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临床肝胆病杂志 2018年第8期34卷 1688-1688页

作者：张晶巧祁兴顺 abou-alfa gk 沈阳军区总医院

【据《NEJM》2018年7月5日在线报道】题：卡博替尼治疗晚期且发生肿瘤进展的肝细胞癌（作者abou-alfa gk等）索拉非尼是晚期肝细胞癌的标准一线治疗药物。卡博替尼是一种酪氨酸激酶抑制剂,通过抑制血管内皮生长因子受体1、2和3,MET和AX... 详细信息

【据《NEJM》2018年7月5日在线报道】题：卡博替尼治疗晚期且发生肿瘤进展的肝细胞癌（作者abou-alfa gk等）索拉非尼是晚期肝细胞癌的标准一线治疗药物。卡博替尼是一种酪氨酸激酶抑制剂,通过抑制血管内皮生长因子受体1、2和3,MET和AXL信号通路而发挥作用。这些信号通路与肝细胞癌进展和索拉非尼的耐药有关。

关键词：肝细胞癌二线治疗晚期血管内皮生长因子受体1 酪氨酸激酶抑制剂索拉非尼信号通路 NEJM

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Novel Non-Protein Biomarkers for Early Detection of Hepatocellular Carcinoma

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Engineering 2021年第10期7卷 1369-1374页

作者： Ghassan K.abou-alfa Lin Wu Augusto Villanueva Memorial Sloan Kettering Cancer Center New York CityNY 10065USA Weill Medical College Cornell UniversityNew York CityNY 10065USA Berry Oncology Corporation Beijing 102200China Division of Liver Diseases Division of Hematology/Medical OncologyLiver Cancer ProgramDepartment of MedicineTisch Cancer InstituteIcahn School of Medicine at Mount SinaiNew York CityNY 10029USA

Early detection of hepatocellular carcinoma(HCC)while in its early stages is critical for reducing HCC mortality in high-risk ***,highly sensitive and specific surveillance biomarkers for early-stage HCC detection are still *** recent years,great efforts have been made to research tumor-derived molecular features that are detectable in circulation,such as circulating tumor deoxyribonucleic acid and circulating tumor ribonucleic acid,in order to explore their potential as noninvasive biomarker candidates in many tumor *** this review,we summarize current studies on these new approaches and their application in early HCC detection.

关键词： Hepatocellular carcinoma Early detection Biomarkers Liquid biopsy

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Current status and future of systemic therapy for hepatocellular carcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 25-25页

作者： Ghassan abou-alfa Memorial Sloan Kettering Cancer Center New YorkUSA

Hepatocellular carcinoma(HCC)has been perceived as a malignancy that is resistant to systemic chemotherapy for long periods of *** initial efforts that were supported by the NCI to help elucidate any potential role for systemic doxorubicin,no standard of care was approved and acknowledged for HCC until the advent of ***,a multi-kinase inhibitor with an anti-angiogenic effect,was evaluated in a large phase III clinical trial versus placebo and showed a clear improvement of survival in its favor,which helped establish it as a standard of *** was back in 2007,and since then we lingered in a long hiatus of several genuine attempts to test potentially more powerful anti-angiogenics to no *** 2017,things changed markedly with 4 clinical trials showing improvements in survival or non-inferiority *** the first line setting,lenvatinib,another multi-kinase inhibitor with anti-angiogenic and anti-FGF activity showed non-inferiority versus sorafenib and is now FDA *** the second line setting,*** multikinase inhibitor with ample similarity to sorafenib but some differences showed improvement in survival after progression on sorafenib when tested against ***,another multi-kinase inhibitor with anti-c-met activity also showed an improvement in survival versus placebo,while ramicirumab also showed an improvement in survival versus placebo in the same setting yet only for patients with elevated alpha fetoprotein(AFP).The advent of checkpoint inhibitors has already led to the approval of anti-PD-1 nivolumab in the second line setting based on a response rate of 15%-20%despite the lack of survival *** studies are now evaluating the combination of different checkpoint inhibitors and also the combination of checkpoint inhibitors plus multikinase *** incredible increase in the number of targeted therapies and checkpoint inhibitors from 1 to 6 cannot go unnoticed,adding to the already

关键词： Current status future systemic

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A Comparison between Sabra and alfa Fibers in Rubber Biocomposites

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Journal of Bionic Engineering 2019年第4期16卷 754-767页

作者： Wafa Ouarhim Hamid Essabif Mohammed-Ouadi Bensalah Denis Rodrigue Rachid Bouhfid abou el kacem Qaiss Moroccan Foundation for Advanced Science Innovation and Research(MAScIR)Composites and Nanocomposites Center(CNC)Rabat 10100Morocco Faculty of Science Laboratory of Mechanic and Materials(LMM)Mohammed V-RabatUniversityRabat 10100Morocco National School of Applied Science(ENSA) Ibn Zohr University-AgadirAgrandir 80000Morocco Department of Chemical Engineering and CERMA Universite LavalQuebec G1V0A6Canada

The main objective of this investigation is to valorize a Moroccan crop residue(Sabra fibers,Agave Americana L.)and to compare with alfa fibers(,Stipa tenacissima L.)as reinforcement in an elastomeric matrix in term of the relaxation properties,mechanical and rheological *** preparation and properties of these two natural fibers embedded in Styrene-Butadiene Rubber(SBR)are presented with and without the addition of Styrene-Ethylene-Butadiene-Styrene grafted with Maleic Anhydride(SEBS-g-MA)as a coupling *** different series(SBR,SBR/alfa,SBR/alfa/SEBS,SBR/Sabra and SBR/Sabra/SEBS)were compounded by extrusion and compression *** a result,the addition of the coupling agent in the elastomeric matrix improves the relaxation properties,mechanical and rheological ***,Sabra fibers show the good results compared to alfa ***,the Zener model was used to determine the rheological time response of the composites.A good agreement between the experimental data and the model was observed(R^2=0.99).

关键词： Sabra fibers alfa fibers SBR biocomposite relaxation mechanical and rheological properties Zener model

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The Mechanical and Crystallographic Evolution of Stipa tenacissima Leaves During In-Soil Biodegradation

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Journal of Renewable Materials 2018年第3期6卷 336-346页

作者： Zakia Khelifi Mohammed Amine Allal Nabil abou-bekr Said Taibi Benoit Duchemin Normandy University ULHCNRSLOMC76600 Le HavreFrance University of Tlemcen Lab-EOLEBP 23013000 TlemcenAlgeria

The in-soil biodegradation of Stipa tenacissima(alfa)leaves was ***-linear mechanical testing was performed at various biodegradation *** strength,loading and unloading Young’s moduli and dissipation energy decreased with the burial time,whereas plasticity ***-emission scanning electron microscopy(FE-SEM)showed that the fracture cracks propagated in the longitudinal direction in the raw material,resulting in a fracture mode consisting of a mixture of middle lamella delamination and fiber *** contrast,the cracks were perpendicular to the stem axis in the biodegraded material,demonstrating an important strength loss of the load-bearing *** strength loss was correlated with rapid cellulose degradation.A novel X-ray diffraction(XRD)model was implemented in order to take into account anisotropic size *** the first time,XRD demonstrated the action of biodegradation on unrefined plant tissues under quasi in-situ *** induced a progressive loss of crystalline cellulose accompanied with anisotropic crystallite thinning.

关键词： alfa mechanical testing FE-SEM XRD biodegradation

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