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Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model

2007水业高级技术论坛

作者： achim Ried Taeyoung Choi ITT-WEDECO GmbH ITT-WEDECO AG Shanghai office

The use of ozone and/or UV process for waste water reuse application is often a combination of ozone and/or UV-step with additional treatment steps, e.g. biological treatment, flocculation, filtration and activated carbon. Therefore, it is necessary to develop an optimized combination of these different steps. This article is going to demonstrate an overall process design approach for waste water reuse application presenting two examples for municipal waste water treatment.

关键词： ozone UV Ultraviolet waste water reuse municipal waste water process design approach

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World Journal of Gastroenterology 2007年第27期13卷 3692-3698页

作者： Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger Department of General and Abdominal Surgery University hospital Mainz Langenbeckstr.1 D-55131 Mainz Germany Institute for Pathology University hospital Mainz Germany Department of Pharmacy Pharmaceutical Biology Saarland University 66123 Saarbrücken Germany

AIM： To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning （IP） as well as pharmacologic pretreatment by α-lipoic acid （LA）. METHODS： Several groups of rats were compared： sham operated animals, non-pretreated animals （nt）, animals receiving IP （10 rain of ischemia by clamping of the portal triad and 10 min of reperfusion） prior to sustained ischemia, animals receiving selective ischemic preconditioning （IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 rain of reperfusion） prior to sustained ichemia, and animals receiving 500 1μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS： Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA（19 ± 2 vs 10 ± 1, P〈 0.05 and 29 ± 5 vs 12 ± 1, P 〈 0.05）. Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment （3.1 ± 0.3 vs 1.8 ± 0.2, P 〈 0.05）. Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation （LPO） in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towards anti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION： IP, consisting of 10 min of ischemia and 10 min of reperfusion, ischemia/reperfusion injury protects only partly against of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax.

关键词： Warm liver ischemia Liver preconditioning Apoptosis Lipid peroxidation Pharmacological preconditioning

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尼伯龙根之歌

GEVREY CLASS REGULARITY FOR THE GLOBAL ATTRACTOR OF A TWO-DIMENSIONAL NON-NEWTONIAN FLUID

丛书名：外教社德语分级注释读物系列

2005年

作者：（德）achim Seiffarth 李晶浩注释

本书是由编者本着尽可能忠实于原文的原则将尼龙根史诗故事简化而成。

ISBN: (纸本)7810952412

本书是由编者本着尽可能忠实于原文的原则将尼龙根史诗故事简化而成。

关键词：史诗德国德语中世纪

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Acta Mathematica Scientia 2022年第1期42卷 265-282页

作者： Caidi ZHAO Zehan LIN T.Tachim MEDJO Department of Mathematics Wenzhou UniversityWenzhou 325035China Department of Mathematics Florida International UniversityBM413B University ParkMiamiFL 33199USA

This article investigates Gevrey class regularity for the global attractor of an incompressible non-Newtonian fluid in a two-dimensional domain with a periodic boundary *** Gevrey class regularity reveals that the solutions lying in the global attractor are analytic in time with values in a Gevrey class of analytic functions in space.

关键词： non-Newtonian fluid global attractor Gevrey class regularity

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礁石旁的房屋

亚苄基乙酰苯的液相加氢：溶剂、催化剂载体、金属种类及反应条件的影响(英文)

2020年

作者： achim Seiffarth，Stefan Czarnecki[]

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Chinese Journal of Catalysis 2011年第8期32卷 1312-1322页

作者： achim STOLLE Christine SCHMGER Bernd ONDRUSCHKA Werner BONRATH Thomas F. KELLER Klaus D. JANDT Institute for Technical Chemistry and Environmental Chemistry (ITUC) Friedrich-Schiller University Jena Institute for Technical Chemistry and Environmental Chemistry (ITUC) Friedrich-Schiller University Jena R&D Chemical Process Technology DSM Nutritional ProductsP.O. Box 2676 Institute of Materials Science and Technology (IMT) Friedrich-Schiller University Jena

Innovative catalysts based on a "porous glass" support material were developed and investigated for the reduction of benzalace-tophenone. The easy preparation conditions and possibility to use different metals (e.g. Pd, Pt, Rh) for impregnation gave a broad variety of these catalysts. Hydrogenation experiments with these supported catalysts were carried out under different hydrogen pressures and temperatures. Porous glass catalysts with Pd as the active component gave chemoselective hydrogenation of benzalacetophenone, while Pt- and Rh-catalysts tended to further reduce the carbonyl group, especially at elevated hydrogen pressures and temperatures. Kinetic analysis of the reactions revealed these had zero order kinetics, which was independent of the type of porous glass support and solvent used.

关键词： chalcone hydrogenation porous glass supported catalyst

视网膜母细胞瘤临床病理分期对患者视力和生命预后的预测价值

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华中科技大学学报（医学版） 2006年第3期35卷 386-388页

作者：杨红 Harald Schilling Rudolf Effert achim Wessing 华中科技大学同济医学院附属同济医院眼科武汉430030 德国埃森综合大学眼科医院德国埃森45122 德国卡塞尔市立医院眼科德国卡塞尔34112

目的探讨视网膜母细胞瘤患者视力和生命预后的分类方法。方法回顾性分析291例视网膜母细胞瘤患儿的297只眼球的病理变化,根据色素上皮-脉络膜分期及视神经浸润分期,并综合相关文献资料总结患者接受后治疗的各种情况及预后。结果大范围... 详细信息

目的探讨视网膜母细胞瘤患者视力和生命预后的分类方法。方法回顾性分析291例视网膜母细胞瘤患儿的297只眼球的病理变化,根据色素上皮-脉络膜分期及视神经浸润分期,并综合相关文献资料总结患者接受后治疗的各种情况及预后。结果大范围的脉络膜浸润和(或)视神经筛板后浸润接受后治疗占所有后治疗的88%,其生存率为90%。结论大范围的脉络膜浸润及视神经筛板后浸润需接受后治疗以提高生存率。

关键词：视网膜母细胞瘤预后

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Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells

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World Journal of Gastroenterology 2008年第24期14卷 3829-3840页

作者： Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik Christoph C Schimanski Martin R Berger Arno Schad achim Weber Steffen Heeger Peter R Galle Markus Moehler First Department of Medicine Johannes-Gutenberg-University Mainz German Cancer Research Center Institute of Pathology University of Mainz Department of Pathology Institute of Surgical PathologyUniversity Hospital Merck Pharma GmbH

AIM： TO explore the role of Bcl-XL and Myeloid cell leukaemia （Mcl）-I for the apoptosis resistance of colorectal carcinoma （CRC） cells towards current treatment modalities. METHODS： Bcl-XL and Mcl-1 mRNA and protein expression were analyzed in CRC cell lines as well as human CRC tissue by Western blot, quantitative PCRand immunohistochemistry. Bcl-XL and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plasmids, respectively. After modulation of protein expression, CRC cells were treated with chemotherapeutic agents, an antagonistic epidermal growth factor receptor （EGFR1） antibody, an EGFR1 tyrosine kinase inhibitor, or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS： Here we show that in human CRC tissue and various CRC cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in CRC tissue than in surrounding non-malignant tissue, both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in malignant tissues. However, protein expression was slightly higher. Viability rates of CRC cells were significantly decreased after knock down of Bcl-xL expression, and, to a lower extent, after knock down of Mcl-1 expression. Furthermore, cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatinand irinotecan-induced apoptosis, and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand, upregulation of Bcl-xL by transfection of an expression plasmid decreased chemotherapeutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in CRC cells. Apoptosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly, CD95- and TRAIL-induced apoptosis was increased by Bcl-xL knock down. CONCLUSION： Our data suggest that Bcl-xL and, to a lower extent, Mcl-1, are important anti-apoptotic

关键词： Colorectal carcinoma Bcl-XL Myeloid cellleukaemia-1 Epidermal growth factor receptor 1 Apoptosis 5-fluorouracil Irinotecan Oxaliplatin

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不同年龄组视网膜母细胞瘤的组织病理学观察

华中科技大学学报（医学版） 2003年第2期32卷 226-228页

作者：杨红 Harald Schilling Rudolf Effert achim Wessing 华中科技大学同济医学院附属同济医院眼科武汉430030 德国埃森综合大学眼科医院德国埃森45122

目的　探讨视网膜母细胞瘤 (retinoblastoma,RB)在不同年龄组中的组织病理特点。方法　对 1985～ 1995年间摘除的 2 97只 RB眼球的病理切片 ,重新在光镜下观察。比较 3个年龄组段 (6 0个月 )的肿瘤细胞分化程度及对球壁和视神经的浸润... 详细信息

目的　探讨视网膜母细胞瘤 (retinoblastoma,RB)在不同年龄组中的组织病理特点。方法　对 1985～ 1995年间摘除的 2 97只 RB眼球的病理切片 ,重新在光镜下观察。比较 3个年龄组段 (6 0个月 )的肿瘤细胞分化程度及对球壁和视神经的浸润情况。结果　小于 18个月组的肿瘤细胞以分化好为主 (5 9.2 4 % ) ,18～ 6 0个月组以及大于 6 0个月组的肿瘤细胞以分化差为主 (6 9.90 %～ 90 .0 0 % )。肿瘤细胞对球壁和视神经的浸润在小于 18个月组和大于 6 0个月组中表现类似 ,浸润轻而少见 ,而在 18～ 6 0个月组中则表现为浸润程度重而多见。结论　随着患者年龄的增长 ,肿瘤细胞逐渐由分化较好转化为以分化较差为主。5岁以内 RB患者的肿瘤细胞分化程度越差。

关键词：视网膜母细胞瘤组织病理学年龄分化程度

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