检索结果-南通市图书馆

Effects of partial portal vein arterialization on the hilar bile duct in a rat model

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 533-538页

作者： shao-Hua Guo, chong-Hui Li,Yong-Liang chen, Jian-Ning Song,Ai-Qun Zhang and cheng Zhou Department of Hepatobiliary Surgery (Guo sh, Li ch, chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo sh), General Hospital of PLA, Beijing 100853, china Department of Hepatobiliary Surgery General Hospital of PLA Beijing 100853 China Department of Surgical Oncology General Hospital of PLA Beijing 100853 China

BACkGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P0.05), but the coun was lower in group B than in group A (Pkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (Pshowed no significan abnormality. chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation.

关键词： portal vein arterialization biliary epithelial cells peribiliary plexus

Ac voltammetric and square wave voltammetric study of the self-assembled monolayers of thiol-functionalized viologen derivative

在线全文

学校读者我要写书评

暂无评论

chinese Journal of chemistry 1997年第2期15卷 130-137页

作者： Li, JH Yang, ch Yan, JC chen, WQ Dong, SJ chINESE ACAD SCI CHANGCHUN INST APPL CHEMELECTROANALYT CHEM LABCHANGCHUN 130022JILINPEOPLES R CHINA

Electroactive self-assembled monolayers (SAMs) containing viologen group are formed through the adsorption of thiol-functionalized viologen compound ch3(ch2)(9)V2+(ch2)(8)sh, where V2+ is N,N'-dialkylbipyridinium (i.e. a viologen group), onto gold electrodes from methanol/water solution and its electrochemical behavior is investigated ty Ac voltammetry and square wave voltammetry, which have the high sensitivity against background charging. The viologen SAM formed is a sub-monolayer and the normal potentials corresponding to the two successive one-electron transfer processes of the active centers (viologen) are -360 mV and -750 mV (vs. Ag/AgCl) in 0.1 mol/L phosphate buffer solutions (pH 6.96) respectively, and the standard electron transfer rate constant is 9.0 s(-1). The electrochemical behavior of this SAM in various solutions has been preliminarily discussed.

关键词： self-assembled monolayers viologen Ac voltammetry square wave voltammetry

在线全文

学校读者我要写书评

暂无评论

数字减影血管造影评价股骨头坏死模型

中国组织工程研究与临床康复 2007年第23期11卷 4538-4541页

作者：王锐英毛小军张其亮杨述华桂林医学院骨科广西壮族自治区桂林市541001 武汉协和医院骨科湖北省武汉市430022 青岛市市立医院(东院)骨科山东省青岛市266011

目的:用数字减影血管造影评价骨膜剥离加髓腔破坏法建立股骨头坏死动物模型的效果。方法:实验于2005-07/2006-01在武汉协和医院中心试验室完成。随机选用成年杂种狗12只,采用骨膜剥离加髓腔破坏法破坏实验动物左侧股骨头的血供,制造股... 详细信息

目的:用数字减影血管造影评价骨膜剥离加髓腔破坏法建立股骨头坏死动物模型的效果。方法:实验于2005-07/2006-01在武汉协和医院中心试验室完成。随机选用成年杂种狗12只,采用骨膜剥离加髓腔破坏法破坏实验动物左侧股骨头的血供,制造股骨头坏死模型,对侧为正常对照。分别于术后1,4,8,16周获取股骨头标本(每个时间点3只动物),制备病理切片进行苏木精-伊红染色观察组织学情况。实验第4周及第16周麻醉后MRI扫描观察股骨头坏死情况。实验动物术前及处死前麻醉后股动脉数字减影血管造影技术检测,比较手术前后股骨头局部的血液循环变化。结果:12只杂种狗均进入结果分析。①病理切片证实全部实验侧标本均出现不同程度股骨头坏死表现,且第16周股骨头标本呈轻度塌陷外观。②狗正常股骨头T1,T2像表现为中低信号影;实验第4周时,造模侧股骨头内表现出散在高信号;第16周时,这些高信号影进一步加大,头下区小片中低信号区。③数字减影血管造影图像显示手术后16周手术区局部出现多量新生血管从股骨颈、髓内等处再生长入有坏死的股骨头内的征象。结论:骨膜剥离加髓腔破坏法能成功建立股骨头坏死模型,且在该模型中存在坏死和重建并存的现象,符合股骨头坏死的病理变化,是一种比较理想的造模方式。

关键词：股骨头坏死动物模型数字减影血管造影

Molecular Profile of Human Serine Palmitoyltransferase-1 Proximate of chromosome 9 Disease Susceptibility Gene Cluster in Inflammatory Cancer Cell Lines

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2014年第10期5卷 885-901页

作者： Tokunbo Yerokun Tamra Neblett chénel Johnson Biology Department Spelman College Atlanta Georgia USA

Background: Over 1100 genes have been annotated for human chromosome 9, including disease genes implicated in inflammation, atherosclerosis, cancer and neurodegeneration. The serine palmitoyltransferase-1, SPTLC1, gene is at the 9q22.2 cytogenetic band, a high G+C content region with common genetic alterations sufficient to modify cellular behavior. The sequence is highly conserved among diverse species from bacteria to humans, including a recently discovered 126 nucleotide alternate open reading frame, AltORF. The protein encoded by the reading frames has domains of biological interest and considerable overlapping molecular functions associated with cellular behavior and cancer progression. Methods: Here we examined molecular features of SPTLC1 in a group of inflammation associated cancer cell lines SkN-sh, MDA-PCa, Glioma LN18, PC3 and 647V. Subcellular localization of SPTLC1 was assessed by immunofluorescence microscopy and recombinant green fluorescent protein expression. In addition, PCR, DNA sequencing and bioinformatics analysis were used for molecular profiling of the SPTLC1 genomic and reverse transcribed cDNA fragments. Results: SPTLC1 is detected in all cell lines examined, with intense peri-nuclear staining, consistent with localization in the cytoplasm. Genomic DNA sample, but not the cD NA of SkN cells could be amplified with an AltORF primer set. The PC3 and MDA-PCa cancer cell lines which are both of prostate origin, show differences in SPTLC1 PCR amplification. Similar levels of SPTLC1 AltORF transcripts were detected by quantitative RT-PCR in all cell lines, except the PC3 cell line with low transcript level whose cDNA did not generate nucleotide base sequence information. Conclusions: This is the first reported transcriptional expression of the SPTLC1 AltORF for the inflammation associated human cancer cell lines. Interestingly, it is proximate of oncogenic cancer susceptibility genes and distal of tumor suppressor genes, the high content of short

关键词： Cytogenetic Band Functional Genomics Human chromosome 9 Microsatellite Instability Serine Palmitoyltransferase-1

Continuous epidermal growth factor receptor-tyrosine kinase inhibitor administration in primary lung adenocarcinoma patients harboring favorable mutations with controlled target lung tumors dose not hinder survival benefit despite small new lesions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Continuous epidermal growth factor receptor-tyrosine kinase ...

PROGRESS OF SYNTHETIC APERTURE SONAR IN chINA

第九届中国肿瘤学术大会暨第十五届海峡两岸肿瘤学术大会

作者： Hsu PC chiu LC Li sh chen ch Wang CL kao kC chang JW Wang CW Yu CT chung FT Yang CT Liu CY 陳志弘 Department of Thoracic Medicine Chang Gung Memorial Hospital at LinkouChang Gung University College of Medicine Department of Oncology Chang Gung Memorial Hospital at LinkouChang Gung University College of Medicine Department of Pathology Chang Gung Memorial Hospital at LinkouChang Gung University College of Medicine 長庚醫院

BACkGROUND:In this study,we investigated the efficacy of continuous epidermal growth factor receptor（EGFR）tyrosine kinase inhibitors（TkIs）administration in lung adenocarcinoma patients harboring favorable mutations regarding the progressive disease（PD）status with appearance of indolent new ***:From June 2010 to October 2012,102 patients with lung adenocarcinoma,harboring favorable EGFR mutations and treated with EGFR-TkI were *** new lesions were detected during EGFR-TkI therapy,even though the primary target tumors were ***:Of the 102 patients,57 continued and 45 discontinued EGFR-TkI *** median overall survival was 529 days for the discontinuation group and 791 days for the continuation group（p=0.0197）.Median survival time after the discontinuation of EGFR-TkI was 181 days and115 days in the discontinuation and continuation groups,respectively（p=0.1776）,whereas median survival time after the appearance of indolent new lesions was 204 days and 262days,respectively（p=0.0237）.CONCLUSION:Continuous EGFR-TkI administration in favorable EGFR-mutative lung adenocarcinoma patients with controlled primary tumors did not hinder the survival benefit,despite the appearance of new lesions.

关键词： Epidermal growth factor receptor-tyrosine kinase inhibitor Overall survival Progression-tree survival Progressive disease Response Evaluation Criteria in Solid Tumors

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

PROGRESS OF SYNTHETIC APERTURE SONAR IN CHINA

2002中国—日本声学学术会议

作者： J. Tang ch. Zhang sh. Li B. Sun J. Liu J. Xu Y. Huang T. Lin sh. Xue L. Li T. Cui H. Huang Y. Li Q. Li Institute of Acoustics chinese Academy of Science 17 Zhongguancun St. Beijing PRC

The Project of synthetic aperture sonar in china started in 1997. Up to now, we have built a prototype of synthetic aperture sonar for lake trial. It is of multi elements, so it can work in high speed

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中心血压测量仪在高血压诊断中的应用

中华高血压杂志 2014年第6期22卷 598-598页

作者： cheng HM Sung sh chuang SY Pearson A Tufanaru C White S Yu WC chen ch 罗冬梅叶鹏

示波中心血压测量仪已成为测量血压的一项新技术。随着新近提出的中心血压诊断阈值,该研究探索新型中心血压测量仪的诊断价值。方法：纳入未使用抗高血压药物人群138名,年龄30～93岁,在导管室同时进行有创和无创血压测量。高血压定义为... 详细信息

示波中心血压测量仪已成为测量血压的一项新技术。随着新近提出的中心血压诊断阈值,该研究探索新型中心血压测量仪的诊断价值。方法：纳入未使用抗高血压药物人群138名,年龄30～93岁,在导管室同时进行有创和无创血压测量。高血压定义为中心血压≥130/90mm Hg（1mm Hg=0.133kPa）,以有创性中心血压为对照,计算新型中心血压测量仪的灵敏度、特异度、阳性预测值（positive predictive value, PPV）和阴性预测值（negative predictive value, NPV）。

关键词：血压测量仪高血压诊断应用抗高血压药物无创血压测量阳性预测值阴性预测值诊断价值

在线全文

学校读者我要写书评

暂无评论

屯田迁徙之塔兰奇人语言文化变迁论略

新疆职业大学学报 2017年第4期25卷 51-55页

作者：覃莎莎伊犁师范学院中国语言分院新疆伊宁835000

在前人研究基础上对比分析了塔兰奇人迁徙前后的语言文化样态,讨论了迁徙后的生活方式等对塔兰奇人语言文化的影响,获得塔兰奇人语言文化变迁的多元性、融合性、适应性及涉外性等特征认知,形成对伊犁维吾尔人——塔兰奇人语言文化多元... 详细信息

在前人研究基础上对比分析了塔兰奇人迁徙前后的语言文化样态,讨论了迁徙后的生活方式等对塔兰奇人语言文化的影响,获得塔兰奇人语言文化变迁的多元性、融合性、适应性及涉外性等特征认知,形成对伊犁维吾尔人——塔兰奇人语言文化多元内涵的多视角了解。屯田迁徙是促进伊犁维吾尔人语言文化嬗变的主要因素,民族进步发展是构筑国家统一稳定大局的基础之一,且具有一定的现实意义。

关键词：维吾尔人屯田迁徙塔兰奇语言文化嬗变

在线全文

学校读者我要写书评

暂无评论

改进粉紋技术的初步研究

金属学报 1965年第4期 537-539页

作者：孙绅太陈炳兆中国科学院冶金研究所

粉纹技术是观察磁畴结构广泛应用的方法。它的中心环节是磁性悬溶胶的制备。制备悬溶胶的方法虽然有过改进和发展(其中多数工作旨在便于利用电子显微镜进行观察),但迄今广泛应用的仍然是Elmore的方法。即便在文献[1]的一些工作中,可以说... 详细信息

粉纹技术是观察磁畴结构广泛应用的方法。它的中心环节是磁性悬溶胶的制备。制备悬溶胶的方法虽然有过改进和发展(其中多数工作旨在便于利用电子显微镜进行观察),但迄今广泛应用的仍然是Elmore的方法。即便在文献[1]的一些工作中,可以说,制备磁性氧化铁粉的配方没有改变。

关键词：磁性氧化铁粉初步研究离心分离溶胶胶体蒸馏水生成自由能多晶晶体磁畴结构油酸钠质量作用定律分子浓度定律