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Tea tree oil,a vibrant source of neuroprotection via neuroinflammation inhibition:a critical insight into repurposing Melaleuca alternifolia by unfolding its characteristics

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第7期24卷 554-573页

作者： Md Atiar RAHMAN abida sultana Mohammad Forhad KHAN Rachasak BOONHOK Sharmin AFROZ Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh School of Allied Health Sciences Walailak UniversityNakhon Si Thammarat 80160Thailand Department of Chemistry University of Massachusetts BostonBostonMA 02125USA Department of Medical Technology School of Allied Health Sciencesand Research Excellence Center for Innovation and Health Products(RECIHP)Walailak UniversityNakhon Si Thammarat 80160Thailand Department of Theoretical and Computational Chemistry University of DhakaDhaka-1000Bangladesh

Over the past few decades,complementary and alternative treatments have become increasingly popular *** purported therapeutic characteristics of natural products have come under increased scrutiny both in vitro and in vivo as part of efforts to legitimize their *** such product is tea tree oil(TTO),a volatile essential oil primarily obtained from the native Australian plant,Melaleuca alternifolia,which has diverse traditional and industrial applications such as topical preparations for the treatment of skin *** anti-inflammatory-linked immunomodulatory actions have also been *** systematic review focuses on the anti-inflammatory effects of TTO and its main components that have shown strong immunomodulatory *** extensive literature search was performed electronically for data curation on worldwide accepted scientific databases,such as Web of Science,Google Scholar,PubMed,ScienceDirect,Scopus,and esteemed publishers such as Elsevier,Springer,Frontiers,and Taylor&*** that the majority of pharmacological studies were conducted on crude oils only,the extracted data were critically analyzed to gain further insight into the prospects of TTO being used as a neuroprotective agent by drug formulation or dietary *** addition,the active constituents contributing to the activity of TTO have not been well justified,and the core mechanisms need to be unveiled especially for anti-inflammatory and immunomodulatory effects leading to ***,this review attempts to correlate the anti-inflammatory and immunomodulatory activity of TTO with its neuroprotective mechanisms.

关键词： Tea tree oil Anti-inflammatory Anti-viral Antibacterial Terpinen-4-ol18-Cineole Neuroprotective effect

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茶树油抑制神经炎症并提供神经保护——探索互花千层的潜力（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第7期 554-574页

作者： Md Atiar RAHMAN abida sultana Mohammad Forhad KHAN Rachasak BOONHOK Sharmin AFROZ Department of Biochemistry and Molecular Biology University of Chittagong School of Allied Health Sciences Walailak University Department of Chemistry University of Massachusetts Boston Department of Medical Technology School of Allied Health Sciences and Research Excellence Center for Innovation and Health Products(RECIHP) Walailak University Department of Theoretical and Computational Chemistry University of Dhaka

在过去的几十年里，补充和替代治疗在世界范围内越来越受欢迎。为使天然产品使用合法化，其治疗特性在体外和体内都受到了越来越多的审查。其中一种产品茶树油（TTO）是一种主要从澳大利亚本土植物互叶千层获得的挥发性精油，具有多种... 详细信息

在过去的几十年里，补充和替代治疗在世界范围内越来越受欢迎。为使天然产品使用合法化，其治疗特性在体外和体内都受到了越来越多的审查。其中一种产品茶树油（TTO）是一种主要从澳大利亚本土植物互叶千层获得的挥发性精油，具有多种传统和工业应用，如用于治疗皮肤感染的外用制剂，或参与抗炎相关的免疫调节作用。本系统综述重点关注TTO及其主要成分的抗炎作用。我们对全球公认的科学数据库（如Web of Science、Google Scholar、Pub Med、Science Direct、Scopus）和知名出版商（如Elsevier、Springer、Frontiers、和Taylor&Francis）进行了电子文献检索和数据管理。考虑到大多数药理学仅研究原油，因此我们对提取的数据进行了严格的分析，了解TTO通过药物制剂或膳食补充剂作为神经保护剂的前景。此外，促进TTO活性的有效成分还没有被很好地证明，特别是导致神经保护的抗炎和免疫调节作用的核心机制需要被揭示。因此，本综述试图将TTO的抗炎和免疫调节活性与其神经保护机制联系起来。

关键词：茶树油抗炎抗病毒抗菌萜烯-4-醇 1,8-桉叶素神经保护作用

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Studies on the Hypoglycemic and Hypolipidemic Effects of <i>Nelumbo nucifera</i>Leaf in Long-Evans Rats

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Journal of Diabetes Mellitus 2017年第3期7卷 55-70页

作者： Dipa Islam Amdadul Huque Liton Chandra Mohanta Evena Parvin Lipy Md. Nazibur Rahman abida sultana Sheuly U. K. Prodhan Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Bangladesh Biomedical and Toxicological Research Institute Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh Department of Biochemistry and Molecular Biology Jahangirnagar University Savar Dhaka Bangladesh Department of Food Technology Kishoreganj Polytechnic Institute Kishoregan Bangladesh Science Secondary Education Quality and Access Enhancement Project (SEQAEP) Ministry ofEducation Dhaka Bangladesh

The study was carried out to evaluate the hypolipidemic and hypoglycemic effect of Nelumbo nucifera leaf powder. In rats, hyperlipidemia was induced by feeding High Fat Diet (Lab diet: Dalda: Coconut oil = 4:3:1) and type 2 diabetes was built inside by injecting Alloxan. The sample N. nucifera leaf powder was added in different percentages with the regular Lab Diet for 21 days feeding. In case of hyperlipidemia developed groups, feeding of Nelumbo nucifera leaf powder at, 30% (70% Lab diet + 30% Sample), 20% (80% Lab diet + 20% Sample) and 10% (90% Lab diet + 10% Sample) showed varied but in a nutshell significant (p Nelumbo nucifera leaf powder for 21 days resulted significant decrease in the blood glucose levels of alloxan-induced diabetic rats. Both the percentages of Nelumbo nucifera leaf powder having 20% with 80% Lab Diet and 10% with 90% Lab Diet significantly (p Nelumbo nucifera powder was found to be exerted to the more prominent effects in lowering the blood glucose level. Nelumbo nucifera leaf powder had 75% efficacy rate in lowering the blood glucose level in comparison to the drug control group treated with glibenclamide which was found with the decreasing capability up to 66%. Although not significant, it, based on the data, can be stated that the sample is endowed with the quality of decreasing capability of body weight. Thus, results of the experimental study reveal that the leaf of Nelumbo nucifera has potent hypoglycemic and hypolipidemic properties.

关键词： Diabetics Hypoglycemia Hypolipidemia Alloxan Monohydrate

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