检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水分管理和外源硒对水稻吸收累积铅的影响

环境科学 2018年第10期39卷 4759-4765页

作者：万亚男刘哲 aboubacar Younoussa camara 余垚王琪李花粉中国农业大学资源与环境学院农田土壤污染防控与修复北京市重点实验室北京100193

通过盆栽试验,研究了不同水分管理和外源亚硒酸盐的添加对水稻根际铅的动态变化和水稻吸收累积铅的影响.结果表明,淹水显著增加了根表铁膜对铅的吸附和根系对铅的吸收,淹水下苗期和成熟期水稻根系铅含量分别是非淹水处理时的4.2~8.5和1.... 详细信息

通过盆栽试验,研究了不同水分管理和外源亚硒酸盐的添加对水稻根际铅的动态变化和水稻吸收累积铅的影响.结果表明,淹水显著增加了根表铁膜对铅的吸附和根系对铅的吸收,淹水下苗期和成熟期水稻根系铅含量分别是非淹水处理时的4.2~8.5和1.4~1.5倍;淹水降低了地上部的铅分配,在苗期和成熟期分别降低85.9%~86.7%和51.8%~74.0%.加硒降低了土壤溶液、苗期水稻根系和地上部的铅含量以及成熟期水稻根表铁膜、根系和茎中的铅含量.与对照相比,淹水和非淹水下加硒处理使苗期水稻根系铅含量分别降低了5.4%~24.3%和2.7%~61.7%,使成熟期水稻根系铅含量分别降低了56.1%~64.1%和53.8%~63.2%.水稻籽粒中的铅含量在不同处理间无显著差异.因此,水分管理和外源硒的添加显著影响了水稻根系对铅的吸收,而对水稻籽粒对铅的累积无显著影响.

关键词：铅水稻水分管理亚硒酸盐吸收累积

幼鼠MTLE模型的建立及TLR4、IL-1β与其发病机制关系的初步探讨

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

幼鼠MTLE模型的建立及TLR4、IL-1β与其发病机制关系的初步探讨

作者： camara aboubacar Damaye（达玛伊）中南大学

学位级别：硕士

癫痫是小儿神经系统最常见疾病之一,主要表现为脑内局部或广泛的痫性放电引起反复、自发的痫样发作（包括痉挛或非痉挛性发作形式）。而且即使是成人癫痫,起病年龄在15岁以下者也接近50%。长期、频繁的癫痫发作可对患儿智能发育、学习... 详细信息

癫痫是小儿神经系统最常见疾病之一,主要表现为脑内局部或广泛的痫性放电引起反复、自发的痫样发作（包括痉挛或非痉挛性发作形式）。而且即使是成人癫痫,起病年龄在15岁以下者也接近50%。长期、频繁的癫痫发作可对患儿智能发育、学习记忆等造成永久性损害,因此控制癫痫发作不仅能有效改善患儿未来的工作和生活质量,也对减轻家庭和社会负担具有重要意义。随着抗癫痫新药的涌现和手术术式的改良,临床上一部分癫痫患儿经早期合理抗癫痫治疗后发作可得到有效控制,然而仍有1/3的癫痫患儿疗效难以令人满意,最终发展成为难治性癫痫（intractable epilepsy, IE）,严重影响患儿的智力发育。难治性癫痫中,以颞叶内侧癫痫（mesial temporal lobe epilepsy, MTLE）最为常见,其多数起源于颞叶海马,具有复杂部分运动性发作的临床特征,多在10岁左右发病,约占全部癫痫患儿的10～30%。迄今为止,仍有大约70%的MTLE患儿经药物治疗及手术治疗均未能取得满意的疗效。因此,深入探讨MTLE的发病机制,对于寻找新的药物治疗靶点和改善患儿预后具有重要意义。已有研究表明,海马是MTLE的解剖起源,以神经元坏死、丢失和胶质增生为主要特征的海马硬化是导致MTLE普遍难治的最常见且最具特异性的病因,其中海马神经元重组以及苔藓纤维出芽,形成异常神经网络是反复自发痫性发作（spontaneous recurrent seizures, SRS）的主要环节。目前认为MTLE合并海马硬化的形成原因与婴幼儿时期的海马区各种损伤（外伤、热性惊厥、癫痫持续状态等）有关,并在经历经数月至数年的潜伏期后出现导致自发痫性发作,但其具体机制尚不明确。当下对MTLE的研究多以成年动物模型和临床术后标本为基础,但绝大多数研究在疾病已完全形成的阶段进行,并不能反映病程中体内环境的动态性改变。而婴幼儿期神经系统损伤后所致的慢性MTLE是一个长期的动态过程,探明在此过程中引导癫痫发生的损伤因素,观察在自发痫性发作前这些损伤因素引起的病理过程,并研究大脑在癫痫各期的改变,对了解MTLE的病理生理特点及寻找新的药物治疗靶点至关重要。此外,发育期的大脑的结构与功能尚未发育成熟,与成熟的大脑比较,在癫痫致病因素、发生发展、临床和脑电图（EEG）表现、对抗癫痫药物的治疗反应性以及预后上亦存在很大区别。因此,有必要建立与小儿颞叶内侧癫痫发生发展相似的幼鼠慢性MTLE模型,这对研究海马发育早期阶段受损后产生成年期癫痫发作的发病机制及可能的早期干预措施有着十分重要的意义。以往对MTLE的机制研究主要集中在神经再生和突触可塑性、离子通道、神经传递和信号传导、神经细胞损伤、细胞骨架的改变、细胞代谢和蛋白合成等各个方面。而由于血脑屏障的存在,长期以来,中枢神经系统（CNS）被认为是一个免疫豁免的场所,因此MTLE一直被认为是一个非炎症性疾病。然而近年来的研究表明炎症反应可能参与了MTLE的发生和发展。Toll-样受体-4（Toll-like receptor-4,TLR4）是固有免疫反应中能识别病原体成分的重要分子,在脑组织中主要表达于星形胶质细胞、小胶质细胞及神经元上。通常情况下,TLR4与其配体结合后促使核转录因子κB （NF-kappaB, NF-κB）活化,导致白细胞介素-1beta （IL-1β）和肿瘤坏死因子-alpha （TNF-a）等炎症介质的生成,最终产生炎症反应。癫痫病人手术切除的海马组织中,TLR4、IL-1β及其受体表达增高,炎症细胞浸润增多。临床观察显示,在伴有海马硬化的颞叶癫痫成人患者中有相当高的比例可以追问到儿童早期有热性惊厥病史,且热性惊厥模型小鼠海马内IL-1β表达水平增高。对癫痫动物模型的研究发现,LPS-TLR4相互作用可促使大鼠产生痫样放电,而IL-1beta受体拮抗剂预处理后则能明显抑制LPS-TLR4的致痫作用。上述结果强烈提示：海马内的炎症过程,尤其是TLR4、IL-1p参与的炎症反应可能与MTLE的发生密切相关。因此,研究发育阶段幼鼠痫性发作后海马内TLR4、IL-1beta动态改变与癫痫发生发展的关系对明确炎症、免疫反应是否参与海马早期损伤及了解炎症在MTLE发生过程中各阶段的作用有重要意义,但目前国内外相关报道少见。因此,本实验中,我们以21日龄（相当于人类婴幼儿阶段）幼鼠为研究对象,选用氯化锂联合匹罗卡品致痫,建立发育早期海马受损致成年后癫痫的大鼠慢性MTLE模型,并结合免疫组化、免疫印迹分析和RT-PCR的方法,检测MTLE不同时期海马组织各区域内TLR4,IL-1β表达水平的动态变化及该变化与海马硬化的关系,证实炎症反应是MTLE早期损伤因素,与海马硬化密切并参与了MTLE发病全过程。对此问题的探讨有助于从一个全

关键词：内侧颞叶癫痫发育期大鼠炎症反应 Toll样受体4 白介素1β

Left Hemispherical Subdural Hematoma on the Same Side as the Motor Deficit (Kernohan)

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Vulvectomy: Indications and Results in the General Surgery Department of the Ignace Deen Chu Hospital in Conakry

Open Journal of Modern Neurosurgery（现代神经外科学进展） 2024年第3期 212页

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2024年第4期14卷 560-564页

作者： camara Mariama Barry Mamadou Sakoba Yattara Abdoulaye Touré aboubacar Department of General Surgery H&#244pital National Ignace Deen Conakry Guinea Faculty of Health Sciences and Technology Gamal Abdel Nasser University of Conakry Conakry Guinea

Introduction: The aim of this study was to report the indications and evaluate the results of vulvectomy in the general surgery department of Ignace Deen Hospital, CHU Conakry. Materials and Methods: This was a retrospective descriptive study, conducted over a period of five (05) years from January 1, 2018 to December 31, 2022, in the general surgery department of Ignace Deen Hospital, CHU Conakry. We included in our study all patient records in whom vulvectomy was performed. Results: We recorded 15 cases of vulvectomy out of 453 perineal surgeries, i.e. 3.31%, with a mean age of 43.56 years and extremes of 35 and 69 years. Vulvar cancer was the most common diagnosis (46.67%), followed by Buschke-Lowenstein (33.33%) and anal canal cancer extending to the vulva (20%). Six patients had undergone biopsy (40%). Vulvectomy with lymph node dissection was performed in only 9 patients (60%), and all surgical specimens were sent to anatomical pathology (100%). Conclusion: Vulvectomy is a surgical technique most often indicated for the treatment of vulvar cancer.

关键词： Vulvectomy Indications Results Ignace Deen Conakry University Hospital

Fertility after Neosalpingostomy through Laparoscopic Way in Point “G” Teaching Hospital

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical Science 2019年第2期10卷 49-58页

作者： Kéita Soumaila Traoré Youssouf Soumaré Lamine Koumaré Sekou Sacko Oumar camara aboubacar camara Moussa Sissoko Moussa Abdoulaye Sissoko Koita Adama Sanogo Z. Zimogo Surgery Department “A” Point G Teaching Hospital Bamako Mali Faculty of Medicine and Odonto Stomatology of Bamako University of Science Technique and Technologies of Bamako (USTTB) Bamako Mali

The endoscopic surgery is actually the golden standard for the management of infertility. Its results look better than classical surgery. The aim of the study was to assess the fertility rate among infertile women who have undergone a laparoscopic distal tubal plasty and to estimate factors influencing this fertility. From January 2007 to December 2016 a descriptive and analytical cross sectional retrospective study was conducted in the departments of general and laparoscopic surgery of the Point “G” Teaching Hospital in Bamako, Mali. Clinical records of 120 laparoscopic patients with distal tubal occlusion who have undergone a neosalpingostomy were collected. Average period of infertility was 6.7 years (from 1 to 25 years), and the average duration before laparoscopic surgery was 5 years. Main abnormalities were: 50 cases of bilateral tubal distal occlusion (41.7%), 14 patients with unilateral tubal distal occlusion (11.7%), 44 cases of bilateral hydrosalpinx (36.6%) and 12 cases with unilateral occlusion (10.0%). Seventeen patients had adhesions (14.1%) including 4.0% of tubo-peritoneal adhesions, 35.5% of tubo-ovary adhesions and Fitz Hugh and Curtis syndrom adhesions in 17.7% of cases. More than half of the patients (58.0%) had a grade II tubal score. Neosalpingostomy had led to bilateral tubal repermeabilization among 60.0% of the patients. Thirty two point five percent (39/120) pregnancies have been observed after the management. Conception probability was null after the 4th post operative year. The majority of pregnancies have been observed in the 11th month after laparoscopic management. During the follow-up, thirty one patients had intrauterine pregnancy (79.5%), four ectopic pregnancies and three miscarriages. The occurrence of pregnancy was influenced by the desire of the woman, the absence of co-morbidity, the tubal score, the result and the quality of the laparoscopic gesture and the duration of the fertility. Conclusion: In our working setting, neosalp

关键词： Fertility Laparoscopy Neosalpingostomy Pregnancy

The Importance of Uterine Tumors in the Day-to-Day Practice of the General Surgery Department of Ignace Deen National Hospital

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1003-1009页

作者： Mamadou Sakoba Barry Mariama camara Aissatou Taran Diallo aboubacar Touré General Surgery Department Ignace Deen National Hospital/Conakry University Hospital Conakry Guinea Faculty of Health Sciences and Technology Gamal Abdel Nasser University of Conakry Conakry Guinea

Introduction: Uterine tumors are all abnormal cell proliferations developed at the expense of one or more tissue types, which may be located in any uterine segment and have anatomopathological characteristics of benignity or malignancy. The aim of this study was to report on the management of uterine tumors in the general surgery department of Ignace Deen Hospital in Conakry. Methodology: This was a retrospective study lasting five (5) years, from January 1, 2011 to December 31, 2015: All complete records of patients with the diagnosis of a uterine tumor managed in the department were included. Our results are presented in tables and figures. Results: 3200 patients underwent surgery. Among them, 82 cases concerned uterine tumors, i.e. 2% of the department’s overall activity. The average age of our patients was 38.5 years, with extremes of 18 and 59 years. The age group most affected was 41 - 50, with a rate of 39.02%. Housewives and married civil servants were the socio-professional strata most affected, with a predominance of married women. We estimated an increasing proportion of patients admitted to the department during the study period, proving that our study site plays a significant role in the management of uterine tumors. Conclusion: The management of uterine tumors is a major public health problem. Information, communication and education of all socio-professional groups seem necessary.

关键词： Uterine Tumors Management Conakry University Hospital

Management of Idiopathic Chronic Hydrocephalus of the Adult in Guinea: A Prospective Study in 16 Patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Modern Neurosurgery 2021年第4期11卷 272-280页

作者： Alpha Boubacar Bah Ibrahima Sory Souare Ibrahima Berete Seylan Diawara Hugues Ghislain Atatla aboubacar M’mah camara Mamadou Khaira Bah Luc Kezely Beavogui Service de Neurochirurgie H&#244 pital National Donka Conakry Guinea Service de Neurochirurgie H&#244 pital de l’Amitié Sino-Guinéenne de Kipé Conakry Guinea

Object: Incidence of Idiopathic chronic hydrocephalus of the adult (ICHA) is increasing in Guinea due to the aging of the population. The goal of this study was to describe its epidemiology, clinical presentation, and surgical outcome in a low-resource medical environment. Method: Sixteen patients operated for a probable ICHA were prospectively studied according to a uniform protocol from June 2019 to December 2020. On computerized tomography, all operated patients had a clinical triad of gait disturbance, incontinence, dementia associated with ventriculomegaly, and transependymal edema. In addition, all patients underwent a single lumbar tap, improved clinically, and were subsequently offered a shunt consisting of a simple catheter in 37.5% and a non-adjustable high-pressure valve in 62.5%. Result: The mean age was 68.31 ± 10.4 (range 49 - 89). The sex ratio H/F was 1.67/1. Clinically, the most frequent comorbidity was a combination of hypertension and diabetes in 56.5% of cases. The mean time to diagnosis was 8.31 ± 2.75 months (range 3 - 14). The immediate postoperative mortality was 12.5% from a status epilepticus and pulmonary sepsis. In addition, we observed 2 cases of chronic subdural hematoma (12.5%) and 2 cas

关键词： Idiopathic Normal Pressure Hydrocephalus Comorbidities Ventriculoperitoneal Shunt Lumbar Puncture

Damage to the External Genitalia by Traction Following Assault and Battery at the C.H.U Gabriel Touré: About a Case

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical Science 2023年第2期14卷 55-60页

作者： Karembé Boubacar Traoré Boureima Tounkara Idrissa Diarra Issaka Coulibaly Mamadou Tidiani Soumaré Modibo Dianguina Coulibaly Abdoulaye camara aboubacar Touré aboubacar Sanogo Seydou Fall Ibrahim Diakité Mané Diarra Mouminy Traoré Abdoulaye Diarra Drissa Diakité Mamadou Lamine Départment of Surgery CHU Gabriel Touré Bamako Mali

Trauma to the external genitalia by tearing is rare. We report the case of a 30-year-old patient, admitted to the emergency room for trauma of the external genitalia by traction following a blow and intentional injury. The authors highlight the lesions that can occur during this type of trauma and insist on the systematic search for urethral and cavernous lesions. Conclusion: Trauma to the external genitalia by intentional assault and battery is rare in our context. They occur most often in a young person and are frequently associated with damage to the corpora cavernosa and urethra.

关键词： Trauma External Genitalia Traction

Right Atrium Myxoma in an 11-Year-Old Girl in Guinea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2020年第7期10卷 432-436页

作者： Barry Ibrahima Sory Balde El Hadj Yaya camara Abdoulaye Koivogui Kokoulo Samoura Aly Koivogui Diarra Soumaoro Morlaye Toure Demba camara aboubacar Bah Mamadou Bassirou Sylla Fatou Beavogui Mariame Balde Mamadou Dadhi Conde Mamady Department of Cardiology at Ignace Deen National Hospital CHU Conakry Republic of Guinea Pneumology department of the Ignace Deen National Hospital CHU Conakry Republic of Guinea

The objective of this study was to describe the myxoma of the right atrium occurring in an 11-year-old girl. It was an 11-year-old girl weighing 22 kg, admitted for exertional dyspnea, dry cough, palpitations, hepatitis, abdominal bloating, fever evolving for more than 9 months without a history of known cardiovascular disease;referral from a pulmonology department for cardiomegaly and right pleurisy. At cardiac auscultation, the rhythm was irregularly fast at 130 beats without added noise with a blood pressure of 110/65 mmhg. In the lungs, there was silence and a decrease in vocal vibrations at the right base, SaO2 at 70%. Elsewhere a thoracic collateral venous circulation was visible. Electrocardiogram recorded rapid atrial fibrillation at 134 cycles. The cardiac ultrasound concluded that there was a mobile mass in the right atrium prolapsing in the right ventricle measuring 25 mm × 18.9 mm suggesting a myxoma. The myxoma of the right atrium is of a rare localization with a polymorphic clinical manifestation. It should be diagnosed as early as possible to avoid the occurrence of dreaded complications. Its management is surgical.

关键词： Myxoma Right Atrium 11-Year-Old Girl Guinea