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mRNA transcriptome profiling of human hepatocellular carcinoma cells HepG2 treated with Catharanthus roseus-silver nanoparticles

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World Journal of Hepatology 2023年第3期15卷 393-409页

作者： Nur Asna Azhar Siti Aishah abu bakar Marimuthu Citartan Nor Hazwani Ahmad Department of Biomedical Science Advanced Medical and Dental InstituteUniversiti Sains MalaysiaKepala Batas 13200Pulau PinangMalaysia Liver Malignancies Research Program Advanced Medical and Dental InstituteUniversiti Sains MalaysiaKepala Batas 13200Pulau PinangMalaysia Faculty of Bioresources and Food Industry Universiti Sultan Zainal AbidinBesut CampusBesut 22200TerengganuMalaysia

BACKGROUND The demand for the development of cancer nanomedicine has increased due to its great therapeutic value that can overcome the limitations of conventional cancer ***,the presence of various bioactive compounds in crude plant extracts used for the synthesis of silver nanoparticles(AgNPs)makes its precise mechanisms of action *** To assessed the mRNA transcriptome profiling of human HepG2 cells exposed to Catharanthus roseus ***(***)-*** The proliferative activity of hepatocellular carcinoma(HepG2)and normal human liver(THLE3)cells treated with *** were measured using MTT *** RNA samples were extracted and sequenced using BGIseq500 *** is followed by data filtering,mapping,gene expression analysis,differentially expression genes analysis,Gene Ontology analysis,and pathway *** The mean IC 50 values of *** on HepG2 was 4.38±1.59μg/mL while on THLE3 cells was 800±1.55μg/*** profiling revealed an alteration of 296 *** induced the expression of stress-associated genes such as MT,HSP and *** signalling pathways were potentially activated through MAPK,TNF and TGF pathways that are responsible for apoptosis and cell cycle *** alteration of ARF6,EHD2,FGFR3,RhoA,EEA1,VPS28,VPS25,and TSG101 indicated the uptake of ***-AgNPs via both clathrin-dependent and clathrinindependent *** This study provides new insights into gene expression study of biosynthesised AgNPs on cancer *** cytotoxicity effect is mediated by the aberrant gene alteration,and more interestingly the unique selective antiproliferative properties indicate the *** as an ideal anticancer candidate.

关键词： Catharanthus roseus HepG2 Silver nanoparticles Transcriptome oxidative stress Apoptosis Cell cycle

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Effect of plant nutrition on aphid size, prey consumption, and life history characteristics of green lacewing

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Insect Science 2014年第1期21卷 74-82页

作者： Muhammad A. Aqueel Catherine M. Collins abu-bakar M. Raza Shahbaz Ahmad Muhammad Tariq Simon R. Leather Division of Ecology & Evolution Imperial College London Silwood Park Campus Ascot SL5 7PY United Kingdom Department of Entomology University College of Agriculture University of Sargodha Institute of Agricultural Sciences University of the Punjab Punjab Department of Entomology PMAS-Arid Agriculture University Rawalpindi Rawalpindi Pakistan

Plant quality can directly and indirectly affect the third trophic level. The predation by all the instars of green lacewing, Chrysoperla carnea （S.）（Neuroptera： Chrysopidae） on the cereal aphids, Rhopalosiphum padi （L.）, and Sitobion avenae （F.） at varying nitrogen fertilizer levels was calculated under laboratory conditions. Wheat plants were grown on four nitrogen fertilizer levels and aphids were fed on these plants and subsequently offered as food to the C. carnea. Aphid densities of 10, 30, and 90 were offered to first, second, and third instar larvae of green lacewing. Increased nitrogen application improved nitrogen contents of the plants and also the body weight of cereal aphids feeding on them. Aphid consumption by green lacewings was reduced with the increase in nitrogen content in the host plants of aphids. Predation of both aphid species by first, second, and third instars larvae of C. carnea was highest on aphids reared on plants with the lowest rate of fertilization, suggesting a compensatory consumption to overcome reduced biomass （lower aphid size）. Total biomass devoured by C. carnea on all nitrogen fertilizer treatments was not statistically different. Additionally, the heavier host prey influenced by the plant nutrition had an effect on the life history characteristics of green lacewings. The larval duration, pupal weight, pupal duration, fecundity, and male and female longevity were significantly affected by the level of nitrogen fertilization to the aphid＇s host plants, except for pupal duration when fed on S. avenae. This study showed that quantity of prey supplied to the larvae affects the prey consumption and thereafter the life history characteristics of green lacewings.

关键词： Chrysoperla carnea host plant nutrition tritrophic interactions

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A Mesh-Independent Brute-Force Approach for Traction-Free Corrections in Dislocation Problems

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Modeling and Numerical Simulation of Material Science 2021年第1期11卷 1-18页

作者： abu bakar Siddique Tariq Khraishi Mechanical Engineering Department University of New Mexico New Mexico USA

Simulation of dislocation dynamics opens the opportunity for researchers and scientists to observe in-depth many plastic deformation phenomena. In 2D or 3D media, modeling of physical boundary conditions accurately is one of the keys to the success of dislocation dynamics (DD) simulations. The scope of analytical solutions is restricted and applies to specific configurations only. But in dynamics simulations, the dislocations’ shape and orientation change over time thus limiting the use of analytical solutions. The authors of this article present a mesh-based generalized numerical approach based on the collocation point method. The method is applicable to any number of dislocations of any shape/orientation and to different computational domain shapes. Several verifications of the method are provided and successful implementation of the method in 3D DD simulations have been incorporated. Also, the effect of free surfaces on the Peach-Koehler force has been computed. Lastly, the effect of free surfaces on the flow stress of the material has been studied. The results clearly showed a higher force with increased closeness to the free surface and with increased dislocation segment length. The simulations’ results also show a softening effect on the flow stress results due to the effect of the free surfaces.

关键词： Free Surfaces Dislocation Theory Dislocation Dynamics Peach-Koehler Force

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Integration of Spatial Analysis for Tsunami Inundation and Impact Assessment

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Journal of Geographic Information System 2014年第1期6卷 11-22页

作者： abu bakar Sambah Fusanori Miura Graduate School of Science and Engineering Yamaguchi University Ube Japan Graduate School of Science and Engineering Yamaguchi University Ube Japan Fisheries and Marine Science Faculty Brawijaya University Malang Indonesia

Disaster mitigation and reconstruction plan due to tsunami can be implemented with various actions. An integration of spatial analysis through Geographical Information System (GIS) application and multi-criteria analysis through Analytical Hierarchy Process (AHP) is one of the methods for tsunami inundation and impact assessment. In this study, vulnerability, inundation and impact assessment due to tsunami hazard in Ofunato city, Iwate Prefecture, Japan was carried out. Appropriate input parameters were derived from Digital Elevation Model data, and satellite remote sensing and field data were analyzed through GIS. We applied the parameter of elevation and slope created from Aster GDEM version 2, coastline distance created from vector map of the study area and vegetation density created from ALOS ANVIR-2 image. We applied AHP process for weighting the parameter through pair-wise comparison using five iterations of normalized matrix. Five classes of vulnerability were defined and analyzed for tsunami inundation mapping. We used weighted overlay through spatial analyst in GIS to create the final map of tsunami vulnerability. The assessment results indicate that 7.39 square kilometer of the study area was under the high vulnerability zone due to tsunami, and 8.13 square kilometer of building area was under the inundation area. Our result showed good agreement with the observed data and historical map. The result presented here can aid as preliminary information for the coastal zone management related to disaster mitigation and for the evacuation process and management strategy during disaster.

关键词： Spatial Analysis GIS AHP Tsunami

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Elevating Localization Accuracy in Wireless Sensor Networks:A Refined DV-Hop Approach

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Computers, Materials & Continua 2024年第10期81卷 1511-1528页

作者： Muhammad Aamer Ejaz Kamalrulnizam abu bakar Ismail Fauzi Bin Isnin Babangida Isyaku Taiseer Abdalla Elfadil Eisa Abdelzahir Abdelmaboud Asma Abbas Hassan Elnour Department of Computer Science Faculty of ComputingUniversiti Technologi MalaysiaJohor Bahru81310Malaysia Department of Computer Science Faculty of Computing and Information TechnologySule Lamido UniversityP.M.B.048Kafin Hausa741103Nigeria Department of Information Systems-Girls Section King Khalid UniversityMahayil62529Saudi Arabia Humanities Research Center Sultan Qaboos UniversityMuscat123Oman

Localization is crucial in wireless sensor networks for various applications,such as tracking objects in outdoor environments where GPS(Global Positioning System)or prior installed infrastructure is ***,traditional techniques involve many anchor nodes,increasing costs and reducing *** solutions do not address the selection of appropriate anchor nodes and selecting localized nodes as assistant anchor nodes for the localization process,which is a critical element in the localization ***,an inaccurate average hop distance significantly affects localization *** propose an improved DV-Hop algorithm based on anchor sets(AS-IDV-Hop)to improve the localization *** simulation analysis,we validated that the ASIDV-Hop proposed algorithm is more efficient in minimizing localization errors than existing *** ASIDV-Hop algorithm provides an efficient and cost-effective solution for localization in Wireless Sensor *** strategically selecting anchor and assistant anchor nodes and rectifying the average hop distance,AS-IDV-Hop demonstrated superior performance,achieving a mean accuracy of approximately 1.59,which represents about 25.44%,38.28%,and 73.00%improvement over other algorithms,*** estimated localization error is approximately 0.345,highlighting AS-IDV-Hop’s *** substantial reduction in localization error underscores the advantages of implementing AS-IDV-Hop,particularly in complex scenarios requiring precise node localization.

关键词： Localization anchor nodes collinearity connectivity hop based

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Transgenerational phenotypic plasticity of diapause induction and related fitness cost in a commercial strain of the parasitoid Aphidius ervi Haliday

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Insect Science 2021年第3期28卷 780-792页

作者： Muhammad Mubashir Saeed Kevin Tougeron abu bakar Muhammad Raza Muhammad Afzal Anjum Aqueel Guillaume Jean Le Goff Frangois Renoz Jennifer Pirotte Thierry Hance Department of Entomology University College of AgricultureUniversity of SargodhaSargodhaPakistan Earth and Life Institute Biodiversity Research CentreUniversite catholique de LouvainLouvain-la-Neuve1348Belgium

Diapause is an adaptation that insects have evolved to synchronize their life cycle with that of seasonal climatic changes and resources ***,cues for its induction are not always clear and,in some cases,a maternal effect may be *** the population level,just a part of the individuals may exhibit diapause with important consequences in terms of winter ***,clear indicators of diapause state are difficult to *** induction was thus investigated in the aphid parasitoid species Aphidius ervi Haliday(Hymenoptera:Braconidae)developing in the aphid Sitobion avenae(Hemiptera:Aphididae)at four crossed photothermal regimes(16℃and 8℃,16:8 h L:D and 8:16 h L:D),and during 2 successive *** analyzed the reliability of changes in mummy color to assess for the diapausing state compared to dissections,and we measured parasitoid morphological and physiological *** observed that the proportion of dark brown mummies increased after one generation under low photothermal regime compared to other *** diapause was recorded at 16℃,16:8 h L:D,while we observed 16.2%and 67.5%diapause incidence at 8℃,8:16 h L:D,at 1st and 2nd generation,*** induction is thus increased by short day-length conditions and low temperatures as well as by maternal *** parasitoid life-history traits(weight,size,fat content,water content,egg-load,and longevity)were affected by the photothermal regime and/or the *** results raise new questions on the environmental thresholds needed to induce diapause and on survival and adaptation potential of commercially available parasitoid strains in different environments.

关键词： dormancy life-history traits mummy color photothermal regimes transgenerational plasticity

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Fraud Prevention Mechanisms of Malaysian Government-Linked Companies： An Assessment of Existence and Effectiveness

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Journal of Modern Accounting and Auditing 2012年第1期8卷 15-31页

作者： Normah Omar Katerina Maria abu bakar Universiti Teknologi MARA Selangor Malaysia

Understanding the root causes of fraud and learning about the most effective fraud prevention mechanisms are critical in reducing the incidence of financial fraud. Therefore, this study solicits the views of fraud investigators on the existence and effectiveness of fraud prevention mechanisms within Government-Linked Companies （GLCs）. Specifically, effective fraud prevention mechanisms （FPM） should be undertaken by five critical groups, namely the board of directors, audit committees, external auditors, internal auditors, and anti-fraud specialists. A total of 147 questionnaires were distributed to fraud investigators of all public listed GLCs in Malaysia. Out of those, a total of 45 usable responses were received, which represents an effective response rate of 30.6%. In terms of existence, the respondents ranked ＂management review of internal controls＂ and ＂external audits of financial statements＂ as the top-most FPMs. This was followed by other mechanisms such as operational audits, internal audits and internal control review/improvements by departments. Out of the 27 fraud prevention mechanisms, fraud investigators perceiyed surprise audits, fraud hotline, fraud prevention program and training, anti-fraud policy, fraud vulnerability reviews, operational audits, whistle-blowing policy, internal audit or fraud examination department, and, imposing penalty and disciplinary action as more effective than the others. Overall, this study provides important insights to practitioners and organizations in identifying fraud prevention mechanisms that are most effective.

关键词： fraud prevention mechanism (FPM) financial fraud government-linked companies (GLCs)

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Methyl gallate isolated from Mangifera pajang kernel induces proliferation inhibition and apoptosis in MCF-7 breast cancer cells via oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 175-184页

作者： Ranneh Yazan abu bakar Mohd Fadzelly Rahim Azlen-Che Kassim Nur Kartinee Stanslas Johnson Teh Yuan-Han Fadel Abdulmannan Ellulu Mohammed S Department of Technology and Natural Resources Faculty of Applied Science and TechnologyUniversiti Tun Hussein Onn MalaysiaPagoh CampusKM1 Panchor RoadMuar JohorMalaysia Department of Chemistry Faculty of ScienceUniversiti Putra MalaysiaSerdang 43300Malaysia Department of Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSelangorMalaysia Sport and Exercises Sciences School Faculty of ScienceLiverpool John Moores UniversityLiverpoolUK Department of Clinical Nutrition Faculty of Applied Medical SciencesAl-Azhar University of GazaGaza CityState of Palestine

Objective:To determine the lead bioactive compound in kernel extract of Mangifera pajang and its anti-cancer activity against human breast cancer cell lines with positive estrogen receptor(MCF-7).Methods:The methanolic extract of dried powder kernel of Mangifera pajang was exposed to column chromatography for *** structural elucidation of the isolated compound was characterized using infrared,nuclear magnetic resonance,mass ***,cytotoxicity,morphological changes,flow cytometry and cell cycle arrest analyses were performed to examine the mechanism of anti-proliferation and apoptosis induced by methyl gallate against ***:One compound was isolated from the methanolic extract of Mangifera pajang kernel and identified as methyl *** flow cytometric results demonstrated induction of apoptosis in MCF-7 cells by three concentrations of methyl *** cell cycle arrest showed a significant(P<0.05)decrease in cell progression at G2/M phase of MCF-7 after treatment with 100μM of methyl *** cell percentage of early and late apoptosis was significant at 10 and 100μM of methyl ***,methyl gallate treatment induced up-regulation of reactive oxygen species levels in MCF-7 cells with a reduction in superoxide dismutase ***:These findings indicate that isolated methyl gallate from Mangifera pajang kernel extracts induces growth inhibition and apoptosis in MCF-7 cells via up-regulating oxidative stress pathway.

关键词： Mangifera pajang Methyl gallate Breast cancer Cell cycle Apoptosis Oxidative stress

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Catalytic methanation reaction over alumina supported cobalt oxide doped noble metal oxides for the purification of simulated natural gas

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燃料化学学报 2012年第7期40卷 822-830页

作者： Wan Azelee Wan abu bakar Rusmidah Alil Abdul Aziz Abdul Kadir Salmiah Jamal Mat Rosid Nurul Shafeeqa Mohammad Department of Chemistry Faculty of Science Universiti Teknologi Malaysia 81310 Skudai Johor Malaysia Faculty of Petroleum and Renewable Energy Engineering Universiti Teknologi Malaysia 81310 Skudai Johor Malaysia

A series of alumina supported cobalt oxide based catalysts doped with noble metals such as ruthenium and platinum were prepared by wet impregnation *** variables studied were difference ratio and calcination ***/Co(10∶90)/Al2O3 catalyst calcined at 700 ℃ was found to be the best catalyst which able to convert 70.10% of CO2 into methane with 47% of CH4 formation at maximum temperature studied of 400 ℃.X-ray diffraction analysis showed that this catalyst possessed the active site Co3O4 in face-centered cubic and PtO2 in the orthorhombic phase with Al2O3 existed in the cubic *** to the FESEM micrographs,both fresh and spent Pt/Co(10∶90)/Al2O3 catalysts displayed small particle size with undefined *** Adsorption analysis showed that 5.50% reduction of the total surface area for the spent Pt/Co(10∶90)/Al2O3 ***,Energy Dispersive X-ray analysis(EDX) indicated that Co and Pt were reduced by 0.74% and 0.14% respectively on the spent Pt/Co(10∶90)/*** using FT-IR and TGA-DTA analysis revealed the existence of residual nitrate and hydroxyl compounds on the Pt/Co(10∶90)/Al2O3 catalyst.

关键词： natural gas cobalt oxide noble metal catalyst methanation reaction

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Tritrophic interactions between parasitoids and cereal aphids are mediated by nitrogen fertilizer

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Insect Science 2015年第6期22卷 813-820页

作者： Muhammad A. Aqueel abu-bakar M. Raza Rashad M. Balal Muhammad A. Shahid Irfan Mustafa Muhammad M. Javaid simon R. Leather Division of Biology Imperial College London Silwood Park Campus Ascot SL5 7PY UK University College of Agriculture Department of Biological Sciences University of Sargodha Pakistan Department of Crop and Environment Sciences Harper Adams UniversityShropshire TFIO 8NB UK

Host plant nutritional quality can directly and indirectly affect the third trophic levels. The aphid-parasitoid relationship provides an ideal system to investigate tritrophic interactions （as the parasitoids are completely dependent for their development upon their hosts） and assess the bottom up forces operating at different concentrations of nitrogen applications. The effects of varying nitrogen fertilizer on the performance of Aphidius colemani （V.） reared on Sitobion avenae （E） and Aphidius rhopalosiphi （D.） reared on Rhopalosiphum padi （L.） were measured. Parasitism and percent emergence ofparasitoids were positively affected by nitrogen fertilizer treatments while developmental duration （egg, larval, and pupal stages） was not affected by increasing nitrogen inputs. In males and females of both parasitoid species, adult longevity increased with the increasing nitrogen fertilizer. Hind tibia length and mummy weight of both parasitoid species increased with nitrogen fertilizer concentrations, as a result of larger aphids. This study showed that nitrogen application to the soil can have important consequences for aboveground multitrophic interactions.

关键词： cereal aphid parasitoids nitrogen fertilization tritrophic interactions

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