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Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders(Amorphous,Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications

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Journal of Materials Science & Technology 2015年第5期31卷 437-444页

作者： Nicole Ostrowski Vidisha Sharma abhijit roy Prashant N.Kumta Department of Bioengineering University of Pittsburgh Center of Complex Engineered Multifunctional Materials University of Pittsburgh Department of Chemical and Petroleum Engineering University of Pittsburgh Department of Mechanical Engineering and Materials Science University of Pittsburgh

Magnesium phosphate cements have come under investigation in recent years for use as an alternative to calcium phosphate cements for bone void repair *** indicates that magnesium phosphate cements obtain higher initial strengths after cement reaction and resorption in more clinically appropriate time frames than commercially available calcium phosphate *** this study,amorphous,partially amorphous and crystalline tri-magnesium phosphate powders were synthesized via an aqueous precipitation reaction with subsequent thermal treatment,and characterized using techniques such as X-ray diffraction and Fourier transform infrared *** materials were assessed for their functionality in cementing reaction with a 3.0 mol/L,pH 7.0 ammonium phosphate solution,including setting time and pH evolution in phosphate buffered saline *** indicated that the amorphous and semi-crystalline tri-magnesium phosphate powders were highly reactive with the setting solution but resulted in mechanically weak cements,while the crystalline tri-magnesium phosphate powder reacted efficiently with the cement solution and were mechanically strong following the cement reaction.X-ray diffraction and scanning electron microscopy analyses indicated significant changes in the phase composition and morphology of the cements following incubation in phosphate buffered *** were perceived to be detrimental to the integrity of the amorphous and semi-crystalline tri-magnesium phosphate derived cements but not to those created with fully crystalline tri-magnesium *** crystalline tri-magnesium phosphate material resulted in the most functional cement as this embodiment displayed the most clinically relevant setting time as well as the highest mechanical resilience and neutral pH during incubation in saline solution rendering them potentially viable as bone void fillers.

关键词： Amorphous magnesium phosphate Tri-magnesium phosph

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A hybrid wavelet and time plane based method for QT interval measurement in ECG signals

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Journal of Biomedical Science and Engineering 2009年第4期2卷 280-286页

作者： Swanirbhar Majumder Saurabh Pal Sidhartha Dhar abhijit Sinha abhijit roy Dept of ECE NERIST (Deemed University) Arunachal Pradesh India Haldia Institute of Technology Haldia West Bengal India.

Here we present a method of QT interval meas-urement for Physionet's online QT Challenge ECG database using the combination of wavelet and time plane feature extraction mechanisms. For this we mainly combined two previous works one done using the Daubechies 6 wavelet and one time plane based with modifications in their algorithms and inclusion of two more wavelets (Daubechies 8 and Symlet 6). But found that out of these three wavelets Daube-chies 6 and 8 gives the best output and when averaged with the interval of time plane feature extraction method it gives least percentage of error with respect to the median reference QT interval as specified by Physionet. Our modified time plane feature extraction scheme along with the wavelet method together produces best re-sults for automated QT wave measurement as its regular verification is important for analyzing cardiac health. For the V2 chest lead particularly whose QT wave is of tremendous significance we have tested on 530 recordings of Physionet. This is because delay in cardiac repolarization causes ventricular tachyarrhythmias as well as Torsade de pointes (TdP). A feature of TdP is pronounced prolongation of the QT interval in the supraventricular beat preceding the ar-rhythmia. TdP can degenerate into ventricular fibrillation, leading to sudden death.

关键词： ECG QT Physionet TdP

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Sustainable Denim Washing by Process Optimization

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Journal of Textile Science and Technology 2022年第4期8卷 149-162页

作者： Md. Abu Bakar Siddiquee A. T. M. Gulam Moula Joy Krisna Saha Md. Humayun Kabir Khan Zihan Kaisar abhijit roy Department of Textile Engineering Mawlana Bhashani Science & Technology University Tangail Bangladesh Department of Fabrics Engineering Bangladesh University of Textiles Dhaka Bangladesh

Now-a-days sustainability is a crucial issue in denim washing. This research initiative is performed aiming to resolve the crisis of sustainability in denim washing by process optimization technique which highlights the reduction of water, chemical and time as well as costing of denim garments. In this research work, process optimization technique is administered by reducing several wash & chemical application baths into a single bath confirming without alteration of physical properties and color fastness of denim fabric. For confirmation without alteration of physical properties and color fastness, several tests are carried out like tensile and tear strength, color fastness to rubbing, color fastness to wash, color fastness to water, color fastness to perspiration and CMC (Carboxy Methyl Cellulose) value for both conventional and sustainable washing method. BOD, COD and pH of waste water is determined which shows better result in sustainable washing method also. Reduction of rinsing time in sustainable washing method results in less consumption of water by 475 and process time by 19% and also saves $0.34/ dozen garments which validate the cost effectiveness of this sustainable washing method.

关键词： Sustainability Denim Wash Color Fastness Cost Analysis

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A Hybrid Wavelet and Time Plane Based Method for QT Interval Measurement in ECG Signals

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Journal of Biomedical Science and Engineering 2009年第4期

作者： Swanirbhar Majumder Saurabh Pal Sidhartha Dhar abhijit Sinha abhijit roy

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Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer

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Genes & Diseases 2022年第4期9卷 868-888页

作者： abhijit Das Barshana Bhattacharya Souvik roy Department of Pharmacology NSHM Knowledge CampusKolkata-Group of InstitutionsKolkata 700053India

Cancer is one of those leading diseases worldwide, which takes millions of lives every year. Researchers are continuously looking for specific approaches to eradicate the deadly disease, ensuring minimal adverse effects along with more therapeutic significance. Targeting of different aberrantly regulated signaling pathways, involved in cancer, is surely one of the revolutionary chemotherapeutic approach. In this instance, GSK3 and PI3K signaling cascades are considered as important role player for both the oncogenic activation and inactivation which further leads to cancer proliferation and metastasis. In this review, we have discussed the potential role of GSK3 and PI3K signaling in cancer, and we further established the crosstalk between PI3K and GSK3 signaling, through showcasing their cross activation, cross inhibition and convergence pathways in association with cancer. We also exhibited the effect of GSK3 on the efficacy of PI3K inhibitors to overcome the drug resistance and preventing the cell proliferation, metastasis in a combinatorial way with GSK3 inhibitors for a better treatment strategy in clinical settings.

关键词： Cancer Chemotherapy Drug resistance GSK3 PI3K

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Biological analysis of an innovative biodegradable antibiotic eluting bioactive glass/gypsum composite bone cement for treating experimental chronic MRSA osteomyelitis

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Journal of Pharmaceutical Analysis 2022年第1期12卷 164-177页

作者： Surajit Mistry Subhasish Burman Subhasis roy Nilendu Jyoti Maitra Rajiv roy abhijit Chanda Department of Periodontics Burdwan Dental College&HospitalBurdwan713101India Department of Oral&Maxillofacial Surgery Burdwan Dental College&HospitalBurdwan713101India Department of Veterinary Clinical Complex(Surgery&Radiology) West Bengal University of Animal&Fishery SciencesKolkata700037India Directorate of Research Extension&Farms West Bengal University of Animal&Fishery SciencesKolkata700037India Department of Orthopaedics Calcutta National Medical College&HospitalKolkata700014India School of Bio-Science&Engineering Jadavpur UniversityKolkata734432India

A multi-barrier antibiotics loaded biodegradable composite bone cement for resolving chronic osteomyelitis has been studied to understand the physico-mechanical properties,drug loading/eluting efficiency,and different merits and demerits prior to clinical *** successful induction of bone infection in 28 rabbits using methicillin-resistant Staphylococcus aureus(MRSA)strains,calcium sulfate/bioactive glass based composite cement was implanted in 12 defects to assess its performance over parenteral therapy with microscopic and radiological examination for 90 *** composite cement revealed acceptable physico-mechanical properties and controlled drug elution ***,the antibiotics concentrations in bone up to 42 days were sufficient to kill MRSA without eliciting adverse drug *** striking feature of platelets aggregation by composite cement could assist bone *** controlled degradation with simultaneous entrapment of composite cement within the osteoid tissues and complete repair of infected cortical defects(holes)in rabbit tibia at 6 weeks indicated the excellent anti-infective and osteoconductive properties of composite ***,the animal study demonstrated the superiority of composite over injectable antibiotic therapy based on infection resolution and bone *** thereby conclude that the composite cement can be effectively applied in the treatment of resistant cases of chronic osteomyelitis.

关键词： Antibiotics Biodegradable composite Osteomyelitis MRSA strains Osteoconduction

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An all-optical comparison scheme between two multi-bit data with optical nonlinear material

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Chinese Optics Letters 2008年第9期6卷 693-696页

作者： Kuladeep roy Chowdhury abhijit Sinha Sourangshu Mukhopadhyay Department of Physics University of BurdwanGolapbagBurdwan-713104India

Over the last few decades, several all-optical circuits have been proposed to meet the need of high-speed data processing. In some information processing architectures, the role of various analog and digital data comparisons is very important. In this letter, we proposed a multi-bit data comparison scheme. The scheme is based on the switching property of optical nonlinear material. Ultrafast operational speed larger than gigahertz can be expected from this all-optical scheme.

关键词： An all-optical comparison scheme between two multi-bit data with optical nonlinear material data than BIBO

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Structural Analysis of Predicted HIV-1 Secis Elements

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World Journal of AIDS 2011年第4期1卷 208-218页

作者： Paushali roy Sayak Ganguli Pooja Sharma Protip Basu abhijit Datta DBT Centre for Bioinformatics Presidency University

Incorporation of Selenocysteine into protein requires an RNA structural motif, SECIS (Selenocysteine insertion sequence) element that, along with other factors, demarcates UGA-Sec from the UGA termination codon, for expression of Selenoproteins (in case of eukaryotes). It has been predicted that during HIV infection, several functional viral selenoproteins are expressed and synthesis of these viral selenoproteins deplete the selenium level of the host. It might be that even the viral genome has the SECIS elements in their Selenoprotein mRNA, and during infection, the host cellular machinery is transformed in such a way that the human Sec tRNA binds to the viral Selenoprotein mRNA, instead of binding to its own Selenoprotein mRNA, thus leading to expression of viral selenoproteins. This hypothesis was tested in this study by identifying the SECIS elements in the HIV-1 genome and further predicting their secondary and tertiary structures. We then tried to dock these tertiary structures with human Sec tRNA. Here we report putatively the presence of 3215 SECIS elements in the HIV-1 genome and that the human Sec tRNAsec binds to the viral SECIS elements present in the viral selenoprotein mRNA. Based on an earlier finding, it was observed that atoms of A8 and U9, which present in human Sec tRNA, are the possible key sites for binding.

关键词： Selenocysteine Selenium SECIS Element Selenoprotein Human Sec tRNAsec UGA Codon

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Structural Analysis of Predicted HIV-1 Secis Elements

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World Journal of AIDS 2011年第4期

作者： Paushali roy Sayak Ganguli Pooja Sharma Protip Basu abhijit Datta

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