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The Combination Effect of Daphne Extract and Imatinib on the Antiproliferative Activity of the K562 Cell Line

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Journal of Biosciences and Medicines 2024年第8期12卷 141-153页

作者： Alireza Khorshid Jafar nouri Nojadeh Javid Sabour Takanlu Alireza Tavasoli Department of Clinical Laboratory Sciences University of Texas Medical Branch at Galveston Galveston TX USA Department of Medical Genetics Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran Apoptosis Research Centre Department of Biochemistry School of Natural Sciences National University of Ireland Galway Galway Ireland Department of Pathology School of Medicine Fasa University of Medical Science Fasa Iran

Background: Herbal medicine is well-known among the ancient medical sciences. Healing properties have been observed in some species of Daphne plant. The effect of Daphne plant extract on the K562 cell line has been previously studied, and Gleevec is a well-known and effective medicine for the treatment of chronic myelogenous leukemia. Material and Methods: In this study, the simultaneous effects of using herbal medicine and a target therapy medicine on the K562 cell line were investigated. The presence of some species of Daphne in Iran motivated us to evaluate the cytotoxic effect of Daphne mucronata on human leukemia cancer cells. The antiproliferative activity of the dichloromethane extract of Daphne mucronate (Thymelaeaceae), a new anticancer medicinal plant, was evaluated. Cell viability was quantitated by MTT assay. Apoptotic and necrotic changes in the cell membrane were examined using flow cytometry. Changes in Bax and Bcl2 gene expression were investigated using real-time PCR. The MIC and the IC50 of the crude extract were calculated, and the MIC and IC50 of the Daphne extract in combination of imatinib were tested in the K-562 cell line. Results: K-562 cells responded to the extract treatments in a dose-dependent manner, and the increase in the expression of Bcl2 and decrease in the expression of the Bax gene intensified with increasing extract concentration. Flow cytometry revealed that most of the cells underwent necrosis. Conclusion: Daphne extract effectively decreased the viability of the K562 cell line. The necrotic effect of the Daphne extract was evaluated, and an increase in the gene expression of Bcl2 was observed in cells exposed to the Daphne extract. The combination of Daphne extracts with imatinib enhances the cytotoxic effect of imatinib.

关键词： Daphne Imatinib Apoptosis Herbal Medicine Bax Bcl-2 CML

Ti6Al4V合金表面渗钽层的制备及力学性能

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太原理工大学学报 2024年

作者：付光远林乃明李小凯 Meisam nouri 曾群锋 Dongyang Li 吴玉程太原理工大学材料科学与工程学院 Department of Materials Engineering， Bu-Ali Sina University 西安交通大学机械工程学院 Department of Chemical and Materials Engineering， University of Alberta 合肥工业大学有色金属与加工技术国家地方联合工程研究中心

为提高Ti6Al4V（TC4）合金的表面性能，借助双层辉光等离子表面合金化技术在其表面制备渗钽层，结合Taguchi实验设计研究了工艺参数对渗钽层表面硬度的影响。借助光学显微镜，X射线衍射仪，扫描电子显微镜及能量谱仪分析渗钽层的特征。... 详细信息

为提高Ti6Al4V（TC4）合金的表面性能，借助双层辉光等离子表面合金化技术在其表面制备渗钽层，结合Taguchi实验设计研究了工艺参数对渗钽层表面硬度的影响。借助光学显微镜，X射线衍射仪，扫描电子显微镜及能量谱仪分析渗钽层的特征。使用显微硬度计和纳米压入仪对比研究TC4基体和渗钽层的力学性能。结果表明：得到优化的工艺参数组合：温度750 ℃，源阴极压差350 V，保温时间2 h。优化工艺参数的渗钽层连续、均匀、致密，主要由α-Ta和金属间化合物相构成。渗钽层表面硬度比TC4基体提高了约3.2倍，其H/E和H3/E2值分别是TC4基体的2.1倍和15.0倍。双辉等离子表面合金化渗钽处理显著提高了TC4合金的抵抗局部塑性变形能力。

关键词：钛合金双辉等离子表面合金化钽力学性能

Effects of Yttrium Addition on Microstructure, Hardness and Resistance to Wear and Corrosive Wear of TiNi Alloy

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Journal of Materials Science & Technology 2011年第9期27卷 851-855页

作者： Hojat Ahmadi Meisam nouri Faculty of Biosystems Engineering University of Tehran Department of Materials Engineering Tarbiat Modares University

TiNi alloy has a high resistance to wear and could be an excellent candidate for various tribological applications. In this paper, it was demonstrated that by addition of yttrium, hardness properties and resistance to wear and corrosive wear of TiNi alloy were improved. New yttrium rich regions were formed in microstructure of TiNi alloy. The improved properties of this alloy by the yttrium addition could be attributed to the formation of these regions. The results showed that there was an optimum content for addition of yttrium between 2% and 5% （in wt%）, and above this content the improvement in properties of TiNi became minor.

关键词： Yttrium TiNi Mechanical behaviour Wear Corrosive wear Microstructure

ELECTROSPINNING OF CYCLODEXTRIN FUNCTIONALIZED CHITOSAN/PVA NANOFIBERS AS A DRUG DELIVERY SYSTEM

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Chinese Journal of Polymer Science 2013年第10期31卷 1343-1351页

作者： Maryam Bazhban Mahdi nouri Javad Mokhtari Department of Textile Engineering Faculty of Engineering University of Guilan

A new type ofnanofibrous structure from chitosan bearing carboxymethyl-β-cyclodextrin （CS-g-β-CD） as a novel drug delivery system was synthesized by grafting carboxymethyl-β-cyclodextrin （CM β-CD） onto chitosan （CS） in the presence of water soluble 1-ethyl-3-（3-dimethylaminopropyl） carbodiimide （EDC） as the condensing agent and N-hydroxysuccinimide （NHS）. Defect free mats containing CS-g-β-CD have been fabricated using electrospirming of an aqueous solution of poly（vinyl alcohol）（PVA）/CS-g-β-CD blends. The morphology and diameter of the electrospun nanofibers were examined by scanning electron microscopy （SEM）. The average fiber diameter was in the range of 130-210 run. SEM images showed that the morphology and diameter of the nanofibers were mainly affected by weight ratio of the blend at constant applied voltage. The results revealed that increasing CS-g-β-CD content in the blends decreases the average fiber diameter. It was observed that the PVA/CS-g-β-CD nanofibrous mat provided a slower release of the entrapped drug in compare to PVA/CS nanofibrous mat.

关键词： Chitosan βcyclodextrin Nanofibers Drug delivery.

NAPHTHALIMIDE BASED DISPERSE DYES FOR NYLON 6 AND POLYESTER(PET) FIBERS:SYNTHESIS AND EVALUATION OF TECHNICAL PROPERTIES IN THE PRESENCE OF UREA

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Chinese Journal of Polymer Science 2011年第6期29卷 712-718页

作者： Javad Mokhtari Mahdi nouri Uranus Goudarzi Department of Textile Engineering Faculty of EngineeringUniversity of GuilanRashtIran

Technical properties of two naphthalimide based disperse dyes on nylon 6 and polyester fibers were investigated in the presence of urea. The two naphthalimide based disperse dyes were synthesized. The dyes were purified and then fully characterized using 1H-NMR, FTIR and melting point analysis. Dispersion of the dyes was prepared in water and applied on nylon 6 and PET fibers. The dyes offered good build-up properties on the substrates. In order to increase dye adsorption of the substrates, urea was added into the dyebath. By adding urea, the dye adsorption of polyester was increased significantly, while the increase of that of nylon 6 was not marked. The dyes showed good fastness properties on the substrates.

关键词： Naphthalimide Nylon 6 Polyester Urea Disperse dye

Applying Sliding Mode Control to Suppress Double Frequency Voltage Ripples in Single-phase Quasi-Z-source Inverters

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CSEE Journal of Power and Energy Systems 2023年第2期9卷 671-681页

作者： Jaber Merrikhi Ahangarkolaei Mahdi Izadi Tohid nouri Department of Electrical Engineering Sari BranchIslamic Azad UniversitySariIran Department of Electrical Engineering Shahriar BranchIslamic Azad UniversityShahriarIran

The inherent double-line frequency ripple(DFR)of the single-phase quasi-Z-Source inverter(qZSI)strongly affects performance and design of the whole system,which requires hardware improvement methods such as additional semiconductor components or increasing the volume of capacitors and *** a result,hardware solutions increase the price,and the volume and also reduces reliability of the *** this paper,as a non-hardware solution,a sliding mode control(SMC)method is presented to control the voltage of the qZSI *** suppress the DFR,a second-order harmonic is injected into the capacitor reference *** and experimental results show that the introduced controller will have satisfactory results in reducing the DFR without any hardware changes in the qZSI,such as increasing the volume of the capacitor and inductor,adding a semiconductor,or increasing the frequency.A simulation model and experimental prototype are provided to demonstrate the validation of the effectiveness of the proposed controller.

关键词： Double-frequency ripple quasi-Z-source inverter sliding mode control

DRAG REDUCTION IN A TURBULENT CHANNEL FLOW WITH HYDROPHOBIC WALL

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Journal of Hydrodynamics 2012年第3期24卷 458-466页

作者： nouri Nowrouz Mohammad SEKHAVAT Setareh MOFIDI Alireza Department of Mechanical Engineering Iran University of Science and TechnologyTehran Iran

This paper investigates a theoretical prediction of friction drag reduction in turbulent channel flow which is achieved by using superhydrophobic surfaces. The effect of the hydrophobic surface is considered to be a slip boundary condition on the wall, and this new boundary condition is added to Large Eddy Simulation （LES） equations. The predicted drag reduction at Rer= 180 is approximately 30%, which concurs with results obtained from Direct Numerical Simulation （DNS）. An important implication of the present finding is that the near-wall turbulence structures are modified with streamwise slip velocity. In addition, a noticeable effect on the turbulence structure occurs when the slin lenmh is ereater than a certain vahle

关键词： superhydrophobic surface Large Eddy Simulation (LES) drag reduction slip length turbulence structures

Constitutive model for monotonic and cyclic responses of loosely cemented sand formations

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第4期10卷 740-752页

作者： Mojtaba Rahimi Dave Chan Alireza nouri Department of Mechanical Engineering Azad UniversityKhomeinishahr BranchIsfahanIran Department of Civil and Environmental Engineering University of AlbertaEdmontonT6G 2W2Canada China Three Gorges University YichangChina

This paper presents a model to simulate the monotonic and cyclic behaviours of weakly cemented *** elastoplastic constitutive model within the framework of bounding surface plasticity theory is adopted to predict the mechanical behaviour of soft sandstone under monotonic and cyclic loadings. In this model, the loading surface always passes through the current stress state regardless of the type of loading. Destruction of the cementation bonds by plastic deformation in the model is considered as the primary mechanism responsible for the mechanical degradation of loosely cemented sands/weak *** model cyclic response, the unloading plastic and elastic moduli are formulated based on the loading/reloading plastic and elastic moduli. The proposed model was implemented in FLAC2D and evaluated against laboratory triaxial tests under monotonic and cyclic loadings, and the model results agreed well with the experimental observations. For cyclic tests, hysteresis loops are captured with reasonable accuracy.

关键词： Cyclic loading Monotonic loading Cemented sand Plasticity Constitutive model

Analysis of shear rate effects on drag reduction in turbulent channel flow with superhydrophobic wall

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Journal of Hydrodynamics 2013年第6期25卷 944-953页

作者： nouri Nowrouz Mohammad BAKHSH Mohammad Saadat SEKHAVAT Setareh School of Mechanical Engineering Iran University of Science and Technology

We examined the shear rate effect on drag reduction of superhydrophobic surfaces with different slip lengths. For this purpose, turbulent channel flow was considered at the friction Reynolds numbers of Reτ = 180, 395, 500. By using Navier＇s slip condition it is shown that increasing shear rate leads to the greater reduction in drag force and also more reduction occurs in larger slip length. Based on the results, more than 25% drag reduction happens at a friction Reynolds number of Reτ= 500 for slip length of 1 ×10 5 m. The simulation results suggest that reduction in drag force occurs because slip condition reduces the Reynolds stresses, also weakens vorticity filed and the near-wall coherent structures, and therefore turbulence production is decreased.

关键词： superhydrophobic shear rate drag reduction coherent structures channel flow