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Annona muricata fruit extract protects against diethylnitrosamine-induced hepatocellular cancer in rats

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Asian Pacific Journal of Tropical Medicine 2019年第6期12卷 272-282页

作者： Subin Varghese Thomas John Paul Akhila Hosur Shrungeswara Subhankar Biswas Aarti abhishek shah Chandrashekar Kodangala Subraya Yogendra Nayak Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalIndia Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalIndia Department of Pharmacognosy Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalIndia

Objective: To evaluate the anticancer potentials of Annona muricata fruit by in vitro and in vivo methods. Methods: The ethanolic extract of Annona muricata fruit was prepared by Soxhlet extraction method and further fractionated with petroleum ether, ethyl acetate and chloroform. The fractions were tested for cytotoxicity, apoptosis, scratch wound assay, and cell cycle analysis. IC50, apoptotic index and percentage cell migration were determined using HepG2 cells. For the in vivo studies, hepatocellular carcinoma was induced by administering 0.01% diethylnitrosamine(DEN) in drinking water in Wistar rats. In pre-treatment, rats were co-administered 200 mg/kg of fruit extract with DEN for 14 weeks. In post-treatment, the extract was co-administered after 8-weeks of DEN-induction for 14 weeks. Liver function test, haematological test, oxidative stress markers, relative liver weight, number of cancer nodules and histopathological parameters were ***: Annona muricata fruit extract =significantly lowered cell proliferation counts. The chloroform-fraction possessed higher activity (IC50=(53.7±4.3) μg/mL)The chloroform fraction inhibited cell migration, which was significant compared to curcumin. Further investigations regarding the mode of anticancer activity revealed that the chloroform fraction induced apoptosis. The cell cycle analysis indicated that cells were being arrested at G0/G1. In the in vivo studies, the DEN-control group showed a significant decrease in body weights with increased mortality rate, hepatic nodules, and impairment of liver function compared to normal rats. The rats pre-treated and post-treated with the extract showed positive results with significant improvement in the parameters that were adversely affected by DEN. In addition, other adverse effects of DEN, such as blood dyscrasias and hepatic endogenous antioxidant, were significantly attenuated by Annona muricata fruit ***: The Annona muricata fruit extract has

关键词： HepG2-cells Apoptosis Liver cancer Acetogenins Rat liver cancer Scratch wound assay

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计算机断层扫描（CT）扫描主动脉瘤的研究

计算机断层扫描（CT）扫描主动脉瘤的研究

作者： abhishek shah 吉林大学

学位级别：硕士

背景和目的: 主动脉是将左心室射出的血液输送到全身动脉床的血管。动脉瘤是指主动脉局部不可逆膨胀、管径超过主动脉正常宽度的50%。主动脉瘤已成为一个与日俱增的死亡病因之一，且很多情况下还没来得及确诊。大多病人是因其它疾病行... 详细信息

背景和目的: 主动脉是将左心室射出的血液输送到全身动脉床的血管。动脉瘤是指主动脉局部不可逆膨胀、管径超过主动脉正常宽度的50%。主动脉瘤已成为一个与日俱增的死亡病因之一，且很多情况下还没来得及确诊。大多病人是因其它疾病行影像检查时偶然发现的。男性和老年群体容易患有主动脉瘤。为此，本课题研究目的是观察我们吉林大学第一医院的主动脉瘤患者的临床表现特征、影像表现及相关的并发症。方法和材料：所有的研究病例是在吉林大学第一医院经CT检查诊断为主动脉瘤的患者。患者所有资料来自我院2010年1月至2012年12月PACS系统中的存档记录，共计134例主动脉瘤患者，其中2例患者同时并有两个主动脉瘤，单个主动脉瘤计为一个单独的患者，因此患者总数累计为136人。胸腹主动脉瘤根据动脉瘤体主要位于胸部或腹部，而归属为胸主动脉瘤或腹主动脉瘤。动脉瘤的大小以其最大横径量值为记数标准。所有的病人接受了64排螺旋或双源CT平扫或增强CT血管造影检查。扫描范围为主动脉弓水平3厘米以上到耻骨联合水平处。结果: 通过对136例主动脉瘤患者研究发现，动脉瘤患者多数为男性病例与老年患者：男女比例2:1。男性患者比女性患者的动脉瘤的直径大(6.14vs5.28m, p<0.05)。患者的平均年龄为(66.36±13.7)岁，动脉瘤平均大小为(5.8±1.9)cm。胸、腹主动脉瘤患者数量基本相同(n=68)。梭形动脉瘤占69.1%(n=94)、囊状动脉瘤占30.9%(n=42)。真性动脉瘤占66.2%(n=90)，而假性动脉瘤占33.8%(n=46)。伴有钙化、血栓形成和破裂的动脉瘤分别占62.5%、51.5%和17.6%。主动脉瘤伴附壁血栓且厚度≥1.5厘米占21.3%(n=29)。在目前的研究中，51.4%(n=35)的胸主动脉瘤和62.3%(n=43)的腹主动脉瘤是意外发现的。710岁年龄段动脉瘤患者数量最多(33%)，其次是610岁年龄组(30%)。腹主动脉瘤好发在610岁年龄组。钙化最多出现在80岁以上年龄组病例(11/13，84.6%)、血栓形成最多是在610岁年龄组(27/41，65.8%)，破裂最多发生在410岁年龄组(4/11，36.4%)。就患者的平均年龄而言，腹主动脉瘤(AAA)显著高于胸主动脉瘤(TAA)(69.75%vs.62.97%，p <0.01)。真性动脉瘤更多地发生在AAA组，假性动脉瘤更多发地生在TAA组(75%vs.57.4%、42.6%vs25%;p <0.05)。梭形动脉瘤更多发生在AAA组，而囊状动脉瘤更多发生在TAA组(79.4%vs58.8%，TAA41.2%vs20.6%， p <0.01)。钙化和血栓形成方面AAA组明显高于TAA组(83.8%vs.41.2%，p <0.001;72.1%vs30.9%, p <0.001)。在真性和假性动脉瘤比较中，真性动脉瘤患者的平均年龄明显大于假性动脉瘤组(69.2vs60.8y，p <0.01)。破裂更多地发生在假性动脉瘤组(50%vs.1.1%，p <0.001)。对比真性胸主动脉瘤(TTAA)和假性胸主动脉瘤(PTAA)，PTAA组的钙化和血栓形成显著高于TTAA (69%vs.20.5%，p <0.001;48.3%vs.17.9%，p <0.01)。动脉瘤破裂几乎均出现在PTAA组(41.4%vs.0%，p <0.001)。在比较真性腹主动脉瘤(TAAA)和假性腹主动脉瘤(PAAA)方面，PAAA组年龄明显高于TAAA组(72vs.63y，p <0.01)。 PAAA组动脉的平均尺寸较TAAA组大(7.1vs5.6cm，p <0.01)。钙化更多地发生在TAAA(92.2%vs.58.8%，p <0.01)，而破裂则常发生在PAAA组(64.7%vs.2%，p <0.001)。胸主动脉瘤发现时直径通常小于5cm，而腹部动脉瘤发现时直径通常大于5cm (56.4%vs.28.6%、71.4%vs43.6%，p <0.01)。在直径≥5厘米的动脉瘤中钙化出现频率明显高于直径<5厘米的动脉瘤(82.9%vs.23.2%，p <0.01)。尽管没有统计学意义，但二期增强扫描动脉瘤的附壁血栓密度差别出现率在破裂组比非破裂组高(71.4%vs.40.9%，p=0.171)。比较动脉瘤相关的并发症与不相关的并发症方面，与动脉瘤相关并发症出现率较高的在高龄患者组(60.39vs68.27y，p <0.01)。与胸主动脉瘤比较，腹主动脉瘤和假性动脉瘤则更容易出现动脉瘤的相关并发症(65%vs3%，p <0.001;40.8%vs12.1%，p <0.01)。与患病年龄组比较，胸主动脉瘤更多地出现在60岁以下年龄组的患者(75%vs41%)，而腹主动脉瘤更多的见于60岁以

关键词：主动脉瘤 CT 假性动脉瘤真性动脉瘤钙化破裂血栓形成

Exploring nitrogen reduction reaction mechanisms in electrocatalytic ammonia synthesis:A comprehensive review

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Journal of Energy Chemistry 2024年第5期92卷 681-697页

作者： abhishek Umesh Shetty Ravi Sankannavar School of Chemical and Materials Science Indian Institute of Technology GoaFarmagudiPonda 403401GoaIndia Department of Chemical Engineering M.S.Ramaiah Institute of TechnologyMSR NagarMSRIT PostBengaluru 560054KarnatakaIndia

The electrochemical nitrogen reduction reaction(eNRR)holds significant promise as a sustainable alternative to the conventional large-scale Haber Bosch process,offering a carbon footprint-free approach for ammonia *** the process is thermodynamically feasible at ambient temperature and pressure,challenges such as the competing hydrogen evolution reaction,low nitrogen solubility in electrolytes,and the activation of inert dinitrogen(N_(2))gas adversely affect the performance of ammonia *** hurdles result in low Faradaic efficiency and low ammonia production rate,which pose obstacles to the commercialisation of the *** have been actively designing and proposing various electrocatalysts to address these issues,but challenges still need to be resolved.A key strategy in electrocatalyst design lies in understanding the underlying mechanisms that govern the success or failure of the electrocatalyst in driving the electrochemical *** mechanistic studies,we gain valuable insights into the factors affecting the reaction,enabling us to propose optimised designs to overcome the *** review aims to provide a comprehensive understanding of the various mechanisms involved in eNRR on the electrocatalyst *** delves into the various mechanisms such as dissociative,associative,Mars-van Krevelen,lithium-mediated nitrogen reduction and surface hydrogenation mechanisms of nitrogen *** unravelling the intricacies of eNRR mechanisms and exploring promising avenues,we can pave the way for more efficient and commercially viable ammonia synthesis through this sustainable electrochemical process by designing an efficient electrocatalyst.

关键词： Green ammonia synthesis Electrolysis Electrocatalysis Nitrogen reductionreaction Electrochemical reaction pathways Reactionmechanism

Multi-head neural networks for simulating particle breakage dynamics

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 130-141页

作者： abhishek Gupta Barada Kanta Mishra School of Mechanical Sciences Indian Institute of Technology(IIT)GoaPonda 403401India School of Chemical and Materials Science Indian Institute of Technology(IIT)GoaPonda 403401India

The breakage of brittle particulate materials into smaller particles under compressive or impact loads can be modelled as an instantiation of the population balance integro-differential *** this paper,the emerging computational science paradigm of physics-informed neural networks is studied for the first time for solving both linear and nonlinear variants of the governing *** conventional methods,the proposed neural network provides rapid simulations of arbitrarily high resolution in particle size,predicting values on arbitrarily fine grids without the need for model *** network is assigned a simple multi-head architecture tailored to uphold monotonicity of the modelled cumulative distribution function over particle *** method is theoretically analyzed and validated against analytical results before being applied to real-world data of a batch grinding *** agreement between laboratory data and numerical simulation encourages the use of physics-informed neural nets for optimal planning and control of industrial comminution processes.

关键词： Particle breakage dynamics Population balance equation Physics-informed neural networks

胰腺假性囊肿并脾动脉假性动脉瘤及结肠瘘致消化道出血一例

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中华消化外科杂志 2013年第1期12卷 66-67页

作者： abhishek shah 孙宇田孙晓艳曹殿波吉林大学第一医院放射线科长春130021 吉林大学中日联谊医院药剂科长春130051

1临床资料患者男，64岁、因便秘及腹泻2d，无明显诱因突发性排新鲜血便1次，总艟约1000ml，伴头晕、乏力，于2011年6月29日急诊入院，患者3年前诊断为急性胰腺炎行保守治疗后痊愈。体格检查：心率90次／min，血压100／70mm Hg（1mm Hg=0... 详细信息

1临床资料患者男，64岁、因便秘及腹泻2d，无明显诱因突发性排新鲜血便1次，总艟约1000ml，伴头晕、乏力，于2011年6月29日急诊入院，患者3年前诊断为急性胰腺炎行保守治疗后痊愈。体格检查：心率90次／min，血压100／70mm Hg（1mm Hg=0．133 kPa）．神志清楚，贫血貌。

关键词：消化道出血胰腺假性囊肿脾动脉假性动脉瘤结肠瘘

Numerical Analysis of Phase Change and Container Materials for Thermal Energy Storage in the Storage Tank of Solar Water Heating System

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Journal of Thermal Science 2024年第2期33卷 408-421页

作者： SINGH Shailendra ANAND abhishek SHUKLA Amritanshu SHARMA Atul Non-Conventional Energy Laboratory Rajiv Gandhi Institute of Petroleum TechnologyJais Amethi229304India

This study evaluates the effectiveness of phase change materials(PCMs) inside a storage tank of warm water for solar water heating(SWH) system through the theoretical simulation based on the experimental model of *** et *** model is explained by five fundamental equations for the calculation of various parameters like the effectiveness of PCMs,the mass of hot water,total heat content,and duration of *** study simulated eleven PCMs to analyze their effectiveness like Sodium hydrogen phosphate dodecahydrate(SHPD),OM 37,N-Eicosane(NE),Lauric acid(LA),Paraffin wax(PW),OM 48,Paraffin wax C_(20-33)(PW-C20-33),Sodium acetate trihydrate(SAT),Palmitic acid(PA),Myristic acid(MA),and Stearic acid(SA).Among all PCMs,the SHPD has found the highest value of effectiveness factor of ***,it is the most recommended PCM for the storage tank of the SWH *** study also includes the melt fraction analysis of all enumerated PCMs corresponding to container materials of stainless steel,glass,aluminum mixed,tin,aluminum,and *** melt fraction analysis is performed by making a coding program in the FORTRAN programming *** the analysis,copper container material is found to have high melting rate for all PCMs so it is superior to other container materials.

关键词： theoretical model solar water heating system phase change material effectiveness factor melt fraction

EVOLUTION AND INTERACTION OFδ-WAVES IN THE ZERO-PRESSURE GAS DYNAMICS SYSTEM

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Acta Mathematica Scientia 2024年第5期44卷 1801-1836页

作者： abhishek DAS K.T.JOSEPH Centre for Data Science Institute of Technical Education and Research(ITER)Siksha‘O’Anusandhan(Deemed to be University)BhubaneswarOdisha751030India Centre for Applicable Mathematics Tata Institute of Fundamental ResearchSharada NagarBangalore560065KarnatakaIndia

Evolution and interaction of plane waves of the multidimensional zero-pressure gas dynamics system leads to the study of the corresponding one dimensional *** this paper,we study the initial value problem for one dimensional zero-pressure gas dynamics *** the first equation is the Burgers equation and the second one is the continuity *** consider the solution with initial data in the space of bounded Borel *** we prove a general existence result in the algebra of generalized functions of *** we study in detail special solutions withδ-measures as initial *** study interaction of waves originating from initial data concentrated on two point sources and interaction with classical shock/rarefaction *** gives an understanding of plane-wave interactions in the multidimensional *** use the vanishing viscosity method in our analysis as this gives the physical solution.

关键词： zero-pressure gas dynamics delta-waves interaction of waves

Effect of metal fractions on rice grain metal uptake and biological parameters in mica mines waste contaminated soils

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Journal of Environmental Sciences 2024年第2期136卷 313-324页

作者： Saibal Ghosh Sandip Mondal Jajati Mandal abhishek Mukherjee Pradip Bhattacharyya Agricultural and Ecological Research Unit Indian Statistical InstituteGiridihJharkhand 815301India School of Science Engineering&EnvironmentUniversity of SalfordManchester M54WTUK

Heavy metals from mica waste not only deteriorate the soil quality but also results in the uptake of metals in the *** present investigation was conducted to evaluate the effects of different fractions of metals on the uptake in rice,soil microbial and biochemical properties in mica waste-contaminated soils of Jharkhand,*** each active mine,soil samples were randomly collected at distances of100 m(zone 3).Sequential metal extraction was used to determine the fractions of different metals(nickel(Ni),cadmium(Cd),chromium(Cr)and lead(Pb))including water-soluble(Ws)and exchangeable metals(Ex),carbonate-bound metals(CBD),Fe/Mn oxide(OXD)bound metals,organically bound metals(ORG),and residues(RS).The Ni,Cr,Cd and Pb in rice grain were 0.83±0.41,0.41±0.19,0.21±0.14 and 0.17±0.08 mg/kg *** the variable importance plot of the random forest(RF)algorithm,the Ws fraction of Ni,Cr and Cd and Ex fraction of Pb was the most important predictor for rice grain metal ***,the partial dependence plots(PDP)give us an insight into the role of the two most important metal fractions on rice grain metal *** microbial and enzyme activity was significantly and negatively correlated with Ws and Ex metal fractions,indicating that water-soluble and exchangeable fractions exert a strong inhibitory effect on the soil microbiological parameters and enzyme activities.

关键词： Metal fractions Microbial parameters Mica waste soil Soil enzymes Rice Random forest

An Interactive Operating Demand Response Approach for Hybrid Power Systems Integrating Renewable Energy Sources

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Protection and Control of Modern Power Systems 2024年第3期9卷 174-194页

作者： abhishek Saxena Ravi Shankar IEEE the Department of Electrical Engineering National Institute of Technology PatnaIndia

The increased deployment of renewable energy in existing power networks has jeopardized rotational inertia,resulting in system degradation and *** address the issue,this paper proposes a demand response strategy for ensuring the future reliability of the electrical power *** addition,a modified fuzzy logic control topology-based two-degree-of-freedom(fractional order proportional integral)-tilt derivative controller is designed to regulate the frequency within a demand response framework of a hybrid two-area deregulated power *** test system includes thermal power plants,renewable energy sources(such as wind,parabolic trough solar thermal plant,biogas),and electric vehicle *** adaptively tune the controller’s coefficients,a quasi-opposition-based harris hawks optimization(QOHHO)algorithm is *** effectiveness of this algorithm is compared to other optimization algorithms,and the stability of the system is *** results demonstrate that the designed control algorithm significantly enhances system frequency stability in various scenarios,including uncertainties,physical constraints,and high penetration of renewables,compared to existing ***,an experimental assessment through OPAL-RT is conducted to verify the practicality of the proposed strategy,considering source and load intermittencies.

关键词： Area control error demand response energy storage vertically integrated utility