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Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders:A review

World Journal of Gastroenterology 2022年第26期28卷 3047-3062页

作者： Risha Ganguly Ashutosh Gupta abhay k pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002Uttar PradeshIndia

Baicalin is a natural bioactive compound derived from Scutellaria baicalensis,which is extensively used in traditional Chinese medicine.A literature survey demonstrated the broad spectrum of health benefits of baicalin such as antioxidant,anticancer,anti-inflammatory,antimicrobial,cardio-protective,hepatoprotective,renal protective,and neuroprotective *** is hydrolyzed to its metabolite baicalein by the action of gut microbiota,which is further reconverted to baicalin via phase 2 metabolism in the *** studies have suggested that baicalin exhibits therapeutic potential against several types of hepatic disorders including hepatic fibrosis,xenobiotic-induced liver injury,fatty liver disease,viral hepatitis,cholestasis,ulcerative colitis,hepatocellular and colorectal *** in vitro and in vivo examinations,it has been observed that baicalin showed a protective role against liver and gut-associated abnormalities by modifying several signaling pathways such as nuclear factor-kappa B,transforming growth factor beta 1/SMAD3,sirtuin 1,p38/mitogen-activated protein kinase/Janus kinase,and calcium/calmodulin-dependent protein kinase kinaseβ/adenosine monophosphate-activated protein kinase/acetyl-coenzyme A carboxylase ***,baicalin also regulates the expression of fibrotic genes such as smooth muscle actin,connective tissue growth factor,β-catenin,and inflammatory cytokines such as interferon gamma,interleukin-6(IL-6),tumor necrosis factor-alpha,and IL-1β,and attenuates the production of apoptotic proteins such as caspase-3,caspase-9 and B-cell lymphoma ***,due to its low solubility and poor bioavailability,widespread therapeutic applications of baicalin still remain a *** review summarized the hepatic and gastrointestinal protective attributes of baicalin with an emphasis on the molecular mechanisms that regulate the interaction of baicalin with the gut microbiota.

关键词： Baicalin Biotransformation Gut microbiota Hepatobiliary and gastrointestinal disorders Signaling pathways

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Aceclofenac-induced hepatotoxicity:An ameliorative effect of Terminalia bellirica fruit and ellagic acid

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World Journal of Hepatology 2020年第11期12卷 949-964页

作者： Ashutosh Gupta abhay k pandey Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia

BACkGROUND Aceclofenac(ACF),a widely used nonsteroidal anti-inflammatory drug,has been associated with a number of severe cases of clinical *** bellirica,an evergreen tree,is known to have several ethnomedicinal uses including antioxidant and hepatoprotective *** *** fruit extracts and its phytoconstituent ellagic acid(EA)are expected to provide protection against oxidative stress and liver damage produced by long-term use of *** To evaluate the antioxidant and hepatoprotective activities of *** fruit extracts and EA against ACF-induced toxicity in albino Wistar *** The in vitro antioxidant activities of *** fruit ethyl acetate and aqueous extracts were measured by metal ion chelation and nitric oxide radical scavenging *** in vivo antioxidant and hepatoprotective effects of *** extracts(200 mg/kg)and EA(40 mg/kg)in ACF-induced hepatotoxic rats were assessed in serum and liver tissue after oral administration for 21 ***(40 mg/kg)was used as a standard *** stress markers in the blood(ferric reducing ability of plasma and lipid peroxidation inhibition)and liver tissues(superoxide dismutase,catalase and malondialdehyde)were analyzed using standard *** function markers such as alkaline phosphatase,glutamic pyruvic transaminase,glutamic oxaloacetic transaminase,lactate dehydrogenase,γ-glutamyl transferase,creatinine,total protein,and uric acid were evaluated in rat *** The *** fruit ethyl acetate extract exhibited superior metal ion chelating and nitric oxide radical scavenging abilities during in vitro antioxidant assays as compared to aqueous *** administration of ACF in rats(15 mg/kg)for 21 d produced oxidative stress and adversely affected liver function suggesting liver *** with extracts(ethyl acetate and aqueous),EA and silymarin accounted for a significant reduction in the adverse effects of ACF on oxidative

关键词： Terminalia bellirica Ellagic acid Aceclofenac Hepatotoxicity Antioxidant Histopathology

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Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation

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World Journal of Hepatology 2022年第4期14卷 729-743页

作者： Risha Ganguly Ramesh kumar abhay k pandey Department of Biochemistry University of AllahabadPrayagraj 211002India

BACkGROUND Fluoxetine is one of the most widely prescribed anti-depressant drugs belonging to the category of selective serotonin reuptake ***-term fluoxetine treatment results in ***,a natural compound obtained from the Chinese herb Scutellaria baicalensis is known to have antioxidant,hepatoprotective and anti-inflammatory ***,the beneficial effects of baicalin against fluoxetine-induced hepatic damage have not previously been *** To evaluate the protective action of baicalin in fluoxetine-induced liver toxicity and *** Male albino Wistar rats were divided into seven *** 1 was the normal *** fluoxetine was administered at 10 mg/kg body weight to groups 2,3,4 and *** addition,groups 3 and 4 were also co-administered oral baicalin(50 mg/kg and 100 mg/kg,respectively)while group 5 received silymarin(100 mg/kg),a standard hepatoprotective compound for *** 6 and 7 were used as a positive control for baicalin(100 mg/kg)and silymarin(100 mg/kg),*** treatments were carried out for 28 *** sacrifice of the rats,biomarkers of oxidative stress[superoxide dismutase(SOD),catalase(CAT),reduced glutathione(GSH),glutathione-S-transferase(GST),advanced oxidation protein products(AOPP),malondialdehyde(MDA)],and liver injury[alanine transaminase(ALT),aspartate transaminase(AST),alkaline phosphatase(ALP),total protein,albumin,bilirubin]were studied in serum and tissue using standard protocols and diagnostic *** markers[tumor necrosis factor(TNF-α),interleukin(IL)-6,IL-10 and interferon(IFN)-γ]in serum were evaluated using ELISA-based *** effect of baicalin on liver was also analyzed by histopathological examination of tissue *** Fluoxetine-treated rats showed elevated levels of the serum liver function markers(total bilirubin,ALT,AST,and ALP)and inflammatory markers(TNF-α,IL-6,IL-10 and IFN-γ),with a decline in total protein and albumin

关键词： Fluoxetine Hepatotoxicity Oxidative stress Baicalin Anti-inflammatory Hepatoprotective and antioxidant

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Modulatory effect of caffeic acid in alleviating diabetes and associated complications

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World Journal of Diabetes 2023年第2期14卷 62-75页

作者： Risha Ganguly Shiv Vardan Singh kritika Jaiswal Ramesh kumar abhay k pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002India

Diabetes mellitus(DM)is one of the most common metabolic disorders characterized by elevated blood glucose *** uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy,nephropathy,retinopathy,cardiovascular disorders,and diabetic foot *** production of free radicals causing oxidative stress in tissues is often considered to be the primary cause of onset and progression of DM and associated *** polyphenols can be used to induce or inhibit the expression of antioxidant enzymes such as glutathione peroxidase,heme oxygenase-1,superoxide dismutase,and catalase that are essential in maintaining redox balance,and ameliorate oxidative *** acid(CA)is a polyphenolderived from hydroxycinnamic acid and possesses numerous physiological properties including antioxidant,anti-inflammatory,anti-atherosclerotic,immune-stimulatory,cardioprotective,antiproliferative,and hepatoprotective *** acts as a regulatory compound affecting numerous biochemical pathways and multiple *** include various transcription factors such as nuclear factor-B,tumor necrosis factor-α,interleukin-6,cyclooxygenase-2,and nuclear factor erythroid 2-related factor ***,this review summarizes the pharmacological properties,molecular mechanisms,and pharmacokinetic profile of CA in mitigating the adverse effects of DM and associated *** bioavailability,drug delivery,and clinical trials of CA have also been discussed.

关键词： Diabetes mellitus Caffeic acid Diabetic foot ulcer Retinopathy Nephropathy

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Molecular signalling during cross talk between gut brain axis regulation and progression of irritable bowel syndrome:A comprehensive review

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World Journal of Clinical Cases 2023年第19期11卷 4458-4476页

作者： Shiv Vardan Singh Risha Ganguly kritika Jaiswal Aditya kumar Yadav Ramesh kumar abhay k pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002Uttar PradeshIndia

Irritable bowel syndrome(IBS)is a chronic functional disorder which alters gastrointestinal(GI)functions,thus leading to compromised health *** of IBS is not fully understood,whereas abnormal gut brain axis(GBA)has been identified as a major etiological *** studies are suggestive for visceral hyper-sensitivity,altered gut motility and dysfunctional autonomous nervous system as the main clinical abnormalities in IBS *** signalling interactions among these abnormalities are derived through various exogenous and endogenous factors,such as microbiota population and diversity,microbial metabolites,dietary uptake,and psychological *** efforts focused to study these interactions including probiotics,antibiotics and fecal transplantations in normal and germfree animals are clearly suggestive for the pivotal role of gut microbiota in IBS ***,neurotransmitters act as communication tools between enteric microbiota and brain functions,where serotonin(5-hydroxytryptamine)plays a key role in pathophysiology of *** regulates GI motility,pain sense and inflammatory responses particular to mucosal and brain *** the absence of a better understanding of various interconnected crosstalks in GBA,more scientific efforts are required in the search of novel and targeted therapies for the management of *** this review,we have summarized the gut microbial composition,interconnected signalling pathways and their regulators,available therapeutics,and the gaps needed to fill for a better management of IBS.

关键词： Irritable bowel syndrome Microbiota Gut brain axis Stress Serotonin

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Current therapeutic modalities and chemopreventive role of natural products in liver cancer:Progress and promise

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World Journal of Hepatology 2023年第1期15卷 1-18页

作者： Amit kumar Singh Shiv Vardan Singh Ramesh kumar Shashank kumar Sabyasachi Senapati abhay k pandey Department of Botany Government Naveen Girls CollegeBalod(Hemchand Yadav University)DurgChattisgarhIndia Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia Department of Biochemistry School of Basic and Applied SciencesCentral University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia

Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year,with an estimated 5-year survival rate of 30%–35%after *** carcinoma(HCC)constitutes a significant subtype of liver cancer(approximate75%)and is considered primary liver *** for liver cancer mainly depends on the stage of its progression,where surgery including,hepatectomy and liver transplantation,and ablation and radiotherapy are the prime *** advanced liver cancer,various drugs and immunotherapy are used as first-line treatment,whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic *** and lenvatinib are first-line therapies,while regorafenib and ramucirumab are secondline *** metabolic and signaling pathways such as Notch,JAk/STAT,Hippo,TGF-β,and Wnt have played a critical role during HCC *** has also been implicated in liver ***-induced toxicity is a key obstacle in the treatment of liver cancer,necessitating the development of effective and safe medications,with natural compounds such as resveratrol,curcumin,diallyl sulfide,and others emerging as promising anticancer *** review highlights the current status of liver cancer research,signaling pathways,therapeutic targets,current treatment strategies and the chemopreventive role of various natural products in managing liver cancer.

关键词： Liver cancer Hepatocellular carcinoma Signaling pathways Therapeutic targets Natural products Chemopreventive

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Peroxisome proliferator-activated receptor agonists:A new hope towards the management of alcoholic liver disease

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World Journal of Gastroenterology 2024年第35期30卷 3965-3971页

作者： Siva Sundara kumar Durairajan abhay kumar Singh Ashok Iyaswamy Department of Microbiology School of Life SciencesCentral University of Tamil NaduTiruvarur 610005India School of Biomedical Sciences Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong 999077China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Biochemistry Karpagam Academy of Higher EducationCoimbatore 641021India

In this editorial,we examine a paper by koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the intestinal barrier and reduced liver fibrosis in a mouse model of *** study also underlines the role of PPARs in intestinal barrier function and lipid homeostasis,which are both affected by *** therapies are necessary for ALD because it is a critical health issue that affects people *** editorial analyzes the possibility of PPAR agonists as treatments for *** key factors of inflammation and metabolism,PPARs offer multiple methods for managing the complex etiology of *** assess the abilities of PPARα,PPARγ,and PPARβ/δagonists to prevent steatosis,inflammation,and fibrosis due to liver *** research carried out in preclinical and clinical settings has shown that PPAR agonists can reduce the severity of liver *** editorial discusses the data analyzed and the obstacles,advantages,and mechanisms of action of PPAR agonists for *** research is needed to understand the efficacy,safety,and mechanisms of PPAR agonists for treating ALD.

关键词： Alcoholic liver disease Peroxisome proliferator-activated receptors Peroxisome proliferator-activated receptors agonists Liver fibrosis Inflammation Metabolic regulation Hepatoprotection

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Editorial

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Big Data Mining and Analytics 2024年第2期7卷 I0001-I0002页

作者： kumar, Sunil Mapp, Glenford Bansal, abhay Cengiz, korhan University of Surrey United Kingdom Middlesex University United Kingdom Amity University India Trakya University Turkey

Advanced technologies in science explore the study of business and *** can learn from and make predictions and decisions based on collected data through intelligent *** by technological advances in Big Data,Artificial Intelligence(AI),and Machine Learning(ML),such systems potentially have many applications,roles,and impacts on business and *** stay ahead of the competition,companies must think creatively about incorporating the latest technologies like AI,ML,and Big Data into their policy.

关键词： such companies Foster

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Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout:Insights and therapeutic strategies

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World Journal of Gastroenterology 2024年第40期30卷 4404-4410页

作者： abhay kumar Singh Siva Sundara kumar Durairajan Ashok Iyaswamy Leonard L Williams Department of Microbiology School of Life SciencesCentral University of Tamil NaduTiruvarurTN 610005India School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Biochemistry Karpagam Academy of Higher EducationCoimbatore 641021India Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State UniversityGreensboroNC 27411United States

Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney *** gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy *** article focused on the complex interconnection between alterations in the gut microbiota and the development of this *** studies have suggested that changes in the composition,diversity,and activity of microbes play a key role in establishing and progressing HUA and gout ***,we discussed how the gut microbiota contributes to HUA through purine metabolism,UA excretion,and intestinal inflammatory *** examined specific changes in the composition of the gut microbiota associated with gout and HUA,highlighting key bacterial taxa and the metabolic pathways ***,we discussed the effect of conventional gout treatments on the gut microbiota composition,along with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and *** also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.

关键词： Gut microbiota Dysbiosis Gout Hyperuricemia Inflammation Intestinal barrier Probiotics Prebiotics Fecal microbiota transplantation

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New Chain Imputation Methods for Estimating Population Mean in the Presence of Missing Data Using Two Auxiliary Variables

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Communications in Mathematics and Statistics 2023年第2期11卷 325-340页

作者： Shashi Bhushan abhay Pratap pandey Department of Mathematics and Statistics Dr.Shakuntala Misra National Rehabilitation UniversityLucknowIndia Department of Statistics Ramanujan College University of DelhiNew DelhiIndia

This article deals with some new chain imputation methods by using two auxiliary variables under missing completely at random(MCAR)*** proposed generalized classes of chain imputation methods are tested from the viewpoint of optimality in terms of *** proposed imputation methods can be considered as an efficient extension to the work of Singh and Horn(Metrika 51:267-276,2000),Singh and Deo(Stat Pap 44:555-579,2003),Singh(Stat A J Theor Appl Stat 43(5):499-511,2009),kadilar and Cingi(Commun Stat Theory Methods 37:2226-2236,2008)and Diana and Perri(Commun Stat Theory Methods 39:3245-3251,2010).The performance of the proposed chain imputation methods is investigated relative to the conventional chain-type imputation *** theoretical results are derived and comparative study is conducted and the results are found to be quite encouraging providing the improvement over the discussed work.

关键词： Missing data Imputation MCAR

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