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Is cirrhosis associated with lower odds of ischemic stroke:A nationwide analysis?

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World Journal of Hepatology 2016年第35期8卷 1564-1568页

作者： abhinav Goyal Kshitij Chatterjee Nishi Shah Shailender Singh Department of Internal Medicine Einstein Medical Center Department of Internal Medicine University of Arkansas for Medical Sciences Division of Gastroenterology Department of Internal Medicine University of Nebraska Medical Center

AIMTo determine the association between cirrhosis and ischemic stroke in a large nationally representative sample. METHODSA retrospective cross-sectional study of all hospitalized patients during 2012 and 2013 in the United States was performed using the National Inpatient Sample database. Hospitalizations with acute stroke, cirrhosis and other risk factors were identified using ICD-9-CM codes. RESULTSThere were a total of 72082638 hospitalizations in the United States during the years 2012 and 2013. After excluding hospitalizations with missing demographic variables, that there were a total of 1175210 (1.6%) out of these were for acute ischemic stroke. Cirrhosis was present among 5605 (0.4%) cases of ischemic stroke. Mean age among the cirrhotic and non-cirrhotic groups with ischemic stroke were 66.4 and 70.5 years, respectively. Prevalence of risk factors among the two groups was also calculated. After adjusting for various known risk factors the odds of having an ischemic stroke (OR = 0.28, P CONCLUSIONOur study suggests that in a large, nationally representative sample of the United States population, cirrhosis is associated with a lower likelihood of stroke.

关键词： Cirrhosis Ischemic stroke Cerebrovascular accident National Inpatient Sample

The Versatility and Diagnostic Potential of VOC Profiling for Noninfectious Diseases

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Biomedical Engineering Frontiers 2023年第1期4卷 274-297页

作者： Micah Oxner Allyson Trang Jhalak Mehta Christopher Forsyth Barbara Swanson Ali Keshavarzian abhinav Bhushan Department of Biomedical Engineering Illinois Institute of TechnologyChicagoIL 60616USA Department of Internal Medicine Division of Digestive Diseases and NutritionSection of GastroenterologyRush Medical CollegeChicagoIL 60612USA Department of Adult Health and Gerontological Nursing Rush University College of NursingChicagoIL 60612USA

variety of volatile organic compounds(VOCs)are produced and emitted by the human body every *** identity and concentration of these VOCs reflect an individual’s metabolic *** regarding the production and origin of VOCs,however,has yet to be congruent among the scientific *** review article focuses on the recent investigations of the source and detection of biological VOCs as a potential for noninvasive discrimination between healthy and diseased *** the changes in the components of VOC profiles could provide information regarding the molecular mechanisms behind disease as well as presenting new approaches for personalized screening and *** research has prioritized the study of cancer,resulting in many research articles and reviews being written on the *** review summarizes the information gained about VOC cancer studies over the past 10 years and looks at how this knowledge correlates with and can be expanded to new and upcoming fields of VOC research,including neurodegenerative and other noninfectious *** advances in analytical techniques have allowed for the analysis of VOCs measured in breath,urine,blood,feces,and *** diagnostic approaches founded on sensor-based techniques allow for cheaper and quicker results,and we compare their diagnostic dependability with gas chromatography-and mass spectrometry-based *** future of VOC analysis as a clinical practice and the challenges associated with this transition are also discussed and future research priorities are summarized.

关键词： VOC gained summarized

Regression analysis and features of negative activation energy for MHD nanofluid flow model:A comparative study

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Propulsion and Power Research 2023年第2期12卷 273-283页

作者： B.Kumara Prachi abhinav Singhal R.Nandkeolyar Pulkit Kumar Ali J.Chamkha School of Mathematics Thapar Institute of Engineering and TechnologyPatiala 147004PunjabIndia Department of Applied Sciences and Humanities RITRoorkee 247667India School of Sciences Christ(Deemed to be University)Delhi NCR 201003India Department of Mathematics National Institute of TechnologyJamshedpur 831014India Department of Applied Mechanics Indian Institute of TechnologyDelhi 110016India Faculty of Engineering Kuwait College of Science and TechnologyDoha DistrictKuwait

This article elucidates the impact of activation energy on magnetohydrodynamic(MHD)stagnation point nanofluid flow over a slippery surface in a porous regime with thermophoretic and Brownian *** activation energy is scarce in practice,but the impact of negative activation energy could not be neglected as it is noticed in chemical *** rate of some Arrhenius-compliant reactions is retarded by increasing the temperature and is therefore associated with negative activation energies,such as exothermic binding of urea or *** some processes,the temperature dependence of the pressure-induced unfolding and the urea-induced unfolding of proteins at ambient pressure give negative activation *** present mathematical model is solved with successive linearization method(a spectral technique).A comparison of results is made for negative and positive values of activation *** from it,the quadratic multiple regression model is discussed briefly and explained with bar *** is observed that with rise in unsteadiness parameter from 0 to 1(taking positive activation energy),skin friction and Sherwood number are increased by 9.36%and 19%respectively,and Nusselt number is decreased by 26%.However,for negative activation energy,9.36%and 112%enhancement is observed in skin friction and Sherwood number,respectively.

关键词： Negative activation energy Regression analysis Successive linearization method Porous medium

Approach to medical therapy in perianal Crohn’s disease

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World Journal of Gastroenterology 2021年第25期27卷 3693-3704页

作者： abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States Department of Radiology Mayo ClinicRochesterMN 55905United States

Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of *** often requires combined surgical and medical ***-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s *** has been shown to be efficacious in improving fistula closure rates in randomized controlled *** can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s *** issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of *** article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s *** will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s ***,new therapies such as local injection of mesenchymal stem cell therapy will be discussed.

关键词： Fistula Biologics Inflammatory bowel disease Surgery Stem cells Infliximab Ustekinumab

Transitioning patients with inflammatory bowel disease from hospital-based to rapid home-based infliximab: A stepwise, safety and patient-orientated process towards sustainability

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World Journal of Gastroenterology 2020年第36期26卷 5437-5449页

作者： Anuj Bohra Qurat-Al-Ain Rizvi Charlotte Yuen Yu Keung abhinav Vasudevan Daniel R van Langenberg Department of Gastroenterology Eastern HealthBox Hill 3128VictoriaAustralia Eastern Health Clinical School Monash UniversityBox Hill 3128VictoriaAustralia

BACKGROUND Infliximab and other intravenous biologic infusions are increasingly used for chronic disorders like inflammatory bowel disease(IBD).Rapid infliximab and home-based infusions are attractive solutions to address resource and capacity issues for infusion centres,yet infliximab infusion reactions reportedly occur in up to 25%of patients with IBD,even at the manufacturers’recommended infusion duration of 2 *** To evaluate the safety,cost and patient satisfaction of transitioning from hospitalbased,standard 2 h to rapid home-based,30-min infliximab *** All patients receiving rapid infliximab infusions for IBD between 2014 to 2017(39 mo)were compared with those who received standard two-hour IFX infusions between 2005-2013(96 mo)at a single IBD ***(per-infusion and perindividual)including adverse drug reactions(ADR),duration(based on needledeparture time)and other clinical data were extracted from electronic medical *** logistical regression analysis assessed factors potentially associated with increased risk of ADRs to rapid *** primary outcome was the safety[as per relative risk(RR)of (ADR)of(1)rapid 30 m infusions(both hospital-and home-based)vs standard 2 h infliximab ***,relative cost per infusion and patient satisfaction and productivity were evaluated in rapid infusion recipients who transitioned to home-based *** Of 129 patients who received 1461 rapid IFX infusions(2014-2017)were compared with 169 patients who received 2214 standard IFX infusions(2005-2013).Within the rapid cohort,55(42.6%)were males,median age 42 years(range 18,86),114(84%)had Crohn’s disease(CD)with a median disease duration 5 years(0,36).Median needle to departure time was higher in the standard than the rapid protocol group,108(70,253)vs 50(33,90)min,(P<0.001),with a per infusion cost of$AUD 107.50 vs$49.77,respectively(both P<0.001).There was no difference in median infusion duration or costs between rapi

关键词： Inflammatory bowel disease Infliximab Safety Cost Therapy Drug reaction

Liver retransplants using living donors:An approach for management

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Liver Research 2023年第3期7卷 252-255页

作者： Hasan Al Harakeh Christopher Hughes Amit Tevar Vikram Gunabushanam Eishan Ashwat Hao Liu abhinav Humar Starzl Transplantation Institute University of Pittsburgh Medical CenterPittsburghPAUSA

Background and aims:Many centers do not offer living donor transplants for patients in need of a liver *** aimed to study our liver retransplant outcomes using living donors and compared them with those of retransplants performed using deceased ***:This study retrospectively analyzed all retransplants performed at our center between 2009 and 2023,and outcomes of living donor retransplants were compared with deceased donor retransplants using standard statistical ***:Between January 2009 and March 2023,a total of 77 retransplants,60 with deceased donors and 17 with living donors,were *** demographic differences between the two groups included a higher model for end-stage liver disease score in the deceased donor group(32.1±6.1 vs.19.4±5.7,P<0.001)and a higher number of early retransplants(within 3 months of the initial transplant),which accounted for 35% of deceased donor transplants but 0 of living donor transplants(P<0.01).Overall,the patient and graft survival rates were comparable between the two *** patient survival rates at 1 and 3 years after transplant were 73% and 67% in the deceased donor group and 84% and 73% in the living donor group,respectively(P=0.57).The hospital length of stay and blood product use were both better in the living donor *** complications did not show significant different between the two groups(P=0.33).Conclusions:Living donors can provide acceptable outcomes for those in need of a retransplant,with results comparable to those seen with deceased donors.A systematic approach to the patient in the pre-,peri-,and post-transplantation period is important in these complicated cases.

关键词： Liver retransplant Living donor liver transplant Deceased donor Outcomes Complications

3D Surface Digitization in Scientific Research and Product Development

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Forensic Medicine and Anatomy Research 2021年第2期9卷 11-23页

作者： abhinav Sood Varsha Dogra Gayatri Pathmanathan Department of Anthropology Panjab University Chandigarh India Department of Environment Studies Panjab University Chandigarh India

This comprehensive review participates in the use of three different non-invasive surface scanning techniques directed in scientific research of medical, anthropology, archaeology forensic science, and product designing. 3D surface examining tools speak to a promising technique to provide reproducible data such as map the facial soft or hard tissues of a subject document skeletal remains, and trauma, generating 3D imitations of the components for documented and illustrative purposes while simultaneously holding exactness and unwavering quality. Three-dimensional imaging is rapidly turning into a vital tool for reconstruction and examination in scientific research. The final 3D mesh can be 3D printed or the digital version can be shared online with scientific researchers. This review manuscript highlights several studies utilizing non-invasive scanning techniques, depicts the pro and cons of the 3D scanning techniques, and different features of the scanners irrespective of the cost which would be helpful for future research work. A resourceful review was conducted using 7 databases;PubMed, CENTRAL, Science Direct, Scopus, Google Scholar, Research Gate, and IEEE Xplore from 2002 to 2020. Search terms were;“3D Laser scanning”, “Photogrammetry”, “Skeleton preservation”, “Documentation”, “Surface Scanning”, etc. Papers with quality work and related to the field of forensic science, anthropometry, 3D facial scanning, and product development were selected. From all the studies, 71 studies met the eligibility criteria, and other articles were excluded which were non-relevant, had duplicate records, and did not meet search criteria. This review provides in-depth understanding and discussions into methods, restrictions, and inferences from respective research publications.

关键词： Anthropometry Non-Invasive Laser Scanners Stereophotogrammetry Structured Light

Management and outcome of pancreatic trauma:a 6-year experience at a level I trauma center

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Emergency and Critical Care Medicine 2023年第1期3卷 6-11页

作者： abhinav Anand Parvez Mohi Ud Din Dar Preksha Rani Supreet Kaur Joses Dany James Junaid Alam Pratyusha Priyadarshini abhinav Kumar Dinesh Bagaria Narendra Choudhary Subodh Kumar Amit Gupta Sushma Sagar Biplab Mishra Division of Trauma Surgery and Critical Care Jai Prakash Narayan Apex Trauma CentreAll India Institute of Medical Sciences(AIIMS)New DelhiIndia Department of Trauma and Emergency Medicine All India Institute of Medical Science(AIIMS)VijaypurJammuJammu and KashmirIndia Department of General Surgery All India Institute of Medical Science(AIIMS)JodhpurRajasthanIndia

Background: Pancreatic trauma (PT) accounts for less than 1% of all trauma admissions. Occasionally, PT is undetected during theprimary survey and becomes apparent only when complications arise. It occurs in up to 5% of blunt abdominal trauma cases and 12%of individuals with penetrating abdominal injuries. Management is determined by the status of the main pancreatic duct and ***: This was an ambispective study conducted at the Jai Prakash Narayan Apex Trauma Center, All India Institute ofMedical Sciences,New Delhi, from January 2015 to December 2017 (retrospective), and January 2019 to December 2020 (prospective). In total, 113patients with PT were included in this ***:We analyzed the data of 113 patients with PT included in this study, of whichmales predominated (93.7%). Blunt PT was presentin 101 patients (89.4%) and penetrating PT in 12 patients (10.6%). Half of the patients (51.3%) had the American Association for theSurgery of Trauma grade III PT, followed by grade II (18.6%), and grade I (15%). Of the total 113 patients, 68 (60.2%) were treated withoperative management, and 45 (39.8%) with nonoperative management. Distal pancreatectomy, with or without splenectomy, was themost common procedure performed in our study, followed by drainage. There were 27 mortalities (23.8%) during the study period, ofwhich 7 were directly related to PT and 20 were due to other organ-related sepsis and hemorrhagic ***: Pancreatic trauma is rare but challenging for trauma surgeons, with persistent management controversies. Early diagnosisis important for favorable results;however, a delay in diagnosis has been associated with higher morbidity and mortality. Low-grade pancreaticinjuries can be successfully managed nonoperatively, whereas high-grade pancreatic injuries require surgical intervention.

关键词： Abdominal trauma Distal pancreatectomy Management Pancreatic trauma

Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 57-63页

作者： Garg Neeraj K Mangal Sharad Sahu Tejram Mehta abhinav Vyas Suresh P Tyagi Rajeev K Department of Pharmaceutical Sciences Dr.H.S.Gour University Biologie et genetiqjue du paludisme Institut Pasteur28 Rue Du Docteur Roux75724 Paris Cedex 15France Biomedical Parasitology Unit Pasteur Institute

Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma ***:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were *** was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell ***:This study reveals and proves the anticancer ***,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2.

关键词： Antioxidants Anticancer Apoptosis ROS Hydrogen peroxide RCC-26