检索结果-南通市图书馆

Pegylated interferon alfa-2b plus ribavirin for treatment of chronic hepatitis C

World Journal of Hepatology 2014年第7期6卷 520-526页

作者： PN Rao abraham koshy Jacob Philip Narayanan Premaletha Joy Varghese Krishnasamy Narayanasamy Samir Mohindra Nitin Vikas Pai Manoj Kumar Agarwal Ashokna Konar Hasmukh B Vora Department of Gastroenterology Asian Institute of Gastroenterology Hyderabad 500082 India Department of Hepatology Lakeshore Hospital Kochi 682040 India Department of Gastroenterology Cosmopolitan Hospital Thiruvananthapuram 695004 India Department of Gastroenterology Medical College Thiruvananthapuram 695011 India Department of Hepatology Global Hospitals and Health City Chennai 600100 India Department of Hepatology GGHand MMC Chennai 600003 India Department of Gastroenterology SGPGIMS Lucknow 226014 India Department of Gastroenterology Pai Clinic and Diagnostic Center Pune 411005 India Department of Gastroenterology Belle Vue Clinic Kolkata 700017 India Department of Gastroenterology PeerlessHospital and B.K. Roy Research Center Kolkata 700094 India Department of Gastroenterology Alka Hospital Ahmedabad 380019 India

AIM: To study the safety and efficacy of pegylated interferon alfa-2b, indigenously developed in India, plus ribavirin in treatment of hepatitis C virus(HCV). METHODS: One-hundred HCV patients were enrolled in an open-label, multicenter trial. Patients were treated with pegylated interferon alfa-2b 1.5 μg/kg per week subcutaneously plus oral ribavirin 800 mg/d for patients with genotypes 2 and 3 for 24 wk. The same dose of peginterferon plus weight-based ribavirin(800 mg/d for ≤ 65 kg; 1000 mg/d for > 65-85 kg; 1200 mg/d for > 85-105 kg; 1400 mg/d for > 105 kg body weight) was administered for 48 wk for patients with genotypes 1 and 4. Serological and biochemical responses of patients were ***: Eighty-two patients(35 in genotypes 1 and 4 and 47 in 2 and 3), completed the study. In genotype 1, 25.9% of patients achieved rapid virologic response(RVR): while the figures were 74.1% for early virologic response(EVR) and 44.4% for sustained virologic response(SVR). For genotypes 2 and 3, all patients bar one belonged to genotype 3, and of those, 71.4%, 87.5%, and 64.3% achieved RVR, EVR, and SVR, respectively. In genotype 4, 58.8%, 88.2%, and 52.9% of patients achieved RVR, EVR, and SVR, respectively. The majority of patients attained normal levels of alanine aminotransferase by 4-12 wk of therapy. Most patients showed a good tolerance for the treatment, although mild-to-moderate adverse events were exhibited; only two patients discontinued the study medication due to serious adverse events(SAEs). Eleven SAEs were observed in nine patients; however, only four SAEs were related to study ***: Peginterferon alfa-2b, which was developed in India, in combination with ribavirin, is a safe and effective drug in the treatment of HCV.

关键词： Hepatitis C virus Genotype Peginterferon alfa-2b Ribavirin Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Introducing robustness in model predictive control with multiple models and switching

引用

Control Theory and Technology 2014年第3期12卷 284-303页

作者： Sachin PRABHU koshy GEORG Department of Telecommunication Engineering PES Institute of Technology Bangalore 560085 India PES Centre for Intelligent Systems Bangalore 560085 IndiaE

Model predictive control is model-based. Therefore, the procedure is inherently not robust to modelling uncertainties. Further, a crucial design parameter is the prediction horizon. Only offline procedures to estimate an upper bound of the optimal value of this parameter are available. These procedures are computationally intensive and model-based. Besides, a single choice of this horizon is perhaps not the best option at all time instants. This is especially true when the control objective is to track desired trajectories. In this paper, we resolve the issue by a time-varying horizon achieved by switching between multiple model-predictive controllers. The stability of the overall system is discussed. In addition, an introduction of multiple models to handle modelling uncertainties makes the overall system robust. The improvement in performance is demonstrated through several examples.

关键词： Receding horizon control Time-varying horizon Multiple models Switching Tracking Robustness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adaptive control of a class of nonlinear time-varying systems with multiple models

引用

Control Theory and Technology 2016年第4期14卷 323-334页

作者： koshy GEORGE Karpagavalli SUBRAMANIAN PES Centre for Intelligent Systems Department of Telecommunication Engineering PES Institute of Technology Bangalore India PES Centre for Intelligent Systems Department of Electronics and Communication Engineering PES University Bangalore India

The adaptive control of nonlinear systems that are linear in the unknown but time-varying parameters are treated in this paper. Since satisfactory transient performance is an important factor, multiple models are required as these parameters change abruptly in the parameter space. In this paper we consider both the multiple models with switching and tuning methodology as well as multiple models with second level adaptation for this class of systems. We demonstrate that the latter approach is better than the former.

关键词： Nonlinear time-varying systems adaptive control multiple models

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prediction and optimization of process parameter of friction stir welded AA5083-H111 aluminum alloy using response surface methodology

引用

Journal of Central South University 2012年第1期19卷 1-8页

作者： R.Palanivel P.koshy Mathews Department of Mechanical Engineering Kalaivani College of TechnologyCoimbatoreIndia Research and Development Department of Mechanical EngineeringKalaivani College of TechnologyCoimbatoreIndia

A systematic approach was presented to develop the empirical model for predicting the ultimate tensile strength of AA5083-H111 aluminum alloy which is widely used in ship building industry by incorporating friction stir welding(FSW) process parameters such as tool rotational speed,welding speed,and axial *** was carried out considering three-factor five-level central composite rotatable design with full replications *** surface methodology(RSM) was applied to developing linear regression model for establishing the relationship between the FSW process parameters and ultimate tensile *** of variance(ANOVA) technique was used to check the adequacy of the developed *** FSW process parameters were also optimized using response surface methodology(RSM) to maximize the ultimate tensile *** joint welded at a tool rotational speed of 1 000 r/min,a welding speed of 69 mm/min and an axial force of 1.33 t exhibits higher tensile strength compared with other joints.

关键词： friction stir welding design expert design of experiments analysis of variance (ANOVA) response surfacemethodology (RSM) optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Establishing two-stage interaction between fly ash and NaOH by X-ray and infrared analyses

引用

Frontiers of Environmental Science & Engineering 2015年第2期9卷 216-221页

作者： Bhagwanjee JHA Nevin koshy Devendra Narain SINGH Civil Engineering Department Indian Institute of Technology Bombay Mumbai 400076 India

The interaction of the fly ash and NaOH, in an open reflux hydrothermal system at 100℃, has been explored by several researchers and formation of fly ash zeolites has been confirmed based on the X-ray diffraction analysis of the residues. However, this method does not reveal much about the characteristic transitions （viz. elemental, electro-negativity and cation exchange capa- city） of the residues. In this situation, resorting to Fourier transform-infrared radiation （FT-IR） spectroscopy on the residues obtained from two-stage hydrothermal treatment process, described in this manuscript, appears to be a novel idea to establish transitions in chemical bonds （viz., -Si- OH-AI-, OH-Na, OH-A1-）, crystallinity and cation exchange capacity of these residues. Based on extensive studies, it has been demonstrated that FT-IR spectroscopy is extremely useful for 1） detection of chemical bonds in the residues, 2） evaluation of zeolites in the residues and 3） also establishing the superiority of the two-stage interac- tion of the fly ash with NaOH for synthesizing better fly ash zeolites （viz., Na-P1 and Hydroxysodalte） as compared to those obtained from the conventional single-stage treatment of the fly ash.

关键词： hydrothermal treatment alkali activation flyash zeolites X-ray diffraction (XRD) and Fourier transform-infrared radiation (FT-IR) spectroscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of process parameters to maximize ultimate tensile strength of friction stir welded dissimilar aluminum alloys using response surface methodology

引用

Journal of Central South University 2013年第11期20卷 2929-2938页

作者： R.Palanivel P.koshy Mathews N.Murugan Kalaivani College of Technology Coimbatore Institute of Technology

Aluminium alloys generally present low weldability by traditional fusion welding process. Development of the friction stir welding （FSW） has provided an alternative improved way of producing aluminium joints in a faster and reliable manner. The quality of a weld joint is stalwartly influenced by process parameter used during welding. An approach to develop a mathematical model was studied for predicting and optimizing the process parameters of dissimilar aluminum alloy （AA6351 T6-AA5083 Hlll）joints by incorporating the FSW process parameters such as tool pin profile, tool rotational speed welding speed and axial force. The effects of the FSW process parameters on the ultimate tensile strength （UTS） of friction welded dissimilar joints were discussed. Optimization was carried out to maximize the UTS using response surface methodology （RSM） and the identified optimum FSW welding parameters were reported.

关键词： frictions stir welding dissimilar aluminum alloy tool pin profile design of experiments RSM material flow behavior optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

引用

Journal of Semiconductors 2015年第12期36卷 24-29页

作者： Jiji koshy Soosen Samuel.M Anoop Chandran K.C.George Department of Physics S.B.College

The ac conduction mechanism in copper oxide nanoparticles with 8 nm size, synthesized by a precipitation method was studied by analyzing ac conductivity in the frequency range of 50 Hz-1 MHz and in the temperature range of 373-573 K. X-ray diffraction and transmission electron microscopy （TEM） were employed for the structural and morphological characterization of CuO nanoparticles. The experimental and theoretical in- vestigations suggested that the ac conduction mechanism in CuO nanoparticles can be successfully explained by a correlated barrier hopping model, which provided reasonable values for the maximum barrier height and characteristic relaxation time. It was also found that bipolaron hopping become prominent up to a particular temperature and beyond that single polaron hopping predominates. Physical parameters such as hopping distance and density of defect states were also calculated. Photoluminescence studies confirm the presence of a surface defect in CuO nanoparticles.

关键词： CuO nanoparticles correlated barrier hopping defect states photoluminescence spectrum single polaron hopping

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of La3+ ion in the yttria matrix in improving the microhardness of infrared transparent nano LaxY2-xO3 sintered via hybrid heating

引用

Journal of Advanced Ceramics 2017年第3期6卷 240-250页

作者： Jijimon K. THOMAS Mathew C. T. Jacob koshy Sam SOLOMON Electronic Materials Research Laboratory Department of Physics Mar Ivanios College Thiruvananthapuram 695015 Kerala India

In the present work, hybrid sintering technique which couples the resistive heating and microwave heating is employed to sinter infrared transparent La0.15Y1.85O3 to 99.2% of the theoretical density for the first time to the best of our knowledge. The presence of La3+ in the yttria matrix improves the hardness properties to a greater extent without affecting the transmittance properties, but there is a deterioration in the thermal properties of the sample. So we have limited our studies to La0.15Y1.85O3 which shows better optical, thermal, and hardness properties. The pellets fabricated from the ultra-fine nano powder with average particle size of ~12 nm synthesized by combustion technique and sintered at 1430 ℃ with an average grain size of 0.22 μm show ~80.1% transmittance in the UV–visible region and 81% in mid infrared region. For a comparative study of the optical, mechanical, and thermal properties, two other variants of sintering strategies namely conventional sintering and microwave sintering are also employed. A comprehensive analysis on the hardness reveals that the hardness of the pellets sintered via hybrid heating is 9.73 GPa and is superior to the pellets sintered using the other two techniques. The thermal conductivity of the sample is also analyzed in detail. The results clearly indicate that the La0.15Y1.85O3 ultra-fine nano powder synthesised by the single-step combustion method and sintered via microwave hybrid heating shows better transmittance properties without compromising the mechanical properties, and can be used very effectively for the fabrication of infrared transparent windows and domes.

关键词： La3+ concentration microhardness hybrid sintering infrared transparent ceramics thermal conductivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modulated orientation-sensitive terahertz spectroscopy

引用

Photonics Research 2016年第3期4卷 1-8页

作者： Rohit Singh Deepu koshy George Chejin Bae K.A.Niessen A.G.Markelz Department of Physics and Astronomy Depauw University Department of Physics Virginia Tech Department of Electrical Engineering University at Buffalo Department of Physics University at Buffalo

Intramolecular vibrations of large macromolecules reside in the terahertz range. In particular, protein vibrations are closely spaced in frequency, resulting in a nearly continuous vibrational density of states. This density of vibrations interferes with the identification of specific absorption lines and their subsequent association with specific functional motions. This challenge is compounded with the absorption being dominated by the solvent and local relaxational motions. A strategy for removing the isotropic relaxational loss and isolating specific vibrations is to use aligned samples and polarization-sensitive measurements. Here, we demonstrate a technique to rapidly attain the anisotropic resonant absorbance using terahertz time domain spectroscopy and a spinning sample. The technique, modulated orientation-sensitive terahertz spectroscopy(MOSTS), has a nonzero signal only for anisotropic samples, as demonstrated by a comparison between a silicon wafer and a wire grid polarizer. For sucrose and oxalic acid molecular crystals, the MOSTS response is in agreement with modeled results for the intermolecular vibrations. Further, we demonstrate that, even in the presence of a large relaxational background, MOSTS isolates underlying vibrational resonances.

关键词： THz Modulated orientation-sensitive terahertz spectroscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Achieving higher strength in Cu–Ag–Zr alloy by warm/hot rolling

引用

Rare Metals 2017年第4期36卷 263-267页

作者： S. Chenna Krishna Abhay K. Jha Bhanu Pant koshy M. George Materials and Mechanical Entity Vikram Sarabhai Space Centre Trivandrum 695022 India

High-strength Cu-3Ag-0.5Zr alloy plates were produced by multi-pass rolling in the temperature range of 500-800 ℃. An increase in strength was observed by rolling in the aforementioned range without significant loss in ductility. All the rolled samples show higher strength than solution-treated and aged samples. The maximum strength was observed for plates rolled at 500 ℃ with a yield strength and ultimate tensile strength of 311 and 385 MPa, respectively, and retaining a ductility of 23 %. Transmission electron microscopy （TEM） studies showed uniform distribution of fine silver precipitates and high dislocation density in the rolled samples. Nevertheless, the size of precipitates and dislocation density varied with the rolling temperature. The superior strength achieved in the rolled samples is attributed to grain refinement, dislocation strengthening, and precipitation hardening. This method can be employed to produce high-strength plates of pre- cipitation hardenable copper alloys.

关键词： Warm/hot rolling Higher strength Copperalloy Strengthening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：