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Single-use flexible ureteroscopes: Comparative in vitro analysis of four scopes

Asian Journal of Urology 2023年第1期10卷 64-69页

作者： Abhijit Patil Shashank Agrawal Rohan Batra abhishek singh Arvind Ganpule Ravindra Sabnis Mahesh Desai Department of Urology Muljibhai Patel Urological HospitalNadiadIndia

Objective:Single-use flexible ureteroscopes(fURSs)have recently been introduced by different companies.Goal of this in-vitro study was to compare four fURSs.Methods:We performed in vitro analysis of Uscope 7.5 Fr and Uscope 9.5 Fr(Pusen Ltd.,Zhuhai,China),LithoVue 9.5 Fr(LithoVue,Boston Scientific,MA,USA),and Indoscope 9.5 Fr(Bioradmedisys,Pune,India).Optical characteristics(image resolution,color representation,and luminosity)were compared at various distances of 10 mm,20 mm,and 50 mm.Deflection and irrigation were evaluated with and without accessories.Results:Color perception was comparable for all scopes at 10 mm(p<0.05),while Lithovue 9.5 Fr was comparable with Indoscope 9.5 Fr at the distances of 20 mm and 50 mm.Both scopes were statistically better than both Uscopes at the distances of 20 mm and 50 mm.Image resolution powers were comparable amongst all fURSs at the distances of 10 mm and 20 mm(3.56 line pairs per millimeter[lp/mm]).However,Indoscope(3.56 lp/mm)was superior to LithoVue and Uscope scopes(3.17 lp/mm)at the distance of 50 mm.Luminosity at the distance of 10 mm was comparable for LithoVue and Uscope 9.5 Fr.However,at the distances of 20 mm and 50 mm,LithoVue had the highest luminosity while Uscope 7.5 Fr had the lowest one.Indoscope had lower luminosity than other 9.5 Fr scopes at all distances.With empty working channel and 200 mm laser fiber,Indoscope had the maximum deflection(285).With basket,Uscope 7.5 Fr had the maximum loss of deflection(30)while Indoscope had no deflection loss.With empty working channel,all scopes had comparable irrigation flow rates in both deflected and undeflected state.Similarly,with 200 mm laser or basket,irrigation flow rates were comparable in all scopes.Conclusion:Color representation was equivalent for Indoscope and LithoVue,while being better than Uscope 7.5 Fr and Uscope 9.5 Fr.Image resolution was comparable in all scopes at the distances of 10 mm and 20 mm.Beyond the distance of 10 mm,luminosity of LithoVue was the highest and that of Uscope 7.5 Fr was

关键词： Single-use Disposable Flexible ureteroscopes In vitro Pusen LithoVue Indoscope

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Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction

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World Journal of Cardiology 2023年第1期15卷 23-32页

作者： Rishi Sethi Lalit Mohan Pravesh Vishwakarma abhishek singh Swati Sharma Monika Bhandari Ayush Shukla Akhil Sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun Shankar Narain Sudhanshu Kumar Dwivedi Department of Cardiology King George's Medical UniversityLucknow 226003Uttar PradeshIndia

BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac biomarkers.Rapid restoration of brisk flow in the coronary vasculature is critical in reducing mortality and morbidity.In patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective option.AIM To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after thrombolysis.METHODS This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary arteries.Patients received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another group.The primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the procedure.The secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 d.RESULTS The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,respectively.Smoking rate was 54.6%and 55.8%in the routine and delayed groups,respectively.Thrombolysis was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,respectively.No significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reported MACCE in the two groups did not demonstrate an

关键词： Coronary artery disease ST-elevation myocardial infarction Primary percutaneous coronary intervention Pharmacoinvasive strategy Thrombolysis Atherosclerosis

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Clinical characteristics of COVID-19 patients who underwent tracheostomy and its effect on outcome:A retrospective observational study

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World Journal of Virology 2022年第6期11卷 477-484页

作者： Yudhyavir singh Kapil Dev Soni abhishek singh Nikita Choudhary Fahina Perveen Richa Aggarwal Nishant Patel Shailendra Kumar Anjan Trikha Department of Anesthesiology Pain Medicine and Critical CareAll India Institute of Medical SciencesNew Delhi 110029India Department of Critical and Intensive Care Jai Prakash Narayan Apex Trauma CenterAll India Institute of Medical SciencesNew Delhi 110029India Department of Anesthesia All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND The exponential rise in Coronavirus disease 2019(COVID-19)cases has resulted in an increased number of patients requiring prolonged ventilatory support and subsequent tracheostomy.With the limited availability of literature regarding the outcomes of COVID-19 patients with tracheostomy,we attempted to study the clinical characteristics and multiple parameters affecting the outcomes in these patients.AIM To determine all-cause mortality following tracheostomy and its association with various risk factors in COVID-19 patients.METHODS This retrospective study included 73 adult COVID-19 patients admitted to the ICU between 1 April,2020 and 30 September,2021 who underwent tracheostomy as a result of acute respiratory failure due to COVID-19.The data collected included demographics(age,sex),comorbidities,type of oxygen support at admission,severity of COVID-19,complications,and other parameters such as admission to tracheostomy,intubation to tracheostomy,ICU stay,hospital stay,and outcome.RESULTS This study included 73 adult patients with an average age of 52±16.67 years,of which 52%were men.The average time for admission to tracheostomy was 18.12±12.98 days while intubation to tracheostomy was 11.97±9 days.The mortality rate was 71.2%and 28.8%of patients were discharged alive.The mean duration of ICU and hospital stay was 25±11 days and 28.21±11.60 days,respectively.Greater age,severe COVID-19,mechanical ventilation,shock and acute kidney injury were associated with poor prognosis;however,early tracheostomy in intubated patients resulted in better outcomes.CONCLUSION Patients with severe COVID-19 requiring mechanical ventilation have a poor prognosis but patients with early tracheostomy may benefit with no added risk.We recommend that the timing of tracheostomy be decided on a case-by-case basis and a well-designed randomised controlled trial should be performed to elucidate the potential benefit of early tracheostomy in such patients.

关键词： COVID-19 Intubation Mechanical ventilation ICU Tracheostomy Oxygen therapy

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Up to 70 THz bandwidth from an implanted Ge photoconductive antenna excited by a femtosecond Er:fibre laser

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Light(Science & Applications) 2020年第1期9卷 1716-1722页

作者： abhishek singh Alexej Pashkin Stephan Winnerl Malte Welsch Cornelius Beckh Philipp Sulzer Alfred Leitenstorfer Manfred Helm Harald Schneider Institute of Ion Beam Physics and Materials Research Helmholtz-Zentrum Dresden-Rossendorf01328 DresdenGermany Cfaed and Institute of Applied Physics TU Dresden01062 DresdenGermany Department of Physics and Center for Applied Photonics University of Konstanz78457 KonstanzGermany

Phase-stable electromagnetic pulses in the THz frequency range offer several unique capabilities in time-resolved spectroscopy.However,the diversity of their application is limited by the covered spectral bandwidth.In particular,the upper frequency limit of photoconductive emitters-the most widespread technique in THz spectroscopy-reaches only up to 7 THz in the regular transmission mode due to absorption by infrared-active optical phonons.Here,we present ultrabroadband(extending up to 70 THz)THz emission from an Au-implanted Ge emitter that is compatible with mode-locked fibre lasers operating at wavelengths of 1.1 and 1.55μm with pulse repetition rates of 10 and 20 MHz,respectively.This result opens up the possibility for the development of compact THz photonic devices operating up to multi-THz frequencies that are compatible with Si CMOS technology.

关键词： antenna emitter fibre

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Randomized controlled trial of topical EMLA and vapocoolant spray for reducing pain during wDPT vaccination

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World Journal of Pediatrics 2017年第3期13卷 236-241页

作者： Navratan Kumar Gupta Amit Upadhyay Ajeet Kumar Dwivedi Astha Agarwal Vijay Jaiswal abhishek singh Department of Pediatrics LLRMMedical CollegeMeerut(UP)India

Background:Intramuscular vaccination is among the most common source of iatrogenic pain in infants.Vapocoolant sprays are rapid-acting alternative to topical anesthetics.They provide transient anesthesia via evaporation induced skin cooling,and reduce pain due to vaccine injection in children and adults.The objective was to compare the synergistic analgesic effect of eutectic mixture of local anesthetics (EMLA) with breastfeeding (EB group) and vapocoolant spay with breastfeeding (VB group) to that of only breastfeeding (BO group) during whole cell diptheria,pertussis and tetanus (wDPT) vaccination.Methods:A double blind randomized controlled trial was done to include infants up to 3 months of age who came for their first wDPT vaccination.The primary outcome variable was the duration of cry after vaccination.Secondary outcome variables were Modified Facial Coding Score,Neonatal Infant Pain Scale and latency of onset of cry.Results:Of the 201 eligible participants,111 babies were excluded and remaining 90 babies were randomized into three groups of thirty each.The groups did not differ significantly in baseline characteristics.Median (interquartile range,IQR) of duration of cry was lesser [35.86 (21.07-107.75) seconds] in babies receiving EMLA cream with breast feeding (EB group) and in babies receiving vapocoolant spray with breast feeding (VB group) [32.58 (21.25-106.21) seconds] as compared to babies receiving only breast feeding (BO group) [67.5 (27.6-180) seconds] (P=-0.147).Difference in median (IQR) of latency of cry was not statistically significant.Modified Facial Coding Score and Neonatal Infant Pain Scale at 1 minute and 3 minutes was significantly lower in the EB and VB group,as compared to the BO group (P<0.05).Conclusions:Addition of topical EMLA application or vapocoolant spray to breastfeeding during wDPT vaccination does not reduce duration of cry in infants up to 3 months of age.However,they are able to show reduction in pain score and further studies are warranted to assess their efficacy as pai

关键词： diptheria,pertussis and tetanus vaccine eutectic mixture of local anesthetics Modified Facial Coding Score Neonatal Infant Pain Scale

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Three-phase AC-DC Converter for Direct-drive PMSG-based Wind Energy Conversion System

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 589-598页

作者： Kumar abhishek singh Ayushi Chaudhary Kalpana Chaudhary Department of Electrical Engineering Indian Institute TechnologyVaranasiIndia Department of Electrical Engineering Indian Institute TechnologyKanpurIndia

In this paper,a wind energy conversion system(WECS)is presented for the electrification of rural areas with wind energy availability.A three-phase AC-DC converter based on a bridgeless Cuk converter is used for power extraction from the permanent magnet synchronous generator(PMSG).The bridgeless topology enables the elimination of the front-end diode bridge rectifier(DBR).Moreover,the converter has fewer components,simple control,and high efficiency,making it suitable for a small-scale WECS.A squirrel cage induction motor(SCIM)is used to emulate a MOD-2 wind turbine to implement the PMSG-based WECS.A direct-drive eight-pole PMSG is used in this study;thus,a low-input-voltage system is designed.The converter is designed to operate in the discontinuous inductor current mode(DICM)for inherent power factor correction(PFC)and the maximum power point tracking(MPPT)is achieved through the tip-speed ratio(TSR)following.The performance of the developed system is analyzed through simulation,and a 500 W hardware prototype is developed and tested in different wind speed conditions.

关键词： Permanent magnet synchronous generator(PMSG) three-phase AC-DC converter wind energy conversion system(WECS) wind turbine emulator

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Cellulose synthase ‘class specific regions’ are intrinsically disordered and functionally undifferentiated

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Journal of Integrative Plant Biology 2018年第6期60卷 481-497页

作者： Tess R.Scavuzzo-Duggan Arielle M.Chaves abhishek singh Latsavongsakda Sethaphong Erin Slabaugh Yaroslava G.Yingling Candace H.Haigler Alison W.Roberts Department of Biological Sciences University of Rhode Island120 Flagg RoadKingstonRI 02881USA Department of Materials Science and Engineering North Carolina State UniversityRaleighNC 27695USA Department of Crop and Soil Sciences and Department of Plant and Microbial Biology North Carolina State UniversityRaleighNC 27695USA

Cellulose synthases （CESAs） are glycosyltransferases that catalyze formation of cellulose microfibrils in plant cell walls. Seed plant CESA isoforms cluster in six phylogenetic clades, whose non-interchangeable members play distinct roles within cellulose synthesis complexes （CSCs）. A ＇class specific region＇（CSR）, with higher sequence similarity within versus between functional CESA classes, has been suggested to contribute to specific activities or interactions of different isoforms. We investigated CESA isoform specificity in the moss, Physcomitrella patens （Hedw.） B. S. G. to gain evolutionary insights into CESA structure/function relationships. Like seed plants, P. patens has oligomeric rosette-type CSCs, but the PpCESAs diverged independently and form a separate CESA clade. We showed that P. patens has two functionally distinct CESAs classes, based on the ability to complement the gametophore-negative phenotype of a ppcesa5 knockout line. Thus, non-interchangeable CESA classes evolved separately in mosses and seed plants. However, testing of chimeric moss CESA genes for complementation demonstrated that functional classspecificity is not determined by the CSR. Sequence analysis and computational modeling showed that the CSR is intrinsically disordered and contains predicted molecular recognition features, consistent with a possible role in CESA oligomerization and explaining the evolution of class-specific sequences without selection for class-specific function.

关键词： Uwe Sonnewald Friedrich-Alexander University Germany

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Organic bulk heterojunction enabled with nanocapsules of hydrate vanadium pentaoxide layer for high responsivity self-powered photodetector

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Journal of Semiconductors 2022年第9期43卷 39-45页

作者： Hemraj Dahiya Anupam Agrawal Ganesh D.Sharma abhishek Kumar singh The LNM Institute of Information Technology Department of PhysicsJaipurRajasthan 302031India Bhilai Institute of Technology DurgChhattisgarh491001India Rajiv Gandhi Institute of Petroleum Technology Department of Electronics EngineeringAmethiU.P.229304India

This article demonstrates the fabrication of organic-based devices using a low-cost solution-processable technique.A blended heterojunction of chlorine substituted 2D-conjugated polymer PBDB-T-2Cl,and PC71BM supported nanocapsules hy-drate vanadium penta oxides(HVO)as hole transport layer(HTL)based photodetector fabricated on an ITO coated glass sub-strate under ambient condition.The device forms an excellent organic junction diode with a good rectification ratio of~200.The device has also shown excellent photodetection properties under photoconductive mode(at reverse bias)and zero bias for green light wavelength.A very high responsivity of~6500 mA/W and high external quantum efficiency(EQE)of 1400%have been reported in the article.The proposed organic photodetector exhibits an excellent response and recovery time of~30 and~40 ms,respectively.

关键词： self-powered detector green light sensor HVO PBDB-T-2Cl detector processable solution sensor

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Disciplined sleep for healthy living: Role of noradrenaline

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World Journal of Neurology 2017年第1期7卷 6-23页

作者： Rachna Mehta abhishek singh Birendra Nath Mallick School of Life Sciences Jawaharlal Nehru University

Sleep is essential for maintaining normal physiological processes. It has been broadly divided into rapid eye movement sleep(REMS) and non-REMS(NREMS); one spends the least amount of time in REMS. Sleep(both NREMS and REMS) disturbance is associated with most altered states, disorders and pathological conditions. It is affected by factors within the body as well as the environment, which ultimately modulate lifestyle.Noradrenaline(NA) is one of the key molecules whose level increases upon sleep-loss, REMS-loss in particular and it induces several REMS-loss associated effects and symptoms. The locus coeruleus(LC)-NAergic neurons are primarily responsible for providing NA throughout the brain. As those neurons project to and receive inputs from across the brain, they are modulated by lifestyle changes, which include changes within the body as well as in the environment. We have reviewed the literature showing how various inputs from outside and within the body integrate at the LC neuronal level to modulate sleep(NREMS and REMS) and vice versa. We propose that these changes modulate NA levels in the brain, which in turn is responsible for acute as well as chronic psychosomatic disorders and pathological conditions.

关键词： Epigenetic changes Healthy living Lifestyle Noradrenaline Sleep disturbance Psycho-somatic and metabolomic disorders

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The clinical outcomes of laser with suction device in mini-percutaneous nephrolithotomy

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Asian Journal of Urology 2022年第1期9卷 63-68页

作者： abhishek Gajendra singh Sundaram Palaniappan Shrikant Jai Gopal Tak Arvind Ganpule Ravindra Sabnis Mahesh Desai Department of Urology Muljibhai Patel Urological HospitalVirendradesai MargNadiadGujaratIndia

Objective:To evaluate the safety,efficacy and feasibility of laser with suction device in mini-percutaneous nephrolithotomy(mini-PCNL).Methods:A retrospective study was conducted including 200 patients who underwent mini-PCNL for renal stones.All patients underwent PCNL using Electro-Medical Systems laser.In addition to the laser in 100 patients,a suction device was used(laser with suction[LWS]).In the other 100,suction device was not used(laser with no additional suction[LOS]).Mini-PCNL was performed using standard technique and Karl Storz minimally invasive PCNL-medium system was used.Primary end point was stone clearance.Results:Both the groups were comparable in terms of demographic data.Mean stone size was 15.24±5.90 mm and 16.16±5.53 mm in LWS and LOS,respectively.Mean Hounsfield unit of stone was 1285.64 and 1206.79 in LWS and LOS,respectively.Operative time was less in LWS group(56.89±19.65 min)as compared to LOS(62.01±28.81 min).At one-month follow-up,radiological complete clearance was 96%in LWS and 92%in LOS.On subgroup analysis of stones larger than 18 mm,the clearance rate was in favour of LWS(85.7%vs.100%)and also the need for nephrostomy placement was less in LWS group.Conclusions:LWS device is safe and efficacious when used with mini-PCNL.For stones greater than 18 mm,it has a better stone free rate as compared to using no suction.

关键词： Mini-percutaneous nephrolithotomy Laser with suction Stone clearance

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