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Pleiotropic attenuating effect of Ginkgo biloba against isoprenalineinduced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na^(+) , K^(+) -ATPase activities

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Chinese Herbal Medicines 2024年第2期16卷 282-292页

作者： Jerome Ndudi Asiwe abodunrin adebayo ojetola Nwoke Enekabokom Ekene Esthinsheen Osirim Anthony Chibuzor Nnamudi Benjamin Oritsemuelebi Jackson Erozueme Onuelu Nicholas Asiwe Harrison Ogheneochuko Eruotor Saviour Inegbenehi Department of Physiology Delta State UniversityAbraka 1Nigeria Department of Physiology University of IbadanIbadan 3017Nigeria Department of Physiology Adeleke UniversityEde 250Nigeria Department of Pharmacology Rivers State UniversityNkpolu-Oroworukwo 5080Nigeria Department of Physiology Redeemer’s UniversityEde 230Nigeria Department of Biochemistry PAMO University of Medical SciencesPort Harcourt 500211Nigeria Department of Pharmacology Delta State UniversityAbraka 1Nigeria Department of Anatomy University of Port HarcourtChoba 5323Nigeria Department of Medical Laboratory Sciences University of Port HarcourtChoba 5323Nigeria

Objective:Myocardial infarction(MI)is linked to an imbalance in the supply and demand of blood oxygen in the heart ***-blockers and calcium antagonists are just two of the common medications used to treat ***,these have reportedly been shown to be either ineffective or to have undesirable side *** of Ginkgo biloba leaves(GBE),a Chinese herbal product offers special compatibility benefits in therapeutic settings relating to inflammatory diseases and oxidative *** order to better understand how GBE affects MI in rats insulted by isoprenaline(ISO),the current study was ***:The heart weight index,serum lipid profile,cardiac marker enzymes,endogenous antioxidants[catalase(CAT),superoxide dismutase(SOD),glutathione(GSH),nitrites and malondialdehyde(MDA)],inflammatory mediators[tumour necrosis factor alpha(TNF-a)and interleukin-6(IL-6)],immunohistochemical expressions of B-cell lymphoma factor-2(Bcl-2),extracellular signal-regulated kinase(ERK1/2),and mammalian target of rapamycin(mTOR)and histopathological analysis were used to assess the cardioprotective properties of ***:The findings showed that GBE effectively attenuated myocardial infarction by boosting the body’s natural antioxidant defense system and reducing the release of inflammatory cytokines as well as heart injury marker *** expression of Bcl-2,ERK1/2 and mTOR was increased while the histomorphological alterations were ***:The cardioprotective effects of GBE may be due to a mechanism involving increased Bcl-2/mTOR/ERK1/2/Na^(+),K^(+)-ATPase activity.

关键词： antioxidants extracellular signal-regulated kinase Ginkgo biloba extract isoprenaline mammalian target of rapamycin myocardial infarction Na^(+),K^(+)-ATPase

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Characterization of Dye Sensitized Cells Using Natural Dye from Oil Bean Leaf (<i>Pentaclethra macrophylla</i>): The Effect of Dye pH on the Photoelectric Parameters

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Materials Sciences and Applications 2015年第7期6卷 646-655页

作者： Temitope abodunrin Adenike Boyo Olugbenga Obafemi Timothy adebayo Department of Physics Covenant University Ota Nigeria Department of Physics Lagos State University Ojo Nigeria Department of Physics Covenant University Ota Nigeria Chemical Science Department Redeemers University Ede Nigeria

Fresh leaves of oil bean (P. macrophylla) were used as sensitizers for fabrication of dye sensitized solar cells (DSSCs) at four dye pH values of 2.58°C at 23.7°C, 2.62°C at 22.2°C, 2.65°C at 22.3°C and 3.61°C at 22.1 °C. The methanol extracts of P. macrophylla were extracted and used as sensitizers for the development of dye sensitized solar cells. The solar cells sensitized by P. macrophylla leaf extracts realised up to short circuit current (Jsc) 0.16 mA/cm2, open circuit voltage (Voc) 0.045 V, Pmax 0.031 mW/ cm2 and fill factor (FF) 0.50. The energy conversion efficiency (η) of the DSSCs is 0.43%. Phytochemical screening of P. macrophylla leaf extract shows the presence of flavonoids and anthraquinones. The nanostructured dye shows conversion of solar energy into electricity using low cost natural dyes as wide band-gap semiconductor sensitizers in DSSCs. This will provide economically viable substitute to silicon p-n junction photovoltaic (PV).

关键词： Dye-Sensitized Solar Cells Dye Sensitizer P. macrophylla Leaf Anthraquinones Conversion Efficiency

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The Effect of Electrolyte on Dye Sensitized Solar Cells Using Natural Dye from Mango (<i>M. indica</i>L.) Leaf as Sensitizer

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Advances in Materials Physics and Chemistry 2015年第6期5卷 205-213页

作者： T. J. abodunrin O. Obafemi A. O. Boyo T. adebayo R. Jimoh Department of Physics Covenant University Ota Nigeria Department of Physics Lagos State University Ojo Nigeria Chemical Science Department Redeemers University Ede Nigeria Instrumentation Department Kwara State University Molete Nigeria

Dye-sensitized solar cells (DSSC) were fabricated with mango leaf dye extracts as natural dye sensitizers at pH value of 5.20 and temperature of 18.1°C. Methanol was used as dye-extracting solvent. DSSCs from dye extract of M. indica L. with KMnO4 electrolyte had the highest photocurrent density of 1.3 mA/cm2 and fill factor FF of 0.46 for the sun at its peak. Potassium permanganate (KMnO4) had a photocurrent density of 1.3 mA/cm2 and FF of 0.8 at sundown. Potassium Iodide (KI), Potassium Bromide (KBr) and Mercury Chloride (HgCl2) electrolytes had 0.2 mA/cm2, 0.08 mA/cm2 and 0.02 mA/cm2 photocurrent densities respectively. The fill factors of 0.09, 0.03 and 0.003 respectively for sun overhead while 0.08 mA/cm2, 0.01 mA/cm2 and 0.01 mA/cm2 were the values of photocurrent densities respectively at sundown. The fill factors were 0.02, 0.0006 and 0.003 respectively at sundown. The maximum power Pmax of the DSSCs were 0.5 mW/cm2, 0.10 mW/cm2, 0.01 mW/cm2 and 0.012 mW/cm2 respectively at 1300 h at 1630 h 0.9 mW/cm2, 0.14 mW/cm2, 0.005 mW/cm2 and 0.0015 mW/cm2 respectively.

关键词： Dye-Sensitized Solar Cells Dye Sensitizer Electrolytes M. indica L. Photocurrent Density Fill Factor

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Non-Fistulous Complications of Prolonged Obstructed Labour among Obstetric Fistula Patients in Southern Nigeria

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Open Journal of Obstetrics and Gynecology 2019年第10期9卷 1372-1387页

作者： O. N. abodunrin A. B. C. Daniyan B. Okusanya K. C. Ekwedigwe S. M. Uguru E. N. Yakubu I. Sunday-Adeoye Department of Obstetrics & Gynaecology Lagos University Teaching Hospital Lagos Nigeria National Obstetric Fistula Centre Abakaliki Nigeria.

Background: Long-term complications of prolonged obstructed labour are multisystemic, obstetric fistula about the most devastating. Efforts at controlling obstetric fistula pay little attention to the non-fistulous injuries which reduce the quality of life of the affected women even after a successful fistula repair. The objectives of this study were to determine the burden of the non-fistulous complications among fistula patients, identify these injuries and the factors associated with them. Methods: This cross-sectional study was conducted at the National Obstetric Fistula Centre, Abakaliki, South-East Nigeria from July to December 2016. The hospital has performed over 2600 free fistula repairs. This study was approved by the Research and Ethics Committee of the hospital. The study population comprised of women who developed obstetric fistula following prolonged obstructed labour. Direct questioning, examination findings, operation findings and laboratory results, using a pre-tested, semi-structured and interviewer-administered proforma were used to collect data. Informed consent was obtained from the subjects. Data were analyzed using the Statistical Package for Social Sciences [SPSS] version 21. Frequency and proportions were used to describe categorical variables while means and standard deviation were used to describe continuous variables. Association between categorical variables and direct obstructed labour injuries was tested using chi-square test and predictors of obstructed labour injuries were determined using logistic regression. A P-value 0.05 was considered statistically significant. Results: One hundred and sixty one (161) women participated in the study. The mean age of the women was 33.4 years while the mean parity was 3.2. Non-fistulous complications of prolonged obstructed labour were found in 96.9% (156) of the women. These included cervical retraction (42.2%), obstetric nerve palsy (30.4%), vaginal scarring (29.8%), partial urethral loss (16.1%

关键词： Non-Fistulous Complications Obstructed Labour Obstructed Labour Injuries Obstetric Fistula

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