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Human impact gradients via anthropogenic pollen indicators:insights gleaned from a case study in the Rif Mountains(Northern Morocco)

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Journal of Mountain Science 2024年第12期21卷 4223-4235页

作者： aboubakr boutahar Paloma Cariñanos GONZALEZ Zouhaire LAMRANI Abderrahmane MERZOUKI Biology Ecologyand Health LaboratoryDepartment of BiologyFaculty of Sciences of TetouanAbdelmalek Essaâdi UniversityTetouan 93002Morocco Department of Botany Faculty of PharmacyUniversity of GranadaGranada 18071Spain Andalusian Institute for Earth System Research(IISTA-CEAMA) University of GranadaGranada 18100Spain Biology Environmentand Sustainable Development LaboratoryENSAbdelmalek Essaadi UniversityTetouan 93000Morocco CANN-MED&BALDIYA CROPS SARL Tangier 90010Morocco

Understanding the relationship between modern pollen and vegetation is crucial for interpreting fossil pollen records and assessing human impact on the environment,both of which are essential for effective environmental management *** numerous studies on fossil pollen records in the Rif landscape,research specifically focusing on modern pollen and its implications for understanding human impact on the natural landscape is notably *** paper presents novel anthropogenic pollen indicators for the Rif Mountains and seeks to evaluate the gradients of human impact on the southern Mediterranean *** employed a combination of modern pollen analysis,vegetation survey,and ordination techniques,incorporating various environmental and land-use *** correspondence analysis(CCA)allowed us to evaluate the relationships between pollen types and environmental variables,helping us identify key anthropogenic pollen indicators associated with land use and human activities:Poaceae,Cannabist,Olea-t,and Asteraceae for cultivation;Brassicaceae,Genista-t,Poaceae,Asteraceae and Plantago-t,for grazing;Apiaceae,Urtica-t and Genista-t for slashing and ***,an anthropogenic index score(AIS)was calculated for each sampled *** analysis(CA)was then used to correlate each specific pollen type with levels of human impact as follows(a)low(e.g.,Cedrus atlantica-t,Quercus canariensis-t),(b)moderate(e.g.,Erica-t,Arbutus unedo-t,Eucalyptus-t),and(c)high(e.g.,Cannabis-t,Brassicaceae,Olea-t,Nicotiana-t).This paper enhances our comprehension of land-use dynamics and impact levels,providing essential insights for evaluating anthropogenic impact trends and human-induced changes in the Rif Mountains landscape.

关键词： Modern Pollen analysis Rif mountains Pollen indicators Human impact Northern Morocco Anthropogenic index score

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Environmental assessment of date(Phoenix doctylifera)production in Iran by life cycle assessment

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Information Processing in Agriculture 2018年第3期5卷 388-393页

作者： Reza Hesampour aboubakr Bastani Kobra Heidarbeigi Mechanical Engineering of Biosystems Department Ilam UniversityIlamIran

Environmental indicators have been considered as a main element of environmental impact assessments because of their role on decision and policy making in different fields of special environmental *** present study was conducted in order to evaluate date(Phoenix doctylifera)production in viewpoint of environmental indicators using life cycle assessment *** required information was collected by questionnaire and interview with farmers and experts in Khuzestan Province,*** SimaPro Software was used to calculate 11 different environmental indicators for producing one Tonne of the produced *** fuel,pesticides and nitrogen fertilizer had the highest shares in the studied environmental indicators.

关键词： Date Life cycle assessment Emissions Environmental indicators Khuzestan

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Serum vascular endothelial growth factor as a tumor marker for hepatocellular carcinoma in hepatitis C virus-related cirrhotic patients

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 600-611页

作者： Ahmed Alzamzamy Huda Elsayed Mona Abd Elraouf Hanan Eltoukhy Tarek Megahed Ashraf aboubakr Department of Gastroenterology and Hepatology Military Medical AcademyCairo 11841Egypt Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexCairo 11841Egypt Department of Internal Medicine Faculty of Medicine for GirlsAl-Azhar UniversityCairo 11311Egypt Department of Clinical Pathology Military Medical AcademyCairo 11311Egypt

BACKGROUND Hepatocellular carcinoma(HCC)accounts for 8.2%of all cancer-related deaths *** a vascular tumor,vascular endothelial growth factor(VEGF)plays a vital role in HCC pathogenesis,growth,and *** To determine the accuracy of serum VEGF and VEGF/platelet(PLT)as tumor markers in the early detection of HCC cases in patients with hepatitis C virus(HCV)-related liver *** We conducted a case-control study with HCV patients from the outpatient and inpatient hepatology *** were classified into three groups:(1)HCC group;(2)Cirrhosis group;and(3)HCV without cirrhosis(control group).Patients were clinically evaluated,and blood samples were drawn for the analysis;serum VEGF levels were measured by a specific VEGF human recombinant enzyme-linked immunosorbent assay *** from the three study groups were compared by the one-way analysis of variance or Kruskal-Wallis *** operating characteristic curves were constructed to determine the optimal cut-off values of alpha fetoprotein(AFP),VEGF,and VEGF/PLT that provided the best diagnostic *** sensitivity and specificity at the optimal cut-off value of each biomarker were then *** This study included one hundred patients(HCC,cirrhosis,and control groups:n=40,30,30,respectively).HCC patients had significantly higher serum VEGF and VEGF/PLT levels than the non-HCC groups(P=0.001).Serum VEGF and VEGF/PLT showed significant positive correlations with and HCC tumor size,stage,vascular invasion,and Child-Pugh ***,a VEGF cut-off the value of 250 pg/mL provided 80%sensitivity and 81.7%specificity for discriminating HCC patient from non-HCC ***,the ratio of VEGF/PLT provided sensitivity and specificity of 77.5%and 80%,respectively which is higher than the accuracy provided by *** combination of AFP,VEGF,and VEGF/PLT increases the accuracy of diagnosing HCC to>95%.CONCLUSION In HCV patients,serum VEGF and VEGF/PLT separ

关键词： Hepatocellular carcinoma Vascular endothelial growth factor Biomarkers Diagnosis

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Cystic pancreatic lesions,the endless dilemma

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World Journal of Gastroenterology 2021年第21期27卷 2664-2680页

作者： Hussein Hassan Okasha Abeer Awad Ahmed El-meligui Reem Ezzat Ashraf aboubakr Sameh AbouElenin Ramy El-Husseiny Ahmed Alzamzamy Department of Internal Medicine and Gastroenterology Hepatology UnitKasr Al-Aini HospitalsCairo UniversityCairo 11562Egypt Department of Internal Medicine and Gastroenterology Hepatology UnitAssuit UniversityAssuit 71515Egypt Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11441Egypt Department of Gastroenterology and Hepatology Military Medical AcademyCairo 11441Egypt Department of Hepatology and Tropical Medicine National Hepatology and Tropical Medicine Research Institute(NHTMRI)Cairo 11441Egypt

Cystic pancreatic lesions involve a wide variety of pathological entities that include neoplastic and non-neoplastic *** proper diagnosis,differentiation,and staging of these cystic lesions are considered a crucial issue in planning further *** are great challenges for their diagnostic *** our time,new emerging methods for this diagnosis have been *** ultrasonography-guided fine-needle aspiration cytology with chemical and molecular analysis of cyst fluid and EUS-guided fine needlebased confocal laser endomicroscopy,through the needle microforceps biopsy,and single-operator cho-langioscopy/pancreatoscopy are promising methods that have been used in the diagnosis of cystic pancreatic *** we discuss the diagnosis of cystic pancreatic lesions and the benefits of various diagnostic models.

关键词： Pancreatic cystic lesion Endoscopic diagnosis Endoscopic ultrasonography Cyst fluid markers Endoscopic ultrasonography-guided fine needle-based confocal laser endomicroscopy Through the needle microforceps biopsy Single operator cholangioscopy/pancreatoscopy

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Effect of Tilmicosin on Fetal Developments in Pregnant Female Albino Rats

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Pharmacology & Pharmacy 2016年第4期7卷 147-152页

作者： Seham Abo-Kora Amany El-Meleh Mohamd aboubakr Department of Pharmacology Faculty of Veterinary Medicine Benha University Toukh Egypt

The effect of tilmicosin on fetal development in pregnant female rats was investigated in this study. Forty pregnant female rats were divided into four groups (each of 10 female rats). Rats in the 1st, 2nd and 3rd groups were received tilmicosin at a dose of 20, 100, 200 mg/kg·b·wt/day orally from the 6th to 15th day of gestation respectively, while the 4th group received 0.5 ml distilled water orally for the same period of gestation and was used as control group. All the pregnant female rats were sacrificed on the 20th day of gestation and their fetuses were subjected to morphological, visceral and skeletal examinations. Tilmicosin at a dose 100, 200 mg/kg·b·wt significantly decreased the number of viable fetuses;the number of resorbed fetuses was increased, and induced retardation in growth of viable fetuses;some skeletal and visceral defects in these fetuses were observed and these effects were dose dependant. It could be concluded that tilmicosin caused some abnormalities and fetal defects, so it is recommended to avoid using pregnancy.

关键词： Tilmicosin Pregnancy Anomalies Fetus

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Bioequivalence Study of Two Oral Doxycycline Formulations (Doxysol<sup>®</sup>and Doxymed<sup>®</sup>) in Healthy Broiler Chickens

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Pharmacology & Pharmacy 2015年第1期6卷 1-8页

作者： Ahmed M. Soliman Mohamed aboubakr Mohamed El-Hewaity Department of Pharmacology Faculty of Veterinary Medicine Cairo University Giza Egypt Department of Pharmacology Faculty of Veterinary Medicine Benha University Qaliobiya Egypt Department of Pharmacology Faculty of Veterinary Medicine University of Sadat City Minoufiya Egypt

Aims: The present study was designed to assess the comparative bio-equivalence of Doxysol® and Doxymed® in healthy broiler chickens after oral administration of both products in a dose of 20 mg doxycycline/***. Materials and Methods: Twenty broiler chickens were divided into two groups. The first group was designed to study the pharmacokinetics of Doxysol, while the 2nd group was designed to study the pharmacokinetics of Doxymed. Each broiler chickens in both groups were injected intravenously with 20 mg doxycycline/***. Blood samples were obtained from the wing vein and collected immediately before and at 5, 15, 30 minute, 1, 2, 4, 6, 8, 12 and 24 hours after a single intravenous or oral administration. Results: Doxycycline in both products obeyed a two compartments open model following I.V. injection in a dose of 20 mg/***. The disposition kinetics of Doxysol® and Doxymed® following oral administration of 20 mg doxycycline base/***. revealed that the maximum blood concentration [Cmax.] were 4.70 and 4.65 μg/ml and attained at [tmax.] of 1.30 and 1.40 hours, respectively. Doxycycline in Doxysol® and Doxymed® was eliminated with half-lives [t0.5(β)] equal to 1.98 and 2.31 hours, respectively. The mean systemic bioavailability of doxycycline in Doxysol® and Doxymed® after oral administration in healthy chickens was 92.57 and 88.21%, respectively. Conclusion: Doxymed® is bioequivalent to Doxysol® since Cmax test/Cmax reference and AUCtest/AUCreference ratios were 99% and 90%, respectively.

关键词： Bioequivalence Doxycycline Broiler Chickens Pharmacokinetics

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Pinealectomy and Exogenous Melatonin Regulate Anxiety-Like and Depressive-Like Behaviors in Male and Female Wistar Rats

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Neuroscience & Medicine 2012年第4期3卷 394-403页

作者： El Mrabet Fatima Zahra Ouaaki Siham Mesfioui Abdelhalim El Hessni aboubakr Ouichou Ali Laboratory of Genetics Neuroendocrinology and Biotechnology Unit of Nervous and Endocrine Physiology Department of Biology Faculty of Sciences University Ibn Tofail Kenitra Morocco

The main objective of this work was to 1) study the influence of endogenous melatonin (Mel) abolishment via pinealectomy and 2) explore exogenous Mel effect on anxiety-like and depressive-like behavior in male and female rats. Rats were shamoperated (Sh) or pinealectomized (Px) and following subgroups were selected 1) Px/NaCl (0.9%) and Sh/NaCl (0.9%) : rats injected subcutaneously, once daily for 8 weeks, with saline solution NaCl (0.9%) as vehicle;2) Px/Mel (4 mg/Kg) and Sh/Mel (4 mg/Kg): Rats similarly injected with 4 mg/Kg of Mel. All animals were housed under a photoperiod of (LD:16/8). After different treatments animals were tested in the open-field test (OFT), elevated plus maze test (EPM) to determine anxiety-like behavior, and forced swimming test (FST) to evaluate depressive-like level. Our results revealed that level of anxiety-like and depressive-like behavior are significantly higher in Px/NaCl (0.9%) when compared to Sh/NaCl (0.9%) group, suggesting that pinelectomy induced an anxiogenic and depressant effects. The Px effects would be due to the absence of endogenous Mel synthesis and release. Additionally, we clearly demonstrated that the level of anxiety-like and depressive-like behavior are higher in Px/Mel (4 mg/Kg) and Sh/Mel when compared respectively to Px/NaCl (4 mg/Kg) and Sh/NaCl groups suggesting an anxiolytic and antidepressant effects of exogenous Mel. Behavioral responses were sex dependent since the difference between females and males, especially, after melatonin administration, were statistically significant. These experiments provide evidence that pinealectomy and Mel regulated emotionally behavior in male and female rats.

关键词： Pinealectomy Melatonin Sex Dependent Anxiety Depression Behavioral Tests

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Erosion and Toughening Mechanisms of Electroless Ni-P-Nano-NiTi Composite Coatings on API X100 Steel under Single Particle Impact

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Journal of Surface Engineered Materials and Advanced Technology 2019年第4期9卷 88-106页

作者： Marissa MacLean Zoheir Farhat George Jarjoura Eman Fayyad aboubakr Abdullah Mohammad Hassan Department of Mechanical Engineering Dalhousie University Halifax Canada Center for Advanced Materials Qatar University Doha Qater Physical Chemistry Department National Research Center Dokki Giza Egypt

The addition of superelastic NiTi to electroless Ni-P coating has been found to toughen the otherwise brittle coatings in static loading conditions, though its effect on erosion behaviour has not yet been explored. In the present study, spherical WC-Co erodent particles were used in single particle impact testing of Ni-P-nano-NiTi composite coatings on API X100 steel substrates at two average velocities—35 m/s and 52 m/s. Erosion tests were performed at impact angles of 30°, 45°, 60°, and 90°. The effect of NiTi concentration in the coating was also examined. Through examination of the impact craters and material response at various impact conditions, it was found that the presence of superelastic NiTi in the brittle Ni-P matrix hindered the propagation of cracks and provided a barrier to crack growth. The following toughening mechanisms were identified: crack bridging and deflection, micro-cracking, and transformation toughening.

关键词： Electroless Ni-P Composite Coating Superelastic NiTi Single Particle Impact Erosion Mechanisms Toughening

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The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones

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Neuroscience & Medicine 2012年第2期3卷 162-173页

作者： El Mrabet Fatima Zahra Lagbouri Ibtissam Mesfioui Abdelhalim El Hessni aboubakr Ouichou Ali Laboratory of Genetics Neuroendocrinology and Biotechnology Unit of Nervous and Endocrine Physiology Department of Biology Faculty of Sciences University Ibn Tofail Kenitra Morocco

The main objective of this study was to analyze the effects of sex, ovariectomy (Ovx) and orchidectomy (Orx) on antidepressant and anxiolytic effect of melatonin in forced swimming test, open field test and elevated plus maze test. Initially, 4 mg/kg of melatonin was daily administered, at 4:00 pm, to intact male and female rats during 8 weeks. Our results have shown that the effect of chronic injection of Mel is sex dependent in the three behaviors tests. Females rats have responded better than males in behavior test study after administration of melatonin, this difference between the sexes may be related to the action of sex hormones (androgens and estrogens) on behavior in males as well as in females. Secondly, to determine the possible interaction between Melatonin and steroid hormones, Ovx/sham female received Mel at dose of 4mg/kg alone or NaCl (0.9%) alone, and Orx/sham male received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone daily and during 8 weeks of treatment at 4:00 pm. All animals were tested in the open-field test, elevated plus maze test for anxiety behavior study, and forced swimming test for depression behavior study. Results revealed that Mel exerts an anxiolytic and antidepressant effects in the orchidectomized males and in intact females, confirming that the suppression of androgens by orchidectomy improved anxiolytic and antidepressant effects of melatonin in males. However in females, the suppression of estrogen by ovariectomy masked the antidepressant and anxiolytic effects of melatonin. Our results confirmed that the antidepressant and anxiolytic effects of melatonin are linked to sex hormones.

关键词： Melatonin Sex Dependent Anxiety Depression Behavior Tests Ovariectomy Orchidectomy Sex Hormones

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Cronkhite-Canada syndrome:First case report from Egypt and North Africa

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World Journal of Gastrointestinal Endoscopy 2022年第10期14卷 642-647页

作者： Ahmed Elsayed Alzamzamy Ashraf aboubakr Hussein H Okasha Abeer Abdellatef Shaimaa Elkholy Mahmoudd Wahba Mohamed Alboraie Hussein Elsayed Mohamed O Othman Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11711Egypt Department of Internal Medicine Division of GastroenterologyHepatology and EndoscopyCairo UniversityCairo 11311Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11311Egypt Department of Pathology Military Medical AcademyCairo 11711Egypt Department of Internal Medicine Baylor College of MedicineHoustonTX 77082United States

BACKGROUND Gastrointestinal(GI)polyposis is a rare condition in GI *** date about 500 cases of Cronkhite-Canada syndrome(CCS)have been reported *** SUMMARY We report a 60-year-old female patient who presented with dyspepsia,abdominal pain,and weight loss of 1-year *** physical examination showed alopecia and *** endoscopy revealed diffuse markedly thickened gastric mucosa involving the whole stomach with thickened gastric rugae and numerous polypoidal *** examination showed marked hyperplasia of the foveolar glands with inflammatory cell *** ultrasound showed a significantly hypertrophic mucosa and muscularis mucosa,while the submucosa and the muscularis propria were spared,favouring its benign *** showed multiple sessile polyps scattered at different parts of the *** examination revealed tubular adenomatous polyps with low-grade *** diagnoses included CCS,Menterier disease(MD),other polyposis syndromes,lymphoma,amyloidosis,and gastric *** presence of alopecia,nail dystrophy,GI polyposis,markedly thickened gastric mucosa and folds,abdominal pain,weight loss,and marked foveolar gland hyperplasia;all was in favour of *** was excluded due to sparing of the muscularis *** presence of colonic polyps and antral and duodenal infiltration,and the absence of hypoproteinaemia decreased the possibility for *** The patient was diagnosed as having CCS.

关键词： Gastrointestinal polyposis Thickened gastric mucosa Cronkhite-Canada syndrome Case report

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