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Treatment patterns and survival outcomes in patients with nonmetastatic early-onset pancreatic cancer

World Journal of Gastroenterology 2024年第12期30卷 1739-1750页

作者： le-Tian Zhang Ying Zhang bi-Yang Cao Chen-Chen Wu Jing Wang Graduate School Chinese PLA Medical SchoolBeijing 100853China Department of Radiation Oncology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Internal Medicine Hospital of University of Science and Technology BeijingBeijing 100083China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND The incidence of patients with early-onset pancreatic cancer(EOPC;age≤50 years at diagnosis)is on the rise,placing a heavy burden on individuals,families,and *** role of combination therapy including surgery,radiotherapy,and chemotherapy in non-metastatic EOPC is not *** To investigate the treatment patterns and survival outcomes in patients with non-metastatic *** A total of 277 patients with non-metastatic EOPC who were treated at our institution between 2017 and 2021 were investigated *** survival(OS),disease-free survival,and progression-free survival were estimated using the Kaplan-Meier *** and multivariate analyses with the Cox proportional hazards model were used to identify prognostic *** With a median follow-up time of 34.6 months,the 1-year,2-year,and 3-year OS rates for the entire cohort were 84.3%,51.5%,and 27.6%,*** median OS of patients with localized disease who received surgery alone and adjuvant therapy(AT)were 21.2 months and 28.8 months,respectively(P=0.007).The median OS of patients with locally advanced disease who received radiotherapy-based combination therapy(RCT),surgery after neoadjuvant therapy(NAT),and chemotherapy were 28.5 months,25.6 months,and 14.0 months,respectively(P=0.002).The median OS after regional recurrence were 16.0 months,13.4 months,and 8.9 months in the RCT,chemotherapy,and supportive therapy groups,respectively(P=0.035).Multivariate analysis demonstrated that carbohydrate antigen 19-9 level,pathological grade,T-stage,N-stage,and resection were independent prognostic factors for non-metastatic *** AT improves postoperative survival in localized *** after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.

关键词： Pancreatic cancer Early-onset Non-metastatic Multimodal treatment Radiotherapy Overall survival

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biomass waste-assisted micro(nano)plastics capture, utilization, and storage for sustainable water remediation

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The Innovation 2024年第4期5卷 119-128,118页

作者： Lu Chen Tingting bi Erlantz Lizundia Anxiong Liu Luhe Qi Yifan Ma Jing Huang Ziyang Lu le Yu Hongbing Deng Chaoji Chen Hubei biomass-Resource Chemistry and Environmental biotechnology Key Laboratory School of Resource and Environmental SciencesWuhan UniversityWuhan 430079China Life Cycle Thinking Group Department of Graphic Design and Engineering ProjectsUniversity of the Basque Country(UPV/EHU)48013 BilbaoSpain BCMaterials Basque Center for MaterialsApplications and NanostructuresEdif.Martina Casiano48940 LeioaSpain Zhongnan Hospital of Wuhan University Wuhan UniversityWuhan 430071China

Micro(nano)plastics(MNPs)have become a significant environmental concern due to their widespread presence in the biosphere and potential harm to ecosystems and human ***,we propose for the first time a MNPs capture,utilization,and storage(PCUS)concept to achieve MNPs remediation from water while meeting economically productive upcycling and environmentally sustainable plastic waste management.A highly efficient capturing material derived from surface-modified woody biomass waste(M-Basswood)is developed to remove a broad spectrum of multidimensional and compositional MNPs from *** M-Basswood delivered a high and stable capture efficiency of>99.1%at different pH or salinity *** exceptional capture performance is driven by multiscale interactions between M-Basswood and MNPs,involving physical trapping,strong electrostatic attractions,and triggered MNPs cluster-like aggregation ***,the in vivo biodistribution of MNPs shows low ingestion and accumulation of MNPs in the mice *** MNPs remediation from water,the M-Basswood,together with captured MNPs,is further processed into a high-performance composite board product where MNPs serve as the glue for utilization and ***,the life cycle assessment(LCA)and techno-economic analysis(TEA)results demonstrate the environmental friendliness and economic viability of our proposed full-chain PCUS strategy,promising to drive positive change in plastic pollution and foster a circular economy.

关键词： remove exceptional electrostatic

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Construction of wavelength-tunable DSE quinoline salt derivatives by regulating the hybridization form of the nitrogen atom and intramolecular torsion angle

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Chinese Chemical letters 2024年第10期35卷 315-320页

作者： Kuan Deng Fei Yang Zhi-Qi Cheng bi-Wen Ren Hua Liu Jiao Chen Meng-Yao She le Yu Xiao-Gang Liu Hai-Tao Feng Jian-Li Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Shaanxi Key Laboratory for Carbon Neutral TechnologyCollege of Chemistry&Materials ScienceNorthwest UniversityXi'an710127China Key Laboratory of Resource biology and biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi'an 710069China Fluorescence Research Group Singapore University of Technology and DesignSingapore 487372Singapore Baoji AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji721013China

Dual-state emission(DSE)molecules displayed conspicuous fluorescent performance both in solid and solution ***,the construction of DSE molecules and the regulation of their emission wavelengths remains a great *** on the structure-function relationship of quinolinonitrile-type fluorophores,this work proposed a feasible strategy for modulating their fluorescent properties into DSE via limiting the torsion angle between the quinoline ring and C=C bond in the range of 4.7°to 30°.Based on this strategy,53 compounds were obtained which displayed tunable emission wavelengths from^(3)97 nm to 740 nm in solid-state and from 360 nm to 672 nm in *** feasibility of the strategy was supported by a series of theoretical calculations,optical characterizations,and crystal analysis,suggesting the compounds have great potential in imaging living cells and tissues with desired wavelengths.

关键词： Fluorescence Dual-state emission Structure-function relationship Wavelength regulation Fluorescent imaging

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Abnormal function of EPHA2/p.R957P mutant in congenital cataract

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： Jing-Jin Zhang Zong-Fu Cao bi-Ting Zhou Ju-Hua Yang Zhong Li Shuang Lin Xiao-le Chen Nan-Wen Zhang Qin Ye Xu Ma Yi-Hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of bioengineering and biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane *** mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

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Circ_0012152 Accelerates Acute Myeloid leukemia Progression through the miR-652-3p/SOX4 Axis

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Current Medical Science 2024年第3期44卷 611-622页

作者： Ying CHEN bi-xia LI Ting-ting NIU Shu-jun YANG Li-chao WU le-huai SHI Duo-bing ZOU Ning-ning WU Li-xia SHENG Xiao YAN Gui-fang OUYANG Qi-tian MU Laboratory of Stem Cell Transplantation The First Affiliated Hospital of Ningbo UniversityNingbo315300China Ningbo Clinical Research Center For Hematologic Malignancies Ningbo315300China Department of Hematology The First Affiliated Hospital of Ningbo UniversityNingbo315300China School of Medicine Hangzhou City UniversityZhejiang UniversityHangzhou310000China Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo315300China

Objective Acute myeloid leukemia(AML)is an aggressive hematological malignancy characterized by abnormal myeloid blast *** studies have demonstrated that circular RNAs play a role in AML *** this study,we aimed to investigate the clinical significance of circ_0012152 in AML and elucidate its underlying molecular mechanism in the pathogenesis of this *** Circ_0012152 expression was detected by quantitative real-time polymerase chain reaction in samples obtained from 247 patients with AML and 40 healthy controls.A systematic analysis of clinical characteristics and prognostic factors was also *** growth was assessed using the Cell Counting Kit-8(CCK-8)assay,and apoptosis and cell cycle progression were evaluated by flow ***,RNA pull-down was performed to identify target microRNAs,and transcriptome RNA sequencing and bioinformatics analyses were utilized to identify downstream mRNA *** Circ_0012152 was significantly upregulated in samples from patients with AML and served as an independent adverse prognostic factor for overall survival(OS)(hazard ratio:2.357;95%confidence interval 1.258–4.415).The circ_0012152 knockdown reduced cell growth,increased apoptosis,and inhibited cell cycle progression in AML cell *** pull-down and sequencing identified miR-652-3p as a target microRNA of circ_*** growth inhibition by circ_0012152 knockdown was significantly relieved by miR-652-3p *** suggested that miR-652-3p targeted SOX4,as the decrease in SOX4 expression resulting from circ_0012152 knockdown was upregulated by miR-652-3p inhibitors in AML *** Circ_0012152 is an independent poor prognostic factor for OS in AML,and it promotes AML cell growth by upregulating SOX4 through miR-652-3p.

关键词： acute myeloid leukemia circ_0012152 miR-652-3p SOX4 cell growth

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台风作用下深圳新世界中心风致响应实测与风洞试验研究

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振动工程学报 2024年第8期37卷 1359-1367页

作者：林旭盛张乐乐谢壮宁王飞石碧青华南理工大学亚热带建筑与城市科学全国重点实验室广东广州510641 中国建筑第二工程局有限公司华南公司广东深圳518040 珠海华发实业股份有限公司广东珠海519020

依据近10年来监测到的5次强台风过境期间深圳新世界中心的实测响应数据,分析了该建筑结构在台风影响下的响应特点和模态参数变化特性,并将实测结果与粗糙度指数α分别为0.22,0.30和0.35地形下的风洞试验结果进行了比较。结果表明:历次... 详细信息

依据近10年来监测到的5次强台风过境期间深圳新世界中心的实测响应数据,分析了该建筑结构在台风影响下的响应特点和模态参数变化特性,并将实测结果与粗糙度指数α分别为0.22,0.30和0.35地形下的风洞试验结果进行了比较。结果表明:历次台风影响下实测建筑达到最大振幅附近时均表现为明显的横风向振动,且最大振动方向均为南北方向;实测最大峰值加速度为17.28 cm/s^(2),满足舒适度要求;台风过境时,建筑结构模态频率表现出明显的振幅依赖性和时变特性,采用“时变”方式描述更加合理,几次台风过程的结构模态频率均是随时间先减小,在最大风速时达到最小值,然后增大并恢复到常态值;结构模态阻尼比在中低振幅区域分布较为离散,随着振幅的增加,阻尼比有所增大,顺风向和横风向的阻尼比最大分别为1.9%和1.2%;实测结果更接近于α为0.35地貌的风洞试验结果,显示C类地貌的风洞试验结果偏于保守。

关键词：超高层建筑现场实测风洞试验参数识别地貌粗糙度

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Angular distribution of products in multinucleon transfer reactions

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Chinese Physics C 2024年第10期48卷 193-200页

作者： Xian-Kai le Kuan Fan Feng-Zhu Xing Shu-Qing Guo Nan Wang College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Nuclear and Radiation Safety Shenzhen 518060China

A method based on the dinuclear system(DNS)is proposed to describe the angular distribution of products in multinucleon transfer(MNT)*** considering fluctuation effects,the angular distributions of reactions involving^(136)Xe+^(208)Pb,^(136)Xe+^(209)bi,^(86)Kr+^(166)Er,^(84)Kr+^(209)bi,and^(84)Kr+^(208)Pb are examined,demonstrating good agreement with experimental ***,the double differential cross-sections(dσ^(2)/dl_(i)dΘand dσ^(2)/dZdΘ)of reactions^(136)Xe+^(208)Pb and^(136)Xe+^(209)bi are analyzed to explore the mechanism of angular distribution in MNT ***,the optimal angles for detecting N=126 isotopes are determined via an analysis on the influence of proton and neutron numbers of the projectiles on the angular distribution of the N=126 isotopic *** results of this study can provide valuable insights for experimental detection.

关键词： angular distribution multinucleon transfer reaction dinuclear system model neutron-rich nuclei

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Galectin-1蛋白在肾透明细胞癌组织中的表达及患者预后判断中的价值

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临床泌尿外科杂志 2024年第4期39卷 307-313页

作者：常晨毕新刚常乐陕西省人民医院病理科西安710068 国家癌症中心/国家肿瘤临床医学中心/中国医学科学院北京协和医学院肿瘤医院泌尿外科陕西省人民医院陕西省感染与免疫疾病重点实验室陕西省人民医院陕西省细胞免疫工程技术研究中心

目的:探讨肾透明细胞癌中半乳糖凝集素-1(Galectin-1)蛋白的表达变化,并评估其在患者预后判断方面的潜在价值。方法:采用组织微阵列和免疫组织化学技术对173例肾透明细胞癌组织及其相应的手术切缘正常组织中Galectin-1蛋白表达水平进行... 详细信息

目的:探讨肾透明细胞癌中半乳糖凝集素-1(Galectin-1)蛋白的表达变化,并评估其在患者预后判断方面的潜在价值。方法:采用组织微阵列和免疫组织化学技术对173例肾透明细胞癌组织及其相应的手术切缘正常组织中Galectin-1蛋白表达水平进行检测。收集患者的随访信息,并分析其表达水平与临床病理参数以及患者预后的相关性。结果:免疫组织化学染色结果显示,在173例肾透明细胞癌组织中,28.9%(50/173)的患者Galectin-1蛋白表达水平升高,而在癌旁正常组织中无表达,两者比较差异有统计学意义(Plectin-1蛋白表达水平与T分期、N分期、M分期、坏死区域存在、侵犯肾盂、伴肉瘤样分化以及临床分期均呈显著正相关(均Plectin-1蛋白的表达水平与肾透明细胞癌患者的预后密切相关。Kaplan-Meier生存曲线显示高表达患者的生存时间明显短于低表达患者(Plectin-1的高表达被确认为肾透明细胞癌患者不良预后的独立预测因素。结论:本研究发现肾透明细胞癌组织中Galectin-1蛋白表达水平升高,该高表达与患者预后不良相关,提示Galectin-1有可能成为肾透明细胞癌预后评估的潜在分子标志。

关键词：肾透明细胞癌免疫组织化学半乳糖凝集素-1 预后标志物总生存率

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C_(4)F_(7)N/CO_(2)混合气体自由燃弧特性仿真研究

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高压电器 2024年第9期60卷 11-19页

作者：李爽理乐陈圣毕海涛林莘庚振新国网辽宁省电力有限公司电力科学研究院沈阳110055 沈阳工业大学电气工程学院沈阳110870

目前电力行业中采用C_(4)F_(7)N/CO_(2)混合气体作为绝缘介质替代SF_(6)的可推广性较高,但对其灭弧性能的研究仍有待深入。文中基于磁流体动力学(MHD)理论模拟了棒—棒电极间隙的自由燃弧动态过程,计算了0.6 MPa的C_(4)F_(7)N/CO_(2)混... 详细信息

目前电力行业中采用C_(4)F_(7)N/CO_(2)混合气体作为绝缘介质替代SF_(6)的可推广性较高,但对其灭弧性能的研究仍有待深入。文中基于磁流体动力学(MHD)理论模拟了棒—棒电极间隙的自由燃弧动态过程,计算了0.6 MPa的C_(4)F_(7)N/CO_(2)混合气体(C_(4)F_(7)N占比分别为7%、10%、20%)和SF_(6)的电弧伏安特性。研究结果表明:C_(4)F_(7)N/CO_(2)混合气体在轴向的扩散能力强于SF_(6)气体;与C_(4)F_(7)N/CO_(2)混合气体相比,SF_(6)气体的燃弧温度更低,增大C_(4)F_(7)N的比例可降低燃弧温度;在燃弧过程中SF_(6)气体的电弧电压最低,增加C_(4)F_(7)N的比例对降低混合气体的电弧电压效果明显。

关键词： C_(4)F_(7)N/CO_(2)混合气体 SF_(6)替代气体 MHD 自由燃弧

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Suppression of intervalley scattering and enhanced phonon anharmonic interactions in 2D bi_(2)TeSe_(2):Crystal-field symmetry and band convergence

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Journal of Materiomics 2024年第2期10卷 386-395页

作者： lei Peng Ao Wu Yujie Xia Haotian Zhang Yuting Yang Hezhu Shao Ying Chen Juan Zhang le Shu Heyuan Zhu Yuxiang Zheng Hao Zhang School of Information Science and Technology Department of Optical Science and EngineeringFudan UniversityShanghai 200433China College of Electrical and Electronic Engineering Wenzhou UniversityWenzhou 325035China Department of Light Sources and Illuminating Engineering Fudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University Yiwu 322000China

The electron-phonon(el-ph)and phonon-phonon interactions play a key role in determining electronic and thermal transport properties,respectively,in promising two-dimensional(2D)semiconductor *** this study,we investigated el-ph interactions using Wannier-Fourier interpolation method and renormalized phonon scattering considering finite-temperature effects in bi_(2)TeSe_(2)*** re-sults show that the optical phonon modes dominate the carrier scattering,where level repulsion induced by crystal field splitting and spin-orbit coupling(SOC)effect effectively suppresses intervalley scattering,leading to high hole ***,the strong anharmonicity in bi_(2)TeSe_(2)monolayer results in the temperature-dependent softening of its optical phonons,along with a corresponding variation in interatomic force constants(IFCs).As a result,the lattice thermal conductivity is remarkably low and exhibits weak temperature ***,the predicted dimensionless thermoelectric figure of merit exceeds unity in the range of 200-800 K,indicating the potential of bi_(2)TeSe_(2)monolayer for thermoelectric *** work provides new insights into the elimination of intervalley scat-tering by crystal field splitting and SOC effects,and paves the way for the evaluation of thermoelectric properties of materials with complex scattering mechanisms and strong anharmonicity.

关键词： El-ph interactions Crystal field splitting Spin-orbit coupling Intervalley scattering Renormalized phonon scattering

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