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Effect and molecular mechanism research of Astragalus membranaceus on inhibiting intestinal absorption of six alkaloids of Aconitum carmichaelii in spleen deficiency rats

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Chinese Herbal Medicines 2022年第1期14卷 117-124页

作者： Xulong Chen Xinli Liang Xiaoqiang Kong Miaomiao Ji abid naeem Cheng Li Hao Zheng Mingxia Gao Zhenggen Liao Key Laboratory of Modern Preparation of Traditional Chinese Medicine Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Affiliated Hospital Jiujiang UniversityJiujiang 332000China

Objective:To investigate the effect and the mechanism of Astragalus membranaceus(Huangqi in Chinese,HQ)extract on the intestinal absorption of six alkaloids of Aconitum carmichaelii(Fuzi in Chinese,FZ)in rats with spleen deficiency and provide novel insights into the application of HQ on modulating intestinal ***:Four-week-old male Sprague-Dawley rats were fed with Xiaochengqi Decoction to induce the spleen deficiency model for 40 ***-pass intestinal perfusion model were used to study the effects of HQ extract on the absorption of *** expression and mRNA levels of MRP2 and BCRP and tight junction proteins(TJ,including Claudin-1,Occludin and ZO-1)were measured using Western blot and real-time PCR,*** location and expression of TJ protein was also investigated by the immunofluorescence ***:Compared with the normal group,the protein expression of MRP2,BCRP and TJ proteins in the model group were significantly *** oral administration of HQ,the alkaloid absorption in intestinal villi was inhibited,MRP2,BCRP and TJ proteins were up-regulated,the green fluorescence staining of Claudin-1,Occludin,and ZO-1 was enhanced,and a thick layer of mucus was deposited on the surface of the epithelium of the intestinal ***:HQ as an intestinal barrier modulator improves the physiological changes of the intestinal environment of spleen deficiency to reduce the absorption of toxic components,leading to a decrease in the absorption of drug-like molecules.

关键词： alkaloids Aconitum carmichaelii Debx. Astragalus membranaceus(Fisch.)Bge.BCRP intestinal absorption MRP2 spleen deficiency tight junction

Visualization of nasal powder distribution using biomimetic human nasal cavity model

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Acta Pharmaceutica Sinica B 2024年第1期14卷 392-404页

作者： Jiawen Su Yan Liu Hongyu Sun abid naeem Huipeng Xu Yue Qu Caifen Wang Zeru Li Jianhua Lu Lulu Wang Xiaofeng Wang Jie Wu Lixin Sun Jiwen Zhang Zhigang Wang Rui Yang Li Wu Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Key Laboratory of Molecular Pharmacology and Drug Evaluation School of PharmacyMinistry of EducationYantai UniversityYantai 264005China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201210China Nantong Haimen People’s Hospital Nantong 226199China Yangtze Delta Drug Advanced Research Institute Nantong 226126China Shenyang Pharmaceutical University Shenyang 110016China National Institutes for Food and Drug Control Beijing 100000China Nanjing University of Chinese Medicine Nanjing 210023China

Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal ***,no reliable method is currently available to assess its impact on delivery *** this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal *** results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and *** nasal cavity model was modified with dimethicone and validated to be suitable for the deposition *** experimental device produced the most satisfactory results with five spray ***,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,***,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo *** conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution.

关键词： Nasal drug deposition Nasal drug distribution Nasal drug delivery Biomimetic nasal model Nasal powder Three-dimensional reconstruction Three-dimensional printing Nasal drug distribution

Mechanism of volatile oil from Chuanxiong(Chuanxiong Rhizoma)-Suhexiang(Styrax)-Bingpian(Borneolum)in treating angina pectoris based on network pharmacology and its protective effects on myocardial damage in rats

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Digital Chinese Medicine 2021年第3期4卷 202-213页

作者： LEI Zhiqiang WANG Chaoping abid naeem YIN Ning CAO Meifang LUO Jing Clinical Medical College of Jiangxi University of Chinese Medicine NanchangJiangxi 330006China School of Pharmacy Jiangxi University of Chinese MedicineNanchangJiangxi 330006China The Islamia University of Bahawalpur Punjab 63100Pakistan Key Laboratory of Modern Chinese Medicine Preparation Ministry of EducationNanchangJiangxi 330006China State Key Laboratory of Innovative Drugs and Pharmaceutical Equipment with High Efficiency Energy Saving and Consumption ReductionNanchangJiangxi 330006China

Objective To explore the pharmacodynamic material basis and mechanism of action of volatile oil from Chuanxiong(Chuanxiong Rhizoma)-Suhexiang(Styrax)-Bingpian(Borneolum)(hereinafter referred to as C-S-B volatile oil)in treating angina pectoris based on network pharmacology and to detect its protective effects against rat myocardial *** Gas chromatography-mass spectrometry(GC-MS)was used to determine the constituents of volatile oils from Chuanxiong(Chuanxiong Rhizoma),Suhexiang(Styrax),and Bingpian(Borneolum),and the targets of the three main constituents were found predicted and screened using the PharmMapper server,and Gene Cards and Coo LGe N *** STRING database and Cytoscape software were used to draw the protein-protein interaction(PPI)network,RStudio software was used to analyze Gene Ontology(GO)and Kyoto Encyclopedia of Genome and Genome(KEGG)pathways,and Cytoscape software was used to construct the component-target-pathwaydisease *** rat model of myocardial injury was established by intraperitoneal injection of a large dose of isoprenaline *** continuous intervention with C-S-B volatile oil for 14 d,the ejection fraction(EF)and short axis shortening rate(FS)of the left ventricle were *** indices of myocardial damage were detected after hematoxylin-eosin(HE)*** Fifteen volatile oil components from the C-S-B formula were *** are 470 targets of these volatile oil components and 401 angina-related *** are 28 core targets,including CHRM4,ADRA1 A,FGFR1,CHRM2,CYP2 A6,CHRM5,CHRM1,CHRM3,HDAC2,and MPO,etc..The results of the KEGG analysis indicated that the C-S-B formula probably interferes with the following pathways:neuroactive ligand-receptor interactions,calcium signaling,cytochrome P450 metabolism of heteropoietin,among *** results of animal experiments showed that the C-S-B formula essential oil could significantly improve the following myocardial indices in rats with

关键词： Chuanxiong(Chuanxiong Rhizoma) Suhexiang(Styrax) Bingpian(Borneolum) Volatile oil Angina pectoris Gas chromatography-mass spectrometry(GC-MS) Network pharmacology Myocardial injury Rat model

In vitro metabolism and inhibitory effects of atractylenolideⅡon various hepatic CYPs in HLMs

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Journal of Chinese Pharmaceutical Sciences 2021年第8期30卷 645-656页

作者： Xulong Chen Zhenggen Liao Cheng Li Guoyong Huang Yunyan Song Wei Dong abid naeem Xinli Liang Key Laboratory of Modem traditional Chinese Medicine preparations Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Affiliated Hospital Jiujiang UniversityJiujiang 332000China Jiujiang Clinical Precision Medicine Research Center Jiujiang 332000China

In the present study,we aimed to investigate the interaction between atractylenolideⅡ(AT-Ⅱ)and CYP450 enzyme in human liver microsomes,and to lay a theoretical foundation for predicting the possible interaction of AT-Ⅱin combination with *** chemical inhibition experiment was carried out with specific inhibitors to clarify the CYP450 subtypes affecting the metabolism of AT-Ⅱ,and the mechanism,kinetics,and type of inhibition of CYP450 enzyme by AT-Ⅱwere studied by using the probe-based determination method of human liver microsome system with the related data of IC50 and Ki as evaluation *** metabolism of AT-Ⅱwas affected by CYP1A2,CYP2C9 and CYP3A4 inhibitors,and the highest inhibition rates were41.35%,41.97%and 82.45%,*** IC50 values of AT-Ⅱto five subtypes of P450 CYP2C9,CYP1A2,CYP2C19,CYP3A4 and CYP2D6 were 69.7,84.3,92.4,173.8 and 190.1μmol/L,*** Ki values of AT-Ⅱto five subtypes of P450 CYP2C9,CYP1A2,CYP2C19,CYP3A4 and CYP2D6 were 190.6,179.1,>200,72.2 and 66.8,*** these enzymes,AT-Ⅱexhibited non-competitive inhibition on CYP1A2,showed competitive inhibition on CYP2C9 and CYP3A4,and displayed mixed AT-Ⅱinhibition on CYP2C19 and ***1A2,CYP2C9 and CYP3A4 were involved in the AT-Ⅱmetabolism,and AT-Ⅱexhibited different inhibitory mechanisms and strengths for the five subtypes of CYP450.

关键词： AtractylenolideⅡ Human liver microsomes Metabolic phenotype Enzymatic activity Drug-drug interaction

Ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris based on data mining

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Digital Chinese Medicine 2022年第2期5卷 123-140页

作者： WANG Chaoping LUO Jing WAN Qiang CAO Meifang ZHA Qinglin LEI Zhiqiang abid naeem YANG Ming School of Pharmacy Jiangxi University of Chinese MedicineNanchangJiangxi 330004China Key Laboratory of Modern Traditional Chinese Medicine Preparation Ministry of EducationJiangxi University of Chinese MedicineNanchangJiangxi 330004China State Key Laboratory of Innovative Drugs and High Efficiency Energy Saving and Consumption Reducing Pharmaceutical EquipmentNanchangJiangxi 330004China The Affiliated Hospital of Jiangxi University of Chinese Medicine NanchangJiangxi 330006China The Second Affiliated Hospital of Jiangxi University of Chinese Medicine NanchangJiangxi 330012China Clinical Medical College Jiangxi University of Chinese MedicineNanchangJiangxi 330004China The Islamia University of Bahawalpur BahawalpurPunjab 63100Pakistan

Objective To explore ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris, and to provide new ideas for the clinical *** With “angina pectoris” as the key word, ancient books prescriptions and Chinese patent medicines related to angina pectoris were collected from China National Knowledge Infrastructure(CNKI), Traditional Chinese Medicine Database System, Chinese Medicine Prescription Database, New National Proprietary Chinese Medicine(2 nd edition), and Chinese Pharmacopoeia(2020 edition) from January 1, 2015 to December 31, 2021. Core highfrequency aromatic Chinese medicines were defined, and their potential medication rules were analyzed and summarized. Microsoft Access 2010 was used for data management. Data analysis software, including Excel and IBM SPSS Modeler 18.0 were used for drug association rule analysis, and Cytoscape 3.7.2 for visual *** There were 67 ancient books prescriptions and 258 Chinese patent medicines containing aromatic Chinese medicines treating angina pectoris collected from relevant databases. In ancient books prescriptions, there were nine aromatic Chinese medicines with the frequency ≥10, and the most commonly used medicine was Danggui(Angelicae Sinensis Radix), followed by Chenpi(Citri Reticulatae Pericarpium). There were 33 aromatic Chinese medicines with the frequency ≥10 in Chinese patent medicines, and the most commonly used medicine was Danshen(Salviae Miltiorrhizae Radix et Rhizoma), followed by Chuanxiong(Chuanxiong Rhizoma) and Sanqi(Notoginseng Radix et Rhizoma). In ancient books prescriptions, the medicines mainly belonged to intenal-warming medicines, Qi-regulating medicines, and blood circulation promoting and blood stasis removing *** were eight medicine pairs with confidence equal to 100% in ancient books prescriptions, the most frequently used pairs were Chuanxiong(Chuanxiong Rhizoma) +Danggui(Angelicae Sinensis Radix), and Xiangfu(Cyperi Rhizo

关键词： Aromatic Chinese medicines Ancient books prescriptions Chinese patent medicines Angina pectoris Medication laws Chuanxiong(Chuanxiong Rhizoma)

Visual analysis of research hotspots and trends in the treatment of immune thrombocytopenia with traditional Chinese medicine

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Digital Chinese Medicine 2022年第3期5卷 326-339页

作者： GAO Yao WU Zhenhui WU Min abid naeem LI Weizhizi ZHANG Daling LIU Fan ZENG Yingjian College of Clinical Medicine Jiangxi University of Chinese MedicineNanchangJiangxi 330004China College of Pharmacy Jiangxi University of Chinese MedicineNanchangJiangxi 330004China Department of Hematology Affiliated Hospital of Jiangxi University of Chinese MedicineNanchangJiangxi 330006China The Islamia University of Bahawalpur BahawalpurPunjab 63100Pakistan

Objective Through bibliometrics and visual analysis of the related studies on traditional Chinese medicine(TCM)treatment of immune thrombocytopenia(ITP),this study aims to sort out the overall research progress,hotspots,and trends in this field,and provide reference for further research in *** The articles on ITP treated by TCM were retrieved from China National Knowledge Infrastructure(CNKI),Wanfang Database,China Science and Technology Journal Database(VIP),Web of Science Core Collection(WOSCC),and *** retrieval time was from the establishment of the databases to July 31,***,CiteSpace,Carrot2,and Note-Express were used for data analysis of the articles in terms of their quantities,types,and journals,and for visualization of research hotspots,authors,institutions,and *** 1493 Chinese articles and 40 English articles were *** articles in Chinese mainly focus on clinical trial research and clinical experience summary,while the English articles mainly focus on clinical trial research and animal *** Chinese articles were published in 317 Chinese journals,while English articles were published in 29 English *** hotspots include the clinical syndrome differentiation of ITP,the therapeutic effect of TCM compounds on ITP,and the mechanism of ITP *** analysis shows that there are many research achievements in integrated traditional Chinese and western medicine treatment,clinical research,famous doctors’experience,TCM treatment,cellular immunity,and humoral *** authors with the most articles in Chinese and English are Professor CHEN Xinyi and Professor MA Rou,respectively,and the research institutions with the most articles are Dongzhimen Hospital of Beijing University of Chinese Medicine and Xiyuan Hospital of China Academy of Chinese Medical *** herbs often used to treat ITP clinically include Xianhecao(Agrimoniae Herba),Nvzhenzi(Ligustri Lucidi Fructus),Mohanlian(Ecli

关键词： Immune thrombocytopenia Traditional Chinese medicine(TCM) Bibliometrics Visual analysis CiteSpace VOSviewer Carrot2 Research hotspot

Recent developments in the physical structure of solid formulations:a comprehensive review

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Journal of Chinese Pharmaceutical Sciences 2024年第10期33卷 877-905页

作者： Zhe Li Xiaosui Luo abid naeem Qiong Li Yao Zhang Yongmei Guan Lihua Chen Weifeng Zhu Zhengji Jin Yi Feng Liangshan Ming Key Laboratory of Modern Preparation of TCM Ministry of EducationInstitute for Advanced StudyJiangxi University of Chinese MedicineNanchang 330004JiangxiChina National Pharmaceutical Engineering Research Center for Solid Formulation in Chinese Herbal Medicine Nanchang 330004JiangxiChina Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China

Solid formulations represent the most widely used dosage forms,and their structural attributes significantly impact the efficacy of ***,delving into the study of solid formulation structures is of paramount *** paper employs bibliometrics to summarize references on solid formulations and physical structure over the past 5 years,providing a visual representation through ***,we explore influential factors affecting the structure of solid formulations at three distinct levels:raw material,intermediate,and final *** delves into the discussion of various characterization techniques employed to analyze the physical structure of solid *** techniques include scanning electron microscopy,transmission electron microscopy,X-ray diffraction,nuclear magnetic resonance,LF-nuclear magnetic resonance,thermal analysis,and *** is placed on the significance of investigating formulation structures,serving as a found ational step for future research and development in this *** comprehensive approach aims to contribute to the understanding and advancement of solid formulations for enhanced drug effectiveness.

关键词： Solid formulations Physical structure CiteSpace Affecting factors Physical characterization

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基于直接压片的多孔核壳粒子优化和应用

Journal of Chinese Pharmaceutical Sciences 2024年第5期33卷 412-429页

作者：李哲肖燕琳朱琳刘文君杨凌宇金正吉 abid naeem 朱卫丰冯怡明良山江西中医药大学高等研究院现代中药制备教育部重点实验室江西南昌330004 澳门大学中医药研究所澳门中医药研究发展中心中药品质研究国家重点实验室中国澳门江中药业股份有限公司江西南昌330049 上海中医药大学中药现代制备技术教育部工程研究中心上海201203

采用中心复合设计优化了影响多孔型核壳复合颗粒(PCPs)直接压片(DC)性能的配方参数。分别以PVP和NH4HCO3作为壳层材料和制孔剂,选择共喷雾干燥为制备工艺。以PCPs的产率、流动性、压缩性和崩解时间作为响应值。结果表明,NH4HCO3和PVPK3... 详细信息

采用中心复合设计优化了影响多孔型核壳复合颗粒(PCPs)直接压片(DC)性能的配方参数。分别以PVP和NH4HCO3作为壳层材料和制孔剂,选择共喷雾干燥为制备工艺。以PCPs的产率、流动性、压缩性和崩解时间作为响应值。结果表明,NH4HCO3和PVPK30的最佳配比分别为4.76%和9.42%。产率、流动性、压缩性和崩解时间的测定值分别为62.00%、38.50°、4.02 MPa和14.33 min。预测误差分别为2.99%、1.09%、5.70%和2.28%。在本研究中,最优的PCPs与四种DC辅料混合用于连续DC。结果表明,优化后的PCPs具有优良的直压性能和适用性,为其他中药制备PCPs及实现DC提供思路和理论支持。

关键词：多孔型核壳复合粒子优化喷雾干燥直接压片应用

Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks

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Computers, Materials & Continua 2025年第1期82卷 1151-1169页

作者： Khalil Ullah Song Jian Muhammad naeem Ul Hassan Suliman Khan Mohammad Babar Arshad Ahmad Shafiq Ahmad Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Department of Computer Science Abbottabad University of Science and TechnologyHavelianAbbottabad22500Pakistan Department of Computing and Electronics Engineering Middle East CollegeMuscat124Oman Department of CS&IT Pak-Austria Fachhochschule Institute of Applied Sciences and Technology MangHaripur22621Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile *** networks are sufficiently scaled to interconnect billions of users and *** in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous *** continuously improves its network functionality to support these *** input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in *** article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial *** technique aims to create long-lasting and secure NextG networks using this extended *** viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this ***,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques.

关键词： Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security