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The effect of downstream resistance on flow diverter treatment of a cerebral aneurysm at a bifurcation: A joint computational-experimental study

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Journal of Hydrodynamics 2018年第5期30卷 803-814页

作者： ANDerson C.O.Tsang Billy y.s.yiu abraham y.s.tang W.C.Chung Gilberto K.K.Leung AlexANDer K.K.Poon Alfred C.H.yu simon s.M.Lai K.W.Chow Department of surgery Li Ka Shing Faculty of Medicine University of Hong Kong Department of Electrical and Computer Engineering University of Waterloo Department of Mechanical Engineering University of Hong Kong Department of Electrical and Electronic Engineering University of Hong Kong

Intracranial aneurysm can lead to hemorrhagic stroke upon rupture. Deployment of flow diverters can restrict the blood flow into aneurysm and mitigate the rupture risk. Computational fluid dynamics（CFD） and ultrasonography with pulse-wave and color Doppler ultrasound measurements were employed jointly to investigate the complex flow pattern in cerebral aneurysms, both before and after the deployment of flow diverters. Patient-specific configurations of both bifurcation and side-wall aneurysms were selected. The effect of downstream flow resistance was investigated by adjusting the volume flow rate and pressure at the outlet vessels computationally and experimentally. Velocity profiles in the aneurysm measured from ultrasonography showed good agreement with those from computer simulations. The discrepancy in velocity between the computational and experimental sets of data is less than 10%. The downstream resistance can alter the volume flux into a bifurcation aneurysm with a flow diverter deployed by 236%, while the corresponding value of a side-wall aneurysm is negligible. The vorticity of the aneurysmal flow was reduced by more than 80% in both cases after stenting. This study demonstrated that careful investigation of downstream flow resistance of a bifurcation aneurysm is essential to provide an accurate assessment of the aneurysmal flow dynamics after flow diverter deployment.

关键词： Intracranial aneurysms computational fluid dynamics (CFD) doppler ultrasound

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A Computational Fluid Dynamics study on the Endovascular Treatment of Intracranial Aneurysms

A Computational Fluid Dynamics Study on the Endovascular Tre...

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The 16th Annual Conference of Hong Kong society of Theoretical and Applied Mechanics 2012、The 1st Mainland-Hong Kong youth Forum on Mechanics 2012、The 8th shanghai-Hong Kong Forum on Mechanics and Its Application 2012

作者： s.K.Lai abraham y.s.tang K.M.Leung Gilberto K.K.Leung K.W.Chow Department of Mechanical Engineering University of Hong Kong Division of Neurosurgery Department of SurgeryLi Ka Shing Faculty of MedicineUniversity of Hong KongQueen Mary Hospital

Intracranial aneurysm,a localized dilation of arterial blood vessels in the brain,is a severe cerebrovascular *** appropriate medical treatment,the rupture of intracranial aneurysms will result in high mortality rate due to excessive bleeding into the cavity surrounding the *** modern technological advances,endovascular stenting technique has now proven to be one effective technique in the clinical management of intracranial *** prime advantage of endovascular intervention over traditional open surgery is that the former procedure is less invasive,and thus a shorter recovery time will *** a mechanical point of view,a metallic stent,serving as a flow diverter,can be deployed to cover the entire aneurysm *** the blood flow inside the aneurysmal sac becomes stagnant,and thrombus formation is likely to *** is expected that a larger extent of thrombosis is capable of reducing the risk of growth and rupture of *** assess this clinical objective quantitatively,we construct a three-dimensional(3D) aneurysm model (see Fig.1) to investigate the blood flow patterns in stented and non-stented *** many idealized models with straight or curved parent blood vessel,the aneurysm of the current model is placed at the bifurcation point of cerebral arteries,a geometric configuration occurring frequently for many *** fluid dynamics techniques are applied to perform the blood flow *** inlet and outlet boundary conditions of this model are subjected to pulsatile velocity and pressure waveforms *** on the present study,the impact of hemodynamic and biomechanical factors on the aneurysm can be *** quantitative findings can also provide valuable information for clinical practitioners to understand and predict the hemodynamic behaviour in patient-specific cases.

关键词： A Computational Fluid Dynamics study on the Endovascular Treatment of Intracranial Aneurysms

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Flexible and Robust Functionalized Boron Nitride/Poly(p‑Phenylene Benzobisoxazole)Nanocomposite Paper with High Thermal Conductivity and Outstanding Electrical Insulation

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Nano-Micro Letters 2024年第2期16卷 423-437页

作者： Lin tang Kunpeng Ruan Xi Liu yusheng tang yali Zhang Junwei Gu Chongqing Key Laboratory of Green synthesis and Applications College of ChemistryChongqing Normal UniversityChongqing 401331People’s Republic of China shaanxi Key Laboratory of Macromolecular science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China

With the rapid development of 5G information technology,thermal conductivity/dissipation problems of highly integrated electronic devices and electrical equipment are becoming *** this work,“high-temperature solid-phase&diazonium salt decomposition”method is carried out to prepare benzidine-functionalized boron nitride(m-BN).subsequently,m-BN/poly(pphenylene benzobisoxazole)nanofiber(PNF)nanocomposite paper with nacremimetic layered structures is prepared via sol–gel film transformation *** obtained m-BN/PNF nanocomposite paper with 50 wt%m-BN presents excellent thermal conductivity,incredible electrical insulation,outstanding mechanical properties and thermal stability,due to the construction of extensive hydrogen bonds andπ–πinteractions between m-BN and PNF,and stable nacre-mimetic layered ***λ∥andλ_(⊥)are 9.68 and 0.84 W m^(-1)K^(-1),and the volume resistivity and breakdown strength are as high as 2.3×10^(15)Ωcm and 324.2 kV mm^(-1),***,it also presents extremely high tensile strength of 193.6 MPa and thermal decomposition temperature of 640°C,showing a broad application prospect in high-end thermal management fields such as electronic devices and electrical equipment.

关键词： Poly(p-phenylene-2,6-benzobisoxazole)nanofiber Boron nitride Thermal conductivity Electrical insulation

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single-cell RNA sequencing in juvenile idiopathic arthritis

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Genes & Diseases 2024年第2期11卷 633-644页

作者： Xiwen Luo Xuemei tang Department of Rheumatology and Immunology Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Child Infection and Immunity Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China

Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children,with onset before age 16 and lasting for more than 6 *** is a highly heterogeneous condition with various consequences for health and quality of *** some JIA patients,early detection and intervention remain *** a result,further investigation of the complex and unknown mechanisms underlying JIA is *** in technology now allow us to describe the biological heterogeneity and function of individual cell populations in *** this review,we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis.

关键词： Juvenile idiopathic arthritis Macrophage Macrophage activation syndrome Monocyte single-cell RNA sequencing synoviocyte T cell

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Video summarization Approach Based on Binary Robust Invariant scalable Keypoints and Bisecting K-Means

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Computers, Materials & Continua 2024年第3期78卷 3565-3583页

作者： sameh Zarif Eman Morad Khalid Amin Abdullah Alharbi Wail s.Elkilani shouze tang Department of Information Technology Faculty of Computers and InformationMenoufia UniversityMenoufia32511Egypt Department of Artificial Intelligence Faculty of Artificial IntelligenceEgyptian Russian UniversityBader11829Egypt Department of Computer science Community CollegeKing Saud UniversityRiyadh11362Saudi Arabia College of Applied Computer science King Saud UniversityAl-Muzahmiya19676Saudi Arabia school of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China

Due to the exponential growth of video data,aided by rapid advancements in multimedia *** became difficult for the user to obtain information from a large video *** process of providing an abstract of the entire video that includes the most representative frames is known as static video *** method resulted in rapid exploration,indexing,and retrieval of massive video *** propose a framework for static video summary based on a Binary Robust Invariant scalable Keypoint(BRIsK)and bisecting K-means clustering *** current method effectively recognizes relevant frames using BRIsK by extracting keypoints and the descriptors from video *** video frames’BRIsK features are clustered using a bisecting K-means,and the keyframe is determined by selecting the frame that is most near the cluster *** applying any clustering parameters,the appropriate clusters number is determined using the silhouette *** were carried out on a publicly available open video project(OVP)dataset that contained videos of different *** proposed method’s effectiveness is compared to existing methods using a variety of evaluation metrics,and the proposed method achieves a trade-off between computational cost and quality.

关键词： BRIsK bisecting K-mean video summarization keyframe extraction shot detection

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Investigation on UV-curing Reprocessable Thermosets Bearing Hindered Urea Bonds and Their Composites with Modified Zinc Oxide Nanoparticles

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Chinese Journal of Polymer science 2024年第6期42卷 751-765页

作者： Jun-Hao Zhou Li-Ming tang Key Laboratory of Advanced Materials of Ministry of Education of China Department of Chemical EngineeringTsinghua UniversityBeijing100084China

In this study,a series of hindered urea bond(HUB)containing polyurethane-urea methacrylate prepolymers and a none HUB containing polyurethane methacrylate prepolymer were prepared using isobornyl methacrylate as the reactive diluent via one-pot *** prepolymers were characterized fully by various ***,their thermosets were fabricated via UV curing in presence of a photo initiator,and their mechanical property and thermal behavior were investigated and *** from the none HUB containing thermoset,the HUB containing thermosets(defined as PUT)could be recycled and reprocessed by hot press under relatively mild conditions with high recovery ratio of mechanical ***,zinc oxide(ZnO)nanoparticles were modified with 3-(trimethoxysilyl)propyl methacrylate and the modified ZnO(defined as ZnO-TPM)was dispersed and polymerized into PUT matrix to prepare their *** influence of ZnO-TPM on the mechanical performance of the composites was evaluated,which indicated that the young’s modulus and tensile strength increased gradually to the maximum values at ZnO-TPM content of 1 wt%and then *** composites also displayed good reprocessability with improved recovery ratio compared to the pure PUT *** addition,the composite materials exhibited strong UV absorption capacity,implying their potential application in the circumstance where UV-shielding was required.

关键词： Polyurethane-urea methacrylate Hindered urea bond ZnO nanoparticles Reprocessing UV curing

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Data-driven modeling on anisotropic mechanical behavior of brain tissue with internal pressure

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Defence Technology（防务技术） 2024年第3期33卷 55-65页

作者： Zhiyuan tang yu Wang Khalil I.Elkhodary Zefeng yu shan tang Dan Peng state Key Laboratory of structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of Technology116023DalianPR China The Department of Mechanical Engineering The American University in CairoNew Cairo11835Egypt Department of Neurology The Second Hospital of Dalian Medical UniversityDalian116023PR China

Brain tissue is one of the softest parts of the human body,composed of white matter and grey *** mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain ***,traumatic brain injury(TBI)and various brain diseases are also greatly influenced by the brain's mechanical *** white matter or grey matter,brain tissue contains multiscale structures composed of neurons,glial cells,fibers,blood vessels,etc.,each with different mechanical *** such,brain tissue exhibits complex mechanical behavior,usually with strong nonlinearity,heterogeneity,and directional *** a constitutive law for multiscale brain tissue using traditional function-based approaches can be very ***,this paper proposes a data-driven approach to establish the desired mechanical model of brain *** focus on blood vessels with internal pressure embedded in a white or grey matter matrix material to demonstrate our *** matrix is described by an isotropic or anisotropic nonlinear elastic model.A representative unit cell(RUC)with blood vessels is built,which is used to generate the stress-strain data under different internal blood pressure and various proportional displacement loading *** generated stress-strain data is then used to train a mechanical law using artificial neural networks to predict the macroscopic mechanical response of brain tissue under different internal ***,the trained material model is implemented into finite element software to predict the mechanical behavior of a whole brain under intracranial pressure and distributed body *** with a direct numerical simulation that employs a reference material model,our proposed approach greatly reduces the computational cost and improves modeling *** predictions made by our trained model demonstrate sufficient ***,we find that the level of internal blood pressur

关键词： Data driven Constitutive law Anisotropy Brain tissue Internal pressure

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Commentary:Mammokine directs beige adipocytes to reserve energy for milk production in breast

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Acta Pharmaceutica sinica B 2024年第3期14卷 1472-1476页

作者： Lina tang Jianping ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Beige/brown adipocytes play a crucial role in regulating the body’s overall energy *** thermogenic function is under the influence of various tissues,including the brain,muscles,and ***,the breast tissue is not in th... 详细信息

关键词： Beige Breast Epitheliail cells scRNA-seq Thermogenesis

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U-Pb zircon ages and petrogeochemistry and tectonic implications of gabbro and granite in southwest Lahad Datu area of sabah, Malaysia

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Acta Oceanologica sinica 2024年第2期43卷 94-110页

作者： Zhigang Zhao Wu tang shixiang Liu Huafeng tang Pujun Wang Zhiwen Tian China National Offshore Oil Corporation(CNOOC)Research Institute Co. Ltd.Beijing 100028China College of Earth sciences Jilin UniversityChangchun 130061China

The southwest Lahad Datu felsic rocks were previously thought to have formed in the late Triassic as part of the microcontinental crystalline *** on U-Pb ages,geochemistry,and the Hfisotopes of zircon from the southeastern sabah gabbro and granite,in this study,the tectonic properties of the sabah area during the Triassic were *** weighted average U-Pb zircon ages of the gabbro and granite samples were determined to be(230.9±2.5)Ma and(207.1±3.3)Ma,*** granite had siO_(2) contents of 66.54%-79.47%,low TiO_(2) contents of 0.08%-0.3%,Al_(2)O_(3) contents of 10.97%-16.22%,Na_(2)O contents of 5.91 %-6.39%,and low K_(2)O contents of 0.15%-0.65%.The chondrite-normalized rare earth element(REE) patterns exhibit light REE enrichment,with right-sloping *** primitive mantle-normalized trace element spider diagrams exhibit Th,U,La,sr,and Zr enrichment and Nb,Ta,P and Ti depletions,i.e.,the geochemical characteristics of typical island arc igneous *** tectonic discriminant diagram indicates that the granite is a volcanic arc *** Hf isotopic an alysis of gabbro zircon revealed that the zircons have ε_(Hf)(t)values of 12.08-16.24(mean of 14.32) and two-stage model ages(t_(DM2)) of 223-491 Ma(mean of 347 Ma).This indicates that the diagenetic magma of the gabbro was mainly derived from melting of newly formed crustal *** ophiolite in southeast sabah has existed since the early Late *** crystalline basement granite in southeastern s abah was emplaced lasted from late Triassic to early *** on previous studies and global plate reconstruction models,it is speculated that the southeastern sabah granite may have been formed in an island arc setting,i.e.,where the oceanic crust of the Paleo-Tethys Ocean collided with the oceanic crust of the Panthalassa Ocean.

关键词： sabah early late Triassic ophiolite granite tectonic properties

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Diet and physical activity influence the composition of gut microbiota,benefit on Alzheimer's disease

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Food science and Human Wellness 2024年第2期13卷 541-555页

作者： Jinyue Zhou Min tang Wanyi Li Rui Fang Chunlan tang Qinwen Wang 无 school of Public Health Health Science CenterNingbo UniversityNingbo 315211China Department of Neurology Ningbo Rehabilitation HospitalNingbo 3151000China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315100China Key Laboratory of Diagnosis and Treatment of Digestive system Tumors of Zhejiang Province Ningbo 315100China

Alzheimer's disease is a neurodegenerative disease with complex *** microbiota influences the gutbrain axis,which may affect pathways related to the pathogenesis of Alzheimer's ***,diet and physical activity are likely to affect the pathology of Alzheimer's disease as well as the gut *** demonstrates that it may be possible to prevent or halt the progression of Alzheimer's disease by regulating the gut microbiota using diet and physical activity ***,the present study reviews the association between these two interventions and gut microbiota in the human *** also summarizes how these two interventions benefit Alzheimer's ***,the primary limitations of these two interventions are discussed and promising strategies are proposed,which may be beneficial to further study and develop the intervening measure for the progression of Alzheimer's disease.

关键词： Alzheimer’s disease Gut microbiota Brain-gut axis Diet Physical activity

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