检索结果-南通市图书馆

Development and Application of a Validated HPLC Method for the Determination of Clindamycin Palmitate Hydrochloride in Marketed Drug Products: An Optimization of the Current USP Methodology for Assay

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Analytical Sciences, Methods and Instrumentation 2013年第4期3卷 202-211页

作者： Geoffrey K. Wu abhay gupta Mansoor A. Khan Patrick J. Faustino Division of Product Quality Research Office of Pharmaceutical Science Food and Drug Administration Silver Spring USA. ivision of Product Quality Research Office of Pharmaceutical Science Food and Drug Administration Silver Spring USA. Office of Generic Drugs Food and Drug Administration Rockville USA

A simple efficient isocratic reversed-phase HPLC method was developed and validated for the determination of clindamycin palmitate hydrochloride (CPH) and its commercially available oral solution products. Separation was achieved on a Phenomenex Zorbax (Luna) cyano column (150 × 4.6 mm, 5 μm) with a Phenomenex cyano guard cartridge (4 × 3.0 mm) on Agilent 1050 series HPLC system. CPH and its resolution standard lincomycin were eluted isocratically at a flow rate of 1 mL/min with a simplified mobile phase (potassium phosphate buffer (5 mM, pH 3.0)—acetonitrile—tetrahydrofuran (20:75:5, v/v/v)) and detected at 210 nm. The column was maintained at 25?C. The method was validated according to USP category I requirements. Robustness and forced degradation studies were also conducted. CPH marketed drug products were obtained from a drug distributor and assayed for potency using the validated method. Validation acceptance criteria were met in all cases. The analytical range for CPH was 15 - 500 μg/mL and the linearity was r2 > 0.999 over three days. The method was determined to be specific and robust. Both accuracy (92.0% - 103.8%) and precision (0.67% - 1.52%) were established across the analytical range for low, intermediate and high QC concentrations. Method applicability was demonstrated by analyzing two marketed products of CPH, in which results showed potency >98%. The method was determined to be an enhancement over the current USP methodology for assay as a result of increased efficiency, reduced organic solvents and the elimination of matrix modifiers. This method was successfully applied for the quality assessment of: 1) currently marketed drug products and 2) will in future assess the product quality of novel dosage forms of CPH for pediatric use.

关键词： Clindamycin Palmitate Hydrochloride (CPH) HPLC Method Validation Pediatric Dosage Form

乳腺癌术后自体组织皮瓣乳房重建(文献综述)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国外医学（外科学分册） 2004年第3期31卷 140-142页

作者：刘庆宏 abhay gupta 江苏省泰州市人民医院普外科泰州225300 美国得克萨斯州大学圣安东尼奥科学健康中心整形重建外科，圣安东尼奥，78229-3900

乳腺癌的治疗已经从起初的根治性治疗发展到缩小手术范围及乳房重建 ,乳房重建已经成为乳腺癌治疗的一部分 ,它包括假体重建和自体组织重建 ,由于假体重建的某些局限性及自体组织重建的自然效果 ,越来越多的医生和患者选择自体组织重建... 详细信息

乳腺癌的治疗已经从起初的根治性治疗发展到缩小手术范围及乳房重建 ,乳房重建已经成为乳腺癌治疗的一部分 ,它包括假体重建和自体组织重建 ,由于假体重建的某些局限性及自体组织重建的自然效果 ,越来越多的医生和患者选择自体组织重建乳房。自体组织皮瓣重建乳房既可以在乳腺癌切除手术后立即进行 ,也可以延期进行 ,乳房立即重建的整形效果好而且在肿瘤学角度上是安全的。最常选用的胸部受体血管是胸背血管和乳内血管 ,立即重建常选择胸背血管因为在乳腺癌手术时该血管已暴露 ,而延期重建常选择乳内血管以避免解剖前次手术过的腋窝疤痕。目前 ,常用的自体组织皮瓣主要有 :背阔肌皮瓣、腹直肌转移皮瓣、臀上游离肌皮瓣 ,其中最常用的是腹直肌转移皮瓣 ,游离腹直肌皮瓣比带蒂腹直肌皮瓣更受到欢迎 ,主要是其血供更丰富、皮瓣植入更容易、重建外形更佳 ,其他皮瓣的应用相对较少 ,但在不适合使用腹直肌转移皮瓣时仍然是极佳的候选皮瓣。自体组织皮瓣有着自然、持久、高满意度的乳房重建效果。

关键词：乳腺癌自体组织皮瓣乳房重建显微外科

Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders:A review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第26期28卷 3047-3062页

作者： Risha Ganguly Ashutosh gupta abhay K Pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002Uttar PradeshIndia

Baicalin is a natural bioactive compound derived from Scutellaria baicalensis,which is extensively used in traditional Chinese medicine.A literature survey demonstrated the broad spectrum of health benefits of baicalin such as antioxidant,anticancer,anti-inflammatory,antimicrobial,cardio-protective,hepatoprotective,renal protective,and neuroprotective *** is hydrolyzed to its metabolite baicalein by the action of gut microbiota,which is further reconverted to baicalin via phase 2 metabolism in the *** studies have suggested that baicalin exhibits therapeutic potential against several types of hepatic disorders including hepatic fibrosis,xenobiotic-induced liver injury,fatty liver disease,viral hepatitis,cholestasis,ulcerative colitis,hepatocellular and colorectal *** in vitro and in vivo examinations,it has been observed that baicalin showed a protective role against liver and gut-associated abnormalities by modifying several signaling pathways such as nuclear factor-kappa B,transforming growth factor beta 1/SMAD3,sirtuin 1,p38/mitogen-activated protein kinase/Janus kinase,and calcium/calmodulin-dependent protein kinase kinaseβ/adenosine monophosphate-activated protein kinase/acetyl-coenzyme A carboxylase ***,baicalin also regulates the expression of fibrotic genes such as smooth muscle actin,connective tissue growth factor,β-catenin,and inflammatory cytokines such as interferon gamma,interleukin-6(IL-6),tumor necrosis factor-alpha,and IL-1β,and attenuates the production of apoptotic proteins such as caspase-3,caspase-9 and B-cell lymphoma ***,due to its low solubility and poor bioavailability,widespread therapeutic applications of baicalin still remain a *** review summarized the hepatic and gastrointestinal protective attributes of baicalin with an emphasis on the molecular mechanisms that regulate the interaction of baicalin with the gut microbiota.

关键词： Baicalin Biotransformation Gut microbiota Hepatobiliary and gastrointestinal disorders Signaling pathways

Causative and preventive action of calcium in cataractogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第10期 10-16页

作者： Purshottam Das gupta,Kaid JOHAR,abhay VASAVADA Iladevi Cataract and 1OL Research Centre Gurukul Road Memnagar Ahmedabad 380 052 India Iladevi Cataract and 1OL Research Centre Gurukul Road Memnagar Ahmedabad 380 052 India Iladevi Cataract and 1OL Research Centre Gurukul Road Memnagar Ahmedabad 380 052 India

Calcium and Ca-dependent enzymes play specific role in the development of human cataracts. Entry of Ca2+ into the lens epithelial cells (LEC) is highly regulated by quantum of receptors. The Ca2+level controls homeostasis and growth of entire lens. Intracellular overload of Ca2+ in the LEC trigger a series of events such as activation of Ca-dependent enzymes, irreversible breakdown of important structural proteins and cell death. Proper maintenance of Ca2+ levels by regulating activity of Ca-pumps and Ca-channels and inhibition of Ca-dependent enzymes can help in prevention of cataract. Induction of cell death in the LEC by increase in the intracellular Ca2+ may be utilized for the prevention of posterior capsular opacification.

关键词： calcium lens cataract

Aceclofenac-induced hepatotoxicity:An ameliorative effect of Terminalia bellirica fruit and ellagic acid

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2020年第11期12卷 949-964页

作者： Ashutosh gupta abhay K Pandey Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia

BACKGROUND Aceclofenac(ACF),a widely used nonsteroidal anti-inflammatory drug,has been associated with a number of severe cases of clinical *** bellirica,an evergreen tree,is known to have several ethnomedicinal uses including antioxidant and hepatoprotective *** *** fruit extracts and its phytoconstituent ellagic acid(EA)are expected to provide protection against oxidative stress and liver damage produced by long-term use of *** To evaluate the antioxidant and hepatoprotective activities of *** fruit extracts and EA against ACF-induced toxicity in albino Wistar *** The in vitro antioxidant activities of *** fruit ethyl acetate and aqueous extracts were measured by metal ion chelation and nitric oxide radical scavenging *** in vivo antioxidant and hepatoprotective effects of *** extracts(200 mg/kg)and EA(40 mg/kg)in ACF-induced hepatotoxic rats were assessed in serum and liver tissue after oral administration for 21 ***(40 mg/kg)was used as a standard *** stress markers in the blood(ferric reducing ability of plasma and lipid peroxidation inhibition)and liver tissues(superoxide dismutase,catalase and malondialdehyde)were analyzed using standard *** function markers such as alkaline phosphatase,glutamic pyruvic transaminase,glutamic oxaloacetic transaminase,lactate dehydrogenase,γ-glutamyl transferase,creatinine,total protein,and uric acid were evaluated in rat *** The *** fruit ethyl acetate extract exhibited superior metal ion chelating and nitric oxide radical scavenging abilities during in vitro antioxidant assays as compared to aqueous *** administration of ACF in rats(15 mg/kg)for 21 d produced oxidative stress and adversely affected liver function suggesting liver *** with extracts(ethyl acetate and aqueous),EA and silymarin accounted for a significant reduction in the adverse effects of ACF on oxidative

关键词： Terminalia bellirica Ellagic acid Aceclofenac Hepatotoxicity Antioxidant Histopathology

Free Convection Flow between Vertical Plates Moving in Opposite Direction and Partially Filled with Porous Medium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics 2011年第8期2卷 935-941页

作者： Umesh gupta abhay Kumar Jha Rama Charan Chaudhary 不详

The laminar fully developed free-convection flow in a channel bounded by two vertical plates, partially filled with porous matrix and partially with a clear fluid, has been discussed when both the plates are moving in opposite direction. Two regions are coupled, by equating the velocity and shear stress at the interface. The momentum transfer in porous medium has been described by the Brinkman-extended Darcy model. The affect of Darcy number on flow velocity has been discussed in fluid region, interface region and porous medium with the help of graphs. Analytic method has been adopted to obtain the expressions of velocity and temperature. The skin-friction component has also been determined and presented with the help of tables.

关键词： Free Convection Porous Medium Skin-Friction

Convective Effects on MHD Flow and Heat Transfer between Vertical Plates Moving in Opposite Direction and Partially Filled with a Porous Medium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Applied Mathematics and Physics 2016年第2期4卷 341-358页

作者： V. G. gupta Ajay Jain abhay Kumar Jha Department of Mathematics University of Rajasthan Jaipur India Department of Mathematics Regional College for Education Research and Technology Jaipur India Department of Mathematics JECRC University Jaipur India

The present paper, a theoretical analysis of steady fully developed flow and heat transfer of two immiscible magneto hydrodynamic and viscous fluid, partially filled with porous matrix and partially with clear fluid bounded by two vertical plates, has been discussed, when both the plates are moving in opposite directions. The plates are maintained at unequal temperatures. The Brink-man-extended Darcy model has described the momentum transfer in a porous medium. The effect of various parameters and Darcy number are discussed in the flow field and the temperature profiles numerically and are expressed by graphs. The non-dimensional governing momentum and energy equations are analytically solved by applying the homotopy perturbation technique and the method of ordinary differential equation. It is observed that magnetic parameter (M) has a retarding effect on the main flow velocity and is to enhance the temperature distribution, whereas the reversal phenomenon occurs for the Darcy dissipation parameter (Da). The skin-friction component has also been determined and is presented with the help of a table. The magnetic parameter (M) reduces the skin friction coefficient for clear fluid region and is to increase the skin friction coefficient for porous region. It is also evident from table that getting bigger the width of the clear fluid layer increases the skin friction. The skin friction coefficient on both the plates (comparing at y = 0 and at y = 1 for A or B) increases when those are heated.

关键词： Free Convection MHD Flow Porosity Skin Friction