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Biological analysis of an innovative biodegradable antibiotic eluting bioactive glass/gypsum composite bone cement for treating experimental chronic MRSA osteomyelitis

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Journal of Pharmaceutical Analysis 2022年第1期12卷 164-177页

作者： Surajit Mistry Subhasish Burman Subhasis Roy Nilendu Jyoti Maitra Rajiv Roy abhijit chanda Department of Periodontics Burdwan Dental College&HospitalBurdwan713101India Department of Oral&Maxillofacial Surgery Burdwan Dental College&HospitalBurdwan713101India Department of Veterinary Clinical Complex(Surgery&Radiology) West Bengal University of Animal&Fishery SciencesKolkata700037India Directorate of Research Extension&Farms West Bengal University of Animal&Fishery SciencesKolkata700037India Department of Orthopaedics Calcutta National Medical College&HospitalKolkata700014India School of Bio-Science&Engineering Jadavpur UniversityKolkata734432India

A multi-barrier antibiotics loaded biodegradable composite bone cement for resolving chronic osteomyelitis has been studied to understand the physico-mechanical properties,drug loading/eluting efficiency,and different merits and demerits prior to clinical *** successful induction of bone infection in 28 rabbits using methicillin-resistant Staphylococcus aureus(MRSA)strains,calcium sulfate/bioactive glass based composite cement was implanted in 12 defects to assess its performance over parenteral therapy with microscopic and radiological examination for 90 *** composite cement revealed acceptable physico-mechanical properties and controlled drug elution ***,the antibiotics concentrations in bone up to 42 days were sufficient to kill MRSA without eliciting adverse drug *** striking feature of platelets aggregation by composite cement could assist bone *** controlled degradation with simultaneous entrapment of composite cement within the osteoid tissues and complete repair of infected cortical defects(holes)in rabbit tibia at 6 weeks indicated the excellent anti-infective and osteoconductive properties of composite ***,the animal study demonstrated the superiority of composite over injectable antibiotic therapy based on infection resolution and bone *** thereby conclude that the composite cement can be effectively applied in the treatment of resistant cases of chronic osteomyelitis.

关键词： Antibiotics Biodegradable composite Osteomyelitis MRSA strains Osteoconduction

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Dynamics of a delay-induced prey-predator system with interaction between immature prey and predators

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International Journal of Biomathematics 2024年第2期17卷 139-176页

作者： Soumik Pandey abhijit Sarkar Debashis Das Sarbani Chakraborty Department of Mathematics West Bengal State University Barasat-7000126West BengalIndia Department of Basic Science&Humanities JIS College of Engineering Kalyani-741235West BengalIndia

In biological pest control systems,several pests(including insects,mites,weeds,etc.)are controlled by biocontrol agents that rely primarily on *** this biocontrol management ecology,we have created a three-tier prey-predator model with prey phase structure and predator gestation *** studies have demonstrated that predators with Holling type-II functional responses sometimes consume immature prey.A study of the well-posedness and local bifurcation(such as saddle-node and transcritical)near the trivial and planer equilibrium points is carried *** any time lag,the prey development coeficient has a stabilizing impact,while increasing attack rate accelerates *** transformation rate and handling time are shown to cause multiple stability switches in the *** results demonstrate time delay is the key destabilizer that destroys *** model can replicate more realistic events by including time-dependent factors and exploring the dynamic behavior of nonautonomous *** the presence of time delay,sufficient conditions of permanence and global attractivity of the nonautonomous system are ***,MATLAB simulations are performed to validate the analytical findings.

关键词： Holling type-II functional response stage-structure bifurcation time delay seasonality

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Tubularized incised plateurethroplasty and grafted tubularized incised plate urethroplasty: systematic review, metaanalysis and trial sequential analysis

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World Journal of Pediatric Surgery 2024年第1期7卷 10-19页

作者： Nitinkumar Borkar Charu Tiwari abhijit Nair Debajyoti Mohanty C K Sinha Jai Kumar Mahajan Paediatric Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Department of Anaesthesiology Ibra HospitalbraOman General Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Paediatric Surgery St George's University Hospitals NHS Foundation TrustLondonUK Pediatric Surgery PGIMERChandigarhIndia

Background Hypospadias is one of the most common genital birth *** are around 300 various techniques available for the repair of *** study aims to compare the reported outcomes of Tubularized incised plate urethroplasty(TIP)and Grafted TIP(GTIP)repair in children undergoing primary *** This meta-analysisadhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,and we framed our research question using the population,intervention,control and outcomes *** conducted comprehensive electronic searches across various databases,employing a Boolean search strategy with predefined search *** randomized controlled trials(RCTs)were included for quantitative *** Totally,10 RCTs met our inclusion criteria for quantitative *** results indicated that urethrocutaneous fistula,glans dehiscence,and stricture rates were comparable between the two *** incidence of meatal stenosis was found to be significantly lower in the GTIP group with a relative risk(RR)of 0.32(95%confidence interval(Cl)0.15 to 0.67).Conclusion The coucomes UCF,glans dehiscence,and stricture rates were comparable between the two ***,the incidence of meatal stenosis was found to be significantly lower in the grafted TIP *** terms of operative time,our quantitative synthesis demonstrated that the TIP group had a shorter operative time than the GTIP group with significant heterogeneity.

关键词： plate grafted analysis

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Hepatitis E virus infections

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World Journal of Virology 2024年第2期13卷 5-10页

作者： Basavraj S Nagoba abhijit S Rayate Department of Microbiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of Surgery Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India

Hepatitis E virus(HEV)infection is now endemic *** patients with acute infection recover *** and sporadic cases,particularly in high-risk individuals are emerging *** patients with risk factors like pregnancy and pre-existing chronic liver disease,present with or progress rapidly to severe ***-suppression in post-transplant patients is an additional risk *** FDA-approved diagnostic tests are the need of the *** studies are needed to establish guideline-based treatment regimen and outbreak preparedness for HEV to decrease global morbidity,mortality,and healthcare *** for screening donors and transplant cases are requi-red.

关键词： Challenges Chronic hepatitis E Hepatitis E virus Post-transplant hepatitis Risk factors

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Advantageous properties of halide perovskite quantum dots towards energy-efficient sustainable applications

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Green Energy & Environment 2024年第6期9卷 949-965页

作者： Qian Zhao Shuo Wang Young-Hoon Kim Shekhar Mondal Qingqing Miao Simiao Li Danya Liu Miao Wang Yaxin Zhai Jianbo Gao abhijit Hazarika Guo-Ran Li School of Materials Science and Engineering Nankai UniversityTianjin300350China Department of Energy Engineering Hanyang UniversitySeoul04763Republic of Korea Polymers and Functional Materials Division CSIR-Indian Institute of Chemical TechnologyUppal RoadTarnakHyderabad500007India Institute of Process Engineering Chinese Academy of SciencesBeijing100190China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangshHunan410081China Department of Chemistry Brock University1812 Sir Isaac WaySt CatharinesOntarioCanada

As lead halide perovskite(LHP)semiconductors have shown tremendous promise in many application fields,and particularly made strong impact in the solar photovoltaic area,low dimensional quantum dot forms of these perovskites are showing the potential to make distinct marks in the fields of electronics,optoelectronics and *** so-called perovskite quantum dots(PQDs)not only possess the most important features of LHP materials,i.e.,the unusual high defect tolerance,but also demonstrate clear quantum size effects,along with exhibiting desirable optoelectronic properties such as near perfect photoluminescent quantum yield,multiple exciton generation and slow hot-carrier ***,we review the advantageous properties of these nanoscale perovskites and survey the prospects for diverse applications which include lightemitting devices,solar cells,photocatalysts,lasers,detectors and memristors,emphasizing the distinct superiorities as well as the challenges.

关键词： Perovskite quantum dot Light-emitting Detector Laser Solar cell

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Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh Kumar Jha Shreesh Ojha Dinesh Kumar Niraj Kumar Jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

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Multi-systemic melioidosis

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World Journal of Clinical Cases 2024年第28期12卷 6151-6154页

作者： Basavraj S Nagoba Shree V Dhotre abhijit S Rayate Sachin S Mumbre Pradnya S Dhotre Department of Microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of Microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Surgery Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413006India Department of Biochemistry Ashwini Rural Medical CollegeSolapur 413001India

This editorial is a commentary on the article by Ni et al,which was published in the World Journal of Clinical *** article discusses the diagnostic and therapeutic challenges of melioidosis caused by Burkholderia *** case study highlights a rare instance of multisystemic melioidosis in a female patient who did not have a travel history,emphasizing the significance of recognizing this condition in non-endemic *** complexities and therapeutic strategies are addressed,emphasizing the need for heightened clinical suspicion,comprehensive evaluation,and multidisciplinary *** editorial delves into the clinical presentation,diagnostic dilemmas,therapeutic approaches,and their implications for patient care in managing multi-systemic melioidosis.

关键词： Melioidosis Burkholderia pseudomallei Multi-systemic Diagnosis Treatment

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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Seismic bearing capacity of strip footing on partially saturated soil using modal response analysis

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Earthquake Engineering and Engineering Vibration 2022年第3期21卷 641-662页

作者： abhijit Anand Rajib Sarkar Department of Civil Engineering IIT(ISM)DhanbadDhanbad 826004India

The present study proposes a novel and simplified methodology to assess the seismic bearing capacity(SBC) of a shallow strip footing by incorporating strength non-linearity arising due to partial saturation of a soil matrix. Furthermore, developed methodology incorporates the modal response analysis of soil layers to assess SBC. A constant matric suction distribution profile has been considered throughout the depth of the soil. The Van Genuchten equation and corresponding fitting parameters have been considered to quantify matric suction in the analysis. SBC has been obtained for three different geomaterials;viz. sand, fly ash and clay, based on their predominant grain size and diverse soil water characteristics curve(SWCC) attributes. Variation of SBC with different modes of vibration and damping ratio are reported for ranges of matric suction pertinent to the geomaterials considered in the study. The relative significance of matric suction on SBC has been reported for suction values within the transition zone of each geomaterial. It is observed that the SBC of sand is drastically reduced, with matric suction reaching beyond the residual suction value. The SBC of fly ash remains constant beyond the residual suction value, whereas the SBC of clay shows an increasing trend toward the practical range of matric suction values.

关键词： seismic bearing capacity modal analysis matric suction

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The effect of carbapenem resistance in Klebsiellae on infection outcomes in animals and birds

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Infectious Diseases Research 2024年第2期5卷 12-14页

作者： Bhoj R Singh abhijit M Pawde Division of Epidemiology ICAR-Indian Veterinary Research InstituteBareilly 243122India Wildlife Cetre ICAR-Indian Veterinary Research InstituteBareilly 243122India

It is often said that the emergence of antimicrobial drug resistance(AMR)in pathogens is the major cause of *** the present study,clinical microbiology data on infections caused by Klebsiella pneumoniae strains and their antimicrobial drug resistance specifically to carbapenems retrieved from Clinical Epidemiology database of the Institute were analysed to determine the impact of carbapenem resistance in Klebsiellae isolated from the clinical samples of veterinary cases and outcome of the infection because in a few recent reports it is claimed that the presence of carbapenem-resistant Klebsiellae is associated with higher mortality in humans due to Klebsiella *** retrospective analysis of Klebsiella infections in animals and birds revealed that 21.8%of *** causing pneumonic or septicemic infections were carbapenem-resistant but the carbapenem resistance was not associated with increased numbers of deaths or *** may be probably due to the fact that carbapenem drugs were not used for the treatment of infected animals and carbapenem resistance may not be associated with the lethality potential of Klebsiellae.

关键词： Klebsiella pneumoniae Klebsiella oxytoca Klebsiella aerogenes abortions

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