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武汉世茂希尔顿酒店

湖北画报（湖北旅游） 2020年第6期 90-90页

作者： alice 无不详武汉世茂希尔顿酒店

推荐理由:尊贵体验开启璀璨之旅萤火在林中荡漾,精灵的密语随风传播,白鸽绕在枝头,鲜花迎着微光,沿着林中小径,走进森林深处,洒下一片皎洁,那就是月光。近日,武汉世茂希尔顿酒店携手诺丁山婚礼开启“月落之森”主题婚礼沙龙,此次婚礼沙... 详细信息

推荐理由:尊贵体验开启璀璨之旅萤火在林中荡漾,精灵的密语随风传播,白鸽绕在枝头,鲜花迎着微光,沿着林中小径,走进森林深处,洒下一片皎洁,那就是月光。近日,武汉世茂希尔顿酒店携手诺丁山婚礼开启“月落之森”主题婚礼沙龙,此次婚礼沙龙可以满足新人对浪漫的一切幻想,“梦幻”“浪漫”“惊喜”等关键词都可以在这里寻到。

关键词：希尔顿酒店推荐理由诺丁山关键词婚礼沙龙

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中国香港地区老年痴呆患者的口腔健康状况

中国口腔医学继续教育杂志 2018年第4期21卷 207-211页

作者： Chun Hung Chu alice Ng Alex M1.H. Chau Eeward C. M.Lo 池莉(译) 滕伟(审) 不详中山大学附属口腔医院广东省广州市陵园西路56号510000

目的：比较中国香港地区痴呆患者组和健康对照组之间．刷牙习惯、静息状态下唾液流率以及口腔健康状况是否存在不同。材料和方法：经过样本量计算．需要纳入82位60岁以上的中国老年痴呆患者．能够配合牙周探诊操作并且加入日常管理中心... 详细信息

目的：比较中国香港地区痴呆患者组和健康对照组之间．刷牙习惯、静息状态下唾液流率以及口腔健康状况是否存在不同。材料和方法：经过样本量计算．需要纳入82位60岁以上的中国老年痴呆患者．能够配合牙周探诊操作并且加入日常管理中心。年龄、性别匹配全身健康的非痴呆老年人作为对照组。用调查问卷收集刷牙情况。此外．测量静息状态下的唾液流率．用龋失补指数DMFT指数和社区牙周指数（CPI）分别记录患龋情况和牙周状况。结果：招募了59名老年痴呆患者作为痴呆组．以及相同数目年龄、性别匹配的健康老年人作为对照组。他们的平均年龄为80岁（SD=7）。相对于对照组，老年痴呆患者较少每天刷牙两次（31％VS5％：P〈0.0001）。再者．唾液流率也较对照组低（0．30ml／***0.41m1／min：P=0．043）。龋患病率平均DMFT值（±SD）与对照组相似（223±8．2vs21．5±82．P=0．59）。牙周袋（CPI〉3）的患病率在两组中没有差异（78％vs74％．P=0.64）。结论：相较于对照组，较少的老年痴呆患者会每天刷牙两次。尽管他们静息状态下唾液分泌量减少．他们的龋发病率和重度牙周病的患病率与对照组相比没有统计学意义上的差异。

关键词：老年痴呆患者中国香港地区口腔健康状况社区牙周指数健康对照组刷牙习惯唾液流率静息状态

中国西北地区汉、回、维、藏民族HLA DRB基因多态性的研究

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中国西北地区汉、回、维、藏民族HLA DRB基因多态性的研究

“科技增强国力，青年开创未来——携手走向辉煌的新世纪”中国科协第三届青年学术年会

作者：赖淑苹任惠民胡海涛李生斌赖江华 alice Lee 李政道西安医科大学免疫遗传研究室

按照第11届国际组织相溶性抗原研讨会(11IHW)工作会议HLAⅡ类PCR-SSO分型标准和美国国立骨髓供者计划组织(NMDP)对HLA DRB位点等位基因分型要求,设计合成一对引物,可同时扩增HLA-DRB1+B3+B4+B5DNA片段,长度为256 bp,设计合成不同片段大... 详细信息

按照第11届国际组织相溶性抗原研讨会(11IHW)工作会议HLAⅡ类PCR-SSO分型标准和美国国立骨髓供者计划组织(NMDP)对HLA DRB位点等位基因分型要求,设计合成一对引物,可同时扩增HLA-DRB1+B3+B4+B5DNA片段,长度为256 bp,设计合成不同片段大小探针27种,可检出DRB座位上DRB1的39种等位基因,DRB3的3种等位基因,DRB4的1种等位基因和DRB5的3种等位基因。对西安地区汉族(183份)、宁夏回族(169份)、新疆维吾尔族(200份)及西藏藏族(188份)DRB的46种等位基因进行多态性分析,建立了4个民族正常群体DRB基因的遗传学参数,分析了他们在等位基因分布上的差异。结果表明:回族与北方汉族血型遗传上没有较大差异DRB102(16.9%)、07(13.1%)和09(12.0%)为最强高频基因;藏族检出等位基因数较前两者多,但没有显著的强高频基因;维吾尔族等位基因分布整体接近高加索血缘,但DRB107(32.8%)基因频率异常显著,提示民族有遗传选择。

关键词： HLA-DRB位点 PCR-SSOP 等位基因汉族回族维吾尔族藏族

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跨越文化的长城

海外英语 2005年第7期 34-页

作者： alice DING

　　对异国文化的接受总是因人而异,有人能够很快接受并适应,有人则恰恰相反,本文则讲述了中国小女孩在澳大利亚的真实感受.……

关键词：越文化异国文化澳大利亚中国女孩

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爱的行动

少年文艺(上旬版) 2004年第4期 1-1页

作者： alice Gray

母亲下班回家,小女儿从屋里跑出来迎接, “妈咪、妈咪,让我告诉你今天发生的事。”听了几句之后,母亲便打断说其余的部分等会儿再说,她得煮晚饭了。电话在吃晚饭时响起,然后其他家人的

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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of Biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene Soares Silva Tiago Soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Amorim Leonardo Alves Miceli Percilene Fazolin Vegi alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

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市场经济:信誉比法律更重要

IT时代周刊 2011年第11期21卷 6-6页

作者： alice Wang 美国新泽西州

本刊第223期封面文章《寻找中国企业的商业诚信》,犹如一石激起千层浪,引发了读者切肤之痛,揪心之憾。痛在某些企业利欲熏心、道德沦丧令人惊诧;憾在某些高层管理者鼠目寸光,昏昏然不知企业诚信为何物。这里摘发的一组读者来信说明,信... 详细信息

本刊第223期封面文章《寻找中国企业的商业诚信》,犹如一石激起千层浪,引发了读者切肤之痛,揪心之憾。痛在某些企业利欲熏心、道德沦丧令人惊诧;憾在某些高层管理者鼠目寸光,昏昏然不知企业诚信为何物。这里摘发的一组读者来信说明,信誉与法律是市场经济的两大基石,而信誉比法律更重要。诚如杰克·韦尔奇所言:"诚信必须是竞争的基础。"所有企业经营者在竞争中必须置身在诚信这一基石之上,才能立于不败之地。

关键词：市场经济法律信誉中国企业读者来信高层管理者企业经营者诚信

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要说服不要命令——CIO管理八个方略

每周电脑报

每周电脑报 2006年第17期 15-15页

作者： alice DRAGOON

Inactivation of Protein Tyrosine Phosphatase 1B （PTP1B） Activity by the Aqueous Partition of Guava Leaf Extract

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Journal of Pharmacy and Pharmacology 2018年第10期6卷 890-906页

作者： Wan-Jung Wu Wei-Li Yan Shiou-Cherng Yu Gerry Gunawan Chien-Yih Lin Chih-Yan Huang Chia-Ting Chang Haw-Wen Chen Chong-Kuei Lii alice L. Yu Ching-Chu Chen Yu-Ting Chung Jeng-Dau Tsai Henry J. Tsai Department of Biotechnology Asia University 500 Lioufeng Rd. Wufeng District Taichung 413 Taiwan Department of Nutrition China Medical University 91 Hsueh-Shih Rd Taichung 404 Taiwan Genomics Research Center Academia Sinica 128 Section 2 of Academia Rd Nankang District Taipei 115 Taiwan Division of Endocrinology and Metabolism Department of Medicine China Medical University Hospital Taichung Taiwan School of Chinese Medicine China Medical University Taichung Taiwan Asia University Hospital Wufeng Taichung College of Medicine Chung Shan Medical University 110 Section 1 of Jianguo North Rd Taichung 402 Taiwan Department of Pediatrics Chung Shan Medical University Hospital 110 Section 1 of Jianguo North Rd Taichung 402 Taiwan Department of Health and Nutrition Asia University 500 Lioufeng Rd. Wufeng District Taichung 413 Taiwan

Guava leaf tea has been used as a folk medicine for treating hyperglycemic conditions in Asia and Africa. The hypoglycemic efficacy of guava leaf has been documented by many scientists in these regions, but the hypoglycemic mechanism is poorly understood. Guava leaves were extracted with methanol and the crude extract was partitioned against hexane, ethyl acetate, and butanol in sequence. The leftover in water is defined as the aqueous partition. A second smaller batch was extracted with hot water directly. Oral glucose tolerance test was carried out on healthy mice instead of diabetic mice that lack endogenous insulin. Glucose uptake was examined with 3T3-L1 adipocytes. Oxidative effect on PTP1B （protein tyrosine phosphatase 1b） was carried out with real-time PTP1B enzymatic assay. The aqueous partition of guava leaf extract possesses a potent inhibitory effect on PTP1B enzymatic activity and this PTP1B inhibition is through a slow oxidative but reversible inactivation on the enzyme. The reversible inactivation would suggest guava leaf extract may augment PTP1B inhibition alongside the endogenous H2O2 which itself is induced by insulin. In addition, our study confirmed the hypoglycemic efficacy being associated with guava leaf and found the most effective molecules reside in the aqueous partition which is also less cytotoxic to Chinese hamster ovary cells when compared to other less polar partitions. The guava leaf extract can modulate insulin activity through a redox regulation on PP1B enzymatic activity. It is speculated that a compound similar to gallocatechin in the aqueous partition can reduce an oxygen molecule to hydrogen peroxide which in turn oxidizes the catalytic residue Cys in PTP1B. Therefore, the guava leaf tea can serve as a functional hypoglycemic drink that is suitable for either healthy or diabetic subjects.

关键词： Guava leaf extract hypoglycemic oxidative protein tyrosine phosphatase 1b slow inactivation.