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Assessment of the safety of Olmesartan in Combination with sorafenib in Mice Bearing Ehrlich’s Ascites Carcinoma

Journal of Cancer Therapy 2013年第8期4卷 1355-1361页

作者： Mohammad M. Abd-Alhaseeb sawsan A. Zaitone soad H. abou-el-ela Yasser M. Moustafa Department of Bio- chemistry Faculty of Pharmacy & Pharmaceutical Industries Sinai University Arish Egypt Department of Pharmacology and Toxicology Faculty of Pharmacy & Pharmaceutical Industries Sinai University Arish Egypt Department of Pharmacology and Toxicology Faculty of Pharmacy Suez Canal University Ismailia Egypt

sorafenib was the first multikinase inhibitor to be approved for use in metastatic renal cell carcinoma. Olmesartan medoxomil used in treatment of hypertension and was reported to inhibit angiogenesis in several models. The present study was designed to assess the safety of a combination of sorafenib plus olmesartan compared to monotherapies in mice bearing Ehrlich’s ascites carcinoma cell line. Mice were divided to seven groups, 1) normal mice, 2) Ehrlich’s ascites carcinoma control, 3 - 5) olmesartan (3, 10, 30 mg/kg/day), respectively, 6) sorafenib (30 mg/kg/day) and 7) the combination group: mice received olmesartan (30 mg/kg/day) plus sorafenib. All drug treatments continued for 21 days. At the end of the experiment, a complete blood count was performed and kidney and liver functions were estimated. The combination therapy produced a non-significant change in most of the measurements of complete blood count and liver enzymes when compared to normal animals. On the other hand, the combined therapy significantly increased blood urea nitrogen when compared to normal group but did not change the serum creatinine level. Concomitant administration of olmesartan with sorafenib did not significantly augment the toxicity of the later. Therefore;olmesartan might be a safe candidate with sorafenib in treatment of cancer if clinical data proved the benefit of this combination.

关键词： Mice Ehrlich’s Ascites Carcinoma Olmesartan sorafenib

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A Novel Method for PID Tuning Using a Modified Biogeography-Based Optimization Algorithm

A Novel Method for PID Tuning Using a Modified Biogeography-...

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第24届中国控制与决策会议

作者： M. M. sayed M. s. saad H. M. Emara E. E. abou el-Zahab the department of electrical Power and Machines Cairo UniversityEgypt.

Proportional integral derivative （PID） controller tuning is an area of interest for researchers. This paper presents a novel method for PID controller tuning using a modified biogeography-based optimization（MBBO） algorithm. Biogeography-based optimization （BBO） is a novel evolutionary algorithm that is based on the mathematical models of biogeography. Biogeography is the study of the geographical distribution of biological organisms. In the BBO model, problem solutions are represented as islands, and the sharing of features between solutions is represented as immigration and emigration between the islands. In this paper, a modified version of the BBO is proposed to improve its convergence. The MBBO algorithm is compared with the BBO using benchmarks functions. The proposed algorithm is applied to the problem of PID controller tuning and is compared with conventional biogeography-based optimization （BBO）, and Particle swarm optimization （PsO）.

关键词： Process Control evolutionary algorithm (EA) Biogeography-Based Optimizationand PID controller

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番茄潜叶蛾危害特征及14目防虫网的隔离效果

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西北农业学报 2022年第7期31卷 921-929页

作者：何云川毛植尧王田珍王树明马丽华普建文宁锦程普群周文武 Amr s.abou el-ela 祝增荣海南浙江大学研究院海南三亚572025 浙江大学昆虫科学研究所浙江省作物病虫生物学重点实验室农业部作物病虫分子生物学重点实验室杭州310058 云南省玉溪市植保植检站云南玉溪653100 云南省峨山县植保植检站云南峨山653200 云南省峨山县小街镇农业农村综合服务中心云南峨山653201 国际生物防治组织茄科作物害虫生物防治国际工作组北京100193 亚历山大大学农学院植保系西宾库姆埃及21531

番茄潜叶蛾Tuta absoluta(Meyrick)是危害茄科作物的重大入侵农业害虫,明确番茄潜叶蛾的田间危害特征及防虫网对番茄潜叶蛾成虫的防控作用,为防虫网在温棚的使用提供技术指导。利用防虫网+性诱剂的方法,分析番茄潜叶蛾的田间治理效果。... 详细信息

番茄潜叶蛾Tuta absoluta(Meyrick)是危害茄科作物的重大入侵农业害虫,明确番茄潜叶蛾的田间危害特征及防虫网对番茄潜叶蛾成虫的防控作用,为防虫网在温棚的使用提供技术指导。利用防虫网+性诱剂的方法,分析番茄潜叶蛾的田间治理效果。采用田间观察和五点取样的方法,进行番茄潜叶蛾危害调查。在不同番茄品种的不同生育期监测到防虫网与对照处理的番茄潜叶蛾种群动态变化规律一致。苗期,‘德尔6’和‘粉帝F1’防虫网和对照处理的平均虫量分别为18.76、24.97只/板和75.92、87.71只/板(P>0.05);防虫网对两个品种的番茄潜叶蛾隔离率分别为39.10%和21.32%(P0.05);防虫网对两个品种的番茄潜叶蛾隔离率分别为22.95%和19.35%(P>0.05)。果期,‘德尔6’、‘鸿图’和‘粉帝F1’的防虫网和对照处理平均虫量分别为53.90、58.52只/板;47.52、65.79只/板和66.37、85.46只/板(P>0.05);防虫网对3个品种的番茄潜叶蛾隔离率分别为24.20%、28.93%和26.83%(P>0.05)。防虫网处理对3个生育期下的3个品种间的平均危害率均差异不显著(P>0.05),但防虫网处理的平均危害率均低于对照处理,差值达8.38%。二次多项式逐步回归分析结果表明番茄叶片或果实的平均危害率主要与潜叶蛾的早期虫口量相关。14目防虫网对番茄潜叶蛾具防控作用,隔离率最大为39.10%。

关键词：番茄潜叶蛾防虫网危害特征危害调查

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Optimal Unit Commitment with Renewable Energy in Regulated and Deregulated systems

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Energy and Power Engineering（能源与动力工程） 2022年第8期

作者： adel a.abou el-ela sohir m.allam amira s.doso

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screening of biological activities of Polygonum maritimum *** A lgerian coast

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Asian Pacific Journal of Tropical Biomedicine 2013年第8期3卷 611-616页

作者： Imad Abdelhamid el-Haci Fawzia Atik Bekkara Wissame Mazari Fay al Hassani Mohamed AmineDidi Laboratoire des Produits Naturels BP 119 Imama13000Université Abou Bekr Belkaid-Tlemcen-Algérie Laboratoire d'Ecologie et Gestion des Ecosystèmes Naturels BP 119 Imama13000Université Abou Bekr Belkaid-Tlemcen-Algérie Laboratoire des Technologies de séparations et de Purifications BP 119 Imama13000Université Abou Bekr Belkaid-Tlemcen-Algérie

Objective:To investigate the antioxidant and the antibacterial activities of crude extract from aerial part of Polygonum maritimumL.(Polygonaceae)(***)and to find new actives ***:The whole plant was collected from the Rechgoune coast(West of Algeria),and methanolic crude extract of aerial parts ***(PMCE)was *** extract was tested against different bacterial strain and tested for his ability to neutralize free radical(DPPH)and to scavenge the ***:PMCE had a very high content of total phenol,which was(352.49依18.03)mg/g dry weight,expressed as gallic acid *** exhibited excellent antioxidant activity,as measured using DPPH and H2O2 scavenging *** also showed a high antibacterial activity against gram-positive bacterial strains:Bacillus cereus,Bacillus subtilisandstaphylococcus aureus with an highest MIC of 120μg/***:The antioxidant and antibacterial activity of the PMCE is probably due to phenolic compounds present in the *** contemporary presence of antioxidant and antibacterialactivities in the PMCE suggests that this plant may be a source of bioactive substances with multifaceted activity.

关键词： Polygonum maritimumL. Phenolic compounds Antioxidant activity Antibacterial activity

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Retraction: Toxic chemotherapeutic nutrition of cancer cells by alkaline glucosodiene molecules via targeting metabolic of cancerous tumors: a promising theory for cancer treatment. Cancer Adv. 2023;6:e23010. doi:10.53388/2023623010

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Cancer Advances 2023年第15期6卷 1-1页

作者： Maher Monir.Akl Amoura Mohammed.abou el Naga Department of Chemistry Faculty of ScienceMansoura UniversityMansoura 35516Egypt Department of Zoology Faculty of ScienceMansoura UniversityMansoura 35516Egypt

Cancer Advance has retracted this article at the request of the corresponding author because there are significant errors in the structure of the compound,which forms the basis of the *** Advance received this manuscript on 15 April *** the plagiarism check on 19 April 2023,the overall similarity rate of this manuscript was 20%,which was *** the manuscript was started to be sent to peer review at 9:17 on 19 April *** manuscript was sent to fourteen reviewers and two of them sent back the *** two reviewers are invited to review on 19 April *** to the journal's single-blind peer review policy,we do not give the names of the two reviewers *** reviewer gave the decision“Accept with major revision”and the other reviewer gave the decision“Accept with minor revision”.

关键词： Cancer alkaline journal

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Genetic Polymorphisms of HBs1L-MYB (rs4895441 and rs9376090) in Egyptian Patients with Hemoglobinopathy

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Open Journal of Blood Diseases 2020年第4期10卷 89-100页

作者： Thoria A. Omar Emad F. Abd-elhalim Rawhia H. eledel Mohamed A. soliman Fatma s. Ebeid Ola H. elshafey Dalia H. abou-elela Clinical Pathology Department Faculty of Medicine Menoufia University Shibin El Kom Egypt Pediatric Department Faculty of Medicine Ain Shams University Ain Shams Egypt

Objective: study the HBs1L-MYB (rs4895441 and rs9376090) genetic polymorphisms in Egyptian patients with β-thalassemia major and sickle cell disease and its relation to Hb F and severity of the disease. Background: H... 详细信息

Objective: Study the HBS1L-MYB (rs4895441 and rs9376090) genetic polymorphisms in Egyptian patients with β-thalassemia major and sickle cell disease and its relation to Hb F and severity of the disease. Background: Hb F is a predominant modulator for the severity of β-thalassemia major & sickle cell disease. Genetic polymorphism in the intergenic region (HBS1L-MYB) between GTP-binding elongation factor HBS1L and myeloblastosis oncogene MYB on chromosome 6q is associated with high fetal hemoglobin levels. Subjects and Methods: 150 subjects were included in this study. For all studied groups: Complete blood picture and serum ferritin were evaluated. For patients, hemoglobin variants were separated by High-performance liquid chromatography. Genotyping of HBS1L-MYB (rs4895441 & rs9376090) was evaluated by real-time polymerase chain reaction technique using TaqMan probe. Results: AG, CT genotypes, and G, C alleles of HBS1L-MYB (rs4895441 & rs9376090) were significantly high in sickle cell patients [OR (3.400);95% C.I (1.482 - 7.799)], (p = 0.003) & [OR (4.522);95%span> C.I (1.854 - 11.029)], (p = 0.001) respectively. Also, a significant association was detected between polymorphisms and disease severity. However, in βspan style="font-famil

关键词： Hemoglobinopathy Beta-Thalassemia sickle Cell Disease HBs1L-MYB Polymorphism Polymerase Chain Reaction

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Experimental and computational chemical studies on the cationic furanylnicotinamidines as novel corrosion inhibitors in aqueous solutions

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中国化学工程学报（英文版） 2020年第2期

作者： Abdelaziz s.Fouda Mohamed A.Ismail Rabab M.abou-shahba Walaa A.Husien Esraa s.el-Habab Ashraf s.abousalem

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sex Hormones Changes in Blood and Their Effect on Fecundity of African Catfish(Clarias gariepinus Burchell,1822)after Being Injected with Different Doses of Human Chorionic Gonadotropin(HCG)Hormone

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Journal of Zoological Research 2020年第4期2卷 19-30页

作者： Hamed H.E.saleh Ahmed I.semaida sayed R.s.Zidan Ramadan M.abou-Zied sobhy M.Allam Aquaculture Division National Institute of Oceanography and Fisheries(NIOF)El-FayoumEgypt Animal Production Department Faculty of AgricultureFayoum UniversityEgypt

This study was conducted to investigate the effect of different doses injection of human chorionic gonadotropin(HCG)hormone on fecundity and serum sex hormones(FsH,LH,estrogen(E2),progesterone(P4),testosterone(T))of African catfish(Clarias gariepinus).African catfish spawners were intermuscularly injected with different doses of HCG(500,1500,3000,6000 IU/kg female),and group is not injected as a control;males were injected at half the female *** results showed that,fish group injected by 6000 IU HCG/kg female had the highest gonadsomatic index,absolute fecundity and relative fecundity,while,the lowest value of absolute fecundity and relative fecundity were recorded with 500 IU HCG/kg *** group injected with the highest amount of HCG(6000 IU/kg female)recorded the lowest value from egg diameter,while the highest egg diameter was observed in 500 IU HCG/kg *** females,the group injected with 6000 IU HCG/kg female reflected the lowest level of FsH and the highest level of LH and the highest level of P4 compared to other *** of T recorded the highest level with 1500 IU HCG/kg *** control group reflected the highest level of FsH and E2,while the control group reflected the lowest level of T and P4 *** males,serum FsH,LH,P4 and E2 in male groups injected with HCG were relatively higher than those recorded in the control *** highest level of T was recorded in treatment injected with the highest dose of HCG and decreased in other treatments until recorded the lowest level of T in the control *** was observed,HCG hormone has successfully and accelerate induced spawning in African catfish(Clarias gariepinus)and increased in reproductive performance with the increase in HCG dosage and as compared to group not injected.

关键词： African catfish HCG hormone Gonadsomatic index Fecundity FsH LH Estrogen Progesterone and testosterone

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