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Safety of Malaysian marine endophytic fungal extract S2 from a brown seaweed Turbinaria conoides

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Journal of Coastal Life Medicine 2014年第7期 527-534页

作者： Siti Alwani Ariffin Kalavathy Ramasamy Paul Davis vasudevan Mani Mahmood Ameen Abdulla Faculty of Pharmacy University Teknologi MARA(UiTM)42300 Bandar Puncak AlamSelangor Darul Ehsan Malaysia Marine Pharmaceutical Research Group(MaReG) Brain and Neuroscience Communities of ResearchUniversity Teknologi MARA(UiTM)40450 Shah AlamSelangor Darul Ehsan Malaysia Collaborative Drug Discovery Research Group Brain and Neuroscience Communities of ResearchUniversity Teknologi MARA(UiTM)40450 Shah AlamSelangor Darul Ehsan Malaysia Department of Medicine University of OtagoPO Box 7343NewtownWellington South 6242New Zealand Department of Medicine University of MalayaMalaysia

Objective:To evaluate the in vivo acute toxicity and antioxidant activity of the marine endophytic fungus extract S2 isolated from Turbinaria ***:Two doses(100 mg/kg and 400 mg/kg)of the S2 extract were administered to rats orally for acute toxicity and antioxidant *** body weight,relative weight of six organs,haematological,biochemical and antioxidant properties were investigated on Day ***:A single oral dose treatment did not cause any mortality or observable adverse effects in *** significant variations in the body and organ weights between the control and the treated groups were *** analysis and clinical blood chemistry also did not reveal any toxic effects of the *** total white blood cell count and haemoglobin levels were *** levels of total serum cholesterol in males treated with 100 and 400 mg/kg were significantly(P<0.05)decreased(1.28 and 1.34 mmol/L respectively)compared to control(1.55 mmol/L)***,neither gross abnormalities nor histopathological changes were *** study showed strong evidence of the non-toxic effects of S2 *** the extract exhibited significant(P<0.05)antioxidant activity through increased levels of superoxide dismutase and glutathione peroxidase enzy mes in serum,liver and ***:The research findings from the present study showed the potential of marine natural products particularly in Malaysia as a source of bioactive *** endophytic fungi as a potential source of anticancer drugs with great potential as they are potent yet safe,thus deserving further extensive investigation.

关键词： Endophytes Turbinaria conoides Acute toxicity Cytotoxicity Antioxidant

Multisystem Inflammatory Syndrome-Neonate: Biochemical Parameters as Early Marker of Adverse Neurodevelopmental Outcome

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Open Journal of Pediatrics 2022年第5期12卷 767-782页

作者： Perumalsathya Sankaranarayanan Harshitha Shanmuganathan Devika Sanil Kumar Lal Devayani vasudevan Nair Santosh Kamalakannan Department of Pediatrics Saveetha Medical College and Hospital Chennai India Department of Research and Development Saveetha Medical College and Hospital Chennai India Department of Neonatology Saveetha Medical College and Hospital Chennai India

Background: Pregnant women and newborns are highly susceptible to Covid-19, manifesting as multisystem inflammatory syndrome-New-born (MISC-N) in many babies born to Covid positive mothers. The relationship between Covid-19 infection during pregnancy and neonatal neurodevelopmental outcome, if any, is unclear necessitating a follow-up study in this aspect. Methods: 16 babies with MIS-N, born to symptomatic Covid antibody positive mothers were enrolled. Demographic profile, treatment details and biochemical parameters were analyzed with neurodevelopmental follow-up. Results: 25% mothers received 2 doses of Covid vaccine;50% had oligohydramnios and 75% received antenatal steroids. 87.5% were preterm of which 62.5% required surfactant with ventilator support and 75% required ionotropic support. Significant association was found between the antibody level and D-dimer levels with the ferritin and LDH levels of the baby (p 0.05);gestational age with LDH and D-dimer levels (p 0.05) and Covid antibody level of the baby vs the duration of ventilator requirement (P-value-0.0009). D-dimer values of babies were positively associated with both maternal antibody and D-dimer levels. Neurodevelopmental follow-up done at 6 months of corrected gestational age showed 37.5% were normal, 37.5% hypertonic and 25% hypotonic. HINE score was below 60 in 62.5%. Development assessment using Bayley-III showed a delay in the motor domain (62.5%), cognitive domain (56.25%) and language domain (62.5%). Conclusion: Neurodevelopmental problems occur in babies born to Covid positive mothers and should be stratified as “high risk”. Anticipatory guidance to prospective mothers for preterm care should be given. Covid antibody titre and D-dimer levels may help to predict the NICU stay, ventilator requirement and the adverse neurodevelopmental outcomes in these babies.

关键词： Neurodevelopment Covid-19 Pregnancy Multisystem Inflammatory Syndrome Biochemical Markers D-Dimer HINE Score

Comparison of ocular modulation transfer function determined by a ray-tracing aberrometer and a double-pass system in early cataract patients

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Chinese Medical Journal 2014年第19期127卷 3454-3458页

作者： Qiao Liya Wan Xiuhua Cai Xiaogu Balamurali vasudevan Xiong Ying Tan Jiaxuan Guan Zheng David A Atchison Wang Ningli Beijing Tongren Eye Center Beijing Tongren Hospital CapitalMedical University Beijing Ophthalmology & Visual Science KeyLaboratory Capital Medical University Beijing 100730 China College of Optometry Midwestem University Glendale ArizonaUnited States School of Optometry & Vision Science and Institute of Health&Biomedical Innovation Queensland University of TechnologyAustralia

Background The evaluation of retinal image quality in cataract eyes has gained importance and the clinical modulation transfer functions （MTF） can obtained by aberrometer and double pass （DP） system. This study aimed to compare MTF derived from a ray tracing aberrometer and a DP system in early cataractous and normal eyes. Methods There were 128 subjects with 61 control eyes and 67 eyes with early cataract defined according to the Lens Opacities Classification System II1. A laser ray-tracing wavefront aberrometer （iTrace） and a double pass （DP） system （OQAS） assessed ocular MTF for 6.0 mm pupil diameters following dilation. Areas under the MTF （AUMTF） and their correlations were analyzed. Stepwise multiple regression analysis assessed factors affecting the differences between iTrace- and OQAS-derived AUMTF for the early cataract group. Results For both early cataract and control groups, iTrace-derived MTFs were higher than OQAS-derived MTFs across a range of spatial frequencies （P 〈0.01）. No significant difference between the two groups occurred for iTrace-derived AUMTF, but the early cataract group had significantly smaller OQAS-derived AUMTF than did the control group （P 〈0.01）. AUMTF determined from both the techniques demonstrated significant correlations with nuclear opacities, higher-order aberrations （HOAs）, visual acuity, and contrast sensitivity functions, while the OQAS-derived AUMTF also demonstrated significant correlations with age and cortical opacity grade. The factors significantly affecting the difference between iTrace and OQAS AUMTF were root-mean-squared HOAs （standardized beta coefficient=-0.63, P 〈0.01） and age （standardized beta coefficient=0.26, P 〈0.01）. Conclusions MTFs determined from a iTrace and a DP system （OQAS） differ significantly in early cataractous and normal subjects. Correlations with visual performance were higher for the DP system. OQAS-derived MTF may be useful as an indicator of visual performance in early cataract eyes.

关键词： cataract contrast sensitivity function double-pass system modulation transfer function retinal image quality," wavefront aberration

Stability-indicating assay method for determination of actarit,its process related impurities and degradation products:Insight into stability profile and degradation pathways

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Journal of Pharmaceutical Analysis 2014年第6期4卷 374-383页

作者： A.Abiramasundari Rahul P.Joshi Hitesh B.Jalani Jayesh A.Sharma Dhaivat H.Pandya Amit N.Pandya vasudevan Sudarsanam Kamala K.Vasu Department of Medicinal Chemistry B.V. Pat el PERD Centre Ahmedcibad Gujarat 380054 India

The stability of the drug actarit was studied under different stress conditions like hydrolysis（acid,alkaline and neutral）,oxidation,photolysis and thermal degradation as recommended hy International Conference on Harmonization（ICH） *** was found to be unstable in acidic,basic and photolytic conditions and produced a common degradation product while oxidative stress condition produced three additional degradation *** was impassive to neutral hydrolysis,dry thermal and accelerated stability *** products were identified,isolated and characterized by different spectroscopic *** and the degradation products were synthesized by a new route using green *** chromatographic separation of the drug and its impurities was achieved in a phenomenex luna C18 column employing a step gradient elution by high performance liquid chromatography coupled to photodiode array and mass spectrometry detectors（HPLC-PDAMS）.A specilic and sensitive stability-indicating assay method for the simultaneous determination of the drug *** process related impurities and degradation products was developed and validated.

关键词： Actarit Forced degradation Stability-indicating assay method

Molecular cloning and characterization of fruit specific promoter from <i>Cucumis sativus</i>L.

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American Journal of Molecular Biology 2012年第2期2卷 132-139页

作者： Sindhu Chandrika Unni Padmanabhan Jayanthikumari Vivek Thakidiyil Thankappan Maju Rintu Thundiyil Varghese Eppurathumana vasudevan Soniya Plant Molecular Biology Lab Rajiv Gandhi Centre for Biotechnology Poojappura India

The isolation and characterization of fruit specific promoters are critical for the manipulation of nutritional value and agronomic quality of fruits by genetic engineering and also opened a new era in edible vaccine technology. Expansins are proteins that induce loosening of individual plant cells by disrupting the non-covalent interactions between cellulose and hemicellulose microfibrils and hence have role in growth programs including fruit ripening. We report the identification of an expansin gene (CsExp) from Cucumis sativus that exhibits high levels of mRNA abundance and is specifically expressed in ripened fruit. The promoter region of CsExp also contains elements responsible for its fruit specific expression. Transient expression studies of the CsExp promoter were conducted with particle bombardment, followed by GUS histochemical assay and real time PCR. CaMV35S promoter was used as the positive control in all these experiments. Clear fruit specificity was observed for CsExp promoter in all the experiments. Thus CsExp promoter from Cucumber is a good candidate to target expression of the foreign genes to engineer fruit specific traits.

关键词： Cucumber Expansin Fruit Specific Promoter Transient Expression Glucuronidase

Prevalence and treatment patterns of ranibizumab and photodynamic therapy in a tertiary care setting in Malaysia

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1889-1897页

作者： Nur Afiqah Mohamad vasudevan Ramachandran Patimah Ismail Hazlita Mohd Isa Yoke Mun Chan Nor Fariza Ngah Norshakimah Md Bakri Siew Mooi Ching Fan Kee Hoo Wan Aliaa Wan Sulaiman Malaysian Research Institute on Ageing Universiti Putra Malaysia Department of Biomedical Science Faculty of Medicine and Health Sciences Malaysian Research Institute on Ageing Universiti PutraMalaysiaSerdangSelangor DE 43400Malaysia Department of Biomedical Science Faculty of Medicine andHealth SciencesUniversiti Putra MalaysiaSerdangSelangorDE 43400Malaysia Department of Ophthalmology Universiti KebangsaanMalaysia Medical CentreCherasKuala Lumpur 56000Malaysia Department of Nutrition and Dietetics Faculty of Medicineand Health SciencesUniversiti Putra MalaysiaSerdangSelangor DE 43400Malaysia Department of Ophthalmology Hospital SelayangLebuhrayaSelayang-KepongBatu Caves 68100Malaysia Department of Family Medicine Faculty of Medicine andHealth SciencesUniversiti Putra MalaysiaSerdangSelangorDE 43400Malaysia Department of Medicine Faculty of Medicine and HealthSciencesUniversiti Putra MalaysiaSerdangSelangor DE43400Malaysia

AIM：To describe the prevalence and changes in treatment patterns of ranibizumab and photodynamic therapy（PDT） among retinal disease patients who attended the Ophthalmology Clinic in the tertiary care Hospital Selayang from 2010 to ***：Study subjects were recruited retrospectively using the Electronic Medical Record（EMR） database software in Hospital *** data,medical history,diagnostic procedure,treatments and diagnosis of patients were ***：The five-year analysis included 821 patients with a mean age of 65.9±11.73 ***,there were a highernumber of males（63.1%） and a higher number of Chinese（47.4%） *** the 821 patients,62.9% received ranibizumab injection followed by 19.2% PDT therapy and 17.9% had ranibizumab combined with PDT ***-related macular degeneration（AMD） and polypoidal choroidal vasculopathy（PCV） were the most common retinal eye diseases reported,recording prevalence of 25.0% and 45.6%,*** trend in ranibizumab treatment was reported to increase while PDT showed a decrease in trend from year 2010 to *** terms of treatment,following multiple logistic regression,AMD was associated with the subjects being more likely to have received ranibizumab monotherapy（P〈0.001） while PCV was associated with more likely to have received PDT（P〈0.001） and PDT combined with ranibizumab therapy（P〈0.001）.CONCLUSION：The tertiary care setting in Malaysia is consistent with management of patients from other countries whereby ranibizumab is the most common treatment given to patients with AMD,while PCV patients most commonly receive PDT and ranibizumab combined with PDT therapy.

关键词： anti-vascular endothelial growth factor therapy photodynamic therapy ranibizumab treatment patterns

马来西亚新山市工作相关眼外伤调查分析（英文）

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国际眼科杂志 2016年第3期16卷 416-422页

作者： Nyo Nyo Min Suresh Kumar vasudevan Azlyn Azwabinti Jasman Aisyahbinti Ali Kay Thi Mvint Sultan Ismail医院眼科马来西亚新山81110 Sultanah Aminah医院眼科马来西亚新山80100 Sultan Ismail医院临床研究中心马来西亚新山81110 马来西亚世纪大学医学院马来西亚沙捞越96000

目的：调查马来西亚南部三级医院的工作相关眼外伤的流行病学与其视力情况。方法：回顾性调查研究。选取2011年1月至2013年12月在马来西亚新山市Sultan Ismail医院就诊的工作相关眼外伤患者的病历资料。运用标准表格形式收集临床表现,... 详细信息

目的：调查马来西亚南部三级医院的工作相关眼外伤的流行病学与其视力情况。方法：回顾性调查研究。选取2011年1月至2013年12月在马来西亚新山市Sultan Ismail医院就诊的工作相关眼外伤患者的病历资料。运用标准表格形式收集临床表现,损伤种类,眼部保护装置的使用和视力情况等数据。结果：在3y内共935例眼外伤患者于Sultan Ismail医院就诊,其中440例为工作相关眼外伤,且男性占绝大多数（98.19%）,常见年龄在21y至30y之间（45%）。最常见的损伤种类为眼表损伤（70.9%）,其次是化学损伤（11.13%）,开放性眼外伤（8.4%）,闭合性眼外伤（6.83%）和热灼伤（2.7%）。虽然工作相关眼外伤普遍为当地人（78.5%）,但其中三分之二的开放性眼外伤出现在外来劳工中。仅59例患者（13.4%）在受伤时配戴眼部保护装置。通常89.9%（n=399）的患者视力良好,5.45%（n=24）的患者视力一般,3.86%（n=17）的患者视力较差。视力预后与损伤类型的相关性分析表明,开放性眼外伤的视力较闭合性眼外伤差（OR=3.33,95%CI=0.68-16.33）。2011/2013年,工作相关眼外伤新病例的整体就诊率为20.7译~51.9译,大约每年下降1.5%（P〈0.05）。相比之下,工作相关眼外伤住院患者在3y期间有所增加。工作相关眼外伤致单眼盲或低视力患者（最佳矫正视力≤3/60）约占就诊人数的1.26译（95%可信区间为0.74至2.02）。结论：工作相关眼外伤是致从业人员眼病的重要原因,特别是年轻人。当地21y到40y的男性为高危人群。大多数我院接收的工作相关眼外伤患者均为可避免的眼表损伤。本研究表明劳工们需要加强安全措施,预防意外失明,避免增加社会经济负担。除此之外,还需建立眼损伤信息记录系统。

关键词：工作相关眼外伤保护装置视力情况

Glycemic Index and Response of a Plant Based Nutritional Supplement and Its Subjective Satiety Following Its Use in Indian Adults

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Food and Nutrition Sciences 2019年第8期10卷 937-946页

作者： Bhoite Rachana Parthasarthy Vijayalakshmi Raman Jeevan Ganesh Viswanathan Gopinath Karthikeyan Parkavi vasudevan Kavitha Nagamuthu Gayathri Rajagopal Gayathri Shanmugam Shobana Ranjit Mohan Anjana Ranjit Unnikrishnan vasudevan Sudha Mehta Suyog Archana Toppo Panda Acharya Shivani Viswanathan Mohan Dr. Reddy’s Laboratories Hyderabad India Department of Foods Nutrition & Dietetics Research Madras Diabetes Research Foundation Chennai India Department of Diabetology Dr. Mohan’s Diabetes Specialities Centre Chennai India

Background: Diet plays a vital role in managing diabetes. Foods with a low glycemic index provide lower postprandial glucose spikes and induce satiety. The objective of this study was to assess the Glycemic index (GI) without milk and Glycemic response (GR) with milk of two different flavours of a plant-based supplement which is high in protein and fibre, along with a subjective assessment of satiety. Methods: Fifteen overweight/obese subjects aged 18 - 45 years were recruited. After overnight fasting, blood samples were drawn at 5 mins before food consumption (-5), 0, 15, 30, 45, 60, 90 and 120 minutes. Participants underwent 3 days of reference food testing and 1 day of test food in random order with 2 days of wash-out period. The GI was assessed using a validated protocol recognized by FAO/WHO, as well as the guidelines by the International Dietary Carbohydrate Task Force for GI Methodology. The satiety index was measured using the Visual Analog Scale (VAS). The dietary intake of the subjects was measured by 24-hour dietary recall. The Incremental Area Under the Curve (IAUC) was calculated using the trapezoid rule. Results: Both the flavours of the supplement had low GI & GR. The GI and GR of Flavour 1 were 27.3 ± 4.8 & 16.4 ± 2.6 (Mean ± SEM) respectively. For Flavour 2 the GI and GR were 36.7 ± 4.4 & 25.7 ± 2.3 (Mean ± SEM). For Flavour 1, 60% and for flavour 2 66.7% of subjects reported feeling hungry only after 3 hours, showing good satiety. Conclusion: The plant-based high fibre high protein supplement in both flavours showed a low glycemic index and hence may be useful to include in the diets to reduce the postprandial glycemic response and could improve satiety.

关键词： Glycemic Index High Protein High Fiber Satiety Visual Analog Scale

Deep data analytics for genetic engineering of diatoms linking genotype to phenotype via machine learning

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npj Computational Materials 2019年第1期5卷 580-587页

作者： Artem A.Trofimov Alison A.Pawlicki Nikolay Borodinov Shovon Mandal Teresa J.Mathews Mark Hildebrand Maxim A.Ziatdinov Katherine A.Hausladen Paulina K.Urbanowicz Chad A.Steed Anton V.Ievlev Alex Belianinov Joshua K.Michener Rama vasudevan Olga S.Ovchinnikova Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Environmental Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37830USA Scripps Institute of Oceanography University of CaliforniaSan DiegoLa JollaCA 92093USA Computer Science and Mathematics Division Oak Ridge National LaboratoryOak RidgeTN 37830USA Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37830USA

Genome engineering for materials synthesis is a promising avenue for manufacturing materials with unique properties under ambient *** in diatoms,unicellular algae that use silica to construct micron-scale cell walls with nanoscale features,is an attractive candidate for functional synthesis of materials for applications including photonics,sensing,filtration,and drug ***,controllably modifying diatom structure through targeted genetic modifications for these applications is a very promising *** this work,we used gene knockdown in Thalassiosira pseudonana diatoms to create modified strains with changes to structural morphology and linked genotype to phenotype using supervised machine *** artificial neural network(NN)was developed to distinguish wild and modified diatoms based on the SEM images of frustules exhibiting phenotypic changes caused by a specific protein(Thaps3_21880),resulting in 94% detection *** activation maps visualized physical changes that allowed the NNs to separate diatom strains,subsequently establishing a specific gene that controls pores.A further NN was created to batch process image data,automatically recognize pores,and extract pore-related *** interrelationship of the extracted paraments was visualized using a multivariate data visualization tool,called CrossVis,and allowed to directly link changes in morphological diatom phenotype of pore size and distribution with changes in the genotype.

关键词： pores walls linking