检索结果-南通市图书馆

Androgen receptor in bladder cancer:A promising therapeutic target

Asian Journal of Urology 2020年第3期7卷 284-290页

作者： abhishek tripathi Shilpa Gupta Section of Hematology Oncology University of Oklahoma Stephenson Cancer CenterOklahoma CityOKUSA Department of Hematology and Medical Oncology Cleveland Clinic Taussig Cancer InstituteClevelandOHUSA

There has been a significant progress in the treatment of metastatic urothelial carcinoma in the last few years with the advent of immunotherapy after a long gap of no drug approvals for over 4 *** immunotherapy with checkpoint inhibitors has revolutionized the treatment of urothelial carcinoma,unfortunately,only a minority of patients respond to *** options for patients who do not respond and/or progress on immunotherapy are very limited and overall prognosis remains dismal in metastatic urothelial *** first targeted therapy targeting the fibroblast growth factor receptor(FGFR)was recently approved for bladder cancer,but it is effective only in select patients harboring the FGFR2 and FGFR 3 *** drug conjugates like enfortumab vedotin have shown promising activity in clinical *** of novel targeted therapies remains an area of investigation and an unmet need in bladder *** of androgen receptor(AR)is a potential strategy for targeted drug development in bladder cancer.A significant proportion of urothelial carcinoma patients express AR irrespective of *** signaling in urothelial carcinoma has been linked to progression through multiple mechanisms,including activation of human epidermal growth factor receptor-2(EGFR or HER-2)signaling and epithelial to mesenchymal transition(EMT).Furthermore,AR is enriched in the luminal papillary mRNA subtype of urothelial carcinoma and also mediates resistance to cisplatin-based *** evidence suggests that AR inhibition can successfully inhibit urothelial carcinoma growth as monotherapy and is synergistic with cisplatin-based *** review the preclinical and clinical evidence supporting the putative role of AR signaling in urothelial carcinoma pathogenesis,progression and its role as a novel therapeutic target and future directions.

关键词： Androgen receptor Urothelial carcinoma Bladder cancer Targeted therapy Enzalutamide Cisplatin Testosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microstructure and texture evolution in AZ31 magnesium alloy during caliber rolling at different temperatures

引用

Journal of Magnesium and Alloys 2017年第3期5卷 340-347页

作者： abhishek tripathi S.V.S.Narayana Murty P.Ramesh Narayanan Department of Metallurgical Engineering and Materials Science Indian Institute of Technology BombayMumbai 400076India Materials Characterisation Division Materials and Metallurgy GroupVikram Sarabhai Space CentreTrivandrum 695022India

Magnesium alloy AZ31 was caliber rolled at different temperatures viz.523K,573K,623K,673K and 723K imposing a total cumulative reduction of 92%and a cumulative strain of *** associated microstructure and texture evolution were studied using Electron Back Scattered Diffraction(EBSD)and X-ray macro-texture observations *** refinement was observed in all the caliber rolled bars indicating the occurrence of dynamic *** parameter and texture index were used to study the evolution of *** doubling of the yield strength at room temperature was observed by caliber rolling at a temperature of *** improvement in mechanical properties was explained on the basis of the fine grain microstructures and suitable development of crystallographic *** on the present study,warm caliber rolling can be used as a good production method for obtaining long bars of high strength magnesium alloy AZ31.

关键词： Magnesium alloy AZ31 Microstructure Caliber rolling Texture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Ficus benghalensis Latex Based Combinatorial Formulations on Various Bio-Molecules in Indian White Termite Odontotermes obesus

引用

Journal of Biosciences and Medicines 2023年第4期11卷 82-102页

作者： abhishek Kumar tripathi Ravi Kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In present investigation, various bioassays were conducted to evaluate the alteration in levels of certain biomolecules, such as glycogen, protein, amino acid, DNA, RNA and lipids. For this purpose, worker termites were treated with sub-lethal dose 40% and 80% of 24 hrs LD50 values and observations were taken at 4 hrs interval up to 24 hrs. Crude latex and its combinatorial mixtures, like S-MLT-A, B-MLT-A, C-MLT-A, CU-MLT-A, AQ-MLT significantly altered level of bio-molecules in Odontotermes obesus. This effect was found time and dose dependent. Reduction or increase in biomolecules was calculated by using corresponding control. Maximum decrease in glycogen level was observed at 16 h when termites were treated with 80% of LD50 of Ficus benghalensis aqueous extract i.e. 56.88% at 16 h of treatment. A similar dose caused very slight decrease in lipid contents at 4 h of treatment but it was found further significantly (p > 0.05) decreased in other successive treatments. 40% and 80% of LD50 of C-MLT-B mixture caused significant (p > 0.05) decrease in DNA and RNA level at 16 h treatment. The level of DNA and RNA level was recorded 83.90%, 90.18% and 85.42% and 74.05% respectively. Similarly, total proteins were also found to be decreased with 40% and 80% of LD50 of C-MLT-B mixture i.e. 71.47% and 66.45% respectively. All these alterations found in levels of various bio-molecules confirm the action of latex ingredients on worker termites that was antifeedant or deterrent types. These ingredients can be used to control not only termites but also other phytophagous insects in a sustainable and eco-friendly way.

关键词： Ficus benghalensis Odontotermes obesus Latexes Antifeedant or Deterrent Termiticides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Toxic Effects of Ficus benghalensis Latex Based Combinatorial Formulations on Various Enzymatic Parameters in Indian White Termite Odontotermes obesus

引用

Advances in Enzyme Research 2023年第2期11卷 34-57页

作者： abhishek Kumar tripathi Ravi Kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present investigation, various bioassays were conducted to evaluate the alteration in levels of various enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and acetylcholinesterase. For this purpose worker termites were treated with sub-lethal doses of 40% and 80% of 24 hrs LD50 of latex-based combinatorial formulations and observations were taken at 4 hours intervals up to 24 hours. Ficus benghalensis crude latex and its combinatorial mixtures, like C-MLT-A, CU-MLT-A, AQ-MLT, P-MLT and EA-MLT significantly altered the level of enzymes in Odontotermes obesus and this effect found time and dose-dependent. Reduction or increase in enzymes was calculated by using the corresponding control. The maximum decrease in acid phosphatase level was observed at 16 h when termites were treated with 80% of LD50 of B-MLT-B and P-MLT i.e. 82.84% at 16 h of treatment. A similar dose caused a very slight decrease in glutamate pyruvate transaminase at 4 h of treatment but with the increase in time. Further decrease was noted in other successive treatments that were significant at p > 0.05. Similarly, 40% and 80% of LD50 of the C-MLT-B mixture caused significant (p > 0.05) decrease in alkaline phosphatase and acid phosphatase level at 16 h treatment i.e. 93.42%, 89.46% and 95.89%, 88.17% respectively. The level of acetylcholinesterase was also found to be decreased when termites were treated with 40% and 80% of LD50 of C-MLT-B mixture i.e. 92.72% and 97.27% respectively. All the above alterations noted in levels of various enzymes confirm the action of latex ingredients on worker termites that were anti-feedant or deterrent types. These ingredients can be used to control not only termites but also other phytophagous insects.

关键词： Ficus benghalensis Enzymes Alteration Odontotermes obesus Latexes Anti-Feedant Termiticides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current concepts in the management of non-cirrhotic non-malignant portal vein thrombosis

引用

World Journal of Hepatology 2024年第5期16卷 751-765页

作者： Adam J Willington Dhiraj tripathi Department of Hepatology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Hepatology University Hospitals BirminghamBirmingham B152THUnited Kingdom

Non-cirrhotic non-malignant portal vein thrombosis(NCPVT)is an uncommon condition characterised by thrombosis of the portal vein,with or without extension into other mesenteric veins,in the absence of cirrhosis or intra-abdominal *** can include intestinal infarction,variceal bleeding and portal *** this article,we address current concepts in the management of NCPVT including identification of risk factors,classification and treatment,and review the latest evidence on medical and interventional management options.

关键词： Non-cirrhotic portal vein thrombosis Portal vein Mesenteric veins Venous thrombosis Portal hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Methyl-salicylate:A surveillance system fortriggering immunity in neighboring plants

引用

Journal of Integrative Plant Biology 2024年第2期66卷 163-165页

作者： Saumya Jaiswal Durgesh Kumar tripathi Ravi Gupta JingHe Zhong-Hua Chen Vijay Pratap Singh Plant Physiology Laboratory Department of Botany C.M.P.Degree CollegeA Constituent Post Graduate College ofUniversity of AllahabadPrayagraj 211002India Crop Nanobiology and Molecular Stress Physiology LabAmity Institute of Organic Agriculture Amity University UttarPradeshNoida 201313India College of General Education Kookmin UniversitySeoul 02707South Korea School of Science Western Sydney UniversitySydney 2751New South WalesAustralia Hawkesbury Institute for the Environment Western SydneyUniversitySydney 2751New South WalesAustralia

Plant behavioral actions have been one of the major topicsof research in plant biology and *** actionsfrom plants are determined by their instant structural andphysical reactions to the circumstances(Bouwmeester et al.,2019).Upon sensing abiotic factors such as salinity,flooding,high temperature,drought,plants make suitable changes intheir physiology and behavior to survive such harsh conditions.

关键词： immunity neighboring salinity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bacterial community network complexity and role of stochasticity decrease during primary succession

引用

Soil Ecology Letters 2024年第3期6卷 45-59页

作者： Yucheng He Binu M.tripathi Jie Fang Zihao Liu Yaping Guo Yue Xue Jonathan M.Adams School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Korea Polar Research Institute Incheon 21990Republic of Korea

In microbial ecology,there is limited understanding of the mechanisms governing patterns in community structure across space and ***,we studied the changes of bacterial co-occurrence network structure over four primary successional soils after glacier retreat,including a sand dune system and three glacier foreland series,varying in timescale from centuries to *** found that in all series,network structure was most complex in the earliest stages of succession,and became simpler over *** and abundance of keystone species and network stability also declined over *** appears that with less productive,nutrient poor and physiologically extreme conditions of early succession,closer interactions among bacterial species are ecologically selected *** may take the form of consortia(with positive interactions)or stronger niche exclusion(with negative interactions).Additionally,we quantified the relative roles of different structuring processes on bacterial community using a bin-based null model analysis(iCAMP).With each successional series,community composition was initially governed by stochasticity,but as succession proceeded there was a progressive increase in deterministic selection over time,correlated with decreasing ***,our results show a consistency among the four series in long-term processes of community succession,with more integrated networks and greater stochasticity in early stages.

关键词： glacial retreat bacteria chronosequence co-occurrence network 16S rRNA sequencing community assembly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Toxic Effects of Ficus benghalensis Latex Based Combinatorial Formulations on Various Enzymatic Parameters in Indian White Termite Odontotermes obesus

引用

Advances in Enzyme Research（酶研究进展） 2023年第2期

作者： abhishek Kumar tripathi Ravi Kant Upadhyay

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Downstaging of advanced hepatocellular carcinoma followed by liver transplantation using immune checkpoint inhibitors:Where do we stand?

引用

World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 24-32页

作者： Hirak Pahari Javid A Peer Shikhar tripathi Suresh K Singhvi Ushast Dhir Department of Liver Transplant and Hepatobiliary Surgery Sir Ganga Ram HospitalNew Delhi 110060DelhiIndia Department of Surgical Gastroenterology and Liver Transplant Sir Ganga Ram HospitalNew Delhi 110060DelhiIndia

Liver transplantation(LT)in patients with hepatocellular carcinoma(HCC)and chronic liver disease(CLD)is limited by factors such as tumor size,number,portal venous or hepatic venous invasion and extrahepatic *** previously established criteria,such as Milan or UCSF,have been relaxed globally to accommodate more potential recipients with comparable 5-year outcomes,there is still a subset of the population that has advanced HCC with or without portal vein tumor thrombosis without detectable extrahepatic spread who do not qualify or are unable to be downstaged by conventional methods and do not qualify for liver *** checkpoint inhibitors(ICI)such as atezolizumab,pembrolizumab,or nivolumab have given hope to this group of *** completed a comprehensive literature review using PubMed,Google Scholar,reference citation analysis,and *** search utilized keywords such as'liver transplant','HCC','hepatocellular carcinoma','immune checkpoint inhibitors','ICI','atezolizumab',and'nivolumab'.Several case reports have documented successful downstaging of HCC using the atezolizumab/bevacizumab combination prior to LT,with acceptable early outcomes comparable to other *** effects of ICI have also been reported during the perioperative *** such cases,a 1.5-month interval between ICI therapy and LT has been ***,the results of downstaging using combination immunotherapy were encouraging and *** reports suggested a potential ray of hope for patients with CLD and advanced HCC,especially those with multifocal HCC or branch portal venous tumor ***,prospective studies and further experience will reveal the optimal dosage,duration,and timing prior to LT and evaluate both short-and long-term outcomes in terms of rejection,infection,recurrence rates,and survival.

关键词： Hepatocellular carcinoma Liver transplant Downstaging Atezolizumab Nivolumab Immune checkpoint inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

One-Pot Green Synthesis of 1, 4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by Solvent Free Method

引用

Open Journal of Composite Materials 2024年第3期14卷 109-123页

作者： Deepak Babasaheb Phasage Sanjay K. Sharma Balram tripathi Sonia Chahar Srivastava Department of Chemistry JECRC University Jaipur India S. S. Jain Subodh PG College Jaipur India

This study used a Polyindole in combination with TiO2 nanocatalyst as an efficient heterogeneous catalyst to carry out a multi-component Hantzsch reaction involving different aromatic aldehydes with methyl acetoacetate, and aqueous ammonium to create 1,4-dihydropyridine derivatives under solvent free condition at ambient temperature. A broad range of aldehydes and methyl acetoacetates, ranging from heteroaromatic to polyaromatic one, with high level of functional group tolerance can be used to provide the desired products possessing relevant medicinal moiety in high yields. This technology has prospective advantages over current protocols, including the utilization of a cheap, stable, recyclable, and safe catalyst, quicker reaction times with higher yields and simple product isolation.

关键词： TiO2 Nanocatalyst Green Synthesis Surface Morphology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：