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Cancer Communications 2022年第12期42卷 1417-1420页

作者： Cohen Idan Campisi-Pinto Salvatore Rozenberg Orit Abaev Ariel Khoury Marah Agbaria Dana Eitam Harel Colodner Raul Khoury Mona Shalabna Hassan Samih Yousef Mahamid Camel abu-amna mahmoud Bar-Sela Gil Department of Oncology Emek Medical CenterAfula 1834111Israel Research Authority Emek Medical CenterAfula 1834111Israel Clalit Clinical Laboratories Emek Medical CenterAfula 1834111Israel Department of Cancer Science Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifa 320002Israel

Dear Editor On July 29,2021,the Israeli Ministry of Health approved the third anti-Coronavirus disease 2019(COVID-19)vaccination(3rd-BNT162b2-booster-dose),leading to a sharp daily drop in diagnosed positive COVID-19 cases and mortality rates in Israel[1].The booster dose increased severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)neutralization efficiency approximately a hundred-fold compared to individuals receiving only the second dose,providing significant protection against infection[2].

关键词： mortality acute Israel

Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： Masashi Fujitani abu Md Mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

Differentiation of murine male germ cells to spermatozoa n a soft agar culture system

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Asian Journal of Andrology 2012年第2期14卷 285-293页

作者： mahmoud abu Elhija Eitan Lunenfeld Stefan Schlatt mahmoud Huleihel The Shraga Segal Department of Microbiology and Immunology Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva 84105 Israel Department of Obstetrics and Gynecology Soroka University Medical Center and Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva 84105 Israel Centre of Reproductive Medicine and Andrology of the University of Menster Menster 84149 Germany

Establishment of an in vitro system that allows the development of testicular germ cells to sperm will be valuable for studies of spermatogenesis and future treatments for male infertility. In the present study, we developed in vitro culture conditions using three-dimensional agar culture system （SACS）, which has the capacity to induce testicular germ cells to reach the final stages of spermatogenesis, including spermatozoa generation. Seminiferous tubules from testes of 7-day-old mice were enzymatically dissociated, and intratubular cells were cultured in the upper layer of the SACS in RPMI medium supplemented with fetal calf serum （FCS）. The lower layer of the SACS contained only RPMI medium supplemented with FCS. Colonies in the upper layer were isolated after 14 and 28 days of culture and were classified according to their size. Immunofluorescence and real-time PCR were used to analyse specific markers expressed in undifferentiated and differentiated spermatogonia （Vasa, Dazl, OCT-4, C-Kit, GFR- a-l, CD9 and a-6-integrin）, meiotic cells （LDH, Crem-1 and Boule） and post-meiotic cells （Protamine-1, Acrosin and SP-IO）. Our results reveal that it is possible to induce mouse testicular pre-meiotic germ cell expansion and induce their differentiation to spermatozoa in SACS. The spermatozoa showed normal morphology and contained acrosomes. Thus, our results demonstrate that SACS could be used as a novel in vitro system for the maturation of pre-meiotic mouse germ cells to post-meiotic stages and morphologically-normal spermatozoa.

关键词： acrosome agar in vitro culture meiosis spermatogenesis spermatogonia spermatozoa testis

Re-appraisal and consideration of minimally invasive surgery in colorectal cancer

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Gastroenterology Report 2017年第1期5卷 1-10,I0001页

作者： mahmoud abu Gazala Steven D.Wexner Department of Colorectal Surgery Cleveland Clinic FloridaWestonFLUSA

Throughout history,surgeons have been on a quest to refine the surgical treatment options for their patients and to minimize operative *** the last three decades,there have been tremendous advances in the field of minimally invasive colorectal surgery,with an explosion of different technologies and approaches offered to treat well-known *** surgery has been shown to be equal or superior to open *** boundaries of laparoscopy have been pushed further,in the form of single-incision laparoscopy,natural-orifice transluminal endoscopic surgery and *** paper critically reviews the pathway of development of minimally invasive surgery,and appraises the different minimally invasive colorectal surgical approaches available to date.

关键词： colon cancer rectal cancer minimally invasive surgery laparoscopy robotic surgery transanal total mesorectal excision natural-orifice specimen extraction

Petrogenesis,Geodynamics and Radioactivity of the Granitic Rocks of the Nugrus Weakness Zone,South Eastern Desert,Egypt

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Acta Geologica Sinica(English Edition) 2021年第4期95卷 1183-1198页

作者： Soliman abu ELATTA Abdallah mahmoud Gehad M.R.MANSOUR Nuclear Materials Authority CairoEgypt.P.O.Box 530 El Maadi

The studied granitic bodies belong to the south Eastern Desert of *** extend in a NNW–SSE trend along the same strike of the Nugrus weakness zone by which they are structurally *** rocks are composed of biotite and biotite-muscovite monzogranites to ***,a higher abundance of Ba and Rb in biotite granites with a relatively low abundance in biotite-muscovite granites as well as the diversity of Th,U,Nb,Ta,Zr,and REE reflects their origin from different sources and geodynamic *** biotite granites are predominantly metaluminous to low peraluminous whereas the biotite-muscovite granites have a peraluminous *** enrichment at the expense of calcium in these rocks reflects a derivation from crustal sources by partial melting in the presence of a volatile *** investigation showed high abundances of U(up to 38 ppm)and Th(up to 26 ppm)in biotite-muscovite granites relative to biotite granites(up to 5 ppm U and 18 ppm Th).Radioactive anomalies furthermore have been recorded in parts of biotite-muscovite granites that were affected by the faults(up to 116 ppm eU and 97 ppm eTh).Consequently,biotite-muscovite granites form a potentially fertile source for uranium mineralization.

关键词： partial melting biotite-muscovite granites peraluminous geodynamic radioactivity Nugrus

△-Resonances in Ground State Properties of _(20)^(40)Ca Spherical Cold Finite Nucleus at Equilibrium and under Compression

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Communications in Theoretical Physics 2010年第8期54卷 339-346页

作者： Mohammed H.E.abu-Sei’leek mahmoud A.Hasan Department of Physics Al-Jouf University Middle East University for Graduate Studies

The ground state properties of the spherical nucleus ^40Ca have been investigated by using constrained spherical Hartree Fock （CSHF） approximation at equilibrium and under high radial compression in a six major shells. The effective baryon-baryon interaction that includes the △（1236） resonance freedom degrees to calculate nuclear properties is used. The nucleon-nucleon （N-N） interaction is based on Reid soft core （RSC） potential. The results of calculations show that much of increase in the nuclear energy generated under compression is used to create the massive △ particles. The number of △ ＇s can be increased to about 2.1% of constituents of nucleus when nuclear density reaches about 1.34 times of normal density. The single particle energy levels are calculated and their behavior under compression is also examined. △ good agreement has been found between current calculations and phenomenological shell model for low lying single-particle spectra. The gap between shells is very clear and L-S coupling become stronger as increasing the static load on the nucleus. The results show a considerable reduction in compressibility when freedom degrees of △＇s are taken into account. It has been found that the total nuclear radial density becomes denser in the interior and less dense in the exterior region of nucleus. The surface of nucleus becomes more and more responsive to compression than outer region.

关键词： nuclear structure compressed finite nuclei △-resonance

An Integrative Meta-analysis of MicroRNAs in Hepatocellular Carcinoma

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Genomics, Proteomics & Bioinformatics 2013年第6期11卷 354-367页

作者： mahmoud ElHefnawi Bangli Soliman Nourhan abu-Shahba Marwa Amer Centre of Excellence for Advanced Sciences Informatics and Systems DepartmentNational Research Centre Stem Cells Research Group Centre of Excellence for Advanced SciencesMedical Molecular Genetics DepartmentNational Research Centre Biology Department American University in Cairo (AUC) Faculty of Biotechnology Misr University for Science and Technology (MUST)

We aimed to shed new light on the roles of microRNAs （miRNAs） in liver cancer using an integrative in silico bioinformatics analysis. A new protocol for target prediction and functional analysis is presented and applied to the 26 highly differentially deregulated miRNAs in hepatocellular carcinoma. This framework comprises：（1） the overlap of prediction results by four out of five target prediction tools, including TargetScan, PicTar, miRanda, DIANA-microT and miRDB （combining machine-learning, alignment, interaction energy and statistical tests in order to minimize false positives）, （2） evidence from previous microarray analysis on the expression of these targets, （3） gene ontology （GO） and pathway enrichment analysis of the miRNA targets and their pathways and （4） linking these results to oncogenesis and cancer hallmarks. This yielded new insights into the roles of miRNAs in cancer hallmarks. Here we presented several key targets and hundreds of new targets that are significantly enriched in many new cancer-related hallmarks. In addition, we also revealed some known and new oncogenic pathways for liver cancer. These included the famous MAPK, TGFβ and cell cycle pathways. New insights were also provided into Wnt signaling, prostate cancer, axon guidance and oocyte meiosis pathways. These signaling and developmental pathways crosstalk to regulate stem cell transformation and implicate a role of miRNAs in hepatic stem cell deregulation and cancer development. By analyzing their complete interactome, we proposed new categorization for some of these miRNAs as either tumor-suppressors or oncomiRs with dual roles. Therefore some of these miRNAs may be addressed as therapeutic targets or used as therapeutic agents. Such dual roles thus expand the view of miRNAs as active maintainers of cellular homeostasis.

关键词： Hepatocellular carcinoma miRNA Target prediction Integrative bioinformatics Cancer hallmarks

EXPERIMENTAL STUDY AND MODELING OF PRESSURE LOSS FOR FOAM-CUTTINGS MIXTURE FLOW IN HORIZONTAL PIPE

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Journal of Hydrodynamics 2011年第4期23卷 431-438页

作者： amna Gumati HIROSHI Takahshi Graduate School of Environmental Studies Tohoku University

In this study, we first sought to elucidate foam rheology to describe foam flow behavior, and then to experimentally investigate the pressure losses for both foam and foam-cuttings flow in a horizontal pipe by considering both varied foam qualities of 80%, 85% and 90% and foam velocities. Also, a two-layer numerical model to predict pressure loss was developed based on experimental observations of cuttings behavior. Results show that the foam behaves like a power-law fluid. Furthermore, and the pressure loss significantly increases as foam velocity increases, while the delivered cuttings concentration dramatically decreases. Moreover, results indicate that both the pressure loss and the delivered cuttings concentration increase with foam quality. Comparisons between the experimental results and numerical model predictions show satisfactory agreement.

关键词： foam rheology pressure loss horizontal pipe cuttings concentration two-layer model

Impact of the injected water salinity on oil recovery from sandstone formations:Application in an Egyptian oil reservoir

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Petroleum 2022年第1期8卷 53-65页

作者： M.Fouad Snosy mahmoud abu El Ela Ahmed El-Banbi Helmy Sayyouh General Petroleum Company Egypt Cairo University Egypt The American University in Cairo Egypt

In the last decade,there has been an increasing interest in understanding the effects of changing injected water salinity on the performance of oil *** paper aims to investigate the effects of injected water salinity on oil recovery of an Egyptian oil reservoir(Bahariya formation).An experimental work program has been performed using 25 core plugs and 5 different water salinities to study the effects of changing water salinity during both secondary and tertiary stages of *** objectives of the experimental work were to(1)investigate the effects of the low water salinity on oil recovery and(2)identify the optimum water salinity and the main reservoir parameters for application of low salinity waterflooding project(LSWF)in Bahariya *** results revealed that there is an optimum salinity for waterflooding in the secondary flooding ***,for the tertiary flooding stage,the results showed that the controlling factor is not decreasing the salinity,but rather changing the salinity(*** increasing or decreasing).It was also clear that applying the optimum salinity in the secondary recovery stage is more effective than applying it in the tertiary recovery ***,the results showed that the positive impact of LSWF may be expected in reservoirs with high amount of kaolinite,high values of CEC,and low amounts of plagioclase *** study is an original contribution to develop guidelines for designing optimum salinity waterflooding projects in sandstone reservoirs.

关键词： Low salinity Waterflooding LSWF Sandstone Bahariya formation Western desert

Role of the injected water salinity and ion concentrations on the oil recovery in carbonate reservoirs

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Petroleum Research 2022年第3期7卷 394-400页

作者： M.Fouad Snosy mahmoud abu El Ela Ahmed El-Banbi Helmy Sayyouh Petroleum Engineer General Petroleum CompanyEgypt Professor of Petroleum Engineering Cairo UniversityEgypt Professor of Petroleum Engineering The American University in CairoEgypt

Low salinity water flooding(LSWF)was initially considered using water with a low concentration of dissolved salts and was later extended to include modifying the ionic content of injected *** work investigates the effects of changing water salinity and composition along with the concentration of sulfate and iodide ions on oil recovery in carbonate reservoirs during the tertiary recovery *** experimental study was carried out using crude oil of 29°API,8 core samples extracted from the Eocene carbonate reservoir(Egypt),and 6 different water *** results showed additional oil recovery up to 5%of the original oil in place(OOIP)in the tertiary recovery stage with changing water salinity and water *** of high salinity(HS)and low salinity(LS)brines with high sulfate concentrations increased the incremental oil recovery by a value ranging from 1.7 to 3.8%of the *** the contrary,injection of HS and LS brines with low sulfate concentrations showed insignificant incremental oil recovery(less than 1%of the OOIP).Furthermore,injection of water with potassium iodide(KI)after injection of water with high sulfate brines showed additional oil recovery of about 1.7%of the *** the other hand,injection of water with KI after injection of water with low sulfate concentration showed insignificant incremental oil recovery(less than 0.4%of the OOIP).The concentration of sulfate in the injected water appeared to be key parameter to achieve effective waterflooding(WF)projects in carbonate ***,the results revealed that the multi-component ion exchange(MIE)mechanism seems to be the primary recovery mechanism for LSWF in carbonate *** results and conclusions of this study can be used to develop guidelines for designing waterflooding projects in carbonate reservoirs with optimum salinity.

关键词： Low salinity waterflooding Carbonate reservoirs Waterflooding LSWF