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Silymarin-laden PVP-PEG polymeric composite for enhanced aqueous solubility and dissolution rate: Preparation and in vitro characterization

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Journal of Pharmaceutical Analysis 2019年第1期9卷 34-39页

作者： abid mehmood Yousaf Usman Rashid Malik Yasser Shahzad Tariq Mahmood Talib Hussain Department of Pharmacy COMSATS University IslamabadLahore Campus Faculty of Pharmacy University of Central Punjab

The aim of this work was to develop, optimize and characterize a silymarin-laden polyvinylpyrrolidone(PVP)-polyethylene glycol(PEG) polymeric composite to resolve low aqueous solubility and dissolution rate problem of the drug. A number of silymarin-laden polymeric formulations were fabricated with different quantities of PVP K-30 and PEG 6000 by the solvent-evaporation method. The effect of PVP K-30 and PEG 6000 on the aqueous solubility and dissolution rate was investigated. The optimized formulation and its constituents were characterized using powder X-ray diffraction(PXRD), differential scanning calorimetry(DSC), scanning electron microscopy(SEM) and Fourier transform infrared spectroscopy(FTIR) techniques. Both the PEG 6000 and PVP K-30 positively affected the aqueous solubility and dissolution rate of the drug. In particular, a formulation consisting of silymarin, PVP K-30 and PEG 6000(0.25/1.5/1.5, w/w/w) furnished the highest solubility(24.3972.95 mg/mL) and an excellent dissolution profile( $100% in 40 min). The solubility enhancement with this formulation was $ 1150-fold as compared to plain silymarin powder. Moreover, all the constituents existed in the amorphous state in this silymarin-laden PVP-PEG polymeric composite. Accordingly, this formulation might be a promising tool to administer silymarin with an enhanced effect via the oral route.

关键词： Silymarin Hydrophilic polymers Inclusion Solid dispersion Aqueous solubility Dissolution rate

Enrichment of bacteria involved in the nitrogen cycle and plant growth promotion in soil by sclerotia of rice sheath blight fungus

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Stress Biology 2022年第1期2卷 299-311页

作者： Mirza abid mehmood Yanping Fu Huizhang Zhao Jiasen Cheng Jiatao Xie Daohong Jiang State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityHubei ProvinceWuhan 430070China Plant Pathology Institute of Plant ProtectionMNS University of AgricultureMultan 60000Pakistan Provincial Key Laboratory of Plant Pathology of Hubei Province College of Plant Science and TechnologyHuazhong Agricultural UniversityHubei ProvinceWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China

Rice sheath blight pathogen,Rhizoctonia solani,produces numerous sclerotia to *** a rich source of nutrients in the soil,sclerotia may lead to the change of soil *** this purpose,we amended the sclerotia of *** in soil and analyzed the changes in bacterial microbiota within the soil at different time *** the phyla level,Proteobacteria,Acidobacteria,Bacteroidetes,Actinobacteria,Chloroflexi and Firmicutes showed varied abundance in the amended soil samples compared to those in the *** increased abundance of ammonia-oxidizing bacterium(AOB)Nitrosospira and Nitrite oxidizing bacteria(NOB)i.e.,Nitrospira was observed,where the latter is reportedly involved in the nitrifier ***,Thiobacillus,Gemmatimonas,Anaeromyxobacter and Geobacter,the vital players in denitrification,N2O reduction and reductive nitrogen transformation,respectively,depicted enhanced abundance in *** sclerotia-amended ***,asymbiotic nitrogen-fixing bacteria,notably,Azotobacter as well as Microvirga and Phenylobacterium with nitrogen-fixing potential also enriched in the amended samples compared to the *** growth promoting bacteria,such as Kribbella,Chitinophaga and Flavisolibacter also enriched in the sclerotia-amended *** per our knowledge,this study is of its kind where pathogenic fungal sclerotia activated microbes with a potential role in N transformation and provided clues about the ecological functions of *** sclerotia on the stimulation of bacterial genera involved in different processes of N-cycle within the soil in the absence of host plants.

关键词： Rice sheath blight Rhizoctonia solani Sclerotia Reductive nitrogen transformation Nitrogen fixation Soil microbiome

Development of RP-HPLC method for simultaneous determination of docetaxel and curcumin in rat plasma: Validation and stability

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Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 105-113页

作者： Dong Wuk Kim abid mehmood Yousaf Dong Xun Li Jong Oh Kim Chul Soon Yong Kwan Hyung Cho Han-Gon Choi College of Pharmacy&Institute of Pharmaceutical Science and Technology Hanyang University55 Hanyangdaehak-roSangnok-guAnsan 426-791South Korea Faculty of Pharmacy University of Central Punjab1-Khayaban-e-JinnahJoharLahore54000Pakistan National Pharmaceutical Engineering Centre for Solid Preparation in Chinese Herbal Medicine Jiangxi University of Traditional Chinese Medicine56 Yangming RoadNanchangJiangxi330006China College of Pharmacy Yeungnam University214-1Dae-DongGyongsan 712-749South Korea College of Pharmacy Inje University197Inje-roGimhae621-749South Korea

The purpose of the present research was to develop a suitable, simple, precise, accurate,robust, and reproducible RP-HPLC method for a reliable simultaneous quantification of docetaxel(DTX) and curcumin(CCM) in rat plasma samples using paclitaxel(PTX) as an internal standard. The samples were assayed by the Agilent 1260 Infinity HPLC instrument using a Capcell Pak C8 column(4.6 mm × 150 mm, 5 μm) under isocratic conditions. The mobile phase consisted of acetonitrile and triple distilled water(40/60, v/v) with a flow rate of 1.0 ml/min. The eluent was monitored at 230 nm for simultaneous measurement of curcumin and docetaxel. The method was validated by determining system suitability, selectivity, sensitivity, linearity, inter-day and intra-day precision, accuracy, robustness, and stability in accordance with the guidelines of the United States Food and Drug Administration(FDA).The developed chromatographic method proved to be simple, precise, accurate, robust and reproducible. Moreover, the samples showed stability at room temperature over a period of 48 h. Thus, this method would be employed for routine simultaneous quantification of docetaxel and curcumin in rat plasma samples.

关键词： Curcumin Docetaxel HPLC Plasma-extraction Simultaneous determination Validation

Evaluation of stability and simultaneous determination of fimasartan and amlodipine by a HPLC method in combination tablets

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Asian Journal of Pharmaceutical Sciences 2014年第3期9卷 123-128页

作者： Hyeon Woo Moon abid mehmood Yousaf Kwan Hyung Cho Chul Soon Yong Jong Oh Kim Han-Gon Choi College of Pharmacy Hanyang University1271Sa-3-DongAnsan 426-791South Korea College of Pharmacy Yeungnam University214-1Dae-DongGyongsan 712-749South Korea College of Pharmacy Inje UniversityInje-ro 197 Gimhae 621-749South Korea

A simple,rapid,accurate,precise and robust HPLC method was developed for the simultaneous determination of fimasartan and amlodipine in tablet dosage ***,stability of active ingredients was evaluated under normal and stress *** isocratic elution was accomplished by Nucleosil C18 column(250 mm×4.6 mm,5 mm)at 40℃.The mobile phase consisted of acetonitrile and 0.02 M monopotassium phosphate buffer(pH 2.2)in the ratio of 50:50(v/v)was eluted at 1.0 ml/*** eluent was monitored by the UV detector for fimasartan and amlodipine at 237 nm for 8 min,detection *** validation of HPLC method was carried out in accordance with the ICH guidelines.

关键词： Fimasartan Amlodipine Validation Stability HPLC Combination tablet

Recent Developments in Authentication Schemes Used in Machine-Type Communication Devices in Machine-to-Machine Communication: Issues and Challenges

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Computers, Materials & Continua 2024年第4期79卷 93-115页

作者： Shafi Ullah Sibghat Ullah Bazai Mohammad Imran Qazi Mudassar Ilyas abid mehmood Muhammad Asim Saleem Muhmmad Aasim Rafique Arsalan Haider Ilyas Khan Sajid Iqbal Yonis Gulzar Kauser Hameed Department of Computer Engineering Balochistan University of Information TechnologyEngineering and Management SciencesQuetta87300Pakistan Department of Information Technology Balochistan University of Information TechnologyEngineeringand Management SciencesQuetta87300Pakistan Department of Information Systems College of Computer Sciences and Information TechnologyKing Faisal UniversityHofuf in Al-Ahsa31982Saudi Arabia Department of Management Information Systems College of Business AdministrationKing Faisal UniversityHofuf in Al-Ahsa31982Saudi Arabia Department of Software Engineering College of ComputingRiphah International UniversityFaisalabad44000Pakistan Department of Electrical Engineering Balochistan University of Information Technology Engineeringand Management SciencesQuetta87300Pakistan Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia

Machine-to-machine (M2M) communication plays a fundamental role in autonomous IoT (Internet of Things)-based infrastructure, a vital part of the fourth industrial revolution. Machine-type communication devices(MTCDs) regularly share extensive data without human intervention while making all types of decisions. Thesedecisions may involve controlling sensitive ventilation systems maintaining uniform temperature, live heartbeatmonitoring, and several different alert systems. Many of these devices simultaneously share data to form anautomated system. The data shared between machine-type communication devices (MTCDs) is prone to risk dueto limited computational power, internal memory, and energy capacity. Therefore, securing the data and devicesbecomes challenging due to factors such as dynamic operational environments, remoteness, harsh conditions,and areas where human physical access is difficult. One of the crucial parts of securing MTCDs and data isauthentication, where each devicemust be verified before data transmission. SeveralM2Mauthentication schemeshave been proposed in the literature, however, the literature lacks a comprehensive overview of current M2Mauthentication techniques and the challenges associated with them. To utilize a suitable authentication schemefor specific scenarios, it is important to understand the challenges associated with it. Therefore, this article fillsthis gap by reviewing the state-of-the-art research on authentication schemes in MTCDs specifically concerningapplication categories, security provisions, and performance efficiency.

关键词： Authentication cyber security internet of things machine-type communication devices machine-to-machine communication

Enrichment of beneficial and suppression of pathogenic microorganisms in response to the addition of Sclerotinia sclerotiorum sclerotia in soil and its effect on microbial diversity

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Enrichment of beneficial and suppression of pathogenic micro...

Intelligent Transmission Control for Efficient Operations in SDN

中国植物病理学会第十一届全国会员代表大会暨2018年学术年会

作者： Mirza abid mehmood Xie Jiatao Cheng Jiasen Fu Yanping Jiang Daohong The State Key Laboratory of Agriculture Microbiology Huazhong Agricultural University The Key Laboratory of Plant Pathology of Hubei Province Huazhong Agricultural University

Soil microbiome plays an imperative role due to their multifunctional activities including suppression of soil-borne *** sclerotiorum is a notorious soil-borne pathogen of various important crops and produce sclerotia to survive within soil for long *** is enriched in carbohydrates,fats,proteins and chitin which can be utilized by microbes to obtain nutrients required for their optimum *** in view the sclerotia as a nutritional source for microbes,we hypothesized that sclerotia in soil may affect the microbial diversity directly or/and *** this study,we incubated sclerotia of *** in soil collected from field to observe shift-in microbial diversity across three months using 16S rRNA and ITS sequencing *** observed surprising shift-in microbial diversity with non-amended soil having more diverse microbes than sclerotia-amended soil *** diversity indices confirmed the decline in diversity of sclerotia-amended soil samples of bacterial and fungal communities with the exception of 3 month in fungal community where more diverse community was observed in sclerotia-amended soil samples compared to the non-amended ***-amended soil activated the antagonists and plant growth promoting microbes whereas,several plant-pathogenic fungi depicted decline in their abundances with the passage of ***,bacteria with potential role in plant growth promotion showed enhanced abundance in sclerotia-amended soils,such as Burkholderia,Chitinophaga and Dyella ***,fungal diversity exhibited enrichment of fungi with reported antagonistic activities such as,Clonostachys,Trichoderma and Talaromyces *** the contrary,we observed a drastic decline in abundance of numerous notorious plant-pathogenic fungi such as,Alternaria alternata,Botrytis cinerea,Fusarium graminearum,***,***,*** and Sclerotiumrolfsii *** sclerotia-amended soil ***,we conclude that

关键词： Enrichment Suppression Microbiome Sclerotinia sclerotiorum Sclerotia 16S rRNA ITS

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Computers, Materials & Continua 2022年第5期71卷 2807-2825页

作者： Reem Alkanhel abid Ali Faisal Jamil Muzammil Nawaz Faisal mehmood Ammar Muthanna Department of Information Technology College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadhSaudi Arabia Department of Computer Science University of Engineering and TechnologyTaxila47080Pakistan Department of Computer Science Govt.Akhtar Nawaz Khan(Shaheed)Degree College KTSHaripur22620Pakistan Department of Computer Engineering Jeju National UniversityJeju-siJeju Special Self-Governing Province63243Korea School of Information and Communication Engineering Zhengzhou UniversityChina Department of Telecommunication Networks and Data Transmission The Bonch-Bruevich Saint-Petersburg State University of Telecommunications193232Saint PetersburgRussia Peoples Friendship University of Russia(RUDN University)6 Miklukho-Maklaya St Moscow117198Russian Federation

Although the Software-Defined Network(SDN)is a well-controlled and efficient network but the complexity of open flow switches in SDN causes multiple *** solutions have been proposed so far for the prevention of errors and mistakes in it but yet,there is still no smooth transmission of pockets from source to destination specifically when irregular movements follow the destination host in SDN,the errors include packet loss,data compromise *** accuracy of packets received at their desired destination is possible if networks for pockets and hosts are monitored instead of analysis of network snapshot statistically for the state,as these approaches with open flow switches,discover bugs after their *** article proposes a design to achieve the said objective by defining the Intelligent Transmission Control Layer(ITCL)*** monitors all the connections of end hosts at their specific locations and performs necessary settlements when the connection state changes for one or multiple *** layer informs the controller regarding any state change at one period and controller collects information of end nodes reported via ***,updates flow tables accordingly to accommodate a location-change scenario with a routechange *** is organized on prototype-based implementation using the popular POX *** this paper,it has been discovered that ITCL produces efficient performance in the trafficking of packets and controlling different states of SDN for errors and packet loss.

关键词： Software-defined network ITCL POX open flow

Influence of P-enriched compost application on economics and P use efficiency of a maize–wheat rotation system

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The Crop Journal 2018年第6期6卷 651-658页

作者： Abdul Majeed Shahzada Munawar Mehdi abid Niaz abid Mahmood Ehsan-Ul-Haq Naeem Ahmad Shahid Javid Atif mehmood Sugarcane Research Institute Faisalabad Ayub Agricultural Research InstitutePunjabPakistan Soil Fertility Research Institute LahoreAyub Agricultural Research InstitutePunjabPakistan Institute of Soil Chemistry and Environmental Sciences Ayub Agricultural Research InstitutePunjabPakistan Ayub Agricultural Research Institute PunjabPakistan Provincial Reference Fertilizer Testing Laboratory Raiwind LahorePunjabPakistan Key Laboratory of Clean Utilization Technology for Renewable Energy Ministry of AgricultureCollege of EngineeringChina Agricultural UniversityBeijing 100083China

Crop phosphorus(P) deficiency and poor utilization of added P is a major agricultural problem due to reduced solubility of soil P and rapid fixation or precipitation of applied P fertilizer in alkaline and calcareous soils. The effects of P-enriched compost and single superphosphate(SSP) fertilization on maize and wheat yields and P use efficiency in a maize–wheat rotation system were studied for three years. On a three-year average, grain yields of maize and wheat after application of P-enriched compost were increased by 18% and 24%, respectively, in comparison with sole addition of a recommended dose of SSP fertilizer. P-enriched compost addition to soil increased maize and wheat yields by 12% and 17%, respectively, compared to P fertilizer plus FYM incorporation. Soil available P concentration and P uptake were affected significantly by the addition of P-enriched compost. On average, increases in P recovery, use efficiency, and agronomic efficiency of 52%, 18%, and 43% were recorded in maize and increases of 50%, 23%, and 49% in wheat. P-enriched compost application yielded 30% and 32%higher economic returns in maize and wheat than SSP fertilization alone.

关键词： P-enriched compost Maize Wheat Farmyard manure P-uptake

A Hybrid Approach for Network Intrusion Detection

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Computers, Materials & Continua 2022年第1期70卷 91-107页

作者： Mavra mehmood Talha Javed Jamel Nebhen Sidra Abbas Rabia abid Giridhar Reddy Bojja Muhammad Rizwan Department of Computer Science Kinnaird College for WomenLahore54000Pakistan ASET Labs IslamabadPakistan Prince Sattam bin Abdulaziz University College of Computer Science and EngineeringAlkharj11942Saudi Arabia College of Business and Information Systems Dakota State UniversityMadisonUnited States of America

Due to the widespread use of the internet and smart devices,various attacks like intrusion,zero-day,Malware,and security breaches are a constant threat to any organization’s network ***,a Network Intrusion Detection System(NIDS)is required to detect attacks in network *** paper proposes a new hybrid method for intrusion detection and attack *** proposed approach comprises three steps to address high false and low false-negative rates for intrusion detection and attack *** the first step,the dataset is preprocessed through the data transformation technique and min-max ***,the random forest recursive feature elimination method is applied to identify optimal features that positively impact the model’s ***,we use various Support Vector Machine(SVM)types to detect intrusion and the Adaptive Neuro-Fuzzy System(ANFIS)to categorize probe,U2R,R2U,and DDOS *** validation of the proposed method is calculated through Fine Gaussian SVM(FGSVM),which is 99.3%for the binary *** Square Error(MSE)is reported as 0.084964 for training data,0.0855203 for testing,and 0.084964 to validate multiclass categorization.

关键词： Network security intrusion detection system machine learning attacks data mining classification feature selection