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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

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准备迎接更严格的美国商标法

进出口经理人 2015年第4期 78-80页

作者： B.Brett Heavner Morgan e.smith 美国飞翰律师事务所

目前，与美国公民和公司相比，非美国的商标所有者在向美国专利及商标局（USPTO）注册其商标时具有显著优势。具体而言，美国法律要求美国公民和位于美国的公司提交证据来证明其所申请的商标在注册签发前已在美国商业市场中使用，参见15... 详细信息

目前，与美国公民和公司相比，非美国的商标所有者在向美国专利及商标局（USPTO）注册其商标时具有显著优势。具体而言，美国法律要求美国公民和位于美国的公司提交证据来证明其所申请的商标在注册签发前已在美国商业市场中使用，参见15 U.S.C.§1051，商标审查程序手册（TMeP）§903、904。美国商标法“用于商业”这一要求的公共政策基础是USPTO商标注册应能反映美国市场的实际状况。企业只能为其在美国实际提供的产品和服务在美国获得商标权。

关键词：美国公民商标法 USPTO 商标注册商业市场美国专利法律要求审查程序

Associations of self-reported and device-assessed physical activity with fatigue,quality of life,and sleep quality in adults living with and beyond cancer

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Journal of Sport and Health Science 2023年第6期12卷 664-673,F0003页

作者： Phillippa Lally Natalie ella Miller Claire Lawrence Rebecca J Beeken abigail Fisher Department of Behavioural Science and Health University College LondonLondon WC1E 6BTUK Department of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Health Sciences Leeds LS29NLUK

Background Greater physical activity is associated with improved outcomes in people living with and beyond ***,most studies in exercise oncology use self-reported measures of physical *** have explored agreement between self-reported and device-based measures of physical activity in people living with and beyond *** study aimed to describe physical activity in adults affected by cancer across self-reported and device-assessed activity,to explore levels of agreement between these measures in terms of their utility for categorizing participants as meeting/not meeting physical activity guidelines,and to explore whether meeting guidelines is associated with fatigue,quality of life,and sleep *** A total of 1348 adults living with and beyond cancer from the Advancing Survivorship Cancer Outcomes Trial completed a survey assessing fatigue,quality of life,sleep quality,and physical *** Godin-Shephard Leisure-Time Physical Activity Questionnaire was used to calculate a Leisure Score Index(LSI)and an estimate of moderate-to-vigorous physical activity(MVPA).Average daily steps and weekly aerobic steps were derived from pedometers worn by *** The percentage of individuals meeting physical activity guidelines was 44.3%using LSI,49.5%using MVPA,10.8%using average daily steps,and 28.5%using weekly aerobic ***(Cohen'sκ)between self-reported and pedometer measures ranged from 0.13(LSI *** daily steps)to 0.60(LSI ***).After adjusting for sociodemographic and health-related covariates,meeting activity guidelines using all measures was associated with not experiencing severe fatigue(odds ratios(ORs):1.43–1.97).Meeting guidelines using MVPA was associated with no quality-of-life issues(OR=1.53).Meeting guidelines using both self-reported measures were associated with good sleep quality(ORs:1.33–1.40).Conclusion Less than half of all adults affected by cancer are meeting physical activity guidelines,

关键词： Cancer survivorship Fatigue Physical activity Quality of life SleepTagedAPTARAend

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Skilful Forecasts of Summer Rainfall in the Yangtze River Basin from November

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Advances in Atmospheric Sciences 2023年第11期40卷 2082-2091页

作者： Philip e.BeTT Nick DUNSTONe Nicola GOLDING Doug smith Chaofan LI Met Office Hadley Centre FitzRoy RoadExeter EX13PBUK Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of earth and Planetary Sciences University of the Chinese Academy of SciencesBeijing 100049China

Variability in the east Asian summer monsoon(eASM)brings the risk of heavy flooding or drought to the Yangtze River basin,with potentially devastating *** forecasts of the likelihood of enhanced or reduced monsoon rainfall can enable better management of water and hydropower resources by decision-makers,supporting livelihoods and major economic and population centres across eastern *** paper demonstrates that the eASM is predictable in a dynamical forecast model from the preceding November,and that this allows skilful forecasts of summer mean rainfall in the Yangtze River basin at a lead time of six *** skill for May–June–July rainfall is of a similar magnitude to seasonal forecasts initialised in spring,although the skill in June–July–August is much weaker and not consistently ***,there is some evidence for enhanced skill following el Niño *** potential for decadal-scale variability in forecast skill is also examined,although we find no evidence for significant variation.

关键词： seasonal forecasting interannual forecasting flood forecasting Yangtze basin rainfall east Asian summer monsoon

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浮游鱼卵和仔鱼的调查规范

福建水产 1984年第4期6卷 74-77页

作者： Paul e.smith Sally L.Richardson 陈枫

估算鱼类种群数量的方法很多，其中鱼卵和仔鱼也可用来作为评估成体种群数量的指标。许多海洋鱼类的卵和仔鱼都是浮游性的，只需用简单的浮游生物网就可进行采样。采样用的调查船无需特殊要求，设备简单，花费较少。并且，使用仔鱼指标... 详细信息

估算鱼类种群数量的方法很多，其中鱼卵和仔鱼也可用来作为评估成体种群数量的指标。许多海洋鱼类的卵和仔鱼都是浮游性的，只需用简单的浮游生物网就可进行采样。采样用的调查船无需特殊要求，设备简单，花费较少。并且，使用仔鱼指标估算出的种群数量较为可靠。由于具有这些优点，所以使用鱼卵和仔鱼来评估种群数量的方法开始受到重视。

关键词：鱼卵仔鱼种群数量成体浮游生物使用鱼类种群海洋鱼类

A Model to Describe the Fracture of Porous Polygranular Graphite Subject to Neutron Damage and Radiolytic Oxidation

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Computers, Materials & Continua 2016年第3期51卷 163-185页

作者： G.smith e.Schlangen P.e.J.Flewitt A.G.Crocker A.Hodgkins Interface Analysis Centre School of PhysicsUniversity of BristolBristolBS81TLUK Faculty of Civil engineering and Geosciences Delft University of TechnologyDelftNetherlands HH Wills Physics Laboratory School of PhysicsUniversity of BristolBristolBS81TLUK Physics Department University of SurreyGuildfordGU27XH AMeC Clean energy now AMEC Foster-WheelerWalton House404 Faraday StreetBirchwood ParkWarringtonCheshireWA36GAUK

Two linked models have been developed to explore the relationship between the amount of porosity arising in service from both radiolytic oxidation and fast neutron damage that influences both the strength and the force-displacement(load-displacement)behaviour and crack propagation in pile grade A graphite used as a nuclear reactor moderator *** models of the microstructure of the porous graphite for both unirradiated and irradiated graphite are *** form the input for the second stage,simulating fracture in lattice-type finite element models,which predicts force(load)-displacement and crack propagation *** comprising aligned filler particles,typical of needle coke,in a porous matrix have been *** purpose was to isolate the contributions of filler particles and porosity to fracture strength and crack paths and consider their implications for the overall failure of reactor core graphite.

关键词： Reactor core graphite Modelling microstructure Fe lattice model Fracture strength Crack path

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法律经济学中财产权怎么了?

私法 2003年第2期5卷 252-297页

作者： Thomas W.Merrill Henry e.smith 罗胜华西北大学法学院北京大学法学院

文章追溯了作为一种特别的对物权的财产权概念在英美法理论中的衰亡,以及财产权只是特定资源的一系列利用权的集合的观点在现代法律经济学中的兴起。文章的第一部分,指出了财产权的对物维度在学术讨论中消失的事实。文章的第二部分,回... 详细信息

文章追溯了作为一种特别的对物权的财产权概念在英美法理论中的衰亡,以及财产权只是特定资源的一系列利用权的集合的观点在现代法律经济学中的兴起。文章的第一部分,指出了财产权的对物维度在学术讨论中消失的事实。文章的第二部分,回顾了财产权的传统概念以及法律现实主义者对于财产权是一个'权利束'的另一种解释的鼓吹。在这个基础上,第三部分重新审视了科斯的经典论文,力求揭示所暗含的支撑其理论的财产权概念,认为科斯采纳了法律现实主义者偏爱的'权利束'财产权概念的一个极端版本。随后的第四部分,选择性地评述了后科斯主义法律经济学者对财产权的各种论述,发现'使用的序列'的概念贯穿于始终。第五部分,简要地考察了承认财产权的对物维度能够有助于法律经济学者更好地解释财产权问题的几个方面。第六部分总结全文。

关键词：财产权对物权对人权法律经济学

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迭代制导及其在火箭飞行中的应用

导弹与航天运载技术(中英文) 1983年第12期 35-45页

作者： DORIS C.CHANDLeR ISAAC e.smith 鸣远

本文讨论了迭代制导模型及其在火箭上面级的三维真空飞行中的应用。迭代制导模型是一种惯性的闭合系统模型,在这种模型中,火箭起飞后只需要火箭导航系统的输入信号。也就是说,迭代制导按照火箭状态(速度,位置,纵向加速度和重力加速度)... 详细信息

本文讨论了迭代制导模型及其在火箭上面级的三维真空飞行中的应用。迭代制导模型是一种惯性的闭合系统模型,在这种模型中,火箭起飞后只需要火箭导航系统的输入信号。也就是说,迭代制导按照火箭状态(速度,位置,纵向加速度和重力加速度)和要求的发动机关机状态来计算操纵指令。制导指令每个制导循环修正一次,以便用来修正火箭状态。迭代制导方案是一种轨道适应制导方案,该方案是火箭在各种预计扰动量的扰动下,轨道均将保持其最佳特性而不使发动机关机点精度受到任何损失。它的最佳特性和精度已由土星1B和土星V的飞行所证实。

关键词：方程火箭飞行迭代制导多级火箭

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重载货车径向转向架的经济效益及其性能

国外铁道车辆 2007年第1期44卷 34-38页

作者： Roy e.smith[加拿大] 李莉（译）刘宏友（校）

介绍了Resco engineering公司研发的货车用构架式径向转向架。经AAR试验表明,与常规转向架及性能良好的转向架相比,Resco径向转向架的曲线通过能力非常优越,动力学稳定性极好。从经济效益角度,概述了采用Resco径向转向架所能产生的一系... 详细信息

介绍了Resco engineering公司研发的货车用构架式径向转向架。经AAR试验表明,与常规转向架及性能良好的转向架相比,Resco径向转向架的曲线通过能力非常优越,动力学稳定性极好。从经济效益角度,概述了采用Resco径向转向架所能产生的一系列节约效果。

关键词：重载货车转向架加拿大