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Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment

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World Journal of Stem Cells 2023年第12期15卷 1093-1103页

作者： Ejlal abu-El-Rub Fatimah Almahasneh Ramada R Khasawneh Ayman Alzu'bi Doaa Ghorab Rawan Almazari Huthaifa Magableh ahmad Sanajleh Haitham Shlool Mohammad Mazari Noor S Bader Joud Al-Momani Department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbid 21163Jordan Department of Pathology Faculty of MedicineMansoura UniversityMansoura 35516Egypt Department of Basic Medical Sciences Yarmouk UniversityIrbid 21163Jordan

BACKGROUND Mesenchymal stem cells(MSCs)are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic *** mellitus(DM)is a frequently diagnosed chronic disease characterized by hyperglycemia which initiates many multisystem complications in the *** patients can benefit from MSCs transplantation to curb down the pathological consequences associated with hyperglycemia persistence and restore the function of damaged *** therapeutic outcomes are found to last for short period of time and ultimately these regenerative cells are eradicated and died in DM disease *** To investigate the impact of high glucose or hyperglycemia on the cellular and molecular characteristics of *** Human adipose tissue-derived MSCs(hAD-MSCs)were seeded in low(5.6 mmol/L of glucose)and high glucose(25 mmol/L of glucose)for 7 ***,viability,mitochondrial dynamics,and apoptosis were deplored using specific *** blotting was performed to measure the protein expression of phosphatidylinositol 3-kinase(PI3K),TSC1,and mammalian target of rapamycin(mTOR)in these *** hAD-MSCs cultured in high glucose for 7 d demonstrated marked decrease in their viability,as shown by a significant increase in lactate dehydrogenase(P<0.01)and a significant decrease in Trypan blue(P<0.05)in these cells compared to low glucose *** membrane potential,indicated by tetramethylrhodamine ethyl ester(TMRE)fluorescence intensity,and nicotinamide adenine dinucleotide(NAD+)/NADH ratio were significantly dropped(P<0.05 for TMRE and P<0.01 for NAD+/NADH)in high glucose exposed hAD-MSCs,indicating disturbed mitochondrial ***3K protein expression significantly decreased in high glucose culture MSCs(P<0.05 compared to low glucose)and it was coupled with significant upregulation in TSC1(P<0.05)and downregulation in mTOR protein expression(P<0.05).Mitochondrial complexes I,IV,and V were downregul

关键词： Mesenchymal stem cells High glucose Mitochondrial dynamics Apoptosis Poor survival Phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

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Development of a zoning management plan for petra archaeological park (PAP), Jordan

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Natural Science 2011年第12期3卷 1040-1049页

作者： Said Damhoureyeh ahmad Disi Ibrahim Al-Khader Mohammed H. abu-Dieyeh 不详

As Petra is increasingly becoming a major tourism destination in Jordan, this underlies not only challenges to conserve the habitats and species in Petra but also offers great opportunities to promote academic research and investigation, demonstrate sustainable development and initiation of environmentally sound development and nature based tourism. This investigation is based on both desktop studies and field missions. The desktop part is relied on reviewing various studies and reports that highlighting natural resources in the area. Two field missions were conducted aiming to document various information from related authorities and institutions operating in Petra and also to undertake ground truthing of habitats and species information. The missions also included interviews with Park staff, representatives from ongoing projects and initiatives in Petra (Seyaha-USAID) and many locals belonging to various tribes in Wadi Musa and The Bdul. The study presents a synthesis to findings from these studies and visits. Broadly, the park can be zoned into three mega zones: 1) Wadi Arabah and the steep gorges to the west including the Artemisia and annual grasses steppe to the west, 2) Mountainous ridges and rocky slopes of the Mediterranean region located almost centrally in the park and at the southern limit and part of the eastern borders and 3) Central basin and steep limestone scarps and weathered sandstone. Based on lists of key and indicator species, some key/sensitive sites of conservation value have been suggested. Aspects of grazing, agricultural activities, tourism and water resources and their implications on management schemes have been discussed.

关键词： Archaeological Park Ecotourism Biodiversity Environmental Management Petra Jordan

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Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone

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International Journal of Organic Chemistry 2015年第3期5卷 153-165页

作者： Mohammed Saleh Tawfek Makki Reda Mohammady Abdel Rahman Ola ahmad abu Ali Chemistry Department Faculty of Science King Abdul Aziz University Jeddah Kingdom of Saudi Arabia

Some new fluorinated 3-N-acyl/3-N-alkylaminophenyl-1,2,4-triazino[3,4-b][1,3,4]thiadiazolones (2-12) have been obtained from treatment of 2-(4'-fluorophenyl)-6-(2'-amino-5'-fluorophenyl)-1,2,4-triazino[3,4-b][1,3,4]thiadiazol-4-one(1) with active functional oxygen, sulfur and halogen compounds in different conditions. Former structures of the products have been characterized from elemental and spectral data (UV, IR, NMR and Mass). The new products were evaluated as potential anthelmintic drugs.

关键词： Synthesis Fluorinated 1 2 4-Triazinothiadiazolones Anthelmintic Drugs

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Association between Sex Differences and the Pharmacokinetics of Repaglinide among a Malaysian Population

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Pharmacology & Pharmacy 2011年第4期2卷 332-337页

作者： Ruzilawati abu Bakar Mohd Suhaimi Ab Wahab Imran ahmad Gan Siew Hua 不详

This study was conducted to evaluate the effect of sex differences on the pharmacokinetics of repaglinide in healthy subjects. One hundred twenty one healthy volunteers (61 male and 60 female;aged 18 - 50 years) were included in the study. Subjects were administered a single 4-mg repaglinide oral dose. Blood samples were taken at 0, 30, 60, 120, 180 and 240 min. Serum repaglinide levels were determined by a high-performance liquid chromatography (HPLC) method. Subjects were also genotyped by polymerase chain reactions - restriction fragment length polymorphisms (PCR-RFLP) for CYP3A4*4, *5 and *18 alleles and by an allele-specific multiplex PCR for CYP2C8*2, *3, *4 and *5 alleles. The pharmacokinetics of repaglinide were comparable between male and female subjects. The mean clearance (CL) of repaglinide was 16.0% lower (p = 0.03), the mean area under the serum concentration-time curve (AUC) was 12.8% higher (p = 0.04) and the peak serum concentration (Cmax) was 13.2% higher (p = 0.03) in females compared to male subjects. The mean rate of elimination (kel) and mean CL of repaglinide were 47.67% (p = 0.03) higher and 29.25% (p = 0.03) higher, respectively, in male subjects having CYP2C8*5 allele compared to female subjects. We also found that the mean half-life (t1/2) of repaglinide was 42.43% higher (p = 0.03), and the mean AUC was 35.83% higher (p = 0.03) in female subjects when compared to the male subjects having CYP2C8*5 allele. Sex differences significantly influence the pharmacokinetics of repaglinide.

关键词： Sex Differences CYP2C8 CYP3A4 Polymorphisms Repaglinide

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Soybean and tempeh total isoflavones improved antioxidant activities in normal and scopolamine-induced rat brain

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Journal of Coastal Life Medicine 2015年第11期 879-885页

作者： Aliya ahmad Vasudevan Mani Kalavathy Ramasamy Atish Prakash abu Bakar Abdul Majeed Faculty of Pharmacy Campus Puncak AlamUniversiti Teknologi MARA42300 Bandar Puncak AlamSelangor Darul EhsanMalaysia Brain Degeneration and Therapeutics Group Pharmaceutical and Life Sciences Communities of ResearchUniversiti Teknologi MARA40450 Shah AlamSelangor Darul EhsanMalaysia Collaborative Drug Discovery Research Group Pharmaceutical and Life Sciences Communities of ResearchUniversiti Teknologi MARA40450 Shah AlamSelangor Darul EhsanMalaysia

Objective:To highlight the comparative studies between total isoflavone extracts from soybean and tempeh on the neuronal oxidative stress and antioxidant ***:The total isoflavones were administered orally for 15 days with 3 selected doses(10,20 and 40 mg/kg).Piracetam(400 mg/kg,p.o.)was used as a standard drug while scopolamine(1 mg/kg,i.p.)was used as a drug that promoted amnesia in selected *** oxidative markers(thiobarbituric acid reactive substances and nitric oxide)were measured in brain *** antioxidant activities evaluated were catalase,superoxide dismutase,glutathione reductase and ***:Our results showed that soybean and tempeh isoflavones significantly improved the levels of catalase,superoxide dismutase,glutathione reductase and glutathione while decreased levels of thiobarbituric acid reactive substances and nitric oxide in both the brain of normal as well as scopolamine-induced ***:Our findings suggested that soybean and tempeh isoflavones could be useful in the management and prevention of age-related neurodegenerative changes including Alzheimer’s disease through its antioxidant activities.

关键词： Soybean Tempeh Isoflavones Antioxidant Neuroprotective

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Dermatomal Somatosensory Evoked Potentials: An Indicator of Improvement of Breast Sensibility after Reduction Mammaplasty

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Neuroscience & Medicine 2016年第3期7卷 106-113页

作者： Mohammad abu-Hegazy Wael Gabr Hossam El-Din A. Ismail ahmad A. Khalil Department of Neurology Mansoura University Mansoura Egypt Department of Plastic and Reconstructive Surgery Mansoura University Mansoura Egypt

Introduction: Many women think about reduction mammaplasty for different reasons. The effect of surgery on the beast sensibility is one of the greatest concerns after reconstructive reductive breast surgery through its affect on patient’s social life and psychological health. The dermatomal somatosensory evoked potential (D-SEP) is a new method to quantitatively evaluate breast sensibility. Patients and Methods: Twenty-five women enrolled in this study presenting with breast enlargement, underwent mammary reduction by using the inferior pyramidal breast reduction technique using the same operative technique described by Robbins with some modifications. All D-SEP amplitudes and latencies were calculated preoperatively and then were reassessed six and twelve months post-surgery in each breast. Result: The results revealed that there is a significant difference in the D-SEP latency pre- and post-operatively. The statistically significant decrease in latency and the breast size demonstrated indicates that the sensibility improved after breast reduction surgery both at six and twelve months. There is also a significant increase in the D-SEP amplitude pre- and post-operatively. The negative and statistically significant increase in amplitude with the decrease in breast size demonstrated indicates that the sensibility improved after breast reduction surgery both at six and twelve months. Conclusion: This study concluded that breast sensibility will improve after breast reduction as indicated by significant reduction of D-SEP latencies and increase of its amplitudes. Our results confirm an inverse relationship between breast size and sensibility, with improvement in sensibility after breast reduction.

关键词： Breast Sensibility Reduction Mammoplasty Dermatomal Somatosensory Evoked Potentials

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Synthesis, Characterization and Antimicrobial Activity of Schiff Base (E)-N-(4-(2-Hydroxybenzylideneamino) Phenylsulfonyl) Acetamide Metal Complexes

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American Journal of Analytical Chemistry 2016年第3期7卷 233-245页

作者： ahmad Sabry abu-Khadra Rabie Saad Farag Alaa El-Dine Mokhtar Abdel-Hady Department of Basic Science Faculty of Engineering Science Sinai University Arish Egypt Department of Chemistry Faculty of Science Al-Azhar University Cairo Egypt Department of Pharmaceutical Chemistry Faculty of Pharmacy Sinai University Arish Egypt

New series of Ag, Cd(II), Ce(III), Co(II), Cr(III), Fe(III), Ni(II) and Pb(II) complexes with (E)-N-(4-(2- hydroxybenzylideneamino) phenylsulfonyl) {S.S} have been synthesized. These compounds have been characterized by different physico-chemical techniques like, melting point, elemental analysis, FT-IR, UV spectroscopy, 1H NMR spectroscopy, conductance measurements, magnetic susceptibility and mass spectral analysis. The metal ions concentrations have been determined using inductively coupled plasma mass spectrometry (ICP-MS). Spectroscopic studies suggest coordination most of complexes in a regular octahedral arrangement in 2L:1M molar ratio by two N azomethine and two OH phenolic from Schiff base {S.S} in the form of [ML2(H2O)2], M metal, L ligand {S.S}. Complexes have been screened for their antibacterial {Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa)}, {Gram positive bacteria (Bacillus subtilis and Sterptococcus pneumoniae)} and antifungal (Aspergillus fumigates and Candida albicans) showing promising antimicrobial biological activity.

关键词： Biological Activity Inductively Coupled Plasma Synthesis Sulfacetamide Transition Metal Complexes

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Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

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BIOCELL 2024年第4期48卷 559-569页

作者： YARA ALZGHOUL HALA J.BANI ISSA ahmad K.SANAJLEH TAQWA ALABDUH FATIMAH RABABAH MAHA AL-SHDAIFAT EJLAL abu-EL-RUB FATIMAH ALMAHASNEH RAMADA R.KHASAWNEH AYMAN ALZU’BI HUTHAIFA MAGABLEH Department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbidJordan

Mesenchymalstemcells(MSCs)*** the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities,which are essential to restore heart *** can be easily isolated from different sources,including bone marrow,adipose tissues,umbilical cord,and dental *** from various sources differ in their regenerative and therapeutic abilities for cardiovascular *** this review,we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function.

关键词： Bone marrow mesenchymal stem cells Adipose tissue mesenchymal stem cells Dental pulp stem cells Umbilical cord mesenchymal stem cells Cardiomyocytes Regeneration Myocardial infarction Mesenchymal stem cells Differentiation Immunomodulation

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Estimation of red tip disease severity in pineapple using a non-contact sensor approach

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Agricultural Sciences 2013年第4期4卷 206-208页

作者： Siva Kumar Balasundram Faizah abu Kassim Ganesan Vadamalai ahmad Husni Mohd Hanif Department of Agriculture Technology Faculty of Agriculture Universiti Putra Malaysia Serdang Malaysia Department of Land Management Faculty of Agriculture Universiti Putra Malaysia Serdang Malaysia Department of Plant Protection Faculty of Agriculture Universiti Putra Malaysia Serdang Malaysia

Red tip disease on pineapple (Ananas comosus) was first recognized about 20 years ago in a commercial pineapple stand located in Simpang Renggam, Johor, Peninsular Malaysia. Since its discovery, there has been no confirmation on the causal agent of red tip disease. The epidemiology of red tip disease is still not fully understood. However, based on disease symptoms and field transmission mode, red tip disease seems to be strongly associated with viral infection. The aim of this work was to assess the feasibility of using an optical sensor to estimate red tip disease severity. This work was performed in a commercial pineapple plantation located in Simpang Renggam, Johor. Four observation plots bearing pineapple variety SR36 were demarcated based on crop growth stage. Each plot comprised a total of eighty corresponding measurements of percent Disease Severity (% DS) and Normalized Difference Vegetation Index (NDVI). Our data showed a strong correlation between % DS and NDVI. The 7- and 11-month plantings registered a correlation coefficient (r) of -0.83 and -0.88, respectively. The negative correlation infers that NDVI increases when disease severity is low. This is expected since healthy leaves reflect more near-infrared light and less visible light which results in a higher NDVI. The regression of NDVI on % DS for the 7-month planting was explained by: % DS = 181.6 - 185.6*NDVI. Meanwhile, the regression of NDVI on % DS for the 11-month planting was explained by: % DS = 213.2 - 219.8*NDVI. The linear fit between measured % DS and estimated % DS from the 7-month and 11-month plantings was relatively strong. This work has demonstrated that NDVI is a reliable predictor of % DS in pineapple.

关键词： Pineapple Red Tip Disease Optical Sensor

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Addressing poxvirus challenges in the Middle East to enhance biosafety and biosecurity measures

Journal of Biosafety and Biosecurity

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Journal of Biosafety and Biosecurity 2024年第3期6卷 142-156页

作者： Laith N.AL-Eitan Haneen O.Ali Hana S.abu Kharmah Maryam K.Alasmar Iliya Y.Khair ahmad H.Mihyar Department of Applied Biological Sciences Jordan University of Science and Technology22110 IrbidJordan Department of Biotechnology and Genetic Engineering Jordan University of Science and Technology22110 IrbidJordan

The emergence and zoonotic transmission of poxviruses in the Middle East have been recognized as complex public health ***,a vast family of DNA viruses,can infect many hosts,including animals and *** Middle East has had multiple epidemics of poxvirus infections(e.g.,Monkeypox,Smallpox,and Camelpox)that have raised concerns owing to their detrimental effects on livestock,wildlife,and sporadic human *** review aims to thoroughly examine the complexity of the epidemiological patterns,intricate genetic diversity,and several contributing factors that support the emergence and zoonotic transmission of poxviruses in the Middle *** aspects of poxviruses contribute to the emergence of endemics and zoonotic breakouts,such as the complex nature of human-animal interactions,environmental changes,and their subtle capacity for viral *** review was compiled in the hopes of contributing to the current understanding of poxvirus biology and its implications for human and animal health in the Middle *** provide a comprehensive overview of the most common poxviruses in the Middle East,including their classification,structure,replication cycle,pathogenesis,route of transmissions,and of how the Middle East has developed ways to mitigate these biological threats.

关键词： Pox viruses Middle East Emergence Zoonotic Transmission

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