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Antioxidant Machinery Related to Decreased MDA Generation by Thymus Algeriensis Essential Oil-induced Liver and Kidney Regeneration

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Biomedical and Environmental Sciences 2016年第9期29卷 639-649页

作者： Guesmi Fatma Amit K tyagi Bellamine Houda Landoulsi Ahmed Laboratory of Biochemistry and Molecular Biology Faculty of Sciences of Bizerte University of Carthage 1054 Tunisia Department of Experimental Therapeutics The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Service of Anatomo-Pathology of Menzel Bourguiba Bizerte 1054 Tunisia

Objective This study was conducted to determine the histopathological and biochemical effects of Thymus algeriensis essential oil （TEO） on hydrogen peroxide （H2O2）-induced oxidative stress in liver and kidney tissues of rats. Methods Rats were treated in six groups and were exposed for 2 weeks to low （LD; 100 μmol/L） and high doses （HD; 1 mmol/L） of H2O2 in the presence or absence of TEO （180 mg/kg）. Liver and kidney atrophy was measured by using biochemical and histopathological assays. Results Our study demonstrated that H2O2 induced liver and kidney atrophy, as evidenced by the significant elevation of serum aminotransferase, urea, and creatinine levels compared with those in the control rats. Urea levels were estimated by evaluating the activity of serum urease that hydrolyzes urea into CO2 and ammonia. However, TEO treatment significantly alleviated oxidative stress in the H2O2-induced liver and kidney toxicity model by reducing the levels of malondialdehyde concomitantly with marked elevations in superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase, as well as decrease in glutathione activity. Conclusion Our data demonstrated that TEO protected against H202 toxicity by decreasing oxidant levels and DNA damage, as well as increasing antioxidant levels, indicating that TEO has a spectrum of antioxidant and DNA-protective properties.

关键词： Liver and kidney atrophy Hydrogen peroxide Thymus algeriensis Antioxidants Toxicity

Alteration of structural, optical and electrical properties of CdSe incorporated polyvinyl pyrrolidone nanocomposite for memory devices

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Journal of Advanced Dielectrics 2018年第3期8卷 64-78页

作者： Chetna tyagi Ambika Devi Department of Applied Sciences The NorthCap University Gurugram 122017 HaryanaIndia

The important enhancement in the structural,dielectric and optical properties of pure polymer and CdSe incorporated polyvinyl pyrrolidone has been reported in this *** surface morphology of CdSe/PVP nanocomposite film is studied by using scanning electron microscopy(SEM).The chemical composition of different elements has been reported using energy dispersive X-ray(EDX)*** structure of polymer nanocomposite is determined with the help of X-ray diffraction(XRD)spectrum and is observed to be *** size,intercrystalline separation,interplanner spacing,lattice parameters,strain and dislocation factors are calculated using XRD *** transform infrared spectroscopy(FTIR)and Photoluminescence(PL)analysis have been studied in order to check the possible interaction between CdSe quantum dots and polyvinyl pyrrolidone(PVP)*** ac conductivity of CdSe/PVP nanocomposite is found to be higher as compared to pure *** highest value of conductivity observed at 60203 Hz and at 523 K is found to be 3:72105 Sm*** study of dielectric constant,dielectric losses,dissipation factor,electric modulus and impedance has been *** semi-circles in impedance measurement for both materials show the bulk electrical properties that result in single relaxation process in CdSe/PVP nanocomposite.

关键词： Nanocomposites activation energy FTIR refractive index

Speed prediction models for car and sports utility vehicleat locations along four-lane median divided horizontal curves

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Journal of Modern Transportation 2018年第4期26卷 278-284页

作者： Avijit Maji Ayush tyagi Department of Civil Engineering Indian Institute of Technology Bombay Mumbai India RITES Ltd. Vashi Navi Mumbai India

Sites with varying geometric features were analyzed to develop the 85 th percentile speed prediction models for car and sports utility vehicle(SUV) at 50 m prior to the point of curvature(PC), PC, midpoint of a curve(MC), point of tangent(PT) and 50 m beyond PT on four-lane median divided rural highways. The car and SUV speed data were combined in the analysis as they were found to be normally distributed and not significantly different. Independent parameters representing geometric features and speed at the preceding section were logically selected in stepwise regression analyses to develop the models. Speeds at various locations were found to be dependent on some combinations of curve length, curvature and speed in the immediately preceding section of the highway. Curve length had a significant effect on the speed at locations 50 m prior to PC, PC and MC. The effect of curvature on speed was observed only at MC. The curve geometry did not have a significant effect on speed from PT onwards. The speed at 50 m prior to PC and curvature is the most significant parameter that affects the speed at PC and MC, respectively. Before entering a horizontal curve, drivers possibly perceive the curve based on its length. Longer curve encourages drivers to maintain higher speed in the preceding tangent section. Further, drivers start experiencing the effect of curvature only after entering the curve and adjust speed accordingly. Practitioners can use these findings in designing consistent horizontal curve for vehicle speed harmony.

关键词： Vehicle speed prediction model Four-lane median divided highway Horizontal curve Regression analysis The 85th percentile speed

Genome-wide association study in historical and contemporary *** wheats identifies heightreducing loci

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The Crop Journal 2020年第2期8卷 243-251页

作者： Sintayehu D.Daba Priyanka tyagi Gina Brown-Guedira Mohsen Mohammadi Department of Agronomy Purdue UniversityWest LafayetteIN 47907USA Department of Crop and Soil Sciences North Carolina State UniversityRaleighNC 27695USA U.S.Department of Agriculture Agricultural Research ServicesSoutheast AreaPlant Science ResearchRaleighNC 27695USA

Plant height has been a major target for selection of high-yielding varieties in *** height-reducing loci(Rht-B1 and Rht-D1)have been widely used since the Green ***,these genes also negatively affect other agronomic traits such as kernel *** alternative height-reducing loci could benefit wheat *** study focused on the genetics of plant height in 260 historical and contemporary winter wheat accessions via genome-wide association studies using 38,693 single nucleotide polymorphism(SNP)markers generated through genotyping by sequencing,two Kompetitive Allele Specific Polymorphismmarkers,and phenotypic data recorded in two seasons(2016 and 2018).The 260 accessions showed wide variation in plant *** accessions developed after 1960 were shorter than earlier *** broad-sense heritability for plant height was high(H2=0.82),whichwas also supported by a high correlation(r=0.82,P<0.0001)between heights from the two *** detected a total of 16 marker–trait associations(MTAs)for plant height at–lg(P)≥4.0 on chromosomes 1A,2B,2D,3B,4D,5A,5D,6A,6B,7A,and *** detected three of the MTAs(QPLH-2D,QPLH-4B.2,and QPLH-4D)consistently in individual-year and combined-year *** MTAs individually explained 10%–16%of phenotypic *** heightreducing alleles at these threeMTAs appeared after 1960 and increased in frequency *** the genes near these loci were gibberellic acid insensitive(GAI)and GRAS transcription factor(GIBBERELLIC-ACID INSENSITIVE(GAI),REPRESSOR of GAI(RGA),and SCARECROW(SCR)).The evidence from this study and previous reports suggests that QPLH-2D is Rht8.A gene encoding a GRAS transcription factor is located near *** of the QPLH-2D locus and associated candidate genes awaits further study.

关键词： GWAS Marker-trait associations Rht-B1 Rht-D1 Candidate genes Position-dependent procedures

Load shedding scheme for the two-area system with linear quadratic regulator

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Frontiers in Energy 2013年第1期7卷 90-102页

作者： D. tyagi Ashwani KUMAR Saurabh CHANANA Department of Electrical Engineering National Institute of Technology Kurukshetra 136119 India

The power system is prone to many emergency conditions which may lead to emergency state of operation with decay in the system frequency. The dramatic change in the frequency can result in cascaded failure of the system. In order to avoid power system collapse, load shedding （LS） schemes are adopted with the optimal amount of load shed. This paper proposed a methodology in a two-area thermal-thermal system for finding the required amount of load to be shed for setting the frequency of the system within minimum allowable limits. The LS steps have been obtained based on the rate of change of frequency with the increase in load in steps. A systematic study has been conducted for three scenarios： the scheme with a conventional integral controller; the scheme with a linear quadratic regulator （LQR）; and the scheme with an LQR and superconducting magnetic energy storage devices （SMES）. A comparison of the results has been presented on the two-area system.

关键词： critical load frequency response load shed- ding (LS) multi-area system rate of change of frequency linear quadratic regulator (LQR) superconducting magnetic energy storage devices (SMES)

Synthesis and electroluminescence properties of tris-[5-choloro-8-hydroxyquinoline]aluminum Al(5-Clq)_3

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Journal of Semiconductors 2015年第6期36卷 35-38页

作者： Rahul Kumar Parag Bhargava Ritu Srivastava Priyanka tyagi Indian Institute of Technology Bombay National Physical Laboratory

A new electroluminescent material tris- [5-choloro-8-hydroxyquinoline] aluminum has been synthesized and characterized. Solution of this material AI（5-Clq）3 in toluene showed absorption maxima at 385 nm which was attributed to the moderate energy （π-π＊） transitions of the aromatic rings. The photoluminescence spectrum of AI（5-Clq）3 in toluene solution showed a peak at 522 nm. This material shows thermal stability up to 400 ℃. The structure of the device is ITO/0.4 wt%F4-TCNQ doped α-NPD （35 nm） / AI（5-Clq）3 （30 nm） / BCP （6 nm）/ Alq3 （30 nm） / LiF （1 nm） / A1 （150 nm）. This device exhibited a luminescence peak at 585 nm （CIE coordinates, x = 0.39, y = 0.50）. The maximum luminescence of the device was 920 Cd/m2 at 25 V. The maximum current efficiency of OLED was 0.27 Cd/A at 20 V and maximum power efficiency was 0.04 lm/W at 18 V.

关键词： organometallic compounds chemical synthesis vapour deposition photoluminescence spectroscopy electrical properties luminescence

Golgi localization and dynamics of hyaluronan binding protein 1 (HABP1/p32/C1QBP) during the cell cycle

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Cell Research 2005年第3期15卷 183-186页

作者： Aniruddha SENGUPTA,Bhaswati BANERJEE,Rakesh K. tyagi,Kasturi DATTA Biochemistry Laboratory School of Environmental Sciences Jawaharlal Nehru University New Delhi-110067 India Biochemistry Laboratory School of Environmental Sciences Jawaharlal Nehru University New Delhi-110067 India Special Centre for Molecular Medicine Jawaharlal Nehru University New Delhi India Biochemistry Laboratory School of Environmental Sciences Jawaharlal Nehru University New Delhi-110067 India2Special Centre for Molecular Medicine Jawaharlal Nehru University New Delhi India

Hyaluronan binding protein 1 (HABP1) is a negatively charged multifunctional mammalian protein with a unique structural fold. Despite the fact that HABP1 possesses mitochondrial localization signal, it has also been localized to other cellular compartments. Using indirect immunofluorescence, we examined the sub-cellular localization of HABP1 and its dynamics during mitosis. We wanted to determine whether it distributes in any distinctive manner after mitotic nuclear envelope disassembly or is dispersed randomly throughout the cell. Our results reveal the golgi localization of HABP1 and demonstrate its complete dispersion throughout the cell during mitosis. This distinctive distribution pattern of HABP1 during mitosis resembles its ligand hyaluronan, suggesting that in concert with each other the two molecules play critical roles in this dynamic process.

关键词： Hyaluronan Binding Protein 1 (HABP1) hyaluronan sub-cellular localization golgi mitosis.

The Receptor-Like Cytoplasmic Kinase （OsRLCK） Gene Family in Rice： Organization, Phylogenetic Relationship, and Expression during Development and Stress

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Molecular Plant 2008年第5期1卷 732-750页

作者： Shubha Vij Jitender Giri Prasant Kumar Dansana Sanjay Kapoor Akhilesh K. tyagi Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology University of Delhi South Campus Benito Juarez Road New Delhi 110021 India

Receptor-like cytoplasmic kinases （RLCKs） in plants belong to the super family of receptor-like kinases （RLKs）. These proteins show homology to RLKs in kinase domain but lack the transmembrane domain. Some of the functionally characterized RLCKs from plants have been shown to play roles in development and stress responses. Previously, 149 and 187 RLCK encoding genes were identified from Arabidopsis and rice, respectively. By using HMM-based domain structure and phylogenetic relationships, we have identified 379 OsRLCKs from rice. OsRLCKs are distributed on all 12 chromosomes of rice and some members are located on duplicated chromosomal segments. Several OsRLCKs probably also undergo alternative splicing, some having evidence only in the form of gene models. To understand their possible functions, expression patterns during landmark stages of vegetative and reproductive development as well as abiotic and biotic stress using microarray and MPSS-based data were analyzed. Real-time PCR-based expression profiling for a selected few genes confirmed the outcome of microarray analysis. Differential expression patterns observed for majority of OsRLCKs during development and stress suggest their involvement in diverse functions in rice. Majority of the stress-responsive OsRLCKs were also found to be localized within mapped regions of abiotic stress QTLs. Outcome of this study would help in selecting organ/development stage specific OsRLCK genes/targets for functional validation studies.

关键词： abiotic stress biotic stress genome-wide analysis kinase rice RLCK.

Load shedding scheme for an interconnected hydro-thermal hybrid system with SMES

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Frontiers in Energy 2012年第3期6卷 227-236页

作者： D. tyagi Ashwani KUMAR Saurabh CHANANA Department of Electrical Engineering National Institute of TechnologyKurukshetra 136119 India

The frequency of based on the load pattern the power system varies of the consumers. With continuous increase in the load, the frequency of the system keeps decreasing and may reach its minimum allowable limits. Further increase in the load will result in more frequency drop leading to the need of load shedding, if excess generation is not available to cater the need. This paper proposed a methodology in a hybrid thermal-hydro system for finding the required amount of load to be shed for setting the frequency of the system within its minimum allowable limits. The load shedding steps were obtained based on the rate of change of frequency with the increase in the load in both areas. The impact of superconducting magnetic energy storage （SMES） was obtained on load shedding scheme. The comparison of the results was presented on the two-area system.

关键词： critical load frequency response load shedding multi-area system rate of change of frequency,superconducting magnetic energy storage (SMES) device