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e-antigen-negative chronic hepatitis B in Bangladesh

Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 379-382页

作者： Nooruddin Ahmad Shahinul Alam Golam Mustafa abul barkat muhammad adnan Rahat Hasan Baig Mobin Khan Department of Hepatology Bangabandhu Sheikh Mujib Medical UniversityShahbagDhakaBangladesh

BACKGROUND:Bangladesh is a densely populated country where about 10 million people are chronically infected with hepatitis B virus(HBV).The aim of the present study was to evaluate the biochemical,virological and histological characteristics of HBeAg-negative chronic hepatitis B(CHB). METHODS:Patients were included in this study if they were chronically infected with HBV with detectable *** patients who were co-infected with human immunodeficiency virus,hepatitis delta virus or hepatitis C virus,and previously subjected to antiviral treatment,and those with hepatocellular carcinoma were *** study was conducted during the period of January 2001 to December *** this period 2617 patients with CHB were ***-positive cases were included to compare the *** them,237 cases underwent liver biopsy. RESULTS:2296 patients(87.7%)were male,with a mean age of 28.9±13.7 years.2375 patients(90.8%)had CHB,and 242(9.2%)were *** DNA levels were 7.6±1.5 copies/ml,ALT was 111.3±212.5 U/L,and AST was 91.5± 148.9 U/*** number of HBeAg-negative CHB cases was 1039(39.7%).HBeAg-negative patients with a lower DNA load were older,and they had more fibrotic changes in the liver than HBeAg-positive *** two groups did not differ in necroinflammatory activity,but the former had lower ALT and AST *** was more common in e-antigen-negative ***:e-antigen-negative CHB patients are older and have more hepatic fibrosis patients than HBeAg-positive patients,although they have similar necroinflammatory activity.

关键词： chronic hepatitis B Bangladesh e-antigen-negative

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Dubin-Johnson syndrome with systemic lupus erythematosus: a case report

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 617-619页

作者： Mamun-Al Mahtab Md. Fazal Karim Salimur Rahman abul barkat muhammad adnan Department of Hepatology Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

BACKGROUND: Dubin-Johnson syndrome (DJS) is a rare clinical entity. We describe a case of DJS complicated by systemic lupus erythematosus (SLE). METHODS: A case of congenital hyperbilirubinemia with SLE was evaluated systematically including review of history, physical examination for the stigmata of chronic liver disease, and other investigations. RESULT: Liver biopsy revealed a black liver with preserved architecture suggestive of DJS. CONCLUSIONS: SLE may develop in DJS. The relationship between DJS and SLE in this case is most likely a chance occurrence.

关键词： Dubin-Johnson syndrome systemic lupus erythematosus conjugated hyperbilirubinemia autoimmune disorder chance occurrence

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