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Treatment patterns of primary care physicians vs specialists prior to subspecialty urogynaecology referral for women suffering from pelvic floor disorders

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World Journal of Methodology 2019年第2期9卷 26-31页

作者： abigail prentice Ali Ahmad Bazzi Muhammad Faisal Aslam Department of Family Medicine Marquette Health System Marquette MI 49855 United States Department of Obstetrics and Gynaecology St. John Hospital and Medical Center MI 48236 United States

BACKGROUND There are approximately 25% of women in the United States suffering from pelvic floor disorders (PFDs) and this number is predicted to rise. The potential complications and increasing healthcare costs that exist with an operation indicate the importance of conservative treatment options prior to attempting surgery. Considering the prevalence of PFDs, it is important for primary care physician and specialists (obstetricians and gynecologists) to be familiar with the initial work-up and the available conservative treatment options prior to subspecialist (urogynecologist) referral. AIM To assess the types of treatments that specialists attempted prior to subspecialty referral and determine the differences in referral patterns. METHODS This is a retrospective cohort study of 234 patients from a community teaching hospital referred to a single female pelvic medicine and reconstructive surgery (FPMRS) provider for PFD. Specialist vs primary care provider (PCP) referrals were compared. Number, length and treatment types were studied using descriptive statistics. RESULTS There were 184 referrals (78.6%) by specialists and 50 (21.4%) by PCP. Treatment (with Kegel exercises, pessary placements, and anticholinergic medications) was attempted on 51%(n = 26) of the PCP compared to 48%(n = 88) of the specialist referrals prior to FPMRS referral (P = 0.6). There was no significant difference in length of treatment prior to referral for PCPs vs specialists (14 mo vs 16 mo, respectively, P = 0.88). However, there was a significant difference in the patient’s average time with the condition prior to referral (35 mo vs 58 mo for PCP compared to specialist referrals)(P = 0.02). CONCLUSION One half of the patients referred to FPMRS clinic received treatment prior to referral. Thus, specialists and generalists can benefit from education regarding therapies for PFD before subspecialty referral.

关键词： Pelvic floor disorders Referral patterns Female pelvic medicine and reconstructive surgery Primary care provider

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Imaging mass spectrometry:a molecular microscope for studying the role of lipids in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam-Mai Jacob M.Samuel Boone M.prentice Department of Neurology University of FloridaGainesvilleFLUSA Department of Chemistry University of FloridaGainesvilleFLUSA

Parkinson's disease–A lipidopathy?The histopathological hallmark of Parkinson's disease(PD)and dementia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only composed of proteins,but also a core of lipid *** has been thus far principally thought of as a“proteinopathy”caused by the misfolding of α-syn.

关键词： lipids species folding

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Intermodal Competition: Cargo Airships versus Long-Haul Trucking for Perishable Commodities

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Journal of Transportation Technologies 2024年第2期14卷 195-211页

作者： Barry Everett prentice Transport Institute I.H. Asper School of Business University of Manitoba Winnipeg Manitoba Canada

Intermodal competition changes with changes in technology, economics, and environmental concerns. Trucks and airships are generally considered not to be competitors, but this depends on the distance of haul. The tonne-kilometer cost of trucking rises much more quickly with distance than it does the cost of a cargo airship. At some distance, the two modes are direct substitutes. The costs of the Mexico-Canada refrigerated truck supply chain are compared with the costs of a 100t-lift, electrically-powered airship. The flight characteristics of the Hindenburg Zeppelin are used as a model for a modern cargo airship. The supply chain cost of trucking tomatoes is used to test the theorical proposition. The cost difference works out to about US10￠/kg (5￠/lb) advantage for trucking Mexican tomatoes to Canada. However, this cost disadvantage of the airship could be made up by their vibrationless ride, better air circulation and one-day service versus four days by truck. This alternative form of transportation could have a positive impact on worldwide north-south distribution of food. Airships can overcome trade barriers and distance to open new markets for perishable food exports. In addition, they would reduce the carbon emissions of transport. Canada imports 160,000 refrigerated truckloads of fruits and vegetables by from the southern US and Mexico. With an average driving distance of 3,000 km, these trucks emit 606,000 MT of CO2 annually. Airships powered by hydrogen fuel cells would have zero-carbon emissions. Markets are not yet incorporating the environmental advantage of airships in any freight comparison, but inevitably this will be important.

关键词： Airship Refrigerated Trucks Mexico Tomatoes Carbon-emissions Perishables

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Intermodal Competition: Cargo Airships versus Long-Haul Trucking for Perishable Commodities

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Journal of Transportation Technologies（交通科技期刊） 2024年第2期 195页

作者： Barry Everett prentice

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Nutritional epidemiology methods and related statistical challenges and opportunities

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Statistical Theory and Related Fields 2018年第1期2卷 2-10页

作者： Ross L.prentice Ying Huang Fred Hutchinson Cancer Research Center and University of Washington SeattleWAUSA

The public health importance of nutritional epidemiology research is discussed,along withmethodological challenges to obtaining reliable information on dietary approaches to chronicdisease *** issues in assessing dietary intake need to be addressed toobtain reliable disease association ***-reported dietary data typically incorporatemajor random and systematic *** biomarkers offer potential for more reliable analyses,but biomarkers have been established only for a few dietary variables,and these may be tooexpensive to apply to all participants in large epidemiologic cohorts.A possible way forwardinvolves additional nutritional biomarker development using high-dimensional metabolomicprofiling,using blood and urine specimens,in conjunction withfurther development of statisticalapproaches for accommodating measurement error with failure time response *** the opportunity to contribute greatly to worldwide public health through the development of statistical methods to address these nutritional epidemiology research challenges,asis elaborated in this contribution.

关键词： Chronic disease epidemiology failure time data hazard ratio measurement error metabolomics nutritional biomarker regression calibration

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Response to discussion of‘Nutritional epidemiology methods and related statistical challenges and opportunities’

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Statistical Theory and Related Fields 2018年第1期2卷 23-26页

作者： Ross L.prentice Ying Huang Fred Hutchinson Cancer Research Center and University of Washington Seattle WAUSA

We very much appreciate each of the three sets of comments on our *** manuscript argued thatthe nutritional epidemiology research area,which is soimportant to worldwide public health,is burdened withchallenges in estimating dietary intakes,both shortterm intakes and intakes over the years or decades thatmay be relevant to chronic disease *** nutritional epidemiology literature having chronic diseaseoutcomes mostly relies on dietary self-report *** few dietary variables having an established objective measure(biomarker),comparison with self-reportdata suggests that the data include not only a large‘noise’component,which available statistical methods can typically accommodate,but frequently also alarge systematic bias component that,for example,maydepend on such study subject body mass index(BMI),age and ethnicity,among other *** is the needto address this systematic bias component of dietaryintake assessment that stimulates our call for additionalreliance on biomarkers,for additional biomarker development,and for the development of novel and flexible statistical methods for use in disease associationanalyses.

关键词： intake epidemiology mostly

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A comparison of handheld and standard ultrasound in Swiss medical students

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World Journal of Emergency Medicine 2022年第2期13卷 85-90页

作者： Mark Slader Hayley Young Margot Barker Kylie prentice Katherine Bogaard Charlene Yuan Soheil Saadat Shadi Lahham School of Medicine University of CaliforniaIrvine 92617USA Department of Emergency Medicine University of CaliforniaIrvine 92868USA

BACKGROUND:The use of ultrasound(US)within healthcare has inspired the development of new US *** have been few studies comparing the use of handheld US to standard US for medical *** research aims to determine whether a handheld US device can provide a comparable primary learning experience to that of a standard US ***:Over two days of instruction,participants were taught and evaluated on core US *** standard group received instruction on standard US machines,while the handheld group received instruction on handheld US *** completed a qualitative survey regarding their *** hundred and four images were obtained and graded by two emergency medicine ***:A total of 119 Swiss medical students were enrolled in our *** was no statistically significant difference in the US assessment measurements,except for faster endpoint septal separation(EPSS)vascular setup time in the handheld group(P=0.001).There was no statistically significant difference in participants’perceived difficulty of US learning(P=0.198),comfort level(P=0.188),or self-estimated capability to perform US in the future(P=0.442).There was no statistically significant difference in the percentage of correctly obtained images(P=0.211)or images that were clinically useful(P=0.256).The median quality score of images obtained by the standard group was eight compared to seven in handheld group(P<0.01).CONCLUSION:Our data suggest a handheld US machine can perform as well as a standard US machine as an educational tool despite sacrifices in image quality.

关键词： Handheld ultrasound Ultrasound education Switzerland Medical education

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Stepsize Selection in Explicit Runge-Kutta Methods for Moderately Stiff Problems

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Applied Mathematics 2011年第6期2卷 711-717页

作者： Justin Steven Calder prentice 不详

We present an algorithm for determining the stepsize in an explicit Runge-Kutta method that is suitable when solving moderately stiff differential equations. The algorithm has a geometric character, and is based on a pair of semicircles that enclose the boundary of the stability region in the left half of the complex plane. The algorithm includes an error control device. We describe a vectorized form of the algorithm, and present a corresponding MATLAB code. Numerical examples for Runge-Kutta methods of third and fourth order demonstrate the properties and capabilities of the algorithm.

关键词： Moderately Stiff Problems Runge-Kutta Stepsize Jacobian Stability Region

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Sulindac for stroke treatment: neuroprotective mechanism and therapy

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Neural Regeneration Research 2014年第23期9卷 2023-2025页

作者： Jigar Pravinchandra Modi Howard prentice Jang-Yen Wu College of Medicine Florida Atlantic University Centre of Complex Systems and Brain Sciences Florida Atlantic University Program in Integrative Biology Florida Atlantic University

Sulindac, a widely used nonsteroidal anti-inflammatory drug （NSAID） is a prodrug that is reduced by methionine sulfoxide reductase to its active form as an inhibitor of cyclooxygenase 1 and 2. The drug has been shown to elicit tissue protection by processes that may include at least three functions： antioxidant, preconditioning and anti-inflammatory. Sulindac demonstrates neuroprotection that involves inhibition of mitochondrial calcium overload or a decrease in protein oxidation.

关键词： NSAIDs Sulindac for stroke treatment neuroprotective mechanism and therapy

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Cargo Airships: International Competition

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Journal of Transportation Technologies 2014年第3期4卷 187-195页

作者： Barry E. prentice Robert Knotts Airship Association London UK I.H. Asper School of Business University of Manitoba Winnipeg Canada

The advance of transportation technology depends on science and economics. During the 1930s, airships and airplanes competed head-to-head for the Atlantic passenger market. When World War 2 broke out, everything changed. Over the next five years, the combined combatants built over half of a million military airplanes. By the end of the war, four-engine, high-altitude bombers and jet engines were developed. Further investment in airplane technology was stimulated by the Cold War. All this public investment was adapted to civilian passenger jet airplanes. By 1980, dedicated jet airplanes were in use as cargo carriers. Despite the growth of the cargojet market over the past three decades, rising fuel costs and environmental concerns are changing the economics of airships and airplanes again. Investment in large cargo airships is returning. Much of the technology developed for fixed-wing aircraft can be applied to cargo airships. New materials, better engines, control systems and engineering eliminate the need for large ground crews and improve airship reliability and safety. However, two fundamental design issues have yet to be resolved: structural integrity and buoyancy control. A worldwide competition is underway on three continents to develop the dominant design for a cargo airship. This paper examines the alternative design approaches and presents the status of the international competition.

关键词： Cargo Airships Dominant Design World Developments

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