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Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats:oxidative/inflammatory/apoptotic pathways

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Asian Journal of Andrology 2024年第4期26卷 396-401页

作者： Ramadan s hussein Moustafa M Eyada Rashad M Mostafa samah M Elaidy shereen h Elsayed hany M saad Department of Dermatology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Department of Dermatology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Andrology and sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Clinical Pharmacology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Rehabilitation sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid hormones play essential roles in spermatogenesis,but their effects on infertile males remain poorly *** study aimed to evaluate the impact of combining carbimazole(CBZ)with vitamin E(VE)on testicular injury induced by experimental hyperthyroidism in adult albino rats,focusing on oxidative,inflammatory,and apoptotic *** this experimental study,64 adult male albino Wistar rats were divided into eight groups:Group I(control-untreated),Group II(CBZ-control),Group III(VE-control),Group IV(CBZ+VE-control),Group V(levothyroxine-induced testicular injury),Group VI(levothyroxine+CBZ-treated),Group VII(levothyroxine+VE-treated),and Group VIII(levothyroxine+CBZ+VE-treated).The study was conducted in the Faculty of Medicine,suez Canal University(Ismailia,Egypt).After cervical decapitation,both testes and epididymis were examined histopathologically and *** differences were observed among groups concerning malondialdehyde(MDA),glutathione(Gsh),superoxide dismutase(sOD),and catalase(CAT;all Plymerase chain reaction analysis showed significant differences in tumor necrosis factor-α(TNF-α),interleukin-10(Il-10),Bcl-2-associated X protein(BAX),B-cell lymphoma 2 protein(Bcl2),p53,Caspase-3,Caspase-8,Caspase-9,and nuclear factor-kappa B(NF-κB)mRNA levels(all Phyperthyroid group treated with CBZ alone(Group VI)exhibited testicular side effects,affecting seminiferous tubules and ***,the Group VIII showed improved spermatogenesis and a decrease in testicular side *** addition of VE to the treatment of hyperthyroid rats with CBZ reduced testicular side effects and seminiferous tubular affection when potentially improving *** research is needed to elucidate the underlying mechanisms fully.

关键词： antithyroid drugs testicular injury thyroid gland vitamin E

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Common coupled fixed point theorem for two pairs compatible and sub-sequentially continuous mapping

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Journal of Ocean Engineering and science 2024年第4期9卷 401-407页

作者： h.M.Abu-Donia Mona s.Bakry h.A.Atia Omnia M.A.Khater Raghda A.M.Attia Department of Mathematics Faculty of ScienceZagazig UniversityZagazigEgypt Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt Department of Basic science Zagazig Higher Institute of Engineering and TechnologyZagazigEgypt Department of Basic science Higher Technological Institute 10th of Ramadan CityEl Sharqia 44634Egypt

This study establishes a common coupled fixed point for two pairs of compatible and sequentially continuous mappings in the intuitionistic fuzzy metric space that satisfy theφ-contractive *** basic definitions and theorems have been used from some recent scientific papers about the binary operator,t-norm,t-conorm,intuitionistic fuzzy metric space,and compatible mapping for reaching to the paper’s purpose.

关键词： Intuitionistic fuzzy metric space φ-contractive mapping Compatible mappings Couple fixed point

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Quantized autoencoder(QAE)intrusion detection system for anomaly detection in resource-constrained loT devices using RT-loT2022 dataset

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Cybersecurity 2024年第2期7卷 13-27页

作者： B s sharmila Rohini Nagapadma Depatment of Electronics and Communication Engineering The National Institute of EngineeringMysoreKarnataka 570008India

In recent years,many researchers focused on unsupervised learning for network anomaly detection in edge devices to identify *** deployment of the unsupervised autoencoder model is computationally expensive in resource-constrained edge *** study proposes quantized autoencoder(QAE)model for intrusion detection systems to detect *** is an optimization model derived from autoencoders that incorporate pruning,clustering,and integer quantization *** autoencoder uint8(QAE-u8)and quantized autoencoder float16(QAE-f16)are two variants of QAE built to deploy computationally expensive Al models into Edge ***,we have generated a Real-Time Internet of Things 2022 dataset for normal and attack *** autoencoder model operates on normal traffic during the training *** same model is then used to reconstruct anomaly traffic under the assumption that the reconstruction error(RE)of the anomaly will be high,which helps to identify the ***,we study the performance of the autoencoders,QAE-u8,and QAE-f16 using accuracy,precision,recall,and F1 score through an extensive experimental *** showed that QAE-u8 outperforms all other models with a reduction of 70.01%in average memory utilization,92.23%in memory size compression,and 27.94%in peak CPU ***,the proposed QAE-u8 model is more suitable for deployment on resource-constrained IoT edge devices.

关键词： IoT constrained system

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Industrial Fusion Cascade Detection of solder Joint

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Computers, Materials and Continua 2024年第1期81卷 1197-1214页

作者： li C. Zhang P. Wang s. liu l. shi M. Chongqing school University of Chinese Academy of Sciences Chongqing University Chongqing 400044 China Automatic Reasoning and Cognition Research Center Chongqing Institute ofGreen and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China College of Artificial Intelligence Chongqing School University of Chinese Academy of Sciences Chongqing 400714 China Design Department Liuzhou Fuzhen Bodywork Industrial Co. Ltd. Liuzhou 545006 China

With the remarkable advancements in machine vision research and its ever-expanding applications, scholars have increasingly focused on harnessing various vision methodologieswithin the industrial realm. specifically, detecting vehicle floor welding points poses unique challenges, including high operational costs and limited portability in practical settings. To address these challenges, this paper innovatively integrates template matching and the Faster RCNN algorithm, presenting an industrial fusion cascaded solder joint detection algorithm that seamlessly blends template matching with deep learning techniques. This algorithm meticulously weights and fuses the optimized features of both methodologies, enhancing the overall detection capabilities. Furthermore, it introduces an optimized multi-scale and multi-template matching approach, leveraging a diverse array of templates and image pyramid algorithms to bolster the accuracy and resilience of object detection. By integrating deep learning algorithms with this multi-scale and multi-template matching strategy, the cascaded target matching algorithm effectively accurately identifies solder joint types and positions. A comprehensive welding point dataset, labeled by experts specifically for vehicle detection, was constructed based on images from authentic industrial environments to validate the algorithm's performance. Experiments demonstrate the algorithm's compelling performance in industrial scenarios, outperforming the single-template matching algorithm by 21.3%, the multi-scale and multitemplate matching algorithm by 3.4%, the Faster RCNN algorithm by 19.7%, and the YOlOv9 algorithm by 17.3% in terms of solder joint detection accuracy. This optimized algorithm exhibits remarkable robustness and portability, ideally suited for detecting solder joints across diverse vehicle workpieces. Notably, this study's dataset and feature fusion approach can be a valuable resource for other algorithms seeking to enhance their

关键词： Cascade object detection deep learning feature fusion multi-scale and multi-template matching solder joint dataset

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A study on the Explainability of Thyroid Cancer Prediction:shAP Values and Association-Rule Based Feature Integration Framework

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Computers, Materials & Continua 2024年第5期79卷 3111-3138页

作者： sujithra sankar s.sathyalakshmi Department of Computer Applications Hindustan Institute of Technology and ScienceChennaiTamil NaduIndia Department of Computer Engineering Hindustan Institute of Technology and ScienceChennaiTamil NaduIndia

In the era of advanced machine learning techniques,the development of accurate predictive models for complex medical conditions,such as thyroid cancer,has shown remarkable *** predictivemodels for thyroid cancer enhance early detection,improve resource allocation,and reduce ***,the widespread adoption of these models in clinical practice demands predictive performance along with interpretability and *** paper proposes a novel association-rule based feature-integratedmachine learning model which shows better classification and prediction accuracy than present *** study also focuses on the application of shapley Additive exPlanations(shAP)values as a powerful tool for explaining thyroid cancer prediction *** the proposed method,the association-rule based feature integration framework identifies frequently occurring attribute combinations in the *** original dataset is used in trainingmachine learning models,and further used in generating shAP values *** the next phase,the dataset is integrated with the dominant feature sets identified through association-rule based *** new integrated dataset is used in re-training the machine learning *** new shAP values generated from these models help in validating the contributions of feature sets in predicting *** conventional machine learning models lack interpretability,which can hinder their integration into clinical decision-making *** this study,the shAP values are introduced along with association-rule based feature integration as a comprehensive framework for understanding the contributions of feature sets inmodelling the *** study discusses the importance of reliable predictive models for early diagnosis of thyroid cancer,and a validation framework of *** proposed model shows an accuracy of 93.48%.Performance metrics such as precision,recall,F1-score,and the area un

关键词： Explainable AI machine learning clinical decision support systems thyroid cancer association-rule based framework shAP values classification and prediction

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Correlation Composition Awareness Model with Pair Collaborative localization for IoT Authentication and localization

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Computers, Materials & Continua 2024年第4期79卷 943-961页

作者： Kranthi Alluri s.Gopikrishnan school of Computer science and Engineering VIT-AP UniversityAmaravathiAndhra Pradesh522241India

secure authentication and accurate localization among Internet of Things(IoT)sensors are pivotal for the functionality and integrity of IoT *** authentication and localization are intricate and symbiotic,impacting both the security and operational functionality of IoT ***,accurate localization and lightweight authentication on resource-constrained IoT devices pose several *** overcome these challenges,recent approaches have used encryption techniques with well-known key ***,these methods are inefficient due to the increasing number of data breaches in their localization *** proposed research efficiently integrates authentication and localization processes in such a way that they complement each other without compromising on security or *** proposed framework aims to detect active attacks within IoT networks,precisely localize malicious IoT devices participating in these attacks,and establish dynamic implicit authentication *** integrated framework proposes a Correlation Composition Awareness(CCA)model,which explores innovative approaches to device correlations,enhancing the accuracy of attack detection and ***,this framework introduces the Pair Collaborative localization(PCl)technique,facilitating precise identification of the exact locations of malicious IoT *** address device authentication,a Behavior and Performance Measurement(BPM)scheme is developed,ensuring that only trusted devices gain access to the *** work has been evaluated across various environments and compared against existing *** results prove that the proposed methodology attains 96%attack detection accuracy,84%localization accuracy,and 98%device authentication accuracy.

关键词： sensor localization IoT authentication network security data accuracy precise location access control security framework

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Convergence,scalarization and Continuity of Minimal solutions in set Optimization

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Journal of the Operations Research society of China 2024年第3期12卷 773-793页

作者： Karuna C.s.lalitha Department of Mathematics University of DelhiDelhiDelhi110007India Department of Mathematics University of Delhi South CampusNew DelhiDelhi110021India

The paper deals with the study of two different aspects of stability in the given space as well as the image space,where the solution concepts are based on a partial order relation on the family of bounded subsets of a real normed linear *** first aspect of stability deals with the topological set convergence of families of solution sets of perturbed problems in the image space and Painlevé–Kuratowski set convergence of solution sets of the perturbed problems in the given *** convergence in the given space is also established in terms of solution sets of scalarized perturbed *** second aspect of stability deals with semicontinuity of the solution set maps of parametric perturbed problems in both the spaces.

关键词： Topological convergence Painlevé-Kuratowski convergence Upper semicontinuity lower semicontinuity stability scalarization

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Impact of Paenibacillus elgii supernatant on screening bacterial strains with potential for biotechnological applications

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Engineering Microbiology 2024年第3期4卷 1-15页

作者： I.C.Cunha-Ferreira C.s.Vizzotto T.D.Frederico J.Peixoto l.s Carvalho M.R.Tótola R.h.Krüger laboratory of Enzymology Department of Cellular BiologyUniversity of Brasília(UNB)Brasília70910-900Brazil laboratory of Environmental sanitation Department of Civil and Environmental EngineeringUniversity of Brasília(UNB)Brasília70910-900Brazil laboratório de Biotecnologia e Biodiversidade para o Meio Ambiente Universidade Federal de Viçosa(UFV)Viçosa36570-900Brazil

The biotechnological industry faces a crucial demand for novel bioactive compounds,particularly antimicrobial agents,to address the rising challenge of bacterial resistance to current available *** strate-gies for cultivating naturally occurring microorganisms often limit the discovery of novel antimicrobial *** study presents a protocol for targeted selection of bacterial strains using the supernatant of Paenibacillus el-gii,which produces abundant signal molecules and antimicrobial *** samples were inoculated in these enriched culture media to selectively cultivate bacteria resistant to the supernatant,indicating their potential to produce similar *** bacterial strains isolated through this method were assessed for their antibac-terial *** addition,the functional annotation of the genome of one of these strains revealed several gene clusters of biotechnological *** study highlights the effectiveness of using this approach for selective cultivation of microorganisms with potential for biotechnological applications.

关键词： Prospecting supernatant Antibacterial activity

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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid h.A.l-hashem salah O.Bashir Amal F.Dawood Moutasem s.Aboonq Ismaeel Bin-Jaliah Abdulaiziz M.Al-Garni Mohamed D.Morsy Department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic Medical sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of Medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

Memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the Morris Water Maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

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Evaluation of red soil-bentonite mixtures for compacted clay liners

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 697-710页

作者： A.s.Devapriya T.Thyagaraj Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India

Compacted clay liners are an integral part of the waste landfills,which are provided to contain the leachate within the landfills and protect the surrounding ***,locally available natural soils are used for the construction of compacted clay liners if they satisfy the design ***,not all soils in their natural state satisfy all the design criteria for the liner ***,there is a definite need to modify the locally available natural soils by blending with bentonite to meet the required design criteria for the *** view of this,the present study evaluates the suitability of an Indian red soil enhanced with bentonite as a liner *** achieve this,a series of experiments were carried out using locally available red soil and ***,the suitability of the red soil was evaluated as a liner *** experimental results showed that the red soil met all the selection criteria stipulated by the Environmental Protection Agencies(EPAs)for the liners except the hydraulic conductivity ***,the red soil was mixed with bentonite contents of 10%,20%and 30%,and the red soil-bentonite mixtures were evaluated for their suitability for liners in their compacted ***,as the liners in the arid and semi-arid regions are subjected to moisture variations due to seasonal moisture fluctuations and other factors,the red soil-bentonite mixtures were subjected to wetdry cycles,and their suitability was evaluated after wet-dry *** experimental results revealed that all the red soil-bentonite mixtures met the stipulated EPA criteria for the liners in the as-compacted ***,the red soil-bentonite mixtures with 20%and 30%bentonite contents only satisfied the hydraulic conductivity requirement even after wet-dry *** experimental findings were supplemented with the microstructural insights captured through digital camera images,scanning electron microscopy(sEM),and mercury intrusion porosimetry(M

关键词： Compacted clay lines hydraulic conductivity Wet-dry cycles Microstructure

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