunwar Singh UniversityAraBihar 802301India Dean Faculty of Science and Head P.G.Department of Zoology Veer Kunwar Singh UniversityAraBihar 802301India Former CMO In charge Department of RBTCHindu Rao HospitalDelhi 110007India Specialist Pathologist Head Department of Regional Blood Transfusion Centre and Department of PathologyHindu Rao HospitalDelhi 110007India

The unforeseen and uncertain life-threatening situation of the COVID-19 pandemic dramatically affected all areas of the human daily work *** study was designed to assess the impact of the COVID-19 pandemic on blood transfusion services and discuss the adopted confrontation measures for uninterrupted blood supply during the pandemic *** data on blood donation,blood component preparation,and issue from January 2019 to December 2022 were collected from the inventory registers of the RBTC,Delhi,*** to the non-pandemic year 2019,during the year 2020,all variables decreased *** observed maximum decrease in variables such as blood collection(–79.16%)in the month of October,blood issue(–71.61%)in the month of August,random donor platelets(RDP)preparation(–98.09%)in the month of October,RDP issue(–86.08%)in the month of September,fresh frozen plasma(FFP)preparation(–100%)in the month of October,and FFP issue(–96.08%)in the month of July with an annual decrease of–45.52%,–42.87%,–33.00%,–59.79%,–40.98%,and–54.48%,respectively,as compared to year *** to year 2020,in year 2021,the annual increase in blood collection,blood issue,FFP preparation,FFP issue,RDP preparation,and RDP issue was+50.20%,+21.68%,+65.31%,+78.52%,+116.23%,and+213.30%,*** study results show that the COVID-19 pandemic has significantly affected blood transfusion services at our blood *** adopted coping strategies to maintain the safe and uninterrupted blood transfusion chain at our blood bank gave us lessons for future preparedness if faced with a similar situation.

关键词： Blood bank inventory Blood components Blood recipients Blood transfusion COVID-19 pandemic