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More to it than meets the eye: a case report of incomitant esotropia in a child caused by a giant basilar aneurysm

Annals of Eye Science 2023年第4期8卷 1-5页

作者： Tianwei Ellen Zhou Carmen Parra Farinas abhaya vkulkarni Peter Dirks Leonardo RBrandão Prakash Muthusami Nasrin Najm-Tehrani Department of Ophthalmology and Vision Sciences University of TorontoTorontoOntarioCanada Department of Diagnostic Imaging the Hospital for Sick ChildrenUniversity of TorontoTorontoOntarioCanada Department of Neurosurgery the Hospital for Sick ChildrenUniversity of TorontoTorontoOntarioCanada Division of Haematology/Oncology Department of Pediatricsthe Hospital for Sick ChildrenUniversity of TorontoTorontoOntarioCanada Dalla Lana School of Public Health University of TorontoTorontoOntarioCanada Department of Ophthalmology the Hospital for Sick ChildrenUniversity of TorontoTorontoOntarioCanada

Background:Esotropia is a common concern in pediatric ophthalmology *** most cases stem from strabismus,it is crucial for physicians to differentiate atypical features that might indicate underlying organic causes,such as VI nerve palsy,hinting at the presence of intracranial spaceoccupying *** the occurrence of cerebral aneurysms in children is rare,they can have severe *** Description:Here,we described an extremely rare case of giant basilar fusiform aneurysm measuring 4.0 cm×3.9 cm×3.9 cm in an otherwise healthy 8-year-old child,and analyzed its atypical features that suggested an intracranial *** further described an endovascular approach,performed by interventional radiologists,and discussed its advantages over the conventional *** patient continued to be followed by our multidisciplinary *** had a stable post-operative course and made an excellent recovery *** the 1-year follow-up,he was orthophoria with excellent vision and ***:To our knowledge,this is the first pediatric case in Canada where a giant intracranial aneurysm was treated *** salient red flags—progressive incomitant esotropia and diplopia,the presence of myopia(rather than hyperopia),nystagmus and abnormal saccadic movements—should be astutely recognized by clinicians as intracranial giant aneurysms carry a poor prognosis.A multidisciplinary approach is essential for the management of such cases.

关键词： Sixth nerve palsy incomitant esotropia giant basilar aneurysm interventional radiology case report

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The proximity between hydroxyl and single atom determines the catalytic reactivity of Rh1/CeO_(2) single-atom catalysts

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Nano Research 2024年第1期17卷 397-406页

作者： Danfeng Wu Shuyun Zhou Congcong Du Juan Li Jianyu Huang Hong-xia Shen abhaya K.Datye Shan Jiang Jeffrey T.Miller Sen Lin Haifeng Xiong State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350002China Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China College of Biology and Chemical Engineering Jiaxing UniversityJiaxing 314000China Department of Chemical&Biological Engineering University of New MexicoAlbuquerqueNM 8731-0001USA Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN 47907-2100USA Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Fujian Key Laboratory of Rare-earth Functional Materials Fujian Shanhai Collaborative Innovation Center of Rare-earth Functional MaterialsLongyan 366300China

The local structure of the metal single-atom site is closely related to the catalytic activity of metal single-atom catalysts(SACs).However,constructing SACs with homogeneous metal active sites is a challenge due to the surface heterogeneity of the conventional ***,we prepared two Rh1/CeO_(2)SACs(0.5Rh1/r-CeO_(2)and 0.5Rh1/c-CeO_(2),respectively)using two shaped CeO_(2)(rod and cube)exposing different facets,i.e.,CeO_(2)(111)and CeO_(2)(100).In CO oxidation reaction,the T100 of 0.5Rh1/r-CeO_(2)SACs is 120°C,while the T100 of 0.5Rh1/c-CeO_(2)SACs is as high as 200°*** in-situ CO diffuse reflectance infrared Fourier transform spectroscopy(CO-DRIFTS),we found that the proximity between OH group and Rh single atom on the plane surface plays an important role in the catalytic activity of Rh1/CeO_(2)SAC system in CO *** Rh single atom trapped at the CeO_(2)(111)crystal surface forms the Rh1(OH)adjacent species,which is not found on the CeO_(2)(100)crystal surface at room ***,during CO oxidation,the OH group far from Rh single atom on the 0.5Rh1/c-CeO_(2)disappears and forms Rh1(OH)adjacent species when the temperature is above 150°*** formation of Rh1(OH)adjacentCO intermediate in the reaction is pivotal for the excellent catalytic activity,which explains the difference in the catalytic activity of Rh single atoms on two different CeO_(2)*** formed Rh1(OH)adjacent-O-Ce structure exhibits good stability in the reducing atmosphere,maintaining the Rh atomic dispersion after CO oxidation even when pre-reduced at high temperature of 500°*** functional theory(DFT)calculations validate the unique activity and reaction path of the intermediate Rh1(OH)adjacentCO species *** work demonstrates that the proximity between metal single atom and hydroxyl can determine the formation of active intermediates to affect the catalytic performances in catalysis.

关键词： crystal plane Rh1/CeO_(2)single-atom catalyst proximity of Rh and hydroxyl coordination structure CO oxidation

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Atom trapping: a novel approach to generate thermally stable and regenerable single-atom catalysts

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National Science Review 2018年第5期5卷 630-632页

作者： abhaya Datye Yong Wang Department of Chemical and Biological Engineering and Center for Micro-Engineered Materials University of New Mexico The Gene & Linda Voiland School of Chemical Engineering and Bioengineering Washington State University Institute for Integrated Catalysis Pacific Northwest National Laboratory

An important goal of heterogeneous catalyst synthesis is the dispersion of the active metal uniformly on a catalyst support, ideally achieving atomic *** single atoms dispersed on oxide supports provide efficient util... 详细信息

关键词： Pt Atom trapping a novel approach to generate thermally stable and regenerable single-atom catalysts

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Determinants of timing and amplitude in the plant general stress response

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Journal of Integrative Plant Biology 2016年第2期58卷 119-126页

作者： Marta Bjornson abhaya Dandekar Katayoon Dehesh Department of Plant Sciences University of California Department of Plant Biology University of California

Plants have evolved intricate signaling cascades to rapidly and effectively respond to biotic and abiotic challenges. The precise timing of these responses enables optimal resource reallocation to maintain the balance between stress adaptation and growth. Thus, an in-depth understanding of the immediate and long-term mechanisms regulating resource allocation is critical in deciphering how plants withstand environmental challenges. To date however, understanding of this tradeoff has focused on the amplitude of long-term responses, rather than the timing of rapid stress responses. This review presents current knowledge on kinetics of secondary messengers involved in regulation of rapid and general stress responses, followed by rapid stress responsive transduction machinery, and finally the transcriptional response of a functional general stress responsive cis-element. Within this context we discuss the role of timing of initial peak activation and later oscillating peak responses, and explore hormonal and stress signaling crosstalk confounding greater understanding of these cascades.

关键词： Calcium general stress response mitogen-activated protein kinase rapid stress response element reactive oxygen species nitric oxide timing

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Spectrum, Manifestations and Outcomes of Dengue Infection in Individuals with and without Liver Disease

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 106-111页

作者： Anand vkulkarni Ashok K.Choudhury Madhumita Premkumar Priyanka Jain Ekta Gupta Shiv Kumar Sarin Department of Hepatology and Transplant Institute of Liver and Biliary SciencesNew DelhiIndia Department of Virology Institute of Liver and Biliary SciencesNew DelhiIndia Department of Statistics Institute of Liver and Biliary SciencesNew DelhiIndia

Background and Aims:Dengue infection is a major health burden,which can result in mild self-limited febrile illness to highly fatal hemorrhagic *** is paucity of literature describing the manifestations of dengue in patients with underlying liver *** studied and compared the manifestations of this tropical infection in patients with and without liver ***:Patients with serologically-confirmed dengue infection were included in this retrospective study,obtained for over a period of 1 *** and laboratory variables were compared for the individuals with no underlying liver disease(Group A,n=71),chronic hepatitis(Group B,n=12),and cirrhosis(Group C,n=12).Results:Males predominated the study population(61%),with a higher mean age in the cirrhotic *** most common clinical manifestation was classical dengue fever,seen in 89 *** presented as dengue hemorrhagic fever(1 each in Group A and Group B),1 presented as acute liver failure,and 3 as acute-on-chronic liver *** was less evident in Group C as compared to Group A and Group B(p<0.001).Patients in Group C had significantly prolonged International Normalized Ratio(INR)and enhanced thrombocytopenia compared to patients in Group A and Group *** in Group C also required prolonged hospital stay(Group A:4.83±2.88,Group B:7.33±2.3,Group C:13±5 days;p<0.001).Three patients expired in Group C compared to the 1 in Group A and none in Group B(p=0.01).On univariate analysis,hemoglobin,albumin,INR,and bilirubin predicted development of liver *** multivariate analysis,INR and bilirubin predicted development of liver ***:Dengue infection can have varied manifestations,ranging from simple fever to acute-on-chronic liver failure and acute liver *** patients lack classical features of dengue and have relatively poor *** should be suspected as a cause of liver failure in endemic areas,where no etiological ca

关键词： Dengue Cirrhosis Acute-on-chronic liver failure Acute liver failure

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Passage of nasogastric tube through tracheo-esophageal fistula into stomach: A rare event

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World Journal of Clinical Cases 2014年第7期2卷 309-310页

作者： Ravikiran Shankar Kamble Rahulkumar Gupta abhaya Gupta Paras Kothari K Vishesh Dikshit Krishnakumar Kesan Kedar Mudkhedkar Department of Pediatric Surgery Lokamany Tilak Municipal Medical College and Government HospitalMaharashtra 400022India

Esophageal atresia with tracheo-oesophageal fistula(TEF) occurs in 1 in 3500 live births. Anorectal malformation is found to be associated with 14% of TEF. Esophageal atresia with TEF is a congenital anomaly which classically presents as excessive frothing from the mouth and respiratory distress. Rarely gastric position of the feeding tube in a case of TEF can be obtained delaying the diagnosis of TEF. We had an uncommon situation where a nasogastric tube reached the stomach through the trachea and tracheo-esophageal fistula, leading to misdiagnosis in a case of esophageal atresia with tracheoesophageal fistula. By using a stiff rubber catheter instead of a soft feeding tube for the diagnosis of esophageal atresia and TEF, such situation can be avoided.

关键词： Esophageal atresia Tracheoesophageal fistula Nasogastric tube Red rubber catheter Misdiagnosis

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Clinical Validation of Global Coagulation Tests to Guide Blood Component Transfusions in Cirrhosis and ACLF

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 210-219页

作者： Madhumita Premkumar Rohit Mehtani Smita Divyaveer Kamal Kajal Anand vkulkarni Syed Ahmed Harmanpreet Kaur Harpreet Kaur Radhakrishna Dhiman Ajay Duseja Arka De Departments of Hepatology Postgraduate Institute of Medical Education and ResearchChandigarhIndia Nephrology Postgraduate Institute of Medical Education and ResearchChandigarhIndia Anesthesia and Intensive CarePostgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Hepatology Asian Institute of GastroenterologyHyderabadIndia Medicine Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Background and Aims:Patients with cirrhosis and acuteon-chronic liver failure(ACLF)may have bleeding complications and need for invasive ***-of-care(POC)coagulation tests like thromboelastography(TEG)and Sonoclot may be better for guiding patient management than the standard coagulation tests(SCTs),like prothrombin time,platelet count and international normalized ***:We prospectively compared and validated the POC tests and SCTs in 70 persons with ACLF and 72 persons with decompensated cirrhosis who had clinical bleeding and checked for episodes of re-bleeding and transfusion *** assessed pre-procedure requirement of blood components when correction was done based on an SCT or POC ***:Episodes of bleeding were seen in 45%and 28%of ACLF and cirrhosis patient,respectively(p=0.036),with the major site of bleeding being gastrointestinal(31%and 16%,respectively).Platelet counts correlated with TEG-maximum amplitude in cirrhosis(p=0.045)and prothrombin time correlated positively with TEG-reaction(R)time(p=0.032),TEG-Clot kinetics(K)time(p=0.042),Son-activated clotting time(p=0.038)and negatively with clot rate(p=0.043)in ACLF,making these correctable target variables in POC transfusion *** 223 procedures,transfusion of fresh frozen plasma and platelet concentrate was reduced by 25%(p=0.035)and 20.8%(p=0.045)by using a POC strategy in 76 *** of deranged Son-activated clotting time and TEG-reaction time was noted in 68%and 72%after 24 h of fresh frozen plasma transfusion in ACLF and 85%and 80%in cirrhosis,***:Our study clinically validates that POC tests can better detect coagulation defects and transfusion thresholds in ACLF and cirrhosis,whereas use of conventional tests appear to be less suitable in patients with clinical *** Registration:NCT04332484.

关键词： Coagulation Cirrhosis ACLF Validation Sonoclot Thromboelastography

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Genome Editing Tools: Need of the Current Era

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American Journal of Molecular Biology 2019年第3期9卷 85-109页

作者： Sabin Aslam Sultan Habibullah Khan Aftab Ahmed abhaya M. Dandekar Center of Agricultural Biochemistry and Biotechnology University of Agriculture Faisalabad Pakistan Center of Advanced Studies in Agriculture and Food Security University of Agriculture Faisalabad Pakistan Department of Plant Sciences University of California Davis CA USA

Genome editing is considered as the most widely used approach of the present era. It had become a basic need of the current micro and molecular biological experiments. Gene engineering finds its widespread applications in medical, industry and agricultural sector. Unlike previous genetic engineering practices to insert or delete a part of genetic material at random place, genome editing allows the precise manipulation of DNA at a specific location. Zinc Finger Nucleases (ZFNs), Transcription Activator like Effector Nucleases (TALENs), Clustered Regularly Interspresed Short Palindromic repeats (CRISPR/Cas system) and meganucleases (recombinases) are the prime tools for editing an organism’s genome. Genome editing tools have an advantage to selectively delete or to integrate specific genes at specific loci. Use of recombinases for specifying site has further reduced time to integrate genes site specifically. Site specific gene stacking by the use of recombinases coupled with ZFNs, TALENs, or CRISPR/Cas genes have paved new pathways to target genes site specifically and to improve germplasm in lesser time than conventional breeding approaches.

关键词： CRISPR/Cas Gene Stacking Recombinases TALENs ZFNs

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The Tale of Cotton Plant: From Wild Type to Domestication, Leading to Its Improvement by Genetic Transformation

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American Journal of Molecular Biology 2020年第2期10卷 91-127页

作者： Sabin Aslam Sultan Habibullah Khan Aftab Ahmed abhaya M. Dandekar Center of Agricultural Biochemistry and Biotechnology University of Agriculture Faisalabad Pakistan Department of Plant Sciences University of California Davis CA USA Center of Advanced Studies in Agriculture and Food Security University of Agriculture Faisalabad Pakistan

Cotton is considered as a major cash crop of the world. It earns huge foreign exchange by its valuable products;fiber, lint, cotton seed oil, hull and a lot more. Being an important fiber crop, it earns huge foreign exchange by contributing to textile and seed oil industry. This review summarizes cotton biology, its diversity and domestication, genome assembly, constraints in its production and methods to improve cotton plant to fulfill the need of textile and oil industry. But cotton is facing enormous biotic and abiotic stresses with insect pests being most prominent. Massive destruction caused by insects needs to be controlled for maintaining fruitful cotton crop production. Conventional breeding approaches are limited to improving single trait and integrate stable genes within plant genome in approximately 7 - 8 years. Improved biotechnological procedures have paved new pathways to target genes specifically and improve cotton germplasm in lesser time than conventional breeding.

关键词： Cotton Colored Cotton Cotton Domestication Genetic Diversity Transformation

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Sugar metabolism and accumulation in the fruit of transgenic apple trees with decreased sorbitol synthesis

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Horticulture Research 2018年第1期5卷 80-90页

作者： Mingjun Li Pengmin Li Fengwang Ma abhaya M.Dandekar Lailiang Cheng State Key Laboratory of Crop Stress Biology in Arid Areas/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F University712100YanglingShaanxiP.R.China Section of Horticulture School of Integrative Plant ScienceCornell UniversityIthacaNY14853USA Department of Plant Sciences University of CaliforniaDavisCA95616USA

Both sorbitol and sucrose are synthesized in source leaves and transported to fruit for supporting fruit growth in tree fruit species of the Rosaceae *** apple(Malus domestica),antisense suppression of aldose-6-phosphate reductase,the key enzyme for sorbitol synthesis,significantly decreased the sorbitol concentration but increased the sucrose concentration in leaves,leading to a lower sorbitol but a higher sucrose supply to fruit in these *** response to this altered carbon supply,the transgenic fruit had lower concentration of sorbitol and much higher concentration of glucose but similar levels of fructose,sucrose,and starch throughout fruit development relative to the untransformed *** of sorbitol dehydrogenase,fructokinase,and sucrose phosphate synthase were lower,whereas activities of neutral invertase,sucrose synthase,and hexokinase were higher in the transgenic fruit during fruit *** levels of MdSOT1,MdSDHs,MdFK2,and MdSPS3/6 were downregulated,whereas transcript levels of MdSUC1/4,MdSUSY1-3,MdNIV1/3,MdHKs,and MdTMT1 were upregulated in the transgenic *** findings suggest that the Sucrose cycle and the sugar transport system are very effective in maintaining the level of fructose and provide insights into the roles of sorbitol and sucrose in regulating sugar metabolism and accumulation in sorbitol-synthesizing species.

关键词： synthesis sugar transformed

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