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L-Norvaline, a new therapeutic agent against Alzheimer’s disease

Neural Regeneration Research 2019年第9期14卷 1562-1572页

作者： Baruh Polis Kolluru D.Srikanth vyacheslav Gurevich Hava Gil-Henn abraham O.Samson Drug Discovery Laboratory The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael Laboratory of Cell Migration and Invasion The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael Laboratory of Cancer Personalized Medicine and Diagnostic Genomics The Azrieli Faculty of MedicineBar-Ilan UniversitySafedIsrael

Growing evidence highlights the role of arginase activity in the manifestation of Alzheimer’s disease(AD).Upregulation of arginase was shown to contribute to *** of arginase activity appears to be a promising approach for interfering with the pathogenesis of ***,the enzyme represents a novel therapeutic *** this study,we administered an arginase inhibitor,L-norvaline(250 mg/L),for 2.5 months to a triple-transgenic model(3×Tg-AD)harboring PS1M146v,APPSwe,and tauP301L ***,the neuroprotective effects of L-norvaline were evaluated using immunohistochemistry,proteomics,and quantitative polymerase chain reaction ***,we identified the biological pathways activated by the ***,L-norvaline treatment reverses the cognitive decline in AD *** treatment is neuroprotective as indicated by reduced beta-amyloidosis,alleviated microgliosis,and reduced tumor necrosis factor transcription ***,elevated levels of neuroplasticity related postsynaptic density protein 95 were detected in the hippocampi of mice treated with ***,we disclosed several biological pathways,which were involved in cell survival and neuroplasticity and were activated by the *** these modes of action,L-norvaline has the potential to improve the symptoms of AD and even interferes with its *** such,L-norvaline is a promising neuroprotective molecule that might be tailored for the treatment of a range of neurodegenerative *** study was approved by the Bar-Ilan University Animal Care and Use Committee(approval No.82-10-2017)on October 1,2017.

关键词： dementia arginase inhibition arginine urea cycle microgliosis neuroinflammation cytokines tumor necrosis factor mTOR neurodegeneration

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Study of linseed oil,its biodiesel and xylene as flow improver for Nigerian waxy crude oils

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Petroleum Research 2022年第1期7卷 138-143页

作者： Ogunkunle Temitope Fred abraham victoria Damilola Adebisi Abimbola Ashonibare Rukayat Adenike Tega-oboh Elohor Sylvia Petroleum Engineering Department Covenant UniversityOtaOgun StateNigeria Chemistry Department Covenant UniversityOtaOgun StateNigeria Nigerian Stored Products Research Institute Asa Dam RoadIlorinKwara StateNigeria

In this study,the physicochemical properties of linseed and linseed biofuel were studied and their effect on the flow properties of Nigerian waxy crude oil at different volume fractions was *** Nigerian wax crude oil was characterized for its specific gravity,API gravity,wax content,pour point and cloud *** properties of the linseed oil and linseed biodiesel investigated include:density,specific gravity,viscosity,pour point,cloud point and flash *** esterification of the free fatty acid(FFA)contained in the linseed oil reduced from 3.5 to 0.75 and the viscosity of the seed oil reduces from 2169 to 362 mm^(2)/*** linseed oil and its biodiesel exhibited similar trend of reduced viscosity at higher shear rate,however,linseed biodiesel demonstrated the lowest viscosities,cloud points and pour points owing to reduced fatty *** effect of the linseed oil and its biodiesel on the pour point and cloud point of the waxy crude oil was determined;and the performance compared to that of xylene.A rapid drop in the pour point and cloud point was observed with the wax crude pre-heated with 0.1 v/v linseed oil,its biodiesel and xylene.

关键词： Seed oils Cloud point Rheological properties Pour point viscosity Waxy crude oil

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Analysis of Flow Dynamics in the High-Flux Gas-Solid Riser Using Trajectory Distances across Attractors Reconstructed from Solid Concentration Signals

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Engineering（科研） 2018年第10期10卷 688-703页

作者： Justin M. Jeremiah Samwel v. Manyele abraham K. Temu Jesse-X. Zhu Department of Chemical and Mining Engineering University of Dar es Salaam Dar es Salaam Tanzania Department of Chemical and Biochemical Engineering University of Western Ontario London ON Canada

The study of the entrance and wall dynamics of a high-flux gas-solid riser was conducted using trajectory distances of the reconstructed attractors from solid concentration signals collected from a 76 mm internal diameters and 10 m high riser of a circulating fluidized bed (CFB) system. The riser was operated at 4.0 to 10.0 m/s gas velocity and 50 to 550 kg/m2s solids flux. Spent fluid catalytic cracking (FCC) catalyst particles with 67 μm mean diameter and density of 1500 kg/m3 together with 70% to 80% humid air was used. Solid concentration data were analyzed using codes prepared in FORTRAN 2008 to get trajectories of the reconstructed attractors and their distances apart. Trajectory distances were found to increase from the centre towards the wall indicating the expansion of the attractor. The probability density function (PDF) of the trajectory distances changes from single peak at the centre to multiple peaked profiles in the wall region. Multiple peaked profiles indicate multifractal flow behaviours. Cumulative distribution functions (CDF) of the trajectory distances changes from single S-shaped at the centre to multiple S-shaped profiles in some locations of the wall region indicating multifractal flow behaviours. The PDF distribution of these distances at the entrance section and in the wall region forms different types of statistical distributions showing differences in gas-solid flow structures in various spatial locations of the wall region and the entrance sections. Most of the distributions at the centre fall under the Gumbel max distribution for all flow development sections of the riser, especially at air velocities of 5.5 m/s and 8 m/s showing uniform flow structures. Further, it was found that increase of the number of the phase space reconstruction embedding dimension increases the trajectory distances between the state vectors leading to the expansion of the attractor.

关键词： Trajectory Distance Probability Density Function Cumulative Distribution Function Euclidian Distance High-Flux Riser

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Mapping the Wall-Region Dynamics of High-Flux Gas-Solid Riser Using Scaling Regions from the Solid Concentration Time Series

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Engineering（科研） 2019年第1期11卷 74-92页

An experimental study of the gas-solid flow dynamics in the high-flux CFB riser was accomplished by analysing the scaling regions from solid concentration signals collected from a 76 mm internal diameters and 10 m high riser of a circulating fluidized bed (CFB) system. The riser was operated at 4.0 to 10.0 m/s gas velocity and 50 to 550 kg/m2s solids flux. Spent fluid catalytic cracking (FCC) catalyst particles of 67 μm mean diameter and 1500 kg/m3 density together with 70% to 80% humid air was used. Solid concentration data were analysed using codes prepared in FORTRAN 2008 to get correlation integrals at different embedding dimensions and operating conditions and plot their profiles. Scaling regions were identified by visual inspection method and their location on planes determined. Scaling regions were analysed based on operating conditions and riser spatial locations. It was found that scaling regions occupy different locations on the plane depending on the number of embedding dimensions and operating conditions. As the number of embedding dimensions increases the spacing between scaling regions decreases until it saturates towards higher embedding dimensions. Slopes of scaling regions increases with embedding dimensions until saturation where they become constant. Slopes of scaling regions towards the wall decrease while the number of scaling regions for a particular profile increases. The span of the scaling region is wider at the initial values of hyperspherical radius than its final values. The scaling regions in some flow development sections show multifractal behaviour for each embedding dimension which manifests into visible basin which is defined in this study as multifractal basin. Further, the end points of the scaling region for each correlation integral profile differ from each other as the embedding dimension changes. This study suggests that identification of scaling region by visual inspection method is useful in understanding the gas-solid flow d

关键词： Scaling Region Correlation Integral Correlation Dimension Embedding Dimensions Multifractal Basin High-Flux Riser

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Mapping Correlation Dimension along the Wall Region of a High-Flux Gas-Solid Riser Using Embedded Solid Concentration Time Series

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Engineering（科研） 2018年第10期10卷 655-679页

Analysis of the entrance and wall dynamics of a high-flux gas-solid riser was conducted using embedded solid concentration time series collected from a 76 mm internal diameter and 10 m high riser of a circulating fluidized bed (CFB) system. The riser was operated at 4.0 to 10.0 m/s air velocity and 50 to 550 kg/m2s solids flux of spent fluid catalytic cracking (FCC) catalyst particles with 67 μm mean diameter and density of 1500 kg/m3. Data were analyzed using prepared FORTRAN 2008 code to get correlation integral followed by determination of correlation dimensions with respect to the hyperspherical radius and their profiles, plots of which were studied. It was found that correlation dimension profiles at the centre have single peak with higher values than the wall region profiles. Towards the wall, these profiles have double or multiple peaks showing bifractal or multifractal flow behaviors. As the velocity increases the wall region profiles become random and irregular. Further it was found that, as the height increases the correlation dimension profiles shift towards higher hyperspherical radius at the centre and towards lower hyperspherical radius in the wall region at r/R = 0.81. The established method of mapping correlation dimension profiles in this study forms a suitable tool for analysis of high-flux riser dynamics compared to other analyses approaches. However, further analysis is recommended to other gas-solid CFB riser of different dimensions operated at high-flux conditions using the established method.

关键词： Correlation Integral Mapping Correlation Dimension High-Flux Gas-Solid Riser Embedded Solid Concentration Time Series

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Investigation of Entrance and Wall Dynamics of the High-Flux Gas-Solid Riser Using Statistical Analysis of Solids Concentration Signals

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Engineering（科研） 2019年第3期11卷 167-187页

Statistical analysis of the entrance and wall dynamics of a high-flux gas-solid riser was done using solid concentration time series data collected from a 76 mm internal diameter and 10 m high riser of a CFB system with a twin-riser operated at 4.0 to 10.0 m/s gas velocity and 50 to 550 kg/m2s solids flux. Spent fluid catalytic cracking catalyst particles with 67 μm mean diameter and density of 1500 kg/m3 together with 70% to 80% humid air was used. Solid concentration data were analysed using code prepared using FORTRAN 2008 to get statistical parameters and plot their profiles. Results obtained show that the gas-solid suspension flow in the riser is dominated by low solid concentration in the centre region and high solid concentration in the wall region which forms a core-annulus flow structure. The mean solid concentration in the wall region decreases with riser height from the dense bottom section to less dense in the fully developed flow section at the top of the riser. The gas-solid suspension flow in the centre region is dominated with uniform flow structure while the wall region is dominated with high fluctuations in solid concentration. Further, it was found that the entrance and developing flow sections of the riser exhibit high flow non-uniformities than the fully developed flow section of the riser. The flow non-uniformities in the entrance and developing flow section increase with increase in superficial gas velocity at constant solid flux. The wall region, from the entrance to the top sections of the riser along the axial direction exhibits both dilute and dense suspension flow.

关键词： Entrance Section Wall Region Statistical Analysis Flow Non-Uniformities Radial Non-Uniformity Index

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Morphological characterization and habitat suitability modeling of the goat population of Benin under climate change scenarios

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Ecological Processes 2022年第1期11卷 631-653页

作者： Habib Rainier vihotogbe Whannou Cossi Ulriche Afatondji Côme Agossa Linsoussi Gnimansou abraham Favi Thanh Thi Nguyen Marcel Romuald Benjamin Houinato Luc Hippolyte Dossa Ecole des Sciences et Techniques de Production Animale Facultédes Sci-ences AgronomiquesUniversitéd’Abomey-CalaviAbomey-CalaviBénin Laboratoire d’Ecologie Appliquée Facultédes Sciences AgronomiquesUni-versitéd’Abomey-CalaviAbomey-CalaviBénin Laboratoire de Botanique et Ecologie végétale Facultédes Sciences et TechniquesUniversitéd’Abomey-CalaviAbomey-CalaviBénin Organic Plant Production and Agroecosys-tems Research in the Tropics and Subtropics Organic Agricultural SciencesUniversity of KasselWitzenhausenGermany.

Background:Insufficient knowledge of the genetic and phenotypic diversity in the local Beninese goat population combined with the lack of understanding of its adaptive capacity to ongoing environmental and societal changes hampers the development of strategies for better management and genetic *** objective of this study was to establish the current geographical distribution of goats in Benin based on their morphology and model the potential habitat suitability of the three known main goat phenotypes(i.e.,Djallonkégoat or TypeⅠ,Sahelian goat or TypeⅡ,and their Crossbreeds or TypeⅢ)under climate change *** qualitative and 26 linear body measurements were taken on 2114 adult female goats sampled across the three vegetation zones of the *** ratios were generated from the quantitative *** data were analyzed using generalized linear model procedures followed by multiple comparisons of least-squares means and multivariate analytical methods,including canonical discrimination analysis and hierarchical ascendant *** goat was then assigned to one of the three aforementioned main goat phenotypes following its morphological characteristics and according to the a priori cluster membership defined in the previous *** Maximum Entropy algorithm was used to model the current and future distribution of the three goat phenotypes under climate change scenario using the Representative Conservation Pathways 4.5 and ***:All linear body measurements varied among vegetation *** the discriminant function analysis,71%of the measured individuals were correctly classified in their vegetation zone of origin by seven measured variables and three *** cluster procedure analysis revealed two groups of goats subdivided into the three main *** modeling results showed that the currently highly favorable habitats were distributed in the South for TypeⅠ,in the North for TypeⅡ,and both South and North for Type

关键词： Capra hircus Climate change Ecological niche modeling Farm animal species MaxEnt model Morphology

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Mapping soil nutrients via different covariates combinations:theory and an example from Morocco

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Ecological Processes 2022年第1期11卷 302-318页

作者： Kingsley John Yassine Bouslihim Isong abraham Isong Lahcen Hssaini Rachid Razouk Ndiye M.Kebonye Prince C.Agyeman vit Penížek Tereza Zádorová Department of Soil Science and Soil Protection Faculty of AgrobiologyFoodand Natural ResourcesCzech University of Life SciencesKamýcká12916500 PragueCzech Republic National Institute of Agricultural Research RabatMorocco Department of Soil Science University of CalabarCalabarNigeria

Background:Mapping of soil nutrients using different covariates was carried out in northern *** study was undertaken in response to the region’s urgent requirement for an updated soil *** aimed to test various covariates combinations for predicting the variability in soil properties using ordinary kriging and kriging with external ***:A total of 1819 soil samples were collected at a depth of 0–40 cm using the 1-km grid sampling *** were screened for their pH,soil organic matter(SOM),potassium(K_(2)O),and phosphorus(P_(2)O_(5))using standard laboratory *** attributes(T)computed using a 30-m resolution digital elevation model,bioclimatic data(C),and vegetation indices(v)were used as covariates in the *** targeted soil property was modeled using covariates separately and then combined(e.g.,pH~T,pH~C,pH~v,and pH~T+C+v).k=tenfold cross-validation was applied to examine the performance of each employed *** statistical parameter RMSE was used to determine the accuracy of different ***:The pH of the area is slightly above the neutral level with a corresponding 7.82%of SOM,290.34 ppm of K_(2)O,and 100.86 ppm of P_(2)O_(5).This was used for all the selected targeted soil *** a result,the studied soil properties showed a linear relationship with the selected ***,SOM,and K 2O presented a moderate spatial autocorrelation,while P2O5 revealed a strong *** cross-validation result revealed that soil pH(RMSE=0.281)and SOM(RMSE=9.505%)were best predicted by climatic variables.P_(2)O_(5)(RMSE=106.511 ppm)produced the best maps with climate,while K_(2)O(RMSE=209.764 ppm)yielded the best map with terrain ***:The findings suggest that a combination of too many environmental covariates might not provide the actual variability of a targeted soil *** demonstrates that specific covariates with close relationships with certain soil properties might perform bet

关键词： Soil mapping Environmental variables Agriculture Soil properties Soil management

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Environmental, morphological and physiological factors analyzes for optimization of potato (<i>Solanum tuberosum</i>L.) microtuber <i>in vitro</i>germination

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Advances in Bioscience and Biotechnology 2013年第11期4卷 986-992页

作者： abraham Dieme Mame Ourèye Sy Laboratoire Campus de Biotechnologies végétales Département de Biologie Végétale Faculté des Sciences & Techniques Uni- versité Cheikh Anta Diop B.P. 5005 Dakar-Fann Sénégal

The microtuber is considered one of the most effective means of spreading basic materials, as well as transporting and preserving potato germplasm varieties. To define the optimal conditions for the potato microtuber in vitro germination of Aida, Atlas and Odessa varieties, the effects of temperature, physiological age and grade (size) were evaluated. The study conducted at three different temperature levels has demonstrated that the most favorable temperature for microtuber germination at a higher and faster germination rate was 25℃, regardless of the variety. In addition, microtubers of large caliber, greater than 4 mm, germinate more quickly, with a higher germination rate, than smaller size ones (less than 4 mm) for all genotypes. For Atlas, Aida and Odessa varieties, a germination rate equal to 86.66%, 70% and 70% respectively, was obtained for microtubers with a caliber superior to 4 mm. Physiological age influences microtuber germination. The mean length of sprouts, reached after a 7 week incubation period, was more marked at “multiple sprout” and “branched sprout” stages than at a “monosprout” stage. The average length was 2.35 cm, 2.48 cm and 1.5 cm, respectively. Thus, it is necessary to plant microtubers at a “multiple sprout” stage to optimize their yield in plants and minitubers.

关键词： Solanum tuberosum Microtubers In vitro Germination Temperature Size Physiological Age

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Risk of hepatitis B reactivation in patients with myeloproliferative neoplasms treated with ruxolitinib

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World Journal of Hepatology 2023年第11期15卷 1188-1195页

作者： Adeniyi abraham Adesola Matei-Alexandru Cozma Yong-Feng Chen Bahadar Singh Srichawla Mihnea-Alexandru Găman Department of Medicine and Surgery Faculty of Clinical SciencesCollege of MedicineUniversity of IbadanIbadanNigeria Faculty of Medicine "Carol Davila"University of Medicine and PharmacyBucharest 050474Romania Department of Gastroenterology Colentina Clinical HospitalBucharest 020125Romania Department of Basic Medical Sciences Medical College of Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Neurology University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Hematology Center of Hematology and Bone Marrow TransplantationFundeni Clinical InstituteBucharest 022328Romania Cellular and Molecular Pathology Department Stefan S.Nicolau Institute of VirologyRomanian AcademyBucharest 030304Romania

Classical Philadelphia-negative myeloproliferative neoplasms(MPNs),i.e.,polycythemia vera,essential thrombocythemia,and primary/secondary myelofibrosis,are clonal disorders of the hematopoietic stem cell in which an uncontrolled proliferation of terminally differentiated myeloid cells *** are characterized by mutations in driver genes,the JAK2v617F point mutation being the most commonly detected genetic alteration in these hematological ***,JAK inhibition has emerged as a potential therapeutic strategy in MPNs,with ruxolitinib being the first JAK inhibitor developed,approved,and prescribed in the management of these blood ***,the use of ruxolitinib has been associated with a potential risk of infection,including opportunistic infections and reactivation of hepatitis ***,we briefly describe the association between ruxolitinib treatment in MPNs and hepatitis B reactivation.

关键词： Ruxolitinib Myeloproliferative neoplasms Hepatitis B Polycythemia vera Myelofibrosis JAK inhibitor

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