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Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson Siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz achim hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

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Rising utilization of stable isotopes in tree rings for climate change and forest ecology

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Journal of Forestry Research 2024年第1期35卷 103-116页

作者： Ru Huang Chenxi Xu Jussi Grießinger Xiaoyu Feng Haifeng Zhu achim Bräuning National Institute of Natural Hazards Beijing 100085People’s Republic of China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029People’s Republic of China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044People’s Republic of China Institute of Geography Friedrich-Alexander-University of Erlangen-Nuremberg91058 ErlangenGermany State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Analyses of stable isotopes(C,O,H)in tree rings are increasingly important cross-disciplinary *** rapid development in this field documented in an increasing number of publications requires a comprehensive *** study includes a bibliometric analysis-based review to better understand research trends in tree ring stable isotope ***,1475 publications were selected from the Web of Science Core Collection for *** findings are that:(1)numbers of annual publications and citations increased since *** 1974 to 1980,there were around two relevant publications per ***,from 2020 to 2022,this rose sharply to 109 publications per ***,average article citations were less than four per year before 1990,but were around four per article per year after 2000;(2)the major subjects using tree ring stable isotopes include forestry,geosciences,and environmental sciences,contributing to 42.5%of the total during 1974-2023;(3)the top three most productive institutions are the Chinese Academy of Sciences(423),the Swiss Federal Institute for Forest,Snow and Landscape Research(227),and the University of Arizona(204).These achievements result from strong collaborations;(4)review papers,for example,(Dawson et al.,Annu Rev Ecol Syst 33:507-559,2002)and(McCarroll and Loader,Quat Sci Rev 23:771-801,2004),are among the most cited,with more than 1000 citations;(5)tree ring stable isotope studies mainly focus on climatology and ecology,with atmospheric CO_(2) one of the most popular *** 2010,precipitation and drought have received increasing *** on this analysis,the research stages,key findings,debated issues,limitations and direc-tions for future research are *** study serves as an important attempt to understand the progress on the use of stable isotopes in tree rings,providing scientific guid-ance for young researchers in this field.

关键词： Tree rings Stable isotopes Web of Science Bibliometric

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Development and characterization of 3D-printed electroconductive pHEMA-co-MAA NP-laden hydrogels for tissue engineering

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Bio-Design and Manufacturing 2024年第3期7卷 262-276页

作者： Sara De Nitto Aleksandra Serafin Alexandra Karadimou achim Schmalenberger John J.EMulvihill Maurice N.Collins DIBRIS Polytechnic Inter-School Section University of Genoa16126 GenoaItaly School of Engineering Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Sciences Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research Institute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue engineering(TE)continues to be widely explored as a potential solution to meet critical clinical needs for diseased tissue replacement and tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with newly synthesized conductive poly(3,4-ethylene-dioxythiophene)(PEDOT)and polypyrrole(PPy)nanoparticles(NPs),and subsequently processed these hydrogels into tissue engineered constructs via three-dimensional(3D)*** presence of the NPs was critical as they altered the rheological properties during ***,all samples exhibited suitable shear thinning properties,allowing for the development of an optimized processing window for 3D *** were 3D printed into pre-determined disk-shaped configurations of 2 and 10 mm in height and diameter,*** observed that the NPs disrupted the gel crosslinking efficiencies,leading to shorter degradation times and compressive mechanical properties ranging between 450 and 550 *** conductivity of the printed hydrogels increased along with the NP concentration to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demonstrated that exposure to the pHEMA-co-MAA NP hydrogels yielded high cellular viability and proliferation ***,hydrogel antimicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various TE strategies.

关键词： Conductive nanoparticles Hydroxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3D printing

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追求卓越向“智”而行——访德国HAINBUCH瀚柏格夹具集团首席执行官achim Feinauer博士

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现代制造 2024年第S1期 24-26页

作者：张欣 achim Feinauer 不详德国HAINBUCH瀚柏格夹具集团

在高精度、高效率以及不断增长的柔性自动化需求的生产环境中,工件夹具的重要性日益凸显。随着行业转型升级步伐加快,多品种小批量生产乃至多品种大批量生产规模的需求快速增长,用户群体愈加重视夹具的选型和管理,这进一步对工装夹具提... 详细信息

在高精度、高效率以及不断增长的柔性自动化需求的生产环境中,工件夹具的重要性日益凸显。随着行业转型升级步伐加快,多品种小批量生产乃至多品种大批量生产规模的需求快速增长,用户群体愈加重视夹具的选型和管理,这进一步对工装夹具提出了更高的要求和挑战,带动了夹具的快速发展与创新。

关键词：多品种小批量生产柔性自动化工装夹具工件夹具大批量生产首席执行官追求卓越

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Anesthetic Management of a Patient with Spinal Muscular Atrophy Type III Undergoing Emergent Caesarean Section: A Case Report

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Open Journal of Anesthesiology 2024年第6期14卷 151-158页

作者： Kwame Awuku achim Younker Breta Osei-Bonsu Joseph Nalbone Aditi Master Dongchen Li Ming Xiong Rutgers New Jersey Medical School Newark New Jersey USA

In this case report, we describe the anesthetic management for a 36-year-old G2P0010 at 36 weeks gestation with Spinal Muscular Atrophy Type III who underwent an emergent caesarean section due to fetal footling breech position. The patient is a wheelchair-bound quadriplegic with kyphoscoliosis and a lack of cough reflex who required nasal continuous noninvasive ventilatory support (CNVS) for chronic hypercapnic respiratory failure. Surgery was done under general anesthesia due to its emergent nature, and the patient was successfully extubated and transitioned to nasal CNVS in the operating room at the end of the case. Postoperative care was provided in the medical intensive care unit for three days without complication and the patient was discharged home uneventfully.

关键词： Spinal Muscular Atrophy General Anesthesia Cesarean Section Obstetric Anesthesia

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Exploring the social,ethical,legal,and responsibility dimensions of artificial intelligence for health-a new column in Intelligent Medicine

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Intelligent Medicine 2022年第2期2卷 103-109页

作者： achim Rosemann Xinqing Zhang Centre for Computing and Social Responsibility De Montfort UniversityLeicesterUnited Kingdom Department of Sociology Philosophy and AnthropologyUniversity of ExeterUnited Kingdom School of Humanities and Social Sciences Peking Union Medical College&Chinese Academy of Medical SciencesBeijing 100005China

This essay is the starting point of a new column in Intelligent Medicine that invites interdisciplinary perspectives on the social,ethical,legal,and responsibility aspects of the use of artificial intelligence(AI)in medicine and health *** in this column will examine the practical,conceptual,and policy dimensions of the use of AI for health-related purposes from comparative and international *** invite contributions from around the world in all application areas of AI for health,including health care,health research,drug development,health care system management,as well as public health and public health *** column aims to provide a forum for reflective and critical scholarship that contributes to the ongoing academic and policy debates about the development,use,governance,and implications of AI in medical and health care *** launch the column,we first provide an overview of recent approaches that have been developed to identify and address the effects and potential impacts of science and technology innovations on human societies and the *** include ethical,legal,and social implications/aspects(ELSI/A)research,responsible research and innovation(RRI),sustainability transitions research,and the use of international standard-setting instruments for responsible and open science issued by the United Nations Educational,Scientific,and Cultural Organization(UNESCO),the World Health Organization(WHO),and other international *** Part Two of this essay,we discuss some of the central challenges that arise with regard to the integration of AI and big data analytics in medical and health care *** includes concerns regarding(i)the control,reliability,and trustworthiness of AI systems,(ii)privacy and surveillance,(iii)the impact of AI and automation on health care staffemployment and the nature of clinical work,(iv)the effects of AI on health inequalities,justice,and access to medical care,and(v)challenges rel

关键词： Artificial intelligence Health Ethical,legal and social implications Responsible research and innovation Global ethics Governance of emerging technologies

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Combining High-Resolution Imaging,Deep Learning,and Dynamic Modeling to Separate Disease and Senescence in Wheat Canopies

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Plant Phenomics 2023年第2期5卷 295-312页

作者： Jonas Anderegg Radek Zenkl achim Walter Andreas Hund Plant Pathology Group Institute of Integrative BiologyETH ZurichZurichSwitzerland Crop Science Group Institute of Agricultural SciencesETH ZurichZurichSwitzerland

Maintenance of sufficiently healthy green leaf area after anthesis is key to ensuring an adequate assimilate supply for grain *** regulated age-related physiological senescence and various biotic and abiotic stressors drive overall greenness decay dynamics under field *** direct effects on green leaf area in terms of leaf damage,stressors often anticipate or accelerate physiological senescence,which may multiply their negative impact on grain ***,we present an image processing methodology that enables the monitoring of chlorosis and necrosis separately for ears and shoots(stems+leaves)based on deep learning models for semantic segmentation and color properties of vegetation.A vegetation segmentation model was trained using semisynthetic training data generated using image composition and generative adversarial neural networks,which greatly reduced the risk of annotation uncertainties and annotation *** of the models to image time series revealed temporal patterns of greenness decay as well as the relative contributions of chlorosis and ***-based estimation of greenness decay dynamics was highly correlated with scoring-based estimations(r≈0.9).Contrasting patterns were observed for plots with different levels of foliar diseases,particularly septoria tritici *** results suggest that tracking the chlorotic and necrotic fractions separately may enable(a)a separate quantification of the contribution of biotic stress and physiological senescence on overall green leaf area dynamics and(b)investigation of interactions between biotic stress and physiological *** high-throughput nature of our methodology paves the way to conducting genetic studies of disease resistance and tolerance.

关键词： Wheat enable image

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The Determinants of China's Minimum Wage Rates

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China & World Economy 2023年第3期31卷 59-91页

作者： achim Schmillen Michael Stops Dewen Wang Human Development World BankIndonesia Institute for Employment Research Germany Senior Social Protection Economist World BankChina.

We use a highly disaggregated panel of macro data and minimum wages at the county level to investigate the processes behind minimum wage adjustments in *** on random effects models,spatial econometrics techniques,and multilevel analyses,we document that a comparatively small number of economic variables-including the local price level and GDP per capita-are important determinants of minimum wage *** between adjacent counties and counties of the same administrative type,and centralized mechanisms,particularly at the provincial level,also play an important role in explaining the variance in minimum wage rates across ***,we show that China's provinces are the key players for setting minimum wage rates and that,when they do so,they are not uniform in the way they weigh different economic variables.

关键词： applied spatial econometrics China highly disaggregated macro data minimum wage setting multilevel analysis strategic interactions between subnationa governments

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Frost Damage Index:The Antipode of Growing Degree Days

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Plant Phenomics 2023年第4期5卷 757-766页

作者： Flavian Tschurr Norbert Kirchgessner Andreas Hund Lukas Kronenberg Jonas Anderegg achim Walter Lukas Roth Department of Environmental System Sciences Institute of Agricultural SciencesETH ZürichZürichSwitzerland Crop Genetics John Innes CentreNorwichUK Department of Environmental System Sciences Institute of Integrative BiologyETH ZürichZürichSwitzerland

Abiotic stresses such as heat and frost limit plant growth and ***-based field phenotyping methods allow quantifying not only plant growth but also plant *** crops show senescence caused by cold spells,visible as declines in leaf *** accurately quantified such declines by monitoring changes in canopy cover based on time-resolved high-resolution imagery in the ***-six winter wheat genotypes were measured in multiple years.A concept termed"frost damage index"(FDI)was developed that,in analogy to growing degree days,summarizes frost events in a cumulative *** measured sensitivity of genotypes to the FDI correlated with visual scorings commonly used in breeding to assess winter *** FDI concept could be adapted to other factors such as drought or heat *** commonly not considered in plant growth modeling,integrating such degradation processes may be key to improving the prediction of plant performance for future climate scenarios.

关键词： winter analogy integrating

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GEVREY CLASS REGULARITY FOR THE GLOBAL ATTRACTOR OF A TWO-DIMENSIONAL NON-NEWTONIAN FLUID

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Acta Mathematica Scientia 2022年第1期42卷 265-282页

作者：赵才地林泽瀚 T.achim MEDJO Department of Mathematics Wenzhou UniversityWenzhou 325035China Department of Mathematics Florida International UniversityBM413B University ParkMiamiFL 33199USA

This article investigates Gevrey class regularity for the global attractor of an incompressible non-Newtonian fluid in a two-dimensional domain with a periodic boundary *** Gevrey class regularity reveals that the solutions lying in the global attractor are analytic in time with values in a Gevrey class of analytic functions in space.

关键词： non-Newtonian fluid global attractor Gevrey class regularity

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