检索结果-南通市图书馆

Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders:A review

World Journal of Gastroenterology 2022年第26期28卷 3047-3062页

作者： Risha Ganguly Ashutosh Gupta abhay k pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002Uttar PradeshIndia

Baicalin is a natural bioactive compound derived from Scutellaria baicalensis,which is extensively used in traditional Chinese medicine.A literature survey demonstrated the broad spectrum of health benefits of baicalin such as antioxidant,anticancer,anti-inflammatory,antimicrobial,cardio-protective,hepatoprotective,renal protective,and neuroprotective *** is hydrolyzed to its metabolite baicalein by the action of gut microbiota,which is further reconverted to baicalin via phase 2 metabolism in the *** studies have suggested that baicalin exhibits therapeutic potential against several types of hepatic disorders including hepatic fibrosis,xenobiotic-induced liver injury,fatty liver disease,viral hepatitis,cholestasis,ulcerative colitis,hepatocellular and colorectal *** in vitro and in vivo examinations,it has been observed that baicalin showed a protective role against liver and gut-associated abnormalities by modifying several signaling pathways such as nuclear factor-kappa B,transforming growth factor beta 1/SMAD3,sirtuin 1,p38/mitogen-activated protein kinase/Janus kinase,and calcium/calmodulin-dependent protein kinase kinaseβ/adenosine monophosphate-activated protein kinase/acetyl-coenzyme A carboxylase ***,baicalin also regulates the expression of fibrotic genes such as smooth muscle actin,connective tissue growth factor,β-catenin,and inflammatory cytokines such as interferon gamma,interleukin-6(IL-6),tumor necrosis factor-alpha,and IL-1β,and attenuates the production of apoptotic proteins such as caspase-3,caspase-9 and B-cell lymphoma ***,due to its low solubility and poor bioavailability,widespread therapeutic applications of baicalin still remain a *** review summarized the hepatic and gastrointestinal protective attributes of baicalin with an emphasis on the molecular mechanisms that regulate the interaction of baicalin with the gut microbiota.

关键词： Baicalin Biotransformation Gut microbiota Hepatobiliary and gastrointestinal disorders Signaling pathways

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation

引用

World Journal of Hepatology 2022年第4期14卷 729-743页

作者： Risha Ganguly Ramesh kumar abhay k pandey Department of Biochemistry University of AllahabadPrayagraj 211002India

BACkGROUND Fluoxetine is one of the most widely prescribed anti-depressant drugs belonging to the category of selective serotonin reuptake ***-term fluoxetine treatment results in ***,a natural compound obtained from the Chinese herb Scutellaria baicalensis is known to have antioxidant,hepatoprotective and anti-inflammatory ***,the beneficial effects of baicalin against fluoxetine-induced hepatic damage have not previously been *** To evaluate the protective action of baicalin in fluoxetine-induced liver toxicity and *** Male albino Wistar rats were divided into seven *** 1 was the normal *** fluoxetine was administered at 10 mg/kg body weight to groups 2,3,4 and *** addition,groups 3 and 4 were also co-administered oral baicalin(50 mg/kg and 100 mg/kg,respectively)while group 5 received silymarin(100 mg/kg),a standard hepatoprotective compound for *** 6 and 7 were used as a positive control for baicalin(100 mg/kg)and silymarin(100 mg/kg),*** treatments were carried out for 28 *** sacrifice of the rats,biomarkers of oxidative stress[superoxide dismutase(SOD),catalase(CAT),reduced glutathione(GSH),glutathione-S-transferase(GST),advanced oxidation protein products(AOPP),malondialdehyde(MDA)],and liver injury[alanine transaminase(ALT),aspartate transaminase(AST),alkaline phosphatase(ALP),total protein,albumin,bilirubin]were studied in serum and tissue using standard protocols and diagnostic *** markers[tumor necrosis factor(TNF-α),interleukin(IL)-6,IL-10 and interferon(IFN)-γ]in serum were evaluated using ELISA-based *** effect of baicalin on liver was also analyzed by histopathological examination of tissue *** Fluoxetine-treated rats showed elevated levels of the serum liver function markers(total bilirubin,ALT,AST,and ALP)and inflammatory markers(TNF-α,IL-6,IL-10 and IFN-γ),with a decline in total protein and albumin

关键词： Fluoxetine Hepatotoxicity Oxidative stress Baicalin Anti-inflammatory Hepatoprotective and antioxidant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modulatory effect of caffeic acid in alleviating diabetes and associated complications

引用

World Journal of Diabetes 2023年第2期14卷 62-75页

作者： Risha Ganguly Shiv Vardan Singh kritika Jaiswal Ramesh kumar abhay k pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002India

Diabetes mellitus(DM)is one of the most common metabolic disorders characterized by elevated blood glucose *** uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy,nephropathy,retinopathy,cardiovascular disorders,and diabetic foot *** production of free radicals causing oxidative stress in tissues is often considered to be the primary cause of onset and progression of DM and associated *** polyphenols can be used to induce or inhibit the expression of antioxidant enzymes such as glutathione peroxidase,heme oxygenase-1,superoxide dismutase,and catalase that are essential in maintaining redox balance,and ameliorate oxidative *** acid(CA)is a polyphenolderived from hydroxycinnamic acid and possesses numerous physiological properties including antioxidant,anti-inflammatory,anti-atherosclerotic,immune-stimulatory,cardioprotective,antiproliferative,and hepatoprotective *** acts as a regulatory compound affecting numerous biochemical pathways and multiple *** include various transcription factors such as nuclear factor-B,tumor necrosis factor-α,interleukin-6,cyclooxygenase-2,and nuclear factor erythroid 2-related factor ***,this review summarizes the pharmacological properties,molecular mechanisms,and pharmacokinetic profile of CA in mitigating the adverse effects of DM and associated *** bioavailability,drug delivery,and clinical trials of CA have also been discussed.

关键词： Diabetes mellitus Caffeic acid Diabetic foot ulcer Retinopathy Nephropathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular signalling during cross talk between gut brain axis regulation and progression of irritable bowel syndrome:A comprehensive review

引用

World Journal of Clinical Cases 2023年第19期11卷 4458-4476页

作者： Shiv Vardan Singh Risha Ganguly kritika Jaiswal Aditya kumar Yadav Ramesh kumar abhay k pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002Uttar PradeshIndia

Irritable bowel syndrome(IBS)is a chronic functional disorder which alters gastrointestinal(GI)functions,thus leading to compromised health *** of IBS is not fully understood,whereas abnormal gut brain axis(GBA)has been identified as a major etiological *** studies are suggestive for visceral hyper-sensitivity,altered gut motility and dysfunctional autonomous nervous system as the main clinical abnormalities in IBS *** signalling interactions among these abnormalities are derived through various exogenous and endogenous factors,such as microbiota population and diversity,microbial metabolites,dietary uptake,and psychological *** efforts focused to study these interactions including probiotics,antibiotics and fecal transplantations in normal and germfree animals are clearly suggestive for the pivotal role of gut microbiota in IBS ***,neurotransmitters act as communication tools between enteric microbiota and brain functions,where serotonin(5-hydroxytryptamine)plays a key role in pathophysiology of *** regulates GI motility,pain sense and inflammatory responses particular to mucosal and brain *** the absence of a better understanding of various interconnected crosstalks in GBA,more scientific efforts are required in the search of novel and targeted therapies for the management of *** this review,we have summarized the gut microbial composition,interconnected signalling pathways and their regulators,available therapeutics,and the gaps needed to fill for a better management of IBS.

关键词： Irritable bowel syndrome Microbiota Gut brain axis Stress Serotonin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aceclofenac-induced hepatotoxicity:An ameliorative effect of Terminalia bellirica fruit and ellagic acid

引用

World Journal of Hepatology 2020年第11期12卷 949-964页

作者： Ashutosh Gupta abhay k pandey Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia

BACkGROUND Aceclofenac(ACF),a widely used nonsteroidal anti-inflammatory drug,has been associated with a number of severe cases of clinical *** bellirica,an evergreen tree,is known to have several ethnomedicinal uses including antioxidant and hepatoprotective *** *** fruit extracts and its phytoconstituent ellagic acid(EA)are expected to provide protection against oxidative stress and liver damage produced by long-term use of *** To evaluate the antioxidant and hepatoprotective activities of *** fruit extracts and EA against ACF-induced toxicity in albino Wistar *** The in vitro antioxidant activities of *** fruit ethyl acetate and aqueous extracts were measured by metal ion chelation and nitric oxide radical scavenging *** in vivo antioxidant and hepatoprotective effects of *** extracts(200 mg/kg)and EA(40 mg/kg)in ACF-induced hepatotoxic rats were assessed in serum and liver tissue after oral administration for 21 ***(40 mg/kg)was used as a standard *** stress markers in the blood(ferric reducing ability of plasma and lipid peroxidation inhibition)and liver tissues(superoxide dismutase,catalase and malondialdehyde)were analyzed using standard *** function markers such as alkaline phosphatase,glutamic pyruvic transaminase,glutamic oxaloacetic transaminase,lactate dehydrogenase,γ-glutamyl transferase,creatinine,total protein,and uric acid were evaluated in rat *** The *** fruit ethyl acetate extract exhibited superior metal ion chelating and nitric oxide radical scavenging abilities during in vitro antioxidant assays as compared to aqueous *** administration of ACF in rats(15 mg/kg)for 21 d produced oxidative stress and adversely affected liver function suggesting liver *** with extracts(ethyl acetate and aqueous),EA and silymarin accounted for a significant reduction in the adverse effects of ACF on oxidative

关键词： Terminalia bellirica Ellagic acid Aceclofenac Hepatotoxicity Antioxidant Histopathology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current therapeutic modalities and chemopreventive role of natural products in liver cancer:Progress and promise

引用

World Journal of Hepatology 2023年第1期15卷 1-18页

作者： Amit kumar Singh Shiv Vardan Singh Ramesh kumar Shashank kumar Sabyasachi Senapati abhay k pandey Department of Botany Government Naveen Girls CollegeBalod(Hemchand Yadav University)DurgChattisgarhIndia Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia Department of Biochemistry School of Basic and Applied SciencesCentral University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia

Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year,with an estimated 5-year survival rate of 30%–35%after *** carcinoma(HCC)constitutes a significant subtype of liver cancer(approximate75%)and is considered primary liver *** for liver cancer mainly depends on the stage of its progression,where surgery including,hepatectomy and liver transplantation,and ablation and radiotherapy are the prime *** advanced liver cancer,various drugs and immunotherapy are used as first-line treatment,whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic *** and lenvatinib are first-line therapies,while regorafenib and ramucirumab are secondline *** metabolic and signaling pathways such as Notch,JAk/STAT,Hippo,TGF-β,and Wnt have played a critical role during HCC *** has also been implicated in liver ***-induced toxicity is a key obstacle in the treatment of liver cancer,necessitating the development of effective and safe medications,with natural compounds such as resveratrol,curcumin,diallyl sulfide,and others emerging as promising anticancer *** review highlights the current status of liver cancer research,signaling pathways,therapeutic targets,current treatment strategies and the chemopreventive role of various natural products in managing liver cancer.

关键词： Liver cancer Hepatocellular carcinoma Signaling pathways Therapeutic targets Natural products Chemopreventive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New Chain Imputation Methods for Estimating Population Mean in the Presence of Missing Data Using Two Auxiliary Variables

引用

Communications in Mathematics and Statistics 2023年第2期11卷 325-340页

作者： Shashi Bhushan abhay Pratap pandey Department of Mathematics and Statistics Dr.Shakuntala Misra National Rehabilitation UniversityLucknowIndia Department of Statistics Ramanujan College University of DelhiNew DelhiIndia

This article deals with some new chain imputation methods by using two auxiliary variables under missing completely at random(MCAR)*** proposed generalized classes of chain imputation methods are tested from the viewpoint of optimality in terms of *** proposed imputation methods can be considered as an efficient extension to the work of Singh and Horn(Metrika 51:267-276,2000),Singh and Deo(Stat Pap 44:555-579,2003),Singh(Stat A J Theor Appl Stat 43(5):499-511,2009),kadilar and Cingi(Commun Stat Theory Methods 37:2226-2236,2008)and Diana and Perri(Commun Stat Theory Methods 39:3245-3251,2010).The performance of the proposed chain imputation methods is investigated relative to the conventional chain-type imputation *** theoretical results are derived and comparative study is conducted and the results are found to be quite encouraging providing the improvement over the discussed work.

关键词： Missing data Imputation MCAR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chemistry and bioactivities of essential oils of some Ocimum species:an overview

引用

Asian Pacific Journal of Tropical Biomedicine 2014年第9期4卷 682-694页

作者： abhay kumar pandey Pooja Singh Nijendra Nath Tripathi Bacteriology and Natural Pesticide Laboratory Department of BotanyDDU Gorakhpur University

Essential oils of different species of the genus Ocimum are natural flavouring materials of commercial *** data given in current literature are pertaining to the chemical composition of essential oils of different Ocimum species viz.,Ocimum basilicum Linn.(*** basilicum ***,Ocimum basilicum ***).Ocimum campechianum Mill.,Ocimum canum Sims.(Ocimum americanum),Ocimum citriodorum,Ocimum gratissimum Linn.,Ocimum kilimandscharicum Linn..Ocimum micranthum Willd.,Ocimum sanctum Linn.,(*** tenuiflorum Linn.),Ocimum selloi Benth..Ocimum trichodon,Ocimum utricifolium from different geographical regions.A considerable difference in chemical composition of a particular species is found,which may be due to their occurrence in different eco-climatic zones and changes in edaphic *** is also focused on the biological properties of Ocimum oils which are related to their various interesting applications as antimicrobial,antioxidant,repellent,insecticidal,larvieidal,nematicidal and therapeutic(anti-inflammatory,antinociceptive,antipyretic,antiulcer,analgesic,anthelmintic,anticarcinogenic,skin permeation enhancer,immunomodulatory,cardio-protective,antilipidemic) agents.

关键词： Ocimum species Essential oil Chemistry Biological properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn,on streptozotocin induced diabetic rats

引用

Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 253-259页

作者： Santram Lodhi abhay k Singhai Department of Pharmaceutical Sciences Dr.H.S.Gour University

Objective:To evaluate wound healing potential of flavonoid fractions of Martynia annua (***) Linn,leaves in diabetic rats on the basis of folkloric information and preliminary ***:The flavonoid compound luteolin and apigenin were isolated from dried leaves of plant by column *** two concenlrations(0.2%and 0.5%w/w) of luteolin and flavonoid fraction were selected for topically applied as ointment on diabetic wound. The Povidone Iodine Ointment USP was used as a *** 18th days,protein content, hydroxyproline and antioxidants(SOD,CAT and GSH) level in granuloma tissues were determined. Results:The results showed that,percent wound contraction were observed significantly(P<0.01) greater in MAF fraction and 0.5%w/w of luteolin treatment *** of matured collagen fibres and fibroblasts with better angiogenesis were observed in histopathological studies. Conclusions:In conclusion,our findings suggest that flavonoid fraction(MAF) and luteolin(0.5% w/w) may have potential benefit in enhancing wound healing in diabetic condition,possibly due to Gee-radical scavenging activity of plant.

关键词： Martynia annua Wound healing Flavonoids Antioxidant Povidone iodine ointment Streptozotocin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Musculoskeletal problems and expressed practices of body mechanics among nursing officers at All India Institute of Medical Sciences Jodhpur,Rajasthan,India

引用

Journal of Integrative Nursing 2021年第3期3卷 128-134页

作者： Subhash kumar SAINI Vandna pandey Ashok kUMAR abhay ELHENCE AIIMS Jodhpur2Department of College of NursingAIIMSJodhpur3Department of OrthopaedicsAIIMSJodhpurIndia

Objective:The objective of the study was to identify musculoskeletal problems(MSPs)among nursing *** and Methods:A nonexperimental research design was *** hundred and seventy nursing officers were selected by purposive sampling *** standardized Nordic questionnaire was used to assess the MSPs and self-structured three-point rating scale was used to assess expressed practice of body mechanics of nursing ***:The study findings revealed that 64.4% of nursing officers suffered from MSP such as ache,pain,and discomfort during the past 12 months and 43.7% during the past 7 *** problem in the low back and the neck were highest 45.1% and 22.2%,*** was followed by MSP of the upper back(14.0%),ankles(13.7%),knees(10.7%),shoulder(10.3%),hip/thighs(5.9%),wrists(4.4%),and elbows(3.3%).Around 49.2%complained that MSPs limit their *** was significant association of MSP with selected personal variables like body mass index(P=0.001)and family history(P=0.02).There were also significant association of expressed practices of body mechanics with gender(P=0.01),area of current work(P=0.00),professional experience(P=0.03)and physical activity(P=0.00).Conclusion:The study indicates the large number of nursing officers had MSPs with the two most common sites being the lower back and the *** creates a need for prompt hospital education programs aimed to create awareness among nursing officers on the prevalence of MSPs.

关键词： Expressed practice musculoskeletal problems nursing officers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：